Details of Drug

Drug General Information (ID: D1845)
Drug Name	Metyrapone
Drug Type	Small molecule
Drug Synonymous	MYT; Mepyrapone; Metapirone; Metapyron; Methapyrapone; Methbipyranone; Methopirapone; Methopyrapone; Methopyrinine; Methopyrone; Metirapona; Metopiron; Metopirone; Metopyrone; Metroprione; Metyrapon; Metyraponum; Alliance Brand of Metyrapone; Metyrapone Alliance Brand; Metyrapone Novartis Brand; Novartis Brand of Metyrapone; Su 4885; METOPIRONE (TN); Metirapona [INN-Spanish]; Metopirone (TN); Metyraponum [INN-Latin]; Su-4885; Metyrapone (JP15/USP/INN); Metyrapone [USAN:INN:BAN:JAN]; 1,2-Di-3-pyridyl-2-methyl-1-propanone; 2-Methyl-1,2-bis(3-pyridyl)-1-propanone; 2-Methyl-1,2-di-3-pyridinyl-1-propanone; 2-Methyl-1,2-di-3-pyridyl-1-propanone; 2-methyl-1,2-dipyridin-3-yl-propan-1-one; 2-methyl-1,2-dipyridin-3-ylpropan-1-one Click to Show/Hide
Disease Class	5A70: Cushing syndrome
Therapeutic Class	Antimetabolites
Structure
Structure	3D Structure		2D Structure
Formula	C14H14N2O
InChI	1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
InChIKey	FJLBFSROUSIWMA-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
External Link
	Pubchem ID	4174
	CAS Number	CAS 54-36-4
	CHEBI ID	CHEBI:44241
	TTD ID	D0Q9JT

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM007 Pharmacodynamic antagonistic effects BM098 Antagonize the effect of serotonergic agents
Relation Graph

Full list of drugs interacting with Metyrapone
Pharmacodynamic antagonistic effects
	Antagonize the effect of serotonergic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[1], [2], [3]

References
1	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
2	Plonk J, Feldman JM "Modification of adrenal function by the anti-serotonin agent cyproheptadine." J Clin Endocrinol Metab 42 (1975): 291-5. [PMID: 177441]
3	Plonk J, Feldman JM "Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine." Metabolism 24 (1975): 1035-46. [PMID: 1171350]