Details of Drug

Drug General Information (ID: D1843)
Drug Name	Methyl salicylate (topical)
Drug Type	Small molecule
Drug Synonymous	methyl salicylate; Methyl 2-hydroxybenzoate; 119-36-8; Wintergreen oil; Gaultheria oil; Betula oil; Teaberry oil; Sweet birch oil; OIL OF WINTERGREEN; Analgit; Spicewood Oil; Wintergruenoel; 2-Hydroxybenzoic acid methyl ester; Gaultheriaoel; Flucarmit; Exagien; Betula; Methyl o-hydroxybenzoate; 2-Carbomethoxyphenol; 2-(Methoxycarbonyl)phenol; Natural Wintergreen Oil; Betula Lenta; BIRCH-ME; Salicylic acid, methyl ester; Synthetic Wintergreen Oil; Benzoic acid, 2-hydroxy-, methyl ester; Gaultheria oil, artificial; Wintergreen Oil, syn Click to Show/Hide
Therapeutic Class	Topical Anti-Irritants
Structure
Structure	3D Structure		2D Structure
Formula	C8H8O3
InChI	1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3
InChIKey	OSWPMRLSEDHDFF-UHFFFAOYSA-N
Canonical SMILES	COC(=O)C1=CC=CC=C1O
External Link
	Pubchem ID	4133
	CAS Number	CAS 119-36-8
	CHEBI ID	CHEBI:31832
	TTD ID	D0Z0AA

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM050 Increased risk of bleeding
Relation Graph

Full list of drugs interacting with Methyl salicylate (topical)
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[1], [2], [3]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[1], [2], [3]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1], [2], [3]

References
1	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
2	Joss JD, LeBlond RF "Potentiation of warfarin anticoagulation associated with topical methyl salicylate." Ann Pharmacother 34 (2000): 729-33. [PMID: 10860133]
3	Chan TY "Adverse interactions between warfarin and nonsteroidal antiinflammatory drugs: mechanisms, clinical significance, and avoidance." Ann Pharmacother 29 (1995): 1274-83. [PMID: 8672833]