Details of Drug

Details of Drug

 Drug General Information (ID: D1814)
  Drug Name
Icatibant
  Drug Type Small molecule
  Drug Synonymous
Firazyr; Icatibant [INN]; HOE 140; HOE140; JE049; WIN 65365; Hoe-140; WIN-65365; D-Arg(Hyp(3)-Thi(5)-D-Tic(7)-Oic(8))BK
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  Disease Class 4A00: Innate/adaptive immunodeficiency
  Therapeutic Class Antiinflammatory Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C59H89N19O13S
  InChI 1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
  InChIKey QURWXBZNHXJZBE-SKXRKSCCSA-N
  Canonical SMILES C1CCC2C(C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)C(CO)NC(=O)C(CC5=CC=CS5)NC(=O)CNC(=O)C6CC(CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)N)O)C(=O)NC(CCCN=C(N)N)C(=O)O
  External Link
Pubchem ID 6918173
CAS Number CAS 130308-48-4
TTD ID D04ZBT

Drug-Drug Interaction Network
  Sunburst Graph
AM007  Pharmacodynamic antagonistic effects
BM089  Antagonize the effect of antihypertensive agents
  Relation Graph
 Full list of drugs interacting with Icatibant
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antihypertensive agents Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0156
 
Benazepril
 
C24H28N2O5
 
5362124 
Moderate    Inter Info   
[1], [2], [3]
D0254
 
Captopril
 
C9H15NO3S
 
44093 
Moderate    Inter Info   
[1], [2], [3]
D0567
 
Enalapril
 
C20H28N2O5
 
5388962 
Moderate    Inter Info   
[1], [2], [3]
D0695
 
Fosinopril
 
C30H46NO7P
 
55891 
Moderate    Inter Info   
[1], [2], [3]
D0938
 
Lisinopril
 
C21H31N3O5
 
5362119 
Moderate    Inter Info   
[1], [2], [3]
D1082
 
Moexipril
 
C27H34N2O7
 
91270 
Moderate    Inter Info   
[1], [2], [3]
D1256
 
Perindopril
 
C19H32N2O5
 
107807 
Moderate    Inter Info   
[1], [2], [3]
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Moderate    Inter Info   
[1], [2], [3]
D1379
 
Ramipril
 
C23H32N2O5
 
5362129 
Moderate    Inter Info   
[1], [2], [3]
D1618
 
Trandolapril
 
C24H34N2O5
 
5484727 
Moderate    Inter Info   
[1], [2], [3]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3 Product Information. Firazyr (icatibant). Shire US Inc, Florence, KY.