Details of Drug

Details of Drug

 Drug General Information (ID: D1791)
  Drug Name
Gadobenic acid
  Drug Type Small molecule
  Drug Synonymous
Gadobenic acid|Q5516409
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  Therapeutic Class Diagnostic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C22H28GdN3O11
  InChI InChI=1S/C22H31N3O11.Gd/c26-18(27)10-23(6-7-24(11-19(28)29)12-20(30)31)8-9-25(13-21(32)33)17(22(34)35)15-36-14-16-4-2-1-3-5-16;/h1-5,17H,6-15H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35);/q;+3/p-3
  InChIKey MXZROTBGJUUXID-UHFFFAOYSA-K
  Canonical SMILES C1=CC=C(C=C1)COCC(C(=O)[O-])N(CCN(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)O)CC(=O)O.[Gd+3]
  External Link
Pubchem ID 9852779

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
BM012  Competitive inhibition of transporters
BM048  Increased risk of angioedema/anaphylactoid reactions
BM072  Increased risk of nephrotoxicity
  Relation Graph
 Full list of drugs interacting with Gadobenic acid
      Affected cellular transport
   Competitive inhibition of transporters Drug Num:  23
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Moderate    Inter Info   
[1], [2]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Moderate    Inter Info   
[1], [2]
D0429
 
Daunorubicin
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[1], [2]
D0430
 
Daunorubicin (liposomal)
 
C27H29NO10
 
30323 
Moderate    Inter Info   
[1], [2]
D0584
 
Epirubicin
 
C27H29NO11
 
41867 
Moderate    Inter Info   
[1], [2]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Moderate    Inter Info   
[1], [2]
D0511
 
Docetaxel
 
C43H53NO14
 
148124 
Moderate    Inter Info   
[1], [2]
D0528
 
Doxorubicin
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[1], [2]
D0529
 
Doxorubicin (liposomal)
 
C27H29NO11
 
31703 
Moderate    Inter Info   
[1], [2]
D0627
 
Etoposide
 
C29H32O13
 
36462 
Moderate    Inter Info   
[1], [2]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Moderate    Inter Info   
[1], [2]
D0788
 
Idarubicin
 
C26H27NO9
 
42890 
Moderate    Inter Info   
[1], [2]
D1212
 
Paclitaxel
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[1], [2]
D1213
 
Paclitaxel (protein-bound)
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[1], [2]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Moderate    Inter Info   
[1], [2]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Moderate    Inter Info   
[1], [2]
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[1], [2]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Moderate    Inter Info   
[1], [2]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Moderate    Inter Info   
[1], [2]
D1678
 
Valrubicin
 
C34H36F3NO13
 
454216 
Moderate    Inter Info   
[1], [2]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[1], [2]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[1], [2]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Moderate    Inter Info   
[1], [2]
      Pharmacodynamic additive effects
   Increased risk of angioedema/anaphylactoid reactions Drug Num:  22
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0117
 
Atenolol
 
C14H22N2O3
 
2249 
Moderate    Inter Info   
[3], [4], [5]
D0173
 
Betaxolol
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[3], [4], [5]
D0174
 
Betaxolol (ophthalmic)
 
C18H29NO3
 
2369 
Moderate    Inter Info   
[3], [4], [5]
D0188
 
Bisoprolol
 
C18H31NO4
 
2405 
Moderate    Inter Info   
[3], [4], [5]
D0265
 
Carteolol
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[3], [4], [5]
D0266
 
Carteolol (ophthalmic)
 
C16H24N2O3
 
2583 
Moderate    Inter Info   
[3], [4], [5]
D0602
 
Esmolol
 
C16H25NO4
 
59768 
Moderate    Inter Info   
[3], [4], [5]
D0010
 
Acebutolol
 
C18H28N2O4
 
1978 
Moderate    Inter Info   
[3], [4], [5]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Moderate    Inter Info   
[3], [4], [5]
D0914
 
Levobetaxolol (ophthalmic)
 
C18H29NO3
 
60657 
Moderate    Inter Info   
[3], [4], [5]
D0915
 
Levobunolol (ophthalmic)
 
C17H25NO3
 
39468 
Moderate    Inter Info   
[3], [4], [5]
D1045
 
Metipranolol (ophthalmic)
 
C17H27NO4
 
31477 
Moderate    Inter Info   
[3], [4], [5]
D1098
 
Nadolol
 
C17H27NO4
 
39147 
Moderate    Inter Info   
[3], [4], [5]
D1114
 
Nebivolol
 
C22H25F2NO4
 
71301 
Moderate    Inter Info   
[3], [4], [5]
D1244
 
Penbutolol
 
C18H29NO2
 
37464 
Moderate    Inter Info   
[3], [4], [5]
D1293
 
Pindolol
 
C14H20N2O2
 
4828 
Moderate    Inter Info   
[3], [4], [5]
D0884
 
Labetalol
 
C19H24N2O3
 
3869 
Moderate    Inter Info   
[3], [4], [5]
D1049
 
Metoprolol
 
C15H25NO3
 
4171 
Moderate    Inter Info   
[3], [4], [5]
D1357
 
Propranolol
 
C16H21NO2
 
4946 
Moderate    Inter Info   
[3], [4], [5]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[3], [4], [5]
D1585
 
Timolol
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[3], [4], [5]
D1586
 
Timolol (ophthalmic)
 
C13H24N4O3S
 
33624 
Moderate    Inter Info   
[3], [4], [5]
   Increased risk of nephrotoxicity Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1826
 
Iopanoic acid
 
C11H12I3NO2
 
3735 
Moderate    Inter Info   
[6], [7], [8]
D0835
 
Iopodic acid
 
C12H13I3N2O2
 
5241 
Moderate    Inter Info   
[6], [7], [8]
D1915
 
Tyropanoic acid
 
C15H18I3NO3
 
5611 
Moderate    Inter Info   
[6], [7], [8]
References
1 Product Information. Multihance (gadobenate dimeglumine). Bracco Diagnostics Inc, Princeton, NJ.
2 Huisman MT, Smit JW, Crommentuyn KM, et al. "Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs." AIDS 16 (2002): 2295-2301. [PMID: 12441801]
3 Cerner Multum, Inc. "Australian Product Information.".
4 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
6 Product Information. Ultravist (iopromide). Berlex, Richmond, CA.
7 Product Information. Visipaque (iodixanol). Nycomed Inc, Princeton, NJ.
8 Product Information. Omniscan (gadodiamide). Novation, Irving, TX.