Details of Drug

Details of Drug

 Drug General Information (ID: D1752)
  Drug Name
Bupivacaine (liposome)
  Drug Type Small molecule
  Drug Synonymous
Anekain; Bloqueina; Bucaine; Bupivacaina; Bupivacainum; Bupivan; CBupivacaine; Carbostesin; DepoBupivacaine; Marcaina; Marcaine; Sensorcaine; Bupivacaine Carbonate; Bupivacaine HCL; Bupivacaine HCL KIT; Marcaine HCL; Marcaine Spinal; AH 250; Win 11318; Win 11318 HCl; Bucaine (TN); Bupivacaina [INN-Spanish]; Bupivacaine (INN); Bupivacaine Monohydrochloride, Monohydrate; Bupivacaine [INN:BAN]; Bupivacainum [INN-Latin]; DL-Bupivacaine; DUR-843; Marcain (TN); Marcaine (TN); Sensorcaine (TN); Sensorcaine-MPF; Sensorcaine-MPFSpinal; Transdur-Bupivacaine; Vivacaine (TN); Dl-1-Butyl-2',6'-pipecoloxylidide; (1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide; (inverted exclamation markA)-bupivacaine; 1-Butyl-2',6'-pipecoloxylidide; 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide; 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
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  Disease Class 9A76-9A78: Corneal disease; MG30-MG3Z: Pain
  Therapeutic Class Anesthetics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C18H28N2O
  InChI 1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
  InChIKey LEBVLXFERQHONN-UHFFFAOYSA-N
  Canonical SMILES CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
  External Link
Pubchem ID 2474
CAS Number CAS 38396-39-3
CHEBI ID CHEBI:77431
TTD ID D0A0FL

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM042  Additive hypotensive effects
BM071  Increased risk of methemoglobinemia
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Bupivacaine (liposome)
      Pharmacodynamic additive effects
   Additive hypotensive effects Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0110
 
Articaine
 
C13H20N2O3S
 
32170 
Major    Inter Info   
[1], [2]
D0319
 
Chloroprocaine
 
C13H19ClN2O2
 
8612 
Major    Inter Info   
[1], [2]
D0622
 
Etidocaine
 
C17H28N2O
 
37497 
Major    Inter Info   
[1], [2]
D0916
 
Levobupivacaine
 
C18H28N2O
 
92253 
Major    Inter Info   
[1], [2]
D1004
 
Mepivacaine
 
C15H22N2O
 
4062 
Major    Inter Info   
[1], [2]
D1337
 
Prilocaine
 
C13H20N2O
 
4906 
Major    Inter Info   
[1], [2]
D1344
 
Procaine
 
C13H20N2O2
 
4914 
Major    Inter Info   
[1], [2]
D1561
 
Tetracaine
 
C15H24N2O2
 
5411 
Major    Inter Info   
[1], [2]
D0927
 
Lidocaine
 
C14H22N2O
 
3676 
Major    Inter Info   
[1], [2]
D1428
 
Ropivacaine
 
C17H26N2O
 
175805 
Major    Inter Info   
[1], [2]
   Increased risk of methemoglobinemia Drug Num:  10
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0163
 
Benzocaine (topical)
 
C9H11NO2
 
2337 
Moderate    Inter Info   
[3], [4], [5]
D0339
 
Cinchocaine (topical)
 
C20H29N3O2
 
3025 
Moderate    Inter Info   
[3], [4], [5]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[3], [4], [5]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[3], [4], [5]
D1852
 
Oxybuprocaine (ophthalmic)
 
C17H28N2O3
 
4633 
Moderate    Inter Info   
[3], [4], [5]
D1870
 
Proparacaine (ophthalmic)
 
C16H26N2O3
 
4935 
Moderate    Inter Info   
[3], [4], [5]
D1904
 
Tetracaine (ophthalmic)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[3], [4], [5]
D1562
 
Tetracaine (topical)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[3], [4], [5]
D1835
 
Lidocaine (ophthalmic)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[3], [4], [5]
D0928
 
Lidocaine (topical)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[3], [4], [5]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1909
 
Tilmanocept
 
NA
 
NA
Moderate    Inter Info   
[6]
References
1 Product Information. Exparel (bupivacaine liposome). Pacira Pharmaceuticals Inc, San Diego, CA.
2 Kharitonov V "A review of the compatibility of liposome bupivacaine with other drug products and commonly used implant materials." Postgrad Med 126 (2014): 129-38. [PMID: 24393760]
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
5 Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
6 Product Information. Lymphoseek (tilmanocept). Navidea Biopharmaceuticals, Dublin, OH.