Details of Drug

Details of Drug

 Drug General Information (ID: D1710)
  Drug Name
Voxilaprevir
  Drug Type Small molecule
  Disease Class 1E50-1E51: Hepatitis virus infection
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C40H52F4N6O9S
  InChI 1S/C40H52F4N6O9S/c1-7-22-27-19-50(28(22)32(51)48-39(18-23(39)31(41)42)35(53)49-60(55,56)38(5)14-15-38)34(52)30(37(2,3)4)47-36(54)59-26-16-20(26)10-8-9-13-40(43,44)29-33(58-27)46-25-17-21(57-6)11-12-24(25)45-29/h11-12,17,20,22-23,26-28,30-31H,7-10,13-16,18-19H2,1-6H3,(H,47,54)(H,48,51)(H,49,53)/t20-,22-,23+,26-,27+,28+,30-,39-/m1/s1
  InChIKey MZBLZLWXUBZHSL-FZNJKFJKSA-N
  Canonical SMILES CCC1C2CN(C1C(=O)NC3(CC3C(F)F)C(=O)NS(=O)(=O)C4(CC4)C)C(=O)C(NC(=O)OC5CC5CCCCC(C6=NC7=C(C=C(C=C7)OC)N=C6O2)(F)F)C(C)(C)C
  External Link
Pubchem ID 89921642
CAS Number 1535212-07-7
TTD ID D07TYE
INTEDE ID DR1714
VARIDT ID DR01315

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
BM010  Transporter inhibition
BM017  CYP450 enzyme inhibition
  Relation Graph
 Full list of drugs interacting with Voxilaprevir
      Affected cellular transport
   Transporter inhibition Drug Num:  33
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[1], [2]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Major    Inter Info   
[3], [2]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Major    Inter Info   
[4], [5], [6]
D1301
 
Pitavastatin
 
C25H24FNO4
 
5282452 
Major    Inter Info   
[2]
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Major    Inter Info   
[2]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Major    Inter Info   
[7], [2]
D0038
 
Aliskiren
 
C30H53N3O6
 
5493444 
Moderate    Inter Info   
[8], [4], [9]
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Moderate    Inter Info   
[2]
D0096
 
Apixaban
 
C25H25N5O4
 
10182969 
Moderate    Inter Info   
[4], [10]
D0109
 
Artesunate
 
C19H28O8
 
6917864 
Moderate    Inter Info   
[2]
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Moderate    Inter Info   
[2]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Moderate    Inter Info   
[2]
D0195
 
Bosutinib
 
C26H29Cl2N5O3
 
5328940 
Moderate    Inter Info   
[4], [11]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Moderate    Inter Info   
[2]
D0376
 
Cobimetinib
 
C21H21F3IN3O2
 
16222096 
Moderate    Inter Info   
[4], [12]
D0408
 
Daclatasvir
 
C40H50N8O6
 
25154714 
Moderate    Inter Info   
[2]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Moderate    Inter Info   
[2]
D0561
 
Eltrombopag
 
C25H22N4O4
 
135449332 
Moderate    Inter Info   
[2]
D0562
 
Eluxadoline
 
C32H35N5O5
 
11250029 
Moderate    Inter Info   
[2]
D0686
 
Fluvastatin
 
C24H26FNO4
 
446155 
Moderate    Inter Info   
[2]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Moderate    Inter Info   
[2]
D0715
 
Gemfibrozil
 
C15H22O3
 
3463 
Moderate    Inter Info   
[2]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[13], [14]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Moderate    Inter Info   
[2]
D0903
 
Lenvatinib
 
C21H19ClN4O4
 
9823820 
Moderate    Inter Info   
[2]
D1160
 
Obeticholic acid
 
C26H44O4
 
447715 
Moderate    Inter Info   
[2]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[2]
D1232
 
Pazopanib
 
C21H23N7O2S
 
10113978 
Moderate    Inter Info   
[2]
D1471
 
Simeprevir
 
C38H47N5O7S2
 
24873435 
Moderate    Inter Info   
[2]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Moderate    Inter Info   
[2]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Moderate    Inter Info   
[2]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Moderate    Inter Info   
[2]
D1686
 
Velpatasvir
 
C49H54N8O8
 
67683363 
Moderate    Inter Info   
[2]
      Affected intra/extra-hepatic metabolism
References
1 Product Information. Reyataz (atazanavir). Bristol-Myers Squibb, Princeton, NJ.
2 Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir). Gilead Sciences, Foster City, CA.
3 Product Information. Sovaldi (sofosbuvir). Gilead Sciences, Foster City, CA.
4 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
5 Mendell J, Zahir H, Matsushima N, et al. "Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor." Am J Cardiovasc Drugs (2013):. [PMID: 23784266]
6 Product Information. Savaysa (edoxaban). Daiichi Sankyo, Inc., Parsippany, NJ.
7 Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
8 Canadian Pharmacists Association.
9 Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
10 Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
11 Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
12 Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
13 Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
14 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.