Details of Drug

Details of Drug

 Drug General Information (ID: D1702)
  Drug Name
Vitamin A
  Drug Type Small molecule
  Drug Synonymous
Retinol; retinol; all-trans-Retinol; 68-26-8; Vitamin A1; Alphalin; Axerophthol; Afaxin; Oleovitamin A; Chocola A; Ophthalamin; Epiteliol; Biosterol; Aquasynth; Apostavit; Alphasterol; Veroftal; Testavol; Anatola; Prepalin; Myvpack; Agoncal; Agiolan; Vogan; Axerol; Vitpex; Avibon; Apexol; Aoral; Vaflol; Dofsol; Avitol; Vitamin A alcohol; Disatabs Tabs; Lard Factor; Bentavit A; Dohyfral A; all-trans-Retinyl alcohol; Alcovit A; Vogan-Neu; Anatola A; Plivit A; A-Mulsal; Vi-Alpha; A-Vitan; All-trans retinol; Atars; Vafol; trans-retinol; all-trans-Vitamin A; ACON; ATAV; Alin; Avita; Axerophtholum; Cylasphere; LPK; Retinolo; Retinolum; TROL; Thalasphere; Wachstumsvitamin; All Trans Retinol; Antixerophthalmic vitamin; Antixerophthalmisches Vitamin; Aquasol A Parenteral; Homagenets Aoral; Homagenets aorl; Hydrovit A; Mvc Plus; Retinol solution; Retinolo [DCIT]; Retrovitamin A; Sehkraft A; Super A; Testavol S; Vitamin A cryst; Vitamine A; Vitaminum A; Vitavel A; Zinosan N; Rovimix A 500; Vitamin A1 alcohol; A-Sol; Anti-infective vitamin; Beta-Retinol; Retinol [INN:BAN]; Retinolum [INN-Latin]; Solu-A; Trans-Vitamin A alcohol; Trans-retinol; Vi-a; Vi-alpha; Vio-A; Vitamin A (Feed); Vitamin A (USP); Vitamin A alcohol (VAN); Vitamin A1 alcohol, all trans; Vitamin-A; Vitamin-A alcohol; Vitamin-A alcohol solution; Vitamin-A1; Vitavel-A; Vogan-nu; A-Vi-Pel; ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1); All-trans-Retinol; All-trans-Retinyl alcohol; All-trans-Vitamin A; All-trans-Vitamin A alcohol; All-trans-Vitamin A1; Del-VI-A; Hi-A-Vita; Nio-A-Let; Ro-a-vit; Trans-Retinol acid (Vitamin A); Vi-Dom-A; [11,12-3H]-Retinol; MVC 9+3; MVI-12; Retinol, all-trans-(8CI); Retin-11,12-t2-ol (9CI); Retinol-(cellular-retinol-binding-protein); Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol; All-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer; Tricyclics
    Click to Show/Hide
  Disease Class 9D45: Light sensitivity impairment; 1F61-1G2Z: Kinetoplastids
  Therapeutic Class Vitamins
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C20H30O
  InChI 1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
  InChIKey FPIPGXGPPPQFEQ-OVSJKPMPSA-N
  Canonical SMILES CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCO)C)C
  External Link
Pubchem ID 445354
CAS Number 11103-57-4
CHEBI ID 17336
TTD ID D0S7WX
INTEDE ID DR1699

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM008  Altered Fat-soluble drugs absorption
BM017  CYP450 enzyme inhibition
BM077  Increased risk of pseudotumor cerebri
  Relation Graph
 Full list of drugs interacting with Vitamin A
      Affected gastrointestinal absorption
   Altered Fat-soluble drugs absorption Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0329
 
Cholestyramine
 
C27H47ClN2
 
137699107 
Moderate    Inter Info   
[4], [1], [24], [25], [26], [27]
D0381
 
Colesevelam
 
C31H67Cl3N4O
 
160051 
Moderate    Inter Info   
[4], [1], [24], [25], [26], [27]
D0382
 
Colestipol
 
C11H28ClN5O
 
62816 
Moderate    Inter Info   
[4], [1], [24], [25], [26], [27]
D1462
 
Sevelamer
 
C6H12ClNO
 
3085017 
Moderate    Inter Info   
[4], [1], [24], [25], [26], [27]
D1187
 
Orlistat
 
C29H53NO5
 
3034010 
Minor    Inter Info   
[29]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[1], [28]
      Pharmacodynamic additive effects
   Increased risk of pseudotumor cerebri Drug Num:  11
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0018
 
Acitretin
 
C21H26O3
 
5284513 
Major    Inter Info   
[1], [2], [3], [4], [5]
D0441
 
Demeclocycline
 
C21H21ClN2O8
 
54680690 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D0530
 
Doxycycline
 
C22H24N2O8
 
54671203 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D0589
 
Eravacycline
 
C27H31FN4O8
 
54726192 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D0863
 
Isotretinoin
 
C20H28O2
 
5282379 
Major    Inter Info   
[1], [2], [3], [4], [5]
D1070
 
Minocycline
 
C23H27N3O7
 
54675783 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D1175
 
Omadacycline
 
C29H40N4O7
 
54697325 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D1209
 
Oxytetracycline
 
C22H24N2O9
 
54675779 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D1445
 
Sarecycline
 
C24H29N3O8
 
54681908 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D1564
 
Tetracycline
 
C22H24N2O8
 
54675776 
Major    Inter Info   
[6], [7], [2], [8], [9], [10], [3], [11], [12], [5], [13], [14], [15], [16], [17], [18], [19], [4], [1], [20], [21], [22], [23]
D1626
 
Tretinoin
 
C20H28O2
 
444795 
Major    Inter Info   
[1], [2], [3], [4], [5]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Product Information. Accutane (isotretinoin). Roche Laboratories, Nutley, NJ.
3 Product Information. Vesanoid (tretinoin). Roche Laboratories, Nutley, NJ.
4 Cerner Multum, Inc. "Australian Product Information.".
5 Product Information. Soriatane (acitretin). Roche Laboratories, Nutley, NJ.
6 Lewis PA, Kearney PJ "Pseudotumor cerebri induced by minocycline treatment for acne vulgaris." Acta Derm Venereol 77 (1997): 83. [PMID: 9059695]
7 Cuddihy J "Case report of benign intercranial hypertension secondary to tetracycline." Ir Med J 87 (1994): 90. [PMID: 8056550]
8 Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
9 Tabibian JH, Gutierrez MA "Doxycycline-induced pseudotumor cerebri." South Med J 102 (2009): 310-1. [PMID: 19204639]
10 Lee AG "Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne." Cutis 55 (1995): 165-8. [PMID: 7634848]
11 Roytman M, Frumkin A, Bohn TG "Pseudotumor cerebri caused by isotretinoin." Cutis 42 (1988): 399-400. [PMID: 2973971]
12 Minutello JS, Dimayuga RG, Carter J "Pseudotumor cerebri, a rare adverse reaction to tetracycline therapy." J Periodontol 59 (1988): 848-51. [PMID: 3225732]
13 Delaney RA, Narayanaswamy TR "Pseudo-tumor cerebri and acne." Mil Med 155 (1990): 511. [PMID: 2146526]
14 Schmitt K, Schwarz R, Tulzer G, Krieger O, Zoubek A, Gadner H "Toxicity of tretinoin in acute promyelocytic leukaemia." Lancet 343 (1994): 361. [PMID: 7905174]
15 Chiu AM, Chuenkongkaew WL, Cornblath WT, Trobe JD, Digre KB, Dotan SA, Musson KH, Eggenberger ER "Minocycline treatment and pseudotumor cerebri syndrome." Am J Ophthalmol 126 (1998): 116-21. [PMID: 9683157]
16 Chan AY, Liu DT, Friedman DI, Gordon LK, Egan RA "Doxycycline and intracranial hypertension." Neurology 64 (2005): 765-6. [PMID: 15728321]
17 Donnet A, Dufour H, Graziani N, Grisoli F "Minocycline and benign intracranial hypertension." Biomed Pharmacother 46 (1992): 171-2. [PMID: 1421048]
18 Product Information. Achromycin (tetracycline). Lederle Laboratories, Wayne, NJ.
19 Moskowitz Y, Leibowitz E, Ronen M, Aviel E "Pseudotumor cerebri induced by vitamin A combined with minocycline." Ann Ophthalmol 25 (1993): 306-8. [PMID: 8239326]
20 Gardner K, Cox T, Digre KB "Idiopathic intracranial hypertension associated with tetracycline use in fraternal twins: case reports and review." Neurology 45 (1995): 6-10. [PMID: 7824136]
21 Walters BN, Gubbay SS "Tetracycline and benign intracranial hypertension: report of five cases." Br Med J 282 (1981): 19-20. [PMID: 6449976]
22 Yokokura M, Hatake K, Komatsu N, Kajitani H, Miura Y "Toxicity of tretinoin in acute promyelocytic leukaemia." Lancet 343 (1994): 361-2. [PMID: 7905175]
23 Weese-Mayer DE, Yang RJ, Mayer JR, Zaparackas Z "Minocycline and Pseudotumor cerebri: The well-known but well-kept secret." Pediatrics 108 (2001): 519-20. [PMID: 11491116]
24 Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21. [PMID: 20921291]
25 Product Information. Fosamax Plus D (alendronate-cholecalciferol). Merck & Company Inc, West Point, PA.
26 Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
27 Product Information. Welchol (colesevelam) Daiichi Sankyo, Inc., Parsippany, NJ.
28 Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
29 Product Information. Xenical (orlistat). Roche Laboratories, Nutley, NJ.