Details of Drug

Drug General Information (ID: D1700)
Drug Name	Vinorelbine
Drug Type	Small molecule
Drug Synonymous	Eunades; Exelbine; NVB; Navelbine; Vinorelbin; Vinorelbina; Vinorelbinum; Navelbine base; Vinorelbina [Spanish]; Vinorelbine Ditartarate; Vinorelbine ditartrate; Vinorelbine tartrate; Vinorelbinum [Latin]; KW 2307; KW 2307 base; ANX-530; KW-2307; Navelbine (TN); SDP-012; Vinorelbine (INN); Vinorelbine [INN:BAN]; Aspidospermidine-3-carboxylic acid; Nor-5'-anhydrovinblastine; Methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-acetoxy-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate; Methyl (2b,3b,4b,5a,12b,19a)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C45H54N4O8
InChI	1S/C45H54N4O8/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3/t28-,37-,38+,39+,42+,43+,44-,45-/m0/s1
InChIKey	GBABOYUKABKIAF-IELIFDKJSA-N
Canonical SMILES	CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC
External Link
	Pubchem ID	5311497
	CAS Number	71486-22-1
	CHEBI ID	480999
	TTD ID	D01HTL
	VARIDT ID	DR01343

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM010 Transporter inhibition BM011 Transporter induction BM012 Competitive inhibition of transporters BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM067 Increased risk of hyponatremia BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Vinorelbine
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[443]
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[443]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[443]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[443]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[443]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[443]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[443]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[443]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[443]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[443]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[443]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[443]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[443]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[443]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[443]
Affected cellular transport
	Transporter inhibition					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[7], [325], [326]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[346]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[7], [350]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[364]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[17], [7], [377]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[7], [378]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[384]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[387]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[7]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[423]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[17], [7], [437], [438]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[7], [329]
	Competitive inhibition of transporters					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1791		Gadobenic acid	C22H28GdN3O11	9852779	Moderate		Inter Info	[373], [374]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 58
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[9], [10], [11], [12], [13], [14], [15], [16], [17], [7], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[281], [282], [283], [284], [285]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[308], [309]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[321], [322]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[324]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[330], [331], [30], [332], [333], [47]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[334]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[338]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[348]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[351]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[352]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[353], [354]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[357]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[358]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[7], [366]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[367], [368], [369], [370], [371]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[330], [331], [30], [332], [333], [47]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[372]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[7], [380]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[381]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[17], [7], [383]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[385]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[386]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[389]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[17], [7], [390], [391]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[394]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[403]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[414], [415], [416], [417], [418], [419], [420], [421], [47]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[424]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[7], [425]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[432]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[7], [436]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[440]
	CYP450 enzyme induction					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[96]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[7], [97], [98]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[96]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[314], [315], [316], [317], [318], [319], [96], [37], [320]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[17], [7], [323]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[96]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[339]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[342]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[96]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[347]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[7], [349]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[96]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[17], [359]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[360]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[361]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[362], [17], [7], [363]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[365]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[314], [315], [316], [317], [318], [319], [96], [37], [320]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[7], [379]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[96]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[382]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[388]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[7], [399]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[400], [401], [402]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[404]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[96]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[7], [412]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[96]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[96]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[96]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[96]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[17], [7], [323]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[17], [7], [429], [323]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[430], [431]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[434]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[7], [435]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[444], [445], [446], [447], [448]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[444], [445], [446], [447], [448]
	Competitive inhibition of metabolic enzyme					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[17], [392], [393]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[426], [427]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[426], [427]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[426], [427]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 85
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [8]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[49]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[17], [7], [53]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[58]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[59], [60]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [61]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[17], [63]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[59], [60]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[83]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[84]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[7], [85], [86]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[95]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[7], [85], [86]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[7], [85], [86]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[7], [85], [86]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[286]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[7], [85], [86]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[311]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[7], [85], [86]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[17], [7]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[7], [85], [86]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[7], [85], [86]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[7], [85], [86]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[7], [85], [86]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[7], [85], [86]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[7], [85], [86]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[7], [85], [86]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[7], [85], [86]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[7], [85], [86]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[7], [85], [86]
D0431		Decitabine	C8H12N4O4	451668	Moderate		Inter Info	[7], [85], [86]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[355]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[356]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[356]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[7], [85], [86]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[7], [85], [86]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[7], [85], [86]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[7], [85], [86]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[7], [85], [86]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[7], [85], [86]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[7], [85], [86]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[7], [85], [86]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[7], [85], [86]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[7], [85], [86]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[7], [85], [86]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[7], [85], [86]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[7], [85], [86]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[7], [85], [86]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[7], [85], [86]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[356]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[395]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[396]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [397]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[398]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[7], [85], [86]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[7], [85], [86]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[413]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1410		Risankizumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [422]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[7], [85], [86]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[428]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[7], [85], [86]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[17], [7], [433]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[7], [85], [86]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[7], [85], [86]
D1583		Tildrakizumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[439]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[7], [87], [88], [89], [90], [91], [92], [93], [94]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[17], [7], [442]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [54], [55]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[17], [56], [57]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[62]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[17], [7], [375], [376]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[17], [7], [375], [376]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
	Increased risk of hyponatremia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[17], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [7], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [15], [276], [277], [278], [279], [280]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[17], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [7], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270], [271], [272], [273], [274], [275], [15], [276], [277], [278], [279], [280]
	Increased risk of peripheral neuropathy					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[99], [100], [101]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[16], [85], [102]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[16], [85], [102]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[16], [85], [102]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[16], [85], [102]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[16], [85], [102]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[16], [85], [102]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[16], [85], [102]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[16], [85], [102]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[16], [85], [102]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[16], [85], [102]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[16], [85], [102]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[16], [85], [102]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[16], [85], [102]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[16], [85], [102]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[16], [85], [102]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[16], [340], [341]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[16], [85], [102]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[16], [85], [102]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[16], [85], [102]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[16], [85], [102]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[16], [85], [102]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[16], [85], [102]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[16], [85], [102]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[16], [85], [102]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[16], [85], [102]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[16], [85], [102]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[16], [85], [102]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[16], [85], [102]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[16], [85], [102]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[16], [85], [102]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[16], [85], [102]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[16], [85], [102]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[16], [85], [102]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[16], [85], [102]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[16], [85], [102]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[16], [85], [102]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[16], [85], [102]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[16], [85], [102]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[16], [85], [102]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[16], [85], [102]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[16], [85], [102]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[16], [85], [102]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[16], [85], [102]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[16], [85], [102]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[16], [85], [102]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[16], [85], [102]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[16], [85], [102]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[16], [85], [102]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[16], [85], [102]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[16], [85], [102]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[16], [85], [102]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[16], [85], [102]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[16], [85], [102]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[16], [85], [102]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[16], [85], [102]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[16], [85], [102]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[16], [85], [102]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[16], [85], [102]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[16], [85], [102]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[16], [85], [102]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[16], [85], [102]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[16], [85], [102]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[16], [85], [102]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[16], [85], [102]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[16], [85], [102]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[16], [85], [102]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[16], [85], [102]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[16], [85], [102]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[99], [441]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[50], [51], [52]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[50], [51], [52]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[50], [51], [52]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[50], [51], [52]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[50], [51], [52]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[64], [17], [65]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[66]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[50], [51], [52]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[50], [51], [52]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[50], [51], [52]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[310]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[64], [327], [328]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[64], [327], [328]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[64], [327], [328]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[64], [327], [328]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[64], [327], [328]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[64], [327], [328]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[64], [327], [328]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[64], [327], [328]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[405], [64], [17], [406], [407], [408], [327], [409], [410], [411], [328]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[64], [327], [328]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[64], [327], [328]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[64], [327], [328]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[335], [336], [337]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[335], [336], [337]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[343], [344], [345]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[343], [344], [345]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[343], [344], [345]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[343], [344], [345]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[287], [288], [289]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[312], [313]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[287], [288], [289]

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52	Product Information. YF-Vax (yellow fever vaccine). sanofi pasteur, Swiftwater, PA.
53	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
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91	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
92	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
93	Product Information. Sylvant (siltuximab). Janssen Biotech, Inc., Horsham, PA, PA.
94	Product Information. Taltz Autoinjector (ixekizumab). Eli Lilly and Company, Indianapolis, IN.
95	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
96	Product Information. Marqibo (vinCRIStine liposome). Talon Therapeutics Inc, South San Francisco,, CA.
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312	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
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323	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
324	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
325	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
326	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
327	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
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329	Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
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332	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
333	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
334	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
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338	Product Information. Blincyto (blinatumomab). Amgen USA, Thousand Oaks, CA.
339	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
340	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
341	Product Information. Danyelza (naxitamab). Y-mAbs Therapeutics, New York, NY.
342	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
343	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
344	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
345	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
346	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
347	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
348	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
349	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
350	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
351	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
352	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
353	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
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358	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
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361	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
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364	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
365	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
366	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
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369	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
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372	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
373	Product Information. Multihance (gadobenate dimeglumine). Bracco Diagnostics Inc, Princeton, NJ.
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375	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
376	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
377	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
378	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
379	Product Information. Ravicti (glycerol phenylbutyrate). Hyperion Therapeutics Inc, South San Francisco, CA.
380	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
381	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
382	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
383	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
384	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
385	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
386	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
387	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
388	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
389	Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
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392	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
393	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
394	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
395	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
396	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
397	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
398	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
399	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
400	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
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404	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
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406	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
407	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
408	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
409	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
410	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
411	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
412	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
413	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
414	DSouza DL, Levasseur LM, Nezamis J, Robbins DK, Simms L, Koch KM "Effect of alosetron on the pharmacokinetics of alprazolam." J Clin Pharmacol 41 (2001): 452-4. [PMID: 11304902]
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418	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
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423	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
424	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
425	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
426	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
427	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
428	AnazaoHealth Corporation "P32 Sodium Phosphate."
429	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
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434	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
435	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
436	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
437	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
438	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
439	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
440	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
441	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
442	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
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445	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
446	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
447	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
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