Details of Drug

Drug General Information (ID: D1664)
Drug Name	Ulipristal
Drug Type	Small molecule
Drug Synonymous	Ella (TN) Click to Show/Hide
Disease Class	QA21: Contraceptive management
Therapeutic Class	Progesterone Receptor Modulators
Structure
Structure	3D Structure		2D Structure
Formula	C28H35NO3
InChI	1S/C28H35NO3/c1-17(30)28(32)14-13-25-23-11-7-19-15-21(31)10-12-22(19)26(23)24(16-27(25,28)2)18-5-8-20(9-6-18)29(3)4/h5-6,8-9,15,23-25,32H,7,10-14,16H2,1-4H3/t23-,24+,25-,27-,28-/m0/s1
InChIKey	HKDLNTKNLJPAIY-WKWWZUSTSA-N
Canonical SMILES	CC(=O)C1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O
External Link
	Pubchem ID	13559281
	CAS Number	159811-51-5
	TTD ID	D0V4WD
	INTEDE ID	DR1657

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Ulipristal
Affected cellular transport
	Transporter inhibition					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[1], [2], [3]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[4]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[5], [6], [7], [8]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[9], [5], [10]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[5], [12], [13]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[14]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[15], [16], [17], [18]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[15], [17], [18]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[20], [13]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[15], [16], [17], [18]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[23]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[25]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[26]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[27]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[29]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[31], [5], [32], [33]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[9], [5], [34]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[5], [37]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[9], [5], [49]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[9], [50]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[52]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[55]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[57]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[9], [5], [58]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[59]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[22]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[30]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[5], [11]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[36]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[5], [11]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[51]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[5], [11]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[54]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[5], [11]
D0100		Aprepitant	C23H21F7N4O3	135413536	Minor		Inter Info	[5], [11]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[5], [11]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[5], [11]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[5], [11]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[5], [11]
D0413		Dalfopristin	C34H50N4O9S	6323289	Minor		Inter Info	[5], [56], [11]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[5], [11]
D0426		Darunavir	C27H37N3O7S	213039	Minor		Inter Info	[5], [11]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[5], [11]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[5], [11]
D0534		Dronedarone	C31H44N2O5S	208898	Minor		Inter Info	[5], [11]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[5], [11]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[5], [11]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Minor		Inter Info	[5], [11]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[5], [11]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Minor		Inter Info	[5], [11]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[5], [11]
D0793		Imatinib	C29H31N7O	5291	Minor		Inter Info	[5], [11]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[5], [11]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[5], [11]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[5], [11]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[5], [11]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[5], [11]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[5], [11]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[5], [11]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[5], [11]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[5], [11]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[5], [11]
D0735		Goldenseal	NA	NA	Minor		Inter Info	[5], [11]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[5], [11]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[5], [11]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[5], [11]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[5], [11]
	CYP450 enzyme induction					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[5], [11]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[5], [11]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[5], [11]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[5], [11]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[5], [11]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[5], [11]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[5], [11]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[5], [11]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[5], [11]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[5], [11]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[5], [11]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[5], [11]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[5], [11]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[5], [24], [11]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[5], [11]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[5], [11]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[5], [11]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[5], [11]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[5], [11]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[5], [11]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[5], [11]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[5], [11]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[5], [11]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[5], [24], [11]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[5], [11]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[5], [11]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[5], [11]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[5], [11]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[9], [5], [28]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[5], [11]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[5], [11]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[5], [11]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[5], [11]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[9], [35]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[5], [24], [11]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[38]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[39]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[9], [5], [28]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[5], [53]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0450		Desogestrel	C22H30O	40973	Moderate		Inter Info	[5], [11], [19]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[5], [11], [19]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[5], [11], [19]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[5], [21], [11]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[5], [11], [19]
D1152		Norelgestromin	C21H29NO2	9568628	Moderate		Inter Info	[5], [11], [19]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[5], [11], [19]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[5], [11], [19]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[5], [11], [19]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[5], [11], [19]

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