Details of Drug

Drug General Information (ID: D1660)
Drug Name	Tucatinib
Drug Type	Small molecule
Drug Synonymous	Irbinitinib; 937263-43-9; ONT-380; UNII-234248D0HH; 234248D0HH; N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine; 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)-; ONT 380; 4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-; Tucatinib [USAN:INN]; 6-DIAMINE Click to Show/Hide
Disease Class	2B72: Stomach cancer; 2C60-2C6Y: Breast cancer
Therapeutic Class	Antineoplastics/Her2 Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C26H24N8O2
InChI	1S/C26H24N8O2/c1-16-10-17(5-7-22(16)36-19-8-9-34-23(12-19)28-15-30-34)31-24-20-11-18(4-6-21(20)27-14-29-24)32-25-33-26(2,3)13-35-25/h4-12,14-15H,13H2,1-3H3,(H,32,33)(H,27,29,31)
InChIKey	SDEAXTCZPQIFQM-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=CC(=C1)NC2=NC=NC3=C2C=C(C=C3)NC4=NC(CO4)(C)C)OC5=CC6=NC=NN6C=C5
External Link
	Pubchem ID	51039094
	CAS Number	937263-43-9
	TTD ID	D09GRX

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM055 Increased risk of hepatotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tucatinib
Affected cellular transport
	Transporter inhibition					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[17], [117], [118], [119]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[350], [351], [352]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[418]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[1]
D0109		Artesunate	C19H28O8	6917864	Moderate		Inter Info	[1]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[543], [544], [545], [546]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[543], [545], [546]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[1]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[1]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1]
D0656		Fexofenadine	C32H39NO4	3348	Moderate		Inter Info	[1]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[543], [544], [545], [546]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[1]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[1]
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1]
D1402		Rifaximin	C43H51N3O11	6436173	Moderate		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[1]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[1]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[1]
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Moderate		Inter Info	[1]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[1]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[1]
D1617		Trametinib	C26H23FIN5O4	11707110	Moderate		Inter Info	[1]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[640]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[1]
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[1]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[1]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[649]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Minor		Inter Info	[668]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 331
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15]
D0036		Alfuzosin	C19H27N5O4	2092	Major		Inter Info	[16], [17], [18], [19], [20]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[16], [17], [21], [19]
D0108		Artemether	C16H26O5	68911	Major		Inter Info	[16], [17], [22]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[16], [19], [23]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[16], [17], [24], [19]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[16], [17], [25], [19]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[26]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[27], [16], [17], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[41]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[16], [17], [42], [19]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Major		Inter Info	[43]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[16], [19], [44]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[17], [45], [46], [47]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[48], [49], [50]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[16], [51], [19]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[52], [53], [54], [16], [17], [55], [56], [57], [58], [59], [60], [61], [62], [37], [19], [38], [63], [64], [65], [66], [67], [68], [69]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[16], [70], [19], [71]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[16], [19], [72]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[73]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[17], [74], [75]
D0424		Darifenacin	C28H30N2O2	444031	Major		Inter Info	[16], [76], [77], [19]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[16], [19], [78]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[79], [80], [81], [82], [17], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[104]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[105], [16], [17], [106], [107], [19], [108], [109], [110], [111]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[16], [112], [19]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[16], [17], [113], [114], [115], [38], [116]
D0557		Eletriptan	C22H26N2O2S	77993	Major		Inter Info	[120]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[16], [17], [121], [19]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[91], [95], [101]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[79], [80], [81], [82], [17], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[122], [123]
D0612		Eszopiclone	C17H17ClN6O3	969472	Major		Inter Info	[124], [125], [83], [126], [127]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[16], [128], [129], [19]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[16], [130], [131], [132], [19], [133], [14]
D0655		Fesoterodine	C26H37NO3	6918558	Major		Inter Info	[16], [19], [134], [135]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[136]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[1]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[17], [137]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[17], [138]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[139], [140], [141]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[142], [143]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[16], [144], [19]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[145]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[146], [16], [17], [147], [148], [149], [150]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[17], [147], [148]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[151]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[16], [17], [152], [19]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[16], [17], [153], [154], [155], [156]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[16], [19], [157]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[160], [161]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[16], [162], [19]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[161]
D0956		Lovastatin	C24H36O5	53232	Major		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170], [83], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[208]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[16], [17], [209], [19]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[210]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[211]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[91], [95], [101]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[212], [18], [213], [214], [215], [216], [217], [218]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[91], [95], [101]
D1060		Midazolam	C18H13ClFN3	4192	Major		Inter Info	[219], [220], [221], [222], [223], [83], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[242], [243]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[244], [245]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[16], [17], [247], [19]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[16], [19], [248]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[249]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[16], [17], [250], [19]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[251]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[16], [17], [252]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[253]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[254], [255]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[16], [19], [256]
D1290		Pimavanserin	C25H34FN3O2	10071196	Major		Inter Info	[257]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[16], [17], [258]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[259], [260], [261], [262], [263], [264], [265], [266], [267]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[16], [17], [268], [19]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[270]
D1440		Salmeterol	C25H37NO4	5152	Major		Inter Info	[16], [17], [271], [19]
D1465		Sildenafil	C22H30N6O4S	135398744	Major		Inter Info	[16], [17], [272], [273], [274], [275], [276], [277], [19], [278], [279]
D1466		Silodosin	C25H32F3N3O4	5312125	Major		Inter Info	[16], [280], [19]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[16], [281], [19]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170], [83], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[16], [282], [283], [284], [285], [286], [19], [287], [38]
D1491		Solifenacin	C23H26N2O2	154059	Major		Inter Info	[16], [17], [19], [134], [288]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[289]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[16], [290]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[291], [292], [293], [294], [295], [296], [16], [17], [283], [297], [298], [299], [128], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327]
D1534		Tamsulosin	C20H28N2O5S	129211	Major		Inter Info	[16], [328], [329], [330], [19]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[16], [17], [332], [19]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[16], [17], [333]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[16], [70], [19], [71]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[334]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[16], [17], [335]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[212], [336], [337], [18], [338], [339], [340], [341], [342], [343], [344], [345]
D1632		Triazolam	C17H12Cl2N4	5556	Major		Inter Info	[219], [220], [221], [222], [223], [83], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[346]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[347]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[17], [348]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[142], [143], [349]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[353]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[354]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[355]
D0436		Deflazacort	C25H31NO6	189821	Major		Inter Info	[17], [356]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[357], [287], [75]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[358]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[17], [359], [360], [361]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[17], [362]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[17], [363]
D0683		Fluticasone	C22H27F3O4S	5311101	Major		Inter Info	[364], [365], [366], [367], [28], [368], [369], [370], [371], [372], [373], [374], [375], [33], [376], [377], [378], [35], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Major		Inter Info	[387], [388], [400]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[401]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[402]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[403], [287], [75]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[16], [17], [404]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[287], [405], [75]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[16], [406]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[407]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[408]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[409], [16], [410]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[411], [412]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[413], [287], [75]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[414]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[415], [75]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[416]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[417], [75]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[17], [419]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[16], [420]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[411], [421]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[422]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[16], [423]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[424]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[425]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[426]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[428], [411], [429]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[430]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[431]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[432]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[433], [434], [435], [436], [437], [438], [146], [439], [16], [17], [440], [441], [442], [443], [444], [445], [446], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [19], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469]
D1698		Vincristine	C46H56N4O10	5978	Major		Inter Info	[433], [434], [435], [436], [437], [438], [146], [439], [16], [17], [440], [441], [442], [443], [444], [445], [446], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [19], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[436], [458], [460]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[433], [434], [435], [436], [437], [438], [146], [439], [16], [17], [440], [441], [442], [443], [444], [445], [446], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [19], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[16], [19], [470]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[1]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[146], [17], [471], [472]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[473]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[219], [220], [221], [222], [223], [83], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[146], [16], [17], [476], [477]
D0086		Anastrozole	C17H19N5	2187	Moderate		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[478], [479]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[480]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[1]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[350], [351], [1]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[1]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[492], [493], [494], [495], [165], [496], [221], [497], [168], [169], [170], [498], [499], [83], [171], [172], [173], [174], [175], [176], [500], [178], [179], [181], [182], [501], [183], [184], [185], [502], [186], [187], [503], [188], [189], [504], [227], [505], [506], [190], [191], [192], [507], [193], [194], [508], [509], [197], [510], [198], [511], [512], [513], [200], [201], [202], [204], [514], [206], [207], [515], [516], [517]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[1]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[518]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[1]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[212], [365], [27], [519], [520], [31], [18], [521], [522], [213], [372], [373], [523], [214], [215], [216], [524], [34], [525], [39], [40], [392], [526], [217], [218], [527], [528], [529], [399]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[530], [531], [532]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[287], [72], [75]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[1]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[27], [16], [17]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[533]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[1]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[16], [534], [19]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[494], [165], [516]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[16]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[212], [18], [535], [536]
D0334		Ciclesonide (nasal)	C32H44O7	6918155	Moderate		Inter Info	[537], [538], [535]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[539]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[540]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[16], [19], [542]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[1]
D0454		Dexamethasone (nasal)	C22H29FO5	5743	Moderate		Inter Info	[31], [521], [392]
D0455		Dexamethasone (ophthalmic)	C22H29FO5	5743	Moderate		Inter Info	[31], [521], [392]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[1]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[547]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[146], [17], [548]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[1]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[212], [483], [16], [17], [549], [550], [551]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[552]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[1]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[553], [554]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[1]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[1]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[1]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[1]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[1]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[1]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[1]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[1]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[1]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[1]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[1]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[1]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[212], [365], [27], [519], [520], [31], [18], [521], [522], [213], [372], [373], [523], [214], [215], [216], [524], [34], [525], [39], [40], [392], [526], [217], [218], [527], [528], [529], [399]
D0672		Flunisolide	C24H31FO6	82153	Moderate		Inter Info	[31], [521], [392]
D0673		Flunisolide (nasal)	C24H31FO6	82153	Moderate		Inter Info	[31], [521], [392]
D0674		Fluorometholone (ophthalmic)	C22H29FO4	9878	Moderate		Inter Info	[31], [521], [392]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[478], [479]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[555]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[553], [556]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[1]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[212], [365], [27], [519], [520], [31], [18], [521], [522], [213], [372], [373], [523], [214], [215], [216], [524], [34], [525], [39], [40], [392], [526], [217], [218], [527], [528], [529], [399]
D0774		Hydrocortisone (ophthalmic)	C21H30O5	5754	Moderate		Inter Info	[31], [521], [392]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[16]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[558]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[17], [563]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[564], [287], [75]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1]
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[16], [17], [565]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[1]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[146], [16], [17], [476], [477]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[17], [566]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[1]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[1]
D0955		Loteprednol (ophthalmic)	C21H27ClO5	9865442	Moderate		Inter Info	[31], [521], [392]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[1]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[567], [568], [569], [570], [571], [572], [573], [574]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[576], [577], [578], [579], [580]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[1]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[582]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[1]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[146], [16], [17]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[1]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[583], [1]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[1]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[584], [585], [16], [586], [587], [588], [589], [109]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[584], [585], [16]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[17], [590]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[16], [17], [591]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[1]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[212], [365], [27], [519], [520], [31], [18], [521], [522], [213], [372], [373], [523], [214], [215], [216], [524], [34], [525], [39], [40], [392], [526], [217], [218], [527], [528], [529], [399]
D1333		Prednisolone (ophthalmic)	C21H28O5	5755	Moderate		Inter Info	[31], [521], [392]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[212], [365], [27], [519], [520], [31], [18], [521], [522], [213], [372], [373], [523], [214], [215], [216], [524], [34], [525], [39], [40], [392], [526], [217], [218], [527], [528], [529], [399]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[16], [17], [592], [593], [594], [595], [596], [597], [598], [599], [600]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[601]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[16], [19], [602]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[603], [604], [605], [606], [607], [608], [609]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[16], [610], [17], [611]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[16], [17], [612]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[16], [17], [613], [19], [614]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[1]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[615], [287], [75]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[17], [616]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[1]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[617], [618], [133]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[16], [19], [619]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[16], [620], [621], [19]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[622]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[1]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[1]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[1]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[1]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[1]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[1]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[625], [626]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[16], [627], [19]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[1]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[628], [629], [630], [631], [632], [633], [634], [635], [636], [637], [638]
D1629		Triamcinolone (nasal)	C21H27FO6	31307	Moderate		Inter Info	[31], [521], [392]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[31], [521], [392]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[639]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Moderate		Inter Info	[1]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[641]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[642]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[17], [643]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[647]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[648]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[650], [510]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[651]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[16], [17], [652]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[384], [75], [397]
D1701		Vismodegib	C19H14Cl2N2O3S	24776445	Moderate		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[1]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[1]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[653], [225], [654], [655], [656], [387], [657]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[658], [659]
D0053		Ambrisentan	C22H22N2O4	6918493	Minor		Inter Info	[660]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[16], [661], [662]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[663], [664]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[665], [578], [666], [667]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[663], [664]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[669]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[670]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[671]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[672]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[673]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[674], [675], [676], [677], [678], [679], [680]
D1464		Sibutramine	C17H26ClN	5210	Minor		Inter Info	[681], [682], [683]
D0589		Eravacycline	C27H31FN4O8	54726192	Minor		Inter Info	[684]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[671]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[685], [686], [687], [688]
	CYP450 enzyme induction					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[269], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[16], [19], [331]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[474], [1], [475]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[474], [1], [475]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[474], [1], [475]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[474], [1], [475]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[474], [1], [475]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[474], [1], [475]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[474], [1], [475]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[474], [1], [475]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[474], [1], [475]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[474], [1], [475]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[1]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[474], [1], [475]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[474], [1], [475]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[474], [1], [475]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[474], [1], [475]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[427]
	Increased risk of hepatotoxicity					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[146], [158], [159]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[246]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[481], [482], [483], [16], [17], [484], [485], [486], [487], [488], [489], [490], [491]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[482], [16], [490]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[541]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[559], [560], [561], [562]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[559], [560], [561], [562]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[17], [575]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[581]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[481], [482], [483], [16], [17], [484], [485], [486], [487], [488], [489], [490], [491]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[559], [560], [561], [562]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[623], [624]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[481], [482], [483], [16], [17], [484], [485], [486], [487], [488], [489], [490], [491]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[16], [17], [644], [645], [646]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[557]

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97	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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156	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
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197	Product Information. Mevacor (lovastatin). Merck & Co, Inc, West Point, PA.
198	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
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234	Product Information. Versed (midazolam). Roche Laboratories, Nutley, NJ.
235	Product Information. Xanax (alprazolam). Pharmacia and Upjohn, Kalamazoo, MI.
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244	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
245	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
246	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
247	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
248	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
249	Product Information. Nimotop (nimodipine). Bayer, West Haven, CT.
250	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
251	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
252	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
253	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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256	Product Information. Votrient (pazopanib). GlaxoSmithKline, Research Triangle Park, NC.
257	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
258	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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278	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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281	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
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286	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
287	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
288	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
289	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
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330	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
331	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
332	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
333	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
334	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
335	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
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347	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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352	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
353	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
354	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
355	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
356	Product Information. Emflaza (deflazacort). Marathon Pharmaceuticals, Deerfield, IL.
357	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
358	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
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361	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
362	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
363	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
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384	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
385	Product Information. Flonase (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
386	Product Information. Flovent (fluticasone). Glaxo Wellcome, Research Triangle Park, NC.
387	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
388	Product Information. Veramyst (fluticasone nasal). GlaxoSmithKline, Research Triangle Park, NC.
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401	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
402	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
403	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
404	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
405	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
406	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
407	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
408	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
409	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
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412	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
413	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
414	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
415	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
416	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
417	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
418	Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
419	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
420	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
421	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
422	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
423	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
424	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
425	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
426	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
427	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
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429	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
430	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
431	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
432	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
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460	Product Information. Velban (vinblastine). Lilly, Eli and Company, Indianapolis, IN.
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479	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
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488	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
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490	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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532	Uttamsingh V, Lu C, Miwa GT, Gan LS "Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4 to the hepatic metabolism of teh protosome inhibitor bortezomib." Drug Metab Dispos 33 (2005): 1723-8. [PMID: 16103134]
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534	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
535	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
536	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
537	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
538	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
539	Product Information. Sensipar (cinacalcet). Amgen USA, Thousand Oaks, CA.
540	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
541	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
542	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
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544	Product Information. Cerubidine (daunorubicin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
545	Product Information. Daunoxome (daunorubicin liposomal). Nexstar Pharmaceuticals Inc, Boulder, CO.
546	Product Information. Idamycin (idarubicin). Pharmacia and Upjohn, Kalamazoo, MI.
547	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
548	Product Information. Cardura (doxazosin). Pfizer US Pharmaceuticals, New York, NY.
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550	Product Information. Droperidol (droperidol). Abbott Pharmaceutical, Abbott Park, IL.
551	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
552	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
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555	Product Information. Reminyl (galantamine) Janssen Pharmaceuticals, Titusville, NJ.
556	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
557	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
558	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
559	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
560	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
561	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
562	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
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565	Product Information. Vimpat (lacosamide). UCB Pharma Inc, Smyrna, GA.
566	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
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573	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
574	Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32. [PMID: 11504799]
575	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
576	Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." Biochem Pharmacol 93 (2015): 104-9. [PMID: 25475885]
577	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
578	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
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581	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
582	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
583	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
584	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
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587	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
588	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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590	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
591	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
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596	Product Information. Qualaquin (quinine). AR Scientific Inc, Philadelphia, PA.
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