Details of Drug

Drug General Information (ID: D1646)
Drug Name	Trimetrexate
Drug Type	Small molecule
Drug Synonymous	TMQ; Trimetrexato; Trimetrexatum; JB 11; Jb-11; Trimetrexato [INN-Spanish]; Trimetrexatum [INN-Latin]; Trimetrexate (USAN/INN); Trimetrexate [USAN:BAN:INN]; 2,4-Diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl)quinazoline; 5-Methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-2,4-quinazolinediamine; 5-methyl-6-({[3,4,5-tris(methyloxy)phenyl]amino}methyl)quinazoline-2,4-diamine; 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine; 6-[((3,4,5-Trimethoxyphenyl)amino)methyl]-5-methyl-2,4-quinazolinediamine Click to Show/Hide
Disease Class	1F57: Toxoplasmosis
Therapeutic Class	Antifungal Agents
Structure
Structure	3D Structure		2D Structure
Formula	C19H23N5O3
InChI	1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)
InChIKey	NOYPYLRCIDNJJB-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC
External Link
	Pubchem ID	5583
	CAS Number	52128-35-5
	CHEBI ID	9737
	TTD ID	D0Y7TS
	VARIDT ID	DR01434

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM026 Increased metabolism (Unspecific) BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Trimetrexate
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[88], [89], [90]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[114]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[114]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[114]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[114]
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1802		Glucarpidase	Zn4+8	21195079	Moderate		Inter Info	[7], [86]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [8]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[12]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[16], [7], [17]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[20]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [23]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[16], [26]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[30]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[31]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[27], [32], [33]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[34]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[35], [36], [37]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[16], [7]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[16], [7], [38]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[16], [7], [38]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[39]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[54]
D1366		Pyrimethamine	C12H13ClN4	4993	Moderate		Inter Info	[7], [68]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[72]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[35], [36], [37]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[84]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[85]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[85]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[85]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[91]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[92]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [93]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[94]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[105]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[35], [36], [37]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [109]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[110]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[16], [7], [68]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[112]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[16], [7], [113]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [9], [10]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[16], [18], [19]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[25]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[16], [7], [45], [46]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[16], [7], [45], [46]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[11]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[21]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[22]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[24]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[11]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[40], [41]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[47], [48], [49], [50]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[47], [48], [49], [50]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[7], [52]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[53]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[55], [56], [57], [16], [7], [58], [59], [60], [61], [62], [63], [64], [65]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[70], [71]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[55], [56], [57], [16], [7], [58], [59], [60], [61], [62], [63], [64], [65]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[75]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[79]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[55], [56], [57], [16], [7], [58], [59], [60], [61], [62], [63], [64], [65]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[7], [83]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[87]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[47], [48], [49], [50]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[16], [7], [106], [107], [108]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[7], [111]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[13], [14], [15]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[13], [14], [15]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[13], [14], [15]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[27], [16], [28]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[29]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[13], [14], [15]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[13], [14], [15]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[51]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[27], [73], [74]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [73], [74]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[27], [73], [74]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[27], [73], [74]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[27], [73], [74]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[27], [73], [74]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [73], [74]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[95], [27], [16], [96], [97], [98], [73], [99], [100], [101], [74]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[27], [73], [74]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[27], [73], [74]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[27], [73], [74]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[76], [77], [78]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[76], [77], [78]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[80], [81], [82]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[80], [81], [82]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[80], [81], [82]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[80], [81], [82]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[42], [43], [44]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[66], [67]
D1884		Sapropterin	C9H15N5O3	135398654	Moderate		Inter Info	[16], [69]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[42], [43], [44]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[102], [103], [104]

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90	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
91	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
92	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
93	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
94	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
95	CDC Centers for Disease Control and Prevention "General Best Practice Guidelines for Immunization: Altered Immunocompetence." .
96	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
97	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
98	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
99	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
100	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
101	CDC Centers for Disease Control and Prevention "Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.".
102	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
103	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
104	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
105	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
106	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
107	Gilead Sciences, Inc "About Remdesivir.".
108	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
109	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
110	AnazaoHealth Corporation "P32 Sodium Phosphate."
111	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
112	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
113	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
114	Product Information. Neutrexin (trimetrexate). US Bioscience, West Conshohocken, PA.

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