Details of Drug

Details of Drug

 Drug General Information (ID: D1627)
  Drug Name
Tretinoin (topical)
  Drug Type Small molecule
  Drug Synonymous
Retinoic acid; tretinoin; 302-79-4; Vitamin A acid; all-trans-Retinoic acid; trans-Retinoic acid; ATRA; Airol; Retin-A; Vesanoid; Renova; Dermairol; Aknoten; Eudyna; Aberel; all-trans-Vitamin A acid; Aknefug; All-trans Retinoic Acid; Cordes vas; Epi-aberel; Atralin; Vitamin A1 acid, all-trans-; Tretin M; Retin-A Micro; all-trans-Vitamin A1 acid; Vitamin A acid, all-trans-; all-trans-Tretinoin; Effederm; Retionic acid; TRETINON; Retinoic acid, all-trans-; Alltrans-retinoic acid; beta-Ra; all-(E)-Retinoic acid; beta-Retinoic acid; Avitoin; Aberela; Acnavit; Atragen; Betarretin; Lsotretinoin; Nexret; Panretyn; REA; Retacnyl; Retinoate; Retinova; Solage; Tretinoina; Tretinoine; Tretinoino; Tretinoinum; Vesnaroid; Vitinoin; Aberela [Norway]; Accutane Roche; Acnavit [Denmark]; All Trans Retinoic Acid; Avita Gel; Avitoin [Norway]; Beta all trans Retinoic Acid; Cordes VAS [Germany]; Effederm [France]; Panretin Gel; Retin A; Trans Retinoic Acid; Tretinoin Potassium Salt; Tretinoin Sodium Salt; Tretinoin Zinc Salt; Tretinoin liposome; AGN100335; AGN 192013; ALRT 1057; BAL4079; LGD 100057; R 2625; [3H]Retinoic acid; A-Vitaminsyre; A-Vitaminsyre [Denmark]; AT-RA; Aberela (TN); Acid, Retinoic; Acid, Vitamin A; All trans-Retinoic acid; Atra-IV; Avita (TN); B-Retinoic acid; BML2-E05; Beta-Ra; Beta-Retinoic acid; Potassium Salt, Tretinoin; RETINOIC ACID, ALL TRANS; Renova (TN); Retin A (TN); Retisol-A; Ro 1-5488; Salt, Tretinoin Potassium; Salt, Tretinoin Sodium; Salt, Tretinoin Zinc; Sodium Salt, Tretinoin; Stieva-A; Stieva-a Forte; Trans-Retinoicacid; Tretinoin (TN); Tretinoina [INN-Spanish]; Tretinoine [INN-French]; Tretinoino [INN-Spanish]; Tretinoinum [INN-Latin]; Tri-Luma; Vesanoid (TN); Zinc Salt, Tretinoin; A-Acido (Argentina); Acid A Vit (Belgium, Netherlands); Acid, trans-Retinoic; Acide retinoique (French) (DSL); All-trans-Retinoic acid; All-trans-Tretinoin; All-trans-Vitamin A acid; All-trans-Vitamin A1 acid; PDT-002-002; Retin-A (TN); Stieva-A (TN); Tretinoin 01% cream or placebo; Tretinoin [USAN:INN:BAN]; Tretinoin/All-Trans Retinoic Acid; Tretinoine (French) (EINECS); Acid, all-trans-Retinoic; All-(E)-Retinoic acid; All-trans-b-Retinoic acid; All-trans-beta-Retinoic acid; Beta-all-trans-Retinoic acid; Tretinoin (JAN/USP/INN); Acid, beta-all-trans-Retinoic; Retinoic acid, all-trans-(8CI); Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Tretinoin; 15-Apo-beta-caroten-15-oic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; 9(Z)-Retinoic acid; 9-cis-RA; 9-trans-retinoic acid
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  Disease Class ED80: Acne vulgaris; 2A60: Acute myeloid leukaemia
  Therapeutic Class Keratolytic Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C20H28O2
  InChI 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
  InChIKey SHGAZHPCJJPHSC-YCNIQYBTSA-N
  Canonical SMILES CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
  External Link
Pubchem ID 444795
CAS Number 302-79-4
CHEBI ID 15367
TTD ID D02DGU
INTEDE ID DR1634
VARIDT ID DR00154

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM075  Increased risk of photosensitivity reactions
BM079  Increased risk of skin rash
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Tretinoin (topical)
      Pharmacodynamic additive effects
   Increased risk of photosensitivity reactions Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0062
 
Aminolevulinic acid
 
C5H9NO3
 
137 
Major    Inter Info   
[1], [2]
D1028
 
Methoxsalen
 
C12H8O4
 
4114 
Moderate    Inter Info   
[3], [4], [5]
D1314
 
Porfimer sodium
 
C68H74N8O11
 
135577896 
Moderate    Inter Info   
[6], [7], [8]
D0063
 
Aminolevulinic acid (topical)
 
C5H9NO3
 
137 
Moderate    Inter Info   
[3], [7], [9]
D1033
 
Methyl aminolevulinate (topical)
 
C6H11NO3
 
157922 
Moderate    Inter Info   
[3], [7], [9]
D1691
 
Verteporfin
 
C82H84N8O16
 
11980904 
Moderate    Inter Info   
[7], [4], [13]
   Increased risk of skin rash Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0863
 
Isotretinoin
 
C20H28O2
 
5282379 
Moderate    Inter Info   
[7], [12]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1746
 
Benzoyl peroxide (topical)
 
C14H10O4
 
7187 
Moderate    Inter Info   
[10], [11]
D1850
 
Octasulfur (topical)
 
S8
 
66348 
Moderate    Inter Info   
[10], [11]
D1878
 
Resorcinol (topical)
 
C6H6O2
 
5054 
Moderate    Inter Info   
[10], [11]
D1883
 
Salicylic acid (topical)
 
C7H6O3
 
338 
Moderate    Inter Info   
[10], [11]
References
1 Product Information. Nulibry (fosdenopterin). Origin Biosciences Inc, Boston, MA.
2 Product Information. Gleolan (aminolevulinic acid). NX Development Corp, Lexington, KY.
3 Cerner Multum, Inc. "Australian Product Information.".
4 Multum Information Services, Inc. Expert Review Panel.
5 Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
6 Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
9 Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
10 Product Information. Retin-A (tretinoin). Ortho Pharmaceutical Corporation, Raritan, NJ.
11 Product Information. Tazorac (tazarotene topical). Allergan Inc, Irvine, CA.
12 Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."
13 Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.