Details of Drug

Drug General Information (ID: D1626)
Drug Name	Tretinoin
Drug Type	Small molecule
Drug Synonymous	Retinoic acid; tretinoin; 302-79-4; Vitamin A acid; all-trans-Retinoic acid; trans-Retinoic acid; ATRA; Airol; Retin-A; Vesanoid; Renova; Dermairol; Aknoten; Eudyna; Aberel; all-trans-Vitamin A acid; Aknefug; All-trans Retinoic Acid; Cordes vas; Epi-aberel; Atralin; Vitamin A1 acid, all-trans-; Tretin M; Retin-A Micro; all-trans-Vitamin A1 acid; Vitamin A acid, all-trans-; all-trans-Tretinoin; Effederm; Retionic acid; TRETINON; Retinoic acid, all-trans-; Alltrans-retinoic acid; beta-Ra; all-(E)-Retinoic acid; beta-Retinoic acid; Avitoin; Aberela; Acnavit; Atragen; Betarretin; Lsotretinoin; Nexret; Panretyn; REA; Retacnyl; Retinoate; Retinova; Solage; Tretinoina; Tretinoine; Tretinoino; Tretinoinum; Vesnaroid; Vitinoin; Aberela [Norway]; Accutane Roche; Acnavit [Denmark]; All Trans Retinoic Acid; Avita Gel; Avitoin [Norway]; Beta all trans Retinoic Acid; Cordes VAS [Germany]; Effederm [France]; Panretin Gel; Retin A; Trans Retinoic Acid; Tretinoin Potassium Salt; Tretinoin Sodium Salt; Tretinoin Zinc Salt; Tretinoin liposome; AGN100335; AGN 192013; ALRT 1057; BAL4079; LGD 100057; R 2625; [3H]Retinoic acid; A-Vitaminsyre; A-Vitaminsyre [Denmark]; AT-RA; Aberela (TN); Acid, Retinoic; Acid, Vitamin A; All trans-Retinoic acid; Atra-IV; Avita (TN); B-Retinoic acid; BML2-E05; Beta-Ra; Beta-Retinoic acid; Potassium Salt, Tretinoin; RETINOIC ACID, ALL TRANS; Renova (TN); Retin A (TN); Retisol-A; Ro 1-5488; Salt, Tretinoin Potassium; Salt, Tretinoin Sodium; Salt, Tretinoin Zinc; Sodium Salt, Tretinoin; Stieva-A; Stieva-a Forte; Trans-Retinoicacid; Tretinoin (TN); Tretinoina [INN-Spanish]; Tretinoine [INN-French]; Tretinoino [INN-Spanish]; Tretinoinum [INN-Latin]; Tri-Luma; Vesanoid (TN); Zinc Salt, Tretinoin; A-Acido (Argentina); Acid A Vit (Belgium, Netherlands); Acid, trans-Retinoic; Acide retinoique (French) (DSL); All-trans-Retinoic acid; All-trans-Tretinoin; All-trans-Vitamin A acid; All-trans-Vitamin A1 acid; PDT-002-002; Retin-A (TN); Stieva-A (TN); Tretinoin 01% cream or placebo; Tretinoin [USAN:INN:BAN]; Tretinoin/All-Trans Retinoic Acid; Tretinoine (French) (EINECS); Acid, all-trans-Retinoic; All-(E)-Retinoic acid; All-trans-b-Retinoic acid; All-trans-beta-Retinoic acid; Beta-all-trans-Retinoic acid; Tretinoin (JAN/USP/INN); Acid, beta-all-trans-Retinoic; Retinoic acid, all-trans-(8CI); Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Tretinoin; 15-Apo-beta-caroten-15-oic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid; 9(Z)-Retinoic acid; 9-cis-RA; 9-trans-retinoic acid Click to Show/Hide
Disease Class	ED80: Acne vulgaris; 2A60: Acute myeloid leukaemia
Therapeutic Class	Keratolytic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H28O2
InChI	1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChIKey	SHGAZHPCJJPHSC-YCNIQYBTSA-N
Canonical SMILES	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
External Link
	Pubchem ID	444795
	CAS Number	302-79-4
	CHEBI ID	15367
	TTD ID	D02DGU
	INTEDE ID	DR1634
	VARIDT ID	DR00154

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM006 Altered intestinal mucosa BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions BM077 Increased risk of pseudotumor cerebri BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tretinoin
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[142]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[142]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[142]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[142]
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[142]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[142]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[142]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[142]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[142]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[142]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[142]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[142]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[142]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[142]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[142]
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 51
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[45], [46]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[78]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[39], [1], [79]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[82]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[88]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[89]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[90], [91]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[92]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[93]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1], [96]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[45], [46]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[99]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1], [101]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[102]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[4], [1], [103]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[104], [105], [106]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[107]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[4], [1], [111], [112]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[113]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[120], [121], [122], [123], [124], [125], [126], [127], [128]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[4], [131]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[132]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1], [134]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[27], [28], [29], [30], [31], [32], [33], [34], [35], [3], [36]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[4], [1]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[140]
	CYP450 enzyme induction					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[58]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[39], [1], [2], [60], [8], [3]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[4], [1], [71], [72]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[4], [1], [75]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[84]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[86]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [87]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[4], [94]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[95]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[108]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[109], [1], [110]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[114], [115], [116]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[129], [130]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[1], [133]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[4], [1], [75]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[4], [1], [135], [75]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[136], [137]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [138]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[143], [144], [145], [146], [147]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[143], [144], [145], [146], [147]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[4], [97], [98]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[4], [97], [98]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0060		Aminocaproic acid	C6H13NO2	564	Major		Inter Info	[3], [6], [7]
D1619		Tranexamic acid	C8H15NO2	5526	Major		Inter Info	[3], [6], [7]
D1741		Aprotinin	C284H432N84O79S7	16130295	Major		Inter Info	[3], [6], [7]
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[39], [40], [41]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[42]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[43]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[44]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[39], [40], [41]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[47], [48], [49], [4], [1], [50], [51], [52], [53], [54], [55], [56], [57]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[59]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[4], [1], [61]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[1], [66]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[70]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[47], [48], [49], [4], [1], [50], [51], [52], [53], [54], [55], [56], [57]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[76], [77]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[47], [48], [49], [4], [1], [50], [51], [52], [53], [54], [55], [56], [57]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[81]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[83]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[47], [48], [49], [4], [1], [50], [51], [52], [53], [54], [55], [56], [57]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1], [85]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[100]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[62], [63], [64], [65]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[4], [1], [117], [118], [119]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [139]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[37], [38]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[4], [67], [37], [68], [69]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[73], [1], [74]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[4], [1], [80]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[4], [1], [80]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[1], [67], [37], [141]
	Increased risk of pseudotumor cerebri					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0018		Acitretin	C21H26O3	5284513	Major		Inter Info	[1], [2], [3], [4], [5]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D0530		Doxycycline	C22H24N2O8	54671203	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D1209		Oxytetracycline	C22H24N2O9	54675779	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D0589		Eravacycline	C27H31FN4O8	54726192	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D0863		Isotretinoin	C20H28O2	5282379	Major		Inter Info	[1], [2], [3], [4], [5]
D1070		Minocycline	C23H27N3O7	54675783	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D1175		Omadacycline	C29H40N4O7	54697325	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D1445		Sarecycline	C24H29N3O8	54681908	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D1564		Tetracycline	C22H24N2O8	54675776	Major		Inter Info	[9], [10], [11], [12], [4], [13], [14], [15], [16], [17], [18], [2], [19], [20], [21], [22], [5], [23], [24], [1], [25], [3], [26]
D1702		Vitamin A	C20H30O	445354	Major		Inter Info	[1], [2], [3], [4], [5]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1], [8]

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