Details of Drug

Details of Drug

 Drug General Information (ID: D1617)
  Drug Name
Trametinib
  Drug Type Small molecule
  Drug Synonymous
GSK 1120212; GSK-1120212; GSK1120212; JTP 74057; JTP-74057; Mekinist; Trametinib (GSK1120212); Trametinib (GSK1120212JTP 74057); Trametinib (MEK inhibitor); 33E86K87QN; A1-01871; AK174783; CHEBI:75998; UNII-33E86K87QN
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  Disease Class 2C30: Melanoma
  Therapeutic Class Multikinase Inhibitors
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C26H23FIN5O4
  InChI 1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
  InChIKey LIRYPHYGHXZJBZ-UHFFFAOYSA-N
  Canonical SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NC(=O)C)C5CC5
  External Link
Pubchem ID 11707110
CAS Number 871700-17-3
CHEBI ID 75998
TTD ID D04XVN

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM011  Transporter induction
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Trametinib
      Affected cellular transport
   Transporter inhibition Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[3]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[3]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[3], [5], [6]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[3], [7]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[8]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[2], [3], [9]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[11]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[12]
   Transporter induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[1], [2], [3], [4]
      Pharmacodynamic additive effects
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[10]
References
1 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
2 Cerner Multum, Inc. "Australian Product Information.".
3 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
5 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
6 Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
7 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
8 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
9 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
10 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
11 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
12 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.