Details of Drug

Drug General Information (ID: D1613)
Drug Name	Tositumomab
Drug Type	Monoclonal antibody
Drug Synonymous	Bexxar (TN) Click to Show/Hide
Disease Class	2B33: Malignant haematopoietic neoplasm
Therapeutic Class	Antineoplastics
External Link
External Link	TTD ID	D0I2AV

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tositumomab
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[3], [4], [5], [6], [7], [8]
D0614		Etanercept	NA	NA	Major		Inter Info	[3], [4], [5], [6], [7], [8]
D0802		Infliximab	NA	NA	Major		Inter Info	[3], [4], [5], [6], [7], [8]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[12], [10], [13]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[3], [7], [8]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[10], [15]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[22]
D0736		Golimumab	NA	NA	Major		Inter Info	[3], [4], [5], [6], [7], [8]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[27], [28]
D1111		Natalizumab	NA	NA	Major		Inter Info	[32]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[10], [34]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[12], [40]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[27], [28]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[45]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[46]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[47], [48], [49]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[41], [54], [55]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[56]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[12], [10]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[47], [48], [49]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[12], [10], [62]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[12], [10], [62]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[101]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[103]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[103]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[103]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[110]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[111]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[10], [112]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[47], [48], [49]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[10], [114]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[12], [10], [115]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[117]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[121]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[12], [10], [122]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[10], [16], [17]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[12], [20], [21]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[39]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[12], [10], [104], [105]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[12], [10], [104], [105]
	Increased risk of bleeding					Drug Num: 100
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1], [2]
D0047		Alteplase	NA	NA	Major		Inter Info	[1], [2]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1], [2]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[1], [2]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1], [2]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[1], [2]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1], [2]
D1395		Reteplase	NA	NA	Major		Inter Info	[1], [2]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1], [2]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[9]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1], [2]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1], [2]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[1], [2]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[1], [2]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1], [2]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1], [2]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[10], [11]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1], [2]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1], [2]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[14]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[1], [2]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[1], [2]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1], [2]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1], [2]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[1], [2]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[18], [19]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[1], [2]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [2]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1], [2]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1], [2]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[1], [2]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1], [2]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1], [2]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [2]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [2]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[1], [2]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[23], [24], [10], [25]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [2]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1], [2]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [2]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[10], [18], [26]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [2]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1], [2]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [2]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [2]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [2]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [2]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[18], [33]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [2]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1], [2]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[35]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1], [2]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[36]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[10], [37], [38]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[1], [2]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1], [2]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [2]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1], [2]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1], [2]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[44]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1], [2]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [2]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1], [2]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[1], [2]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1], [2]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[18]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[59], [60], [61]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[18], [102]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[59], [60], [61]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[59], [60], [61]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[59], [60], [61]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[59], [60], [61]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[59], [60], [61]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[18], [113]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[66], [95], [96]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[59], [60], [61]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[10], [116]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[63], [64], [65], [66], [12], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100]
D0253		Capsicum	NA	NA	Minor		Inter Info	[123]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[123], [124], [125]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[106]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[29], [30], [31]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[29], [30], [31]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[41], [12], [42]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[43]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[29], [30], [31]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[29], [30], [31]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[29], [30], [31]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[41], [57], [58]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[41], [57], [58]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[41], [57], [58]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[41], [57], [58]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[41], [57], [58]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[41], [57], [58]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[41], [57], [58]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[41], [57], [58]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[41], [57], [58]
	Antagonize the effect of probiotics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[107], [108], [109]
	Diminish the response to diagnostic skin test antigens					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[118], [119], [120]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[118], [119], [120]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[18], [50]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[51], [52], [53]

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