Details of Drug

Drug General Information (ID: D1606)
Drug Name	Tolmetin
Drug Type	Small molecule
Drug Synonymous	Tolectin; Tolmetina; Tolmetine; Tolmetino; Tolmetinum; Tolmetina [DCIT]; MCN 2559; McN-2559; Tolectin (TN); Tolmetin Sodium, Dihydrate; Tolmetine [INN-French]; Tolmetino [INN-Spanish]; Tolmetinum [INN-Latin]; Tolmetin (USAN/INN); Tolmetin [USAN:BAN:INN]; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico; Acido 1-metil-5-(p-tolnil)-pirrol-2-acetico [Spanish]; 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic acid; 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid; 1-Methyl-5-p-toluoylpyrrole-2-acetic acid; 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetic acid; 5-(p-Toluoyl)-1-methylpyrrole-2-acetic acid Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C15H15NO3
InChI	1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18)
InChIKey	UPSPUYADGBWSHF-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=C(C=C1)C(=O)C2=CC=C(N2C)CC(=O)O
External Link
	Pubchem ID	5509
	CAS Number	26171-23-3
	CHEBI ID	71941
	TTD ID	D09BHB

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM027 Decreased renal excretion due to nephrotoxicity BM032 Decreased renal excretion (Unspecific) BM038 Additive CNS depression effects BM039 Additive CNS stimulant effects BM050 Increased risk of bleeding BM054 Increased risk of GI mucosal injury/bleeding risk BM055 Increased risk of hepatotoxicity BM058 Increased risk of hyperkalemia BM064 Increased risk of hypoglycemia BM067 Increased risk of hyponatremia BM072 Increased risk of nephrotoxicity BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tolmetin
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[507]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[560]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[565]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[566], [567], [568]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[580]
	Decreased renal excretion (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[53], [54], [55]
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[490], [491], [492]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[576]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
	Additive CNS stimulant effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D0340		Cinoxacin	C12H10N2O5	2762	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[493], [494], [495], [496], [497], [498], [499], [500], [501], [502], [503], [504], [505], [506]
	Increased risk of bleeding					Drug Num: 87
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[21], [22], [23]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[24]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[28]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[30]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[21], [22], [23]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[31], [32]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[31], [33]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[34]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[35]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D0415		Danaparoid	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[36]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[39], [40]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[41]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[45]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[46], [47], [31], [48]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[87], [88]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[89], [31], [90]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[92]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[31], [93]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[94]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[31], [65], [95]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[96]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[97]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[21], [22], [23]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[87]
D1613		Tositumomab	NA	NA	Major		Inter Info	[98], [99]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[98], [99]
D0005		Abciximab	NA	NA	Moderate		Inter Info	[100], [101]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[89], [47], [31], [203]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[204], [205], [206]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[204], [205], [206]
D0088		Anistreplase	NA	NA	Moderate		Inter Info	[204], [205], [206]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[215], [216], [217]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[218], [89], [31], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[216]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[100], [101]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[31], [511], [512]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[215], [216], [217]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[218], [89], [31], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[204], [205], [206]
D1506		Streptokinase	C11H19NO2	9815560	Moderate		Inter Info	[204], [205], [206]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[204], [205], [206]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[529]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[204], [205], [206]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[204], [205], [206]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[218], [89], [31], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[218], [89], [31], [219], [220], [221], [222], [223], [224], [225], [226], [227], [228]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[204], [205], [206]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[204], [205], [206]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[204], [205], [206]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[543]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[204], [205], [206]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[204], [205], [206]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[556], [557], [558]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[1], [2], [4], [10], [11], [12]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[556], [557], [558]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[31], [564]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[31], [511], [512]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[484], [569]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[204], [205], [206]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[204], [205], [206]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[31], [581]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[100], [101]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[556], [557], [558]
D1669		Urokinase	NA	NA	Moderate		Inter Info	[204], [205], [206]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[270], [271], [272], [273], [89], [274], [275], [276], [277], [278], [279], [280], [281], [282], [283], [284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307]
D0368		Clove	NA	NA	Minor		Inter Info	[595], [596], [597], [598]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[29]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[89], [31], [269]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[513], [514], [515]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[513], [514], [515]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[525], [526], [527]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[531], [31], [532]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[525], [526], [527]
D0146		Baricitinib	C16H17N7O2S	44205240	Moderate		Inter Info	[538], [539]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[513], [514], [515]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[513], [514], [515]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[513], [514], [515]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[559]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[525], [526], [527]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[513], [514], [515]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[513], [514], [515]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[513], [514], [515]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[513], [514], [515]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[513], [514], [515]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[513], [514], [515]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[513], [514], [515]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[513], [514], [515]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[513], [514], [515]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[513], [514], [515]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[513], [514], [515]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[513], [514], [515]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[31]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[525], [526], [527]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[89], [31], [269]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[513], [514], [515]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[525], [526], [527]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[538], [539]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[262], [266], [268]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[89], [31], [269]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[31], [588], [589], [525], [590], [526], [591], [527], [592], [593], [594]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[599]
	Increased risk of hepatotoxicity					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[50], [51], [52]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[56]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[86]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[91]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[50], [51], [52]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[516], [517], [518], [519]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[52], [530]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[540]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[31], [541]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[31], [542]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[544]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[547], [548]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[562]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[563]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[516], [517], [518], [519]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[89], [31], [577], [578], [579]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[31], [582]
	Increased risk of hyperkalemia					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0059		Aminobenzoic acid	C7H7NO2	978	Moderate		Inter Info	[535], [536], [89]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[545], [546]
D1086		Monopotassium phosphate	H2KO4P	516951	Moderate		Inter Info	[535], [536], [89]
D1317		Potassium bicarbonate	CHKO3	516893	Moderate		Inter Info	[536], [89], [535], [573], [574], [575]
D1318		Potassium chloride	ClK	4873	Moderate		Inter Info	[536], [89], [535], [573], [574], [575]
D1319		Potassium citrate	C6H5K3O7	13344	Moderate		Inter Info	[536], [89], [535], [573], [574], [575]
D1320		Potassium gluconate	C6H11KO7	16760467	Moderate		Inter Info	[536], [89], [535], [573], [574], [575]
D1321		Potassium Iodide	IK	4875	Moderate		Inter Info	[536], [89], [535], [573], [574], [575]
D1322		Potassium perchlorate	ClKO4	516900	Moderate		Inter Info	[536], [89], [535], [573], [574], [575]
	Increased risk of hypoglycemia					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202]
	Increased risk of hyponatremia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[89], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [302], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [31], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469], [470], [471], [472], [473], [474], [475], [476], [477], [478], [479], [480], [481], [482], [483], [484], [485], [486], [487], [488], [489]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[89], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [302], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384], [385], [386], [387], [388], [389], [390], [391], [392], [393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406], [407], [408], [409], [410], [411], [412], [413], [414], [415], [416], [417], [418], [419], [420], [421], [422], [423], [424], [425], [426], [427], [428], [429], [430], [431], [432], [433], [434], [435], [436], [437], [438], [439], [440], [441], [442], [443], [444], [445], [446], [31], [447], [448], [449], [450], [451], [452], [453], [454], [455], [456], [457], [458], [459], [460], [461], [462], [463], [464], [465], [466], [467], [468], [469], [470], [471], [472], [473], [474], [475], [476], [477], [478], [479], [480], [481], [482], [483], [484], [485], [486], [487], [488], [489]
	Increased risk of nephrotoxicity					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[13]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[25], [26], [27]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[37], [38]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[42], [43], [44]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[25], [26], [27]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[25], [26], [27]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[25], [26], [27]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[31], [49]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[16], [17], [18]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[14], [15], [16], [17], [18], [19], [20]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[42], [43], [44]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[42], [43], [44]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[42], [43], [44]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[207], [208], [209], [210], [211], [212]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[308], [61], [309], [310], [75], [311]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[31]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[520], [521], [522]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[537], [520], [521], [522]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[207], [208], [209], [210], [211], [212]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[207], [208], [209], [210], [211], [212]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[207], [208], [209], [210], [211], [212]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[537], [520], [521], [522]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[207], [208], [209], [210], [211], [212]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[537], [520], [521], [522]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[207], [208], [209], [210], [211], [212]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[89], [31], [583], [584], [29], [585]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[570], [571], [572]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[570], [571], [572]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[570], [571], [572]
D0929		Linaclotide	C59H79N15O21S6	16158208	Minor		Inter Info	[533], [600]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 61
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[213], [75], [214]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[229], [230], [231]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[229], [230], [231]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[213], [75], [214]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[229], [230], [231]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[508], [509], [510]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[213], [75], [214]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[213], [75], [214]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[213], [75], [214]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[523], [29], [524]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[524], [528]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[508], [509], [510]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[229], [230], [231]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[229], [230], [231]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[229], [230], [231]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[31], [533], [534]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[523], [29], [524]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[508], [509], [510]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[213], [75], [214]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[229], [230], [231]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[508], [509], [510]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[229], [230], [231]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[508], [509], [510]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[549], [524], [508], [509], [550], [551], [552], [510], [553], [554], [555]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[523], [29], [524]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[232], [233], [234]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[213], [75], [214]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[561]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[236], [233], [234], [247], [239], [254], [256], [235], [242], [238], [240], [250], [243], [232], [244], [253], [245], [257], [255], [249], [251], [237], [241], [246], [248], [252]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[523], [29], [524]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[229], [230], [231]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[213], [75], [214]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[508], [509], [510]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[523], [29], [524]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[508], [509], [510]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[229], [230], [231]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[213], [75], [214]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[213], [75], [214]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[229], [230], [231]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[508], [509], [510]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[229], [230], [231]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[229], [230], [231]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[523], [29], [524]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[508], [509], [510]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[213], [75], [214]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[232], [233], [234]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[523], [29], [524]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[586], [587]

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86	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
87	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
88	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
89	Cerner Multum, Inc. "Australian Product Information.".
90	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
91	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
92	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
93	Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
94	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
95	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
96	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
97	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
98	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
99	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
100	Product Information. Integrilin (eptifibatide). Schering Laboratories, Kenilworth, NJ.
101	Product Information. ReoPro (abciximab). Lilly, Eli and Company, Indianapolis, IN.
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165	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
166	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
167	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
168	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
169	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
170	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
171	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
172	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
173	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
174	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
175	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
176	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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204	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
205	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
206	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
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215	Product Information. Acova (argatroban) SmithKline Beecham, Philadelphia, PA.
216	Product Information. Angiomax (bivalirudin) The Medicines Compny, Cambridge, MA.
217	Product Information. Refludan (lepirudin). Hoechst Marion-Roussel Inc, Kansas City, MO.
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224	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
225	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
226	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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495	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
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515	Product Information. Duexis (famotidine-ibuprofen). Horizon Pharma USA Inc, Northbrook, IL.
516	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
517	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
518	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
519	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
520	Product Information. Canasa (mesalamine (5-aminosalicylic acid)). Axcan Scandipharm Inc, Birmingham, AL.
521	Product Information. Lialda (mesalamine (5-aminosalicylic acid)). Shire US Inc, Florence, KY.
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530	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
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536	Product Information. Potassium Chloride ER (potassium chloride). Zydus Pharmaceuticals (USA) Inc, Princeton, NJ.
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542	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
543	Product Information. Plavix (clopidogrel). Bristol-Myers Squibb, Princeton, NJ.
544	Product Information. Solaraze (diclofenac topical). Doak Dermatologics Division, Fairfield, NJ.
545	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
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557	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
558	Product Information. Ventavis (iloprost). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
559	Product Information. Motrin (ibuprofen). Pharmacia and Upjohn, Kalamazoo, MI.
560	Product Information. Ancobon (flucytosine). Roche Laboratories, Nutley, NJ.
561	Cinquegrani MP, Liang CS "Indomethacin attenuates the hypotensive action of hydralazine." Clin Pharmacol Ther 39 (1986): 564-70
562	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
563	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
564	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
565	Product Information. Eloxatin (oxaliplatin). Sanofi Winthrop Pharmaceuticals, New York, NY.
566	Tietjen DP "Recurrence and specificity of nephrotic syndrome due to tolmetin." Am J Med 87 (1989): 354-5
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569	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
570	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
571	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
572	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
573	Product Information. Potassium Chloride (potassium chloride). Pharmaceutical Assoc Inc Div Beach Products, Greenville, SC.
574	Product Information. Phospho-Trin 250 Neutral (potassium phosphate-sodium phosphate). Patrin Pharma, Skokie, IL.
575	Product Information. SSKI (potassium iodide). Upsher-Smith Laboratories Inc, Minneapolis, MN.
576	Product Information. Folotyn (pralatrexate). Allos Therapeutics, Westminster, CO.
577	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
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580	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
581	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
582	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
583	Hazlewood KA, Brouse SD, Pitcher WD, Hall RG "Vancomycin-associated nephrotoxicity: grave concern or death by character assassination?" Am J Med 123 (2010): 182.e1-7. [PMID: 20103028]
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585	Product Information. Vancocin (vancomycin). Lilly, Eli and Company, Indianapolis, IN.
586	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
587	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
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590	Product Information. Aredia (pamidronate). Novartis Pharmaceuticals, East Hanover, NJ.
591	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
592	Product Information. Didronel Tablets (etidronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
593	Product Information. Fosamax (alendronate). Merck & Co, Inc, West Point, PA.
594	Product Information. Zometa (zoledronic acid). Novartis Pharmaceuticals, East Hanover, NJ.
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599	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
600	Product Information. Linzess (linaclotide). Forest Pharmaceuticals, St. Louis, MO.

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