Details of Drug

Drug General Information (ID: D1595)
Drug Name	Tivozanib
Drug Type	Small molecule
Drug Synonymous	ASP4130/AV-951 Click to Show/Hide
Disease Class	2C90: Renal cell carcinoma
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C22H19ClN4O5
InChI	1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
InChIKey	SPMVMDHWKHCIDT-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl
External Link
	Pubchem ID	9911830
	CAS Number	475108-18-0
	CHEBI ID	91327
	TTD ID	D0W7JZ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM022 CYP450 enzyme induction BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Tivozanib
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1], [2]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1], [2]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[1], [2], [3]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Fotivda (tivozanib). Aveo Pharmaceuticals, Inc., Boston, MA.
3	Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]