Details of Drug

Drug General Information (ID: D1594)
Drug Name	Tisagenlecleucel
Drug Type	Autologous cell transplant
Drug Synonymous	Tisagenlecleucel-T Click to Show/Hide
Disease Class	2A81: Diffuse large B-cell lymphoma; 2A82: Mature B-cell leukaemia; 2A80: Follicular lymphoma; 2A85: Mature B-cell lymphoma; 2A60: Acute myeloid leukaemia
Therapeutic Class	Antineoplastics
External Link
External Link	TTD ID	D0IM6T

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tisagenlecleucel
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[10], [11], [12]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[11], [13]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[18]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[19], [20]
D1111		Natalizumab	NA	NA	Major		Inter Info	[21]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[11], [22]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [24]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[19], [20]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[28]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[29]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[25], [30], [31]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[32]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[33], [34], [35]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[10], [11]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[33], [34], [35]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [41]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [41]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[42]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[43]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[44]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[50]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[11], [51]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[52]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[33], [34], [35]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[11], [53]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[54]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[10], [11], [55]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[43]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[43]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[66]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[67]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[10], [11], [68]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[11], [14], [15]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[10], [16], [17]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[23]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[10], [11], [46], [47]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[10], [11], [46], [47]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[48]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[7], [8], [9]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[25], [10], [26]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[27]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[7], [8], [9]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[7], [8], [9]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[25], [36], [37]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [36], [37]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[25], [36], [37]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[25], [36], [37]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[25], [36], [37]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[49]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [36], [37]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[25], [36], [37]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[25], [36], [37]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[25], [36], [37]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[59], [25], [10], [60], [61], [62], [36], [63], [64], [65], [37]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[25], [36], [37]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[25], [36], [37]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[56], [57], [58]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[56], [57], [58]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[38], [39], [40]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[38], [39], [40]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[45]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[45]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[45]

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