Details of Drug

Drug General Information (ID: D1589)
Drug Name	Tioguanine
Drug Type	Small molecule
Drug Synonymous	6-thioguanine; Lanvis; THG; Tabloid; ThioguaninGSK; Tioguanin; Tioguanina; Tioguanine; Tioguaninum; Glaxo Wellcome Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; GlaxoSmithKline Brand of Tioguanine; Thioguanin GSK; Thioguanine Hemihydrate; Thioguanine Monosodium Salt; Thioguanine Tabloid; Tioguanina Wellcome; Tioguanine GlaxoSmithKline Brand; Wellcome Brand of Thioguanine; BW 5071; DX4; LT00455187; Wellcome U3B; Lanvis (TN); Thioguanin-GSK; Thioguanine [USAN:BAN]; Tioguanina[INN-Spanish]; Tioguanine (INN); Tioguaninum [INN-Latin]; Purine antimetabolite: antimetabolite: inhibits nucleic acid replication; Guanine, thio-(VAN); 2 Amino 6 Purinethiol; 2-Amino 6MP; 2-Amino-1,7-dihydro-6H-purin-6-thion; 2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]; 2-Amino-1,7-dihydro-6H-purine-6-thione; 2-Amino-6-MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-merkaptopurin [Czech]; 2-Amino-6-purinethiol; 2-Amino-9H-purine-6-thiol; 2-Aminopurin-6-thiol; 2-Aminopurin-6-thiol [Czech]; 2-Aminopurine-6(1H)-thione; 2-Aminopurine-6-thiol; 2-Thioguanine; 2-amino-3,7-dihydropurine-6-thione; 6 Thioguanine; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-TG; 6-Thioguanine; 6-Thioguanine (6-TG); 6-Thioguanine, Thioguanine; Thioguanine (Guanine analog) Click to Show/Hide
Disease Class	2A60: Acute myeloid leukaemia
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C5H5N5S
InChI	1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChIKey	WYWHKKSPHMUBEB-UHFFFAOYSA-N
Canonical SMILES	C1=NC2=C(N1)C(=S)N=C(N2)N
External Link
	Pubchem ID	2723601
	CAS Number	154-42-7
	CHEBI ID	9555
	TTD ID	D02ZXM
	INTEDE ID	DR1597
	VARIDT ID	DR00510

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM018 Non-CYP450 enzyme inhibition BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Tioguanine
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[89]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[89]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[89]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[89]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[89]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[89]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[89]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[89]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[89]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[89]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[89]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[89]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[89]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[50], [51], [52]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[50], [51], [52]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[50], [51], [52]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[50], [51], [52]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 62
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[4], [5]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3]
D1111		Natalizumab	NA	NA	Major		Inter Info	[6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[10], [4], [11]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [2], [3]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[16]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[4], [20]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [23]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[30]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[31]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[24], [34], [35]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[36], [35]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[37], [38], [39]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[4], [40], [41]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[4], [40], [41]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[42]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[4], [40], [41]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[4], [40], [41]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[53]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[10], [4], [35]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[4], [40], [41]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[37], [38], [39]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[4], [40], [41]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [4], [67]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [4], [67]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[4], [40], [41]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[4], [40], [41]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[4], [40], [41]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[4], [40], [41]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[35], [69]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[4], [40], [41]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[4], [40], [41]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[4], [40], [41]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[4], [40], [41]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[4], [40], [41]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[4], [40], [41]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[4], [40], [41]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[4], [40], [41]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[4], [40], [41]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[4], [40], [41]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[4], [40], [41]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[4], [40], [41]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[75]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[76]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[4], [77]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[78]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[79]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[37], [38], [39]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[4], [83]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[4], [40], [41]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[84]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[4], [40], [41]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[10], [4], [85]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[4], [40], [41]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[4], [40], [41]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[86]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[88]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[4], [40], [41]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[4], [40], [41]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[4], [12], [13]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[10], [14], [15]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[22]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[10], [4], [70]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[10], [4], [70]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[27], [28], [29]
	Increased risk of hepatotoxicity					Drug Num: 251
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[17]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[18]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[19]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[21]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[17]
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[32], [33]
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[32], [33]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[32], [33]
D0065		Aminosalicylic acid	C7H7NO3	4649	Moderate		Inter Info	[32], [33]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[32], [33]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[32], [33]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[32], [33]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[32], [33]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[32], [33]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[32], [33]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[32], [33]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[32], [33]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[32], [33]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[32], [33]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[32], [33]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[32], [33]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[32], [33]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[32], [33]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[32], [33]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[32], [33]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[32], [33]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[46], [47], [48]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[46], [47], [48]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[32], [33]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[32], [33]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[32], [33]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[32], [33]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[32], [33]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[32], [33]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[32], [33]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[32], [33]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[32], [33]
D1364		Pyrazinamide	C5H5N3O	1046	Moderate		Inter Info	[32], [33]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[32], [33]
D1519		Sulfisoxazole	C11H13N3O3S	5344	Moderate		Inter Info	[32], [33]
D0001		Abacavir	C14H18N6O	441300	Moderate		Inter Info	[32], [33]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[32], [33]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[32], [33]
D0018		Acitretin	C21H26O3	5284513	Moderate		Inter Info	[32], [33]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[32], [33]
D0031		Alectinib	C30H34N4O2	49806720	Moderate		Inter Info	[32], [33]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[32], [33]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[32], [33]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[32], [33]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[32], [33]
D0121		Atovaquone	C22H19ClO3	74989	Moderate		Inter Info	[32], [33]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[32], [33]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[58], [59]
D0153		Belinostat	C15H14N2O4S	6918638	Moderate		Inter Info	[32], [33]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[32], [33]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[32], [33]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[32], [33]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[32], [33]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[32], [33]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[32], [33]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[32], [33]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[32], [33]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[32], [33]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[32], [33]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [66]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[32], [33]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[32], [33]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[32], [33]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[32], [33]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[32], [33]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[32], [33]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[32], [33]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Moderate		Inter Info	[32], [33]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[32], [33]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[32], [33]
D0350		Clavulanic acid	C8H9NO5	5280980	Moderate		Inter Info	[32], [33]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[68]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[32], [33]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[32], [33]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[32], [33]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[32], [33]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[32], [33]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[32], [33]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[32], [33]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[32], [33]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[32], [33]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[32], [33]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[32], [33]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[32], [33]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[32], [33]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[32], [33]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[32], [33]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[32], [33]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[32], [33]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[32], [33]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[32], [33]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[32], [33]
D0566		Emtricitabine	C8H10FN3O3S	60877	Moderate		Inter Info	[32], [33]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[32], [33]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[32], [33]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[32], [33]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[32], [33]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[32], [33]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[32], [33]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[32], [33]
D0637		Febuxostat	C16H16N2O3S	134018	Moderate		Inter Info	[32], [33]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[32], [33]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[32], [33]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[32], [33]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[32], [33]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[32], [33]
D0677		Fluoxymesterone	C20H29FO3	6446	Moderate		Inter Info	[32], [33]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[32], [33]
D0682		Flutamide	C11H11F3N2O3	3397	Moderate		Inter Info	[32], [33]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[32], [33]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[32], [33]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[32], [33]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[32], [33]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[32], [33]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[32], [33]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[32], [33]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[32], [33]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[58], [71]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[32], [33]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[32], [33]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[32], [33]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[32], [33]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[32], [33]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[32], [33]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[32], [33]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[32], [33]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[32], [33]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[32], [33]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[32], [33]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[32], [33]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[32], [33]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[32], [33]
D0889		Lamivudine	C8H11N3O3S	60825	Moderate		Inter Info	[32], [33]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[32], [33]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[32], [33]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[32], [33]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[32], [33]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[32], [33]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[32], [33]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[32], [33]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[32], [33]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[32], [33]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[32], [33]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[32], [33]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[32], [33]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[32], [33]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[32], [33]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[32], [33]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[32], [33]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[32], [33]
D1021		Methimazole	C4H6N2S	1349907	Moderate		Inter Info	[32], [33]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[4], [72], [73]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[32], [33]
D1042		Methyltestosterone	C20H30O2	6010	Moderate		Inter Info	[32], [33]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[32], [33]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[32], [33]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[32], [33]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[32], [33]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[32], [33]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[74]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[32], [33]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[32], [33]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[32], [33]
D1132		Nicotinamide	C6H6N2O	936	Moderate		Inter Info	[32], [33]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[32], [33]
D1137		Nilutamide	C12H10F3N3O4	4493	Moderate		Inter Info	[32], [33]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[32], [33]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[32], [33]
D1180		Onasemnogene abeparvovec	NA	NA	Moderate		Inter Info	[32], [33]
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[32], [33]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[32], [33]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[32], [33]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[32], [33]
D1207		Oxymetholone	C21H32O3	5281034	Moderate		Inter Info	[32], [33]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[32], [33]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[32], [33]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[32], [33]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[46], [47], [48]
D1243		Pemoline	C9H8N2O2	4723	Moderate		Inter Info	[32], [33]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[32], [33]
D1261		Phenazopyridine	C11H11N5	4756	Moderate		Inter Info	[32], [33]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[32], [33]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[32], [33]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[32], [33]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[32], [33]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[32], [33]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[32], [33]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[32], [33]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[32], [33]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[32], [33]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[32], [33]
D1327		Prasterone enantate	C26H40O3	163331	Moderate		Inter Info	[32], [33]
D1359		Propylthiouracil	C7H10N2OS	657298	Moderate		Inter Info	[32], [33]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[32], [33]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[32], [33]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[80], [81], [82]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[32], [33]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[32], [33]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[32], [33]
D1405		Riluzole	C8H5F3N2OS	5070	Moderate		Inter Info	[32], [33]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[32], [33]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[32], [33]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[32], [33]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[32], [33]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[32], [33]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[32], [33]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[32], [33]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[32], [33]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[32], [33]
D1503		Stanozolol	C21H32N2O	25249	Moderate		Inter Info	[32], [33]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[32], [33]
D1514		Sulfadoxine	C12H14N4O4S	17134	Moderate		Inter Info	[32], [33]
D1515		Sulfamethizole	C9H10N4O2S2	5328	Moderate		Inter Info	[32], [33]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[32], [33]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[32], [33]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[32], [33]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[32], [33]
D1531		Tagraxofusp	NA	NA	Moderate		Inter Info	[32], [33]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[32], [33]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[32], [33]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[32], [33]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[32], [33]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[32], [33]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[32], [33]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[32], [33]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[32], [33]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[32], [33]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[32], [33]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [87]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[32], [33]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[32], [33]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[32], [33]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[32], [33]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[32], [33]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[32], [33]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[32], [33]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[32], [33]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[32], [33]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[32], [33]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[32], [33]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[32], [33]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[32], [33]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[32], [33]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[32], [33]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[32], [33]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[32], [33]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[7], [8], [9]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[24], [10], [25]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[26]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[7], [8], [9]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[7], [8], [9]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[49]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[24], [56], [57]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[24], [56], [57]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[24], [56], [57]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[24], [56], [57]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[24], [56], [57]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[24], [56], [57]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[24], [56], [57]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[24], [56], [57]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[24], [56], [57]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[24], [56], [57]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[24], [56], [57]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[24], [56], [57]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[60], [61], [62]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[60], [61], [62]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[63], [64], [65]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[63], [64], [65]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[63], [64], [65]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[54], [55]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[43], [44], [45]

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32	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
33	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
34	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
35	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
36	Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
37	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
38	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
39	Product Information. Kineret (anakinra). Amgen, Thousand Oaks, CA.
40	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
41	Product Information. Fluorouracil injection (fluorouracil). Roche Laboratories, Nutley, NJ.
42	Product Information. Raptiva (efalizumab). Genentech, South San Francisco, CA.
43	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
44	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
45	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
46	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
47	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
48	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
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51	Product Information. Imuran (azathioprine). Glaxo Wellcome, Research Triangle Park, NC.
52	Product Information. Purinethol (mercaptopurine). Glaxo Wellcome, Research Triangle Pk, NC.
53	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
54	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
55	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
56	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
57	Department of Health. National Health Service "Immunisation Against Infectious Disease - "The Green Book". Chapter 6: Contraindications and special considerations.".
58	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
59	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
60	Borriello SP, Hammes WP, Holzapfel W, et.al "Safety of probiotics that contain lactobacilli or bifidobacteria." Clin Infect Dis 36 (2003): 775-80. [PMID: 12627362]
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63	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
64	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
65	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
66	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
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69	Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
70	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
71	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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73	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
74	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
75	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
76	Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
77	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
78	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
79	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
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86	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
87	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
88	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
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