Details of Drug

Drug General Information (ID: D1559)
Drug Name	Testosterone (topical)
Drug Type	Small molecule
Drug Synonymous	AndroGel; Androderm; Androlin; Andronaq; Andropatch; Androsorb; Andrusol; Depotest; Halotensin; Homosteron; Homosterone; Intrinsa; LibiGel; Malerone; Mertestate; Neotestis; Oreton; Orquisteron; Perandren; Primotest; Primoteston; Relibra; Striant; Sustanon; Sustanone; Teslen; Testandrone; Testaqua; Testiculosterone; Testim; Testobase; Testoderm; Testogel; Testolin; Testopropon; Testosteroid; Testosteron; Testosterona; Testosteronum; Testostosterone; Testoviron; Testrone; Testryl; Virormone; Virosterone; Beta testosterone; Cristerona T; Cristerone T; Malogen in Oil; Oreton F; Percutacrine androgenique; Synandrol F; Testoderm Tts; Testopel Pellets; Testosterone and its esters; Testosterone hydrate; Testosterone solution; Testoviron Schering; Testoviron T; Testro AQ; Virilon IM; AA 2500; Andro 100; Andronate 100; Andronate 200; Andropository 200; Andryl 200; CDB 111C; CMC_13449; COL 1621; CP 601B; Everone 200; Sustason 250; Testamone 100; Testred Cypionate 200; Androderm (TN); Androgel (TN); Geno-cristaux gremy; Malestrone (amps); Malogen, aquaspension injection; Neo-Hombreol F; Neo-testis; Oreton-F; Scheinpharm Testone-Cyp; Striant (TN); T-Cypionate; Testim (TN); Testoject-50; Testosterona [INN-Spanish]; Testosterone [Androgenic steroids, anabolic]; Testosterone [INN:BAN]; Testosteronum [INN-Latin]; Trans-Testosterone; Testosterone (JAN/USP); Testrin-P.A; Delta4-Androsten-17beta-ol-3-one; Delta4-androsten-17b-ol-3-one; Androst-4-en-17beta-ol-3-one; Delta(sup 4)-Androsten-17(beta)-ol-3-one; (17beta)-17-Hydroxyandrost-4-en-3-one; (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 17-Hydroxy-(17-beta)-androst-4-en-3-one; 17-Hydroxy-(17beta)-androst-4-en-3-one; 17-Hydroxy-4-androsten-3-one; 17-beta-Hydroxy-delta(sup 4)-androsten-3-one; 17-beta-Hydroxyandrost-4-en-3-one; 17b-hydroxy-4-androsten-3-one; 17beta-Hydroxy-3-oxo-4-androstene; 17beta-Hydroxy-4-androsten-3-one; 17beta-Hydroxy-delta(sup4)-androsten-3-one; 17beta-Hydroxyandrost-4-en-3-one; 17beta-Hydroxyandrost-4-ene-3-one; 4-Androsten-17-ol-3-one; 4-Androsten-17beta-ol-3-one; 4-androstene-17beta-ol-3-one; 7-beta-Hydroxyandrost-4-en-3-one Click to Show/Hide
Disease Class	FB83: Low bone mass disorder; 5A81: Testicular dysfunction; 5A60-5A61: Pituitary gland disorder
Therapeutic Class	Antiandrogens
Structure
Structure	3D Structure		2D Structure
Formula	C19H28O2
InChI	1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1
InChIKey	MUMGGOZAMZWBJJ-DYKIIFRCSA-N
Canonical SMILES	CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
External Link
	Pubchem ID	6013
	CAS Number	58-22-0
	CHEBI ID	17347
	TTD ID	D06XMU
	VARIDT ID	DR00108

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM047 Additive thrombogenic effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM083 Potentiated the pharmacological effects (Unspecific) BM108 Increased risk of hypercalcemia
Relation Graph

Full list of drugs interacting with Testosterone (topical)
Affected cellular transport
	Transporter inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[75]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[3], [61], [78]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[19], [20], [21]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[22], [23], [24]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[25], [26], [27]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[2], [3], [31]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[43]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[44], [45], [46]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[48]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[49], [50]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[51], [52]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[59], [60]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[63]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[64], [65]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[2], [66]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[61], [67]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[68]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[71], [59], [72]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[49], [50]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[51], [52]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[79], [2], [80]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[15], [81], [27]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[2], [3], [82]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[83]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[3], [85], [86]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[15], [88], [27]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[89], [27]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[96], [97], [98]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[2], [101], [102]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[103], [27]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[106], [27], [107]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[110]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[71], [59], [111]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[2], [3], [114]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[118], [119], [120]
	CYP450 enzyme induction					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[14], [15], [16]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[2], [3], [47]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [61], [62]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[69]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[70]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[3], [84]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[90], [91], [92]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[99], [100]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[2], [3], [47]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[59], [105]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[3], [108]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[115], [116], [117]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[115], [116], [117]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[2], [73], [74]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[2], [73], [74]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[104], [46], [27]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[104], [46], [27]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[104], [46], [27]
Pharmacodynamic additive effects
	Additive thrombogenic effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[1], [2], [3]
D0385		Conestat alfa	NA	NA	Moderate		Inter Info	[56], [57], [58]
D0762		Human C1-esterase inhibitor	NA	NA	Moderate		Inter Info	[56], [57], [58]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[4], [5], [6]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[7]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[8]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[9]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[4], [5], [6]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[10], [2], [11]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[35], [36], [37]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[35], [36], [37]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3], [41], [42]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[10], [2], [11]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[10], [2], [11]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[53]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[10], [2], [11]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[3], [54]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[55]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[76], [77]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[87]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[35], [36], [37]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[93], [94], [95]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[3], [109]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[112], [113]
	Increased risk of hypoglycemia					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[28], [29], [30]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[32], [33], [34]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[32], [33], [34]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[32], [33], [34]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[28], [29], [30]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[28], [29], [30]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[28], [29], [30]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[32], [33], [34]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[32], [33], [34]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[32], [33], [34]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[32], [33], [34]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[28], [29], [30]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[28], [29], [30]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[28], [29], [30]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[28], [29], [30]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[12], [13]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[38], [39], [40]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[38], [39], [40]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[12], [13]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[12], [13]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[12], [13]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[12], [13]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[12], [13]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[12], [13]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[38], [39], [40]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[12], [13]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[12], [13]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[12], [13]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[12], [13]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[38], [39], [40]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[12], [13]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[12], [13]
	Increased risk of hypercalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1754		Calcitriol (topical)	C27H44O3	5280453	Moderate		Inter Info	[17], [18]
D1753		Calcipotriol (topical)	C27H40O3	5288783	Moderate		Inter Info	[17], [18]

References
1	Product Information. Kyprolis (carfilzomib). Onyx Pharmaceuticals Inc, South San Francisco, CA.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Canadian Pharmacists Association.
5	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
6	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
7	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
8	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
9	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
10	Bodmer M, Sulz M, Stadlmann S, Droll A, Terracciano L, Krahenbuhl S "Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase." Digestion 74 (2006): epub. [PMID: 16988508]
11	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
12	Product Information. AndroGel (testosterone). Unimed Pharmaceuticals, Buffalo Grove, IL.
13	Product Information. Oxandrin (oxandrolone). Bio-Tech, Levittown, PA.
14	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
15	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
16	Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
17	Product Information. Vectical (calcitriol topical). Galderma Laboratories Inc, Cranbury, NJ.
18	Product Information. Dovonex (calcipotriene). Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.
19	Renton KW "Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil." Biochem Pharmacol 34 (1985): 2549-53. [PMID: 4015695]
20	Sakai H, Kobayashi S, Hamada K, et al "The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates." Br J Clin Pharmacol 31 (1991): 353-5. [PMID: 2054276]
21	Sutton D, Butler AM, Nadin L, Murray M "Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites." J Pharmacol Exp Ther 282 (1997): 294-300. [PMID: 9223567]
22	Assan R, Fredj G, Larger E, Feutren G, Bismuth H "FK 506/fluconazole interaction enhances FK 506 nephrotoxicity." Diabete Metab 20 (1994): 49-52. [PMID: 7520007]
23	Sinofsky FE, Pasquale SA "The effect of fluconazole on circulating ethinyl estradiol levels in women taking oral contraceptives." Am J Obstet Gynecol 178 (1998): 300-4. [PMID: 9500490]
24	Ulivelli M, Rubegni P, Nuti D, Bartalini S, Giannini F, Rossi S "Clinical evidence of fluconazole-induced carbamazepine toxicity." J Neurol 251 (2004): 622-3. [PMID: 15164201]
25	Damkier P, Hansen LL, Brosen K "Effect of fluvoxamine on the pharmacokinetics of quinidine." Eur J Clin Pharmacol 55 (1999): 451-6. [PMID: 10492058]
26	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
27	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
28	Christensen LK, Hansen JM, Kristensen M "Sulphaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics." Lancet 2 (1963): 1298-301. [PMID: 14071924]
29	Field JB, Ohta M, Boyle C, Remer A "Potentiation of acetohexamide hypoglycemia by phenylbutazone." N Engl J Med 277 (1967): 889-94. [PMID: 6061822]
30	Turtle JR, Burgess JA "Hypoglycemic action of fenfluramine in diabetes mellitus." Diabetes 22 (1973): 858-67. [PMID: 4749404]
31	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
32	Asplund K, Wiholm BE, Lithner F "Glibenclamide-associated hypoglycaemia: a report on 57 cases." Diabetologia 24 (1983): 412-7. [PMID: 6411511]
33	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
34	Semel JD, Wortham E, Karl DM "Fasting hypoglycemia associated with disopyramide." Am Heart J 106 (1983): 1160-1. [PMID: 6356848]
35	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
36	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
37	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
38	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
39	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
40	Arafah BM "Decreased levothyroxine requirement in women with hypothyroidism during androgen therapy for breast cancer." Ann Intern Med 121 (1994): 247-51
41	Nesher G, Mates M, Zevin S "Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis." Arthritis Rheum 48 (2003): 571-572. [PMID: 12571869]
42	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
43	Product Information. Viracept (nelfinavir). Agouron Pharma Inc, La Jolla, CA.
44	Olkkola KT, Palkama VJ, Neuvonen PJ "Ritonavir's role in reducing fentanyl clearance and prolonging its half-life." Anesthesiology 91 (1999): 681-5. [PMID: 10485779]
45	Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
46	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
47	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
48	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
49	Product Information. Agenerase (amprenavir). Glaxo Wellcome, Research Triangle Pk, NC.
50	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
51	Product Information. Emend (aprepitant). Merck &amp Company Inc, West Point, PA.
52	Product Information. Emend for Injection (fosaprepitant). Merck &amp Company Inc, West Point, PA.
53	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
54	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
55	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
56	Product Information. Berinert (complement C1 esterase inhibitor). CSL Behring, King of Prussia, PA.
57	Product Information. Ruconest (conestat alfa). Valeant Pharmaceuticals, Costa Mesa, CA.
58	Gandhi PK, Gentry WM, Bottorff MB "Thrombotic events associated with C1 esterase inhibitor products in patients with hereditary angioedema: investigation from the United States Food and Drug Administration adverse event reporting system database." Pharmacotherapy 32 (2012): 902-9. [PMID: 23033229]
59	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
60	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
61	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
62	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
63	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
64	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
65	Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
66	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
67	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
68	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
69	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
70	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
71	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
72	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
73	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
74	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
75	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
76	Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
77	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
78	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
79	Auclair B, Berning SE, Huitt GA, Peloquin CP "Potential interaction between itraconazole and clarithromycin." Pharmacotherapy 19 (1999): 1439-44. [PMID: 10600094]
80	Kaukonen KM, Olkkola KT, Neuvonen PJ "Itraconazole increases plasma concentrations of quinidine." Clin Pharmacol Ther 62 (1997): 510-7. [PMID: 9390107]
81	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
82	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
83	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
84	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
85	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
86	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
87	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
88	Product Information. Serzone (nefazodone). Bristol-Myers Squibb, Princeton, NJ.
89	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
90	Product Information. Trileptal (oxcarbazepine) Novartis Pharmaceuticals, East Hanover, NJ.
91	Rosche J, Froscher W, Abendroth D, Liebel J "Possible oxcarbazepine interaction with cyclosporine serum levels: A single case study." Clin Neuropharmacol 24 (2001): 113-6. [PMID: 11307049]
92	Zaccara G, Gangemi PF, Bendoni L, Menge GP, Schwabe S, Monza GC "Influence of single and repeated doses of oxcarbazepine on the pharmacokinetic profile of felodipine." Ther Drug Monit 15 (1993): 39-42. [PMID: 8451779]
93	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
94	Gilead Sciences, Inc "About Remdesivir.".
95	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
96	Kane GC, Lipsky JJ "Drug-grapefruit juice interactions." Mayo Clin Proc 75 (2000): 933-42. [PMID: 10994829]
97	Rawden HC, Kokwaro GO, Ward SA, Edwards G "Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes." Br J Clin Pharmacol 49 (2000): 313-22. [PMID: 10759686]
98	Trivier JM, Libersa C, Belloc C, Lhermitte M "Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report)." Life Sci 52 (1993): pl91-6. [PMID: 8445979]
99	Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
100	Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90. [PMID: 11038154]
101	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
102	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
103	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
104	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
105	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
106	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
107	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
108	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
109	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
110	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
111	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
112	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
113	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
114	Product Information. VFEND (voriconazole). Pfizer U.S. Pharmaceuticals, New York, NY.
115	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
116	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
117	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
118	Cheng CL, Smith DE, Carver PL, Cox SR, Watkins PB, Blake DS, Kauffman CA, Meyer KM, Amidon GL, Stetson PL "Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test." Clin Pharmacol Ther 61 (1997): 531-43. [PMID: 9164415]
119	Fichtenbaum CJ, Gerber JG "Interactions between antiretroviral drugs and drugs used for the therapy of the metabolic complications encountered during HIV infection." Clin Pharmacokinet 41 (2002): 1195-211. [PMID: 12405866]
120	vonMoltke LL, Greenblatt DJ, Granda BW, Giancarlo GM, Duan SX, Daily JP, Harmatz JS, Shader RI "Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors." J Clin Pharmacol 41 (2001): 85-91. [PMID: 11225565]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence