Details of Drug

Drug General Information (ID: D1543)
Drug Name	Telbivudine
Drug Type	Small molecule
Drug Synonymous	Epavudine; LLT; LdT; Sebivo; Telbivudin; Tyzeka; Telbivudine [USAN]; LDT600; NB 02B; NV 02B; L-Deoxythymidine; L-Thymidine; L-dT; LDT-600; NV-02B; Tyzeka (TN); Beta-L-Thymidine; Telbivudine (USAN/INN); Tyzake/Sebivo (TN); Tyzeka, Sebivo, Telbivudine; 1-(2-Deoxy-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-(2-Deoxy-beta-L-erythropentafuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Deoxy-L-thymidine Click to Show/Hide
Disease Class	1E50-1E51: Hepatitis virus infection
Therapeutic Class	Antiviral Agents
Structure
Structure	3D Structure		2D Structure
Formula	C10H14N2O5
InChI	1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
InChIKey	IQFYYKKMVGJFEH-CSMHCCOUSA-N
Canonical SMILES	CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O
External Link
	Pubchem ID	159269
	CAS Number	3424-98-4
	CHEBI ID	63624
	TTD ID	D0CL9S

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM027 Decreased renal excretion due to nephrotoxicity BM074 Increased risk of peripheral neuropathy BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Telbivudine
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1187		Orlistat	C29H53NO5	3034010	Moderate		Inter Info	[13]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 71
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[3]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[3]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[3]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[3]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[3]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[3]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[3]
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[3]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[3]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[3]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[3]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[3]
D0335		Cidofovir	C8H14N3O6P	60613	Moderate		Inter Info	[3]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[3]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[3]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[3]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[3]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[3]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[3]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[3]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[3]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[3]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[3]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[3]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[3]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[3]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[3]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[3]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[3]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[3]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[3]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[3]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[3]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[3]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[3]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[3]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[3]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[3]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[3]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[3]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[3]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[3]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[3]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[3]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[3]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[3]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[3]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[3]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[3]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[3]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[3]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[3]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[3]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[3]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[3]
D0709		Gallium nitrate	GaN3O9	61635	Moderate		Inter Info	[3]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Moderate		Inter Info	[3]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[3]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[3]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[3]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[3]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[3]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[3]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[3]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[3]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[3]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[3]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[3]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[3]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[3]
Pharmacodynamic additive effects
	Increased risk of peripheral neuropathy					Drug Num: 68
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[1], [2], [3]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[1], [2], [3]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[1], [2], [3]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[1], [2], [3]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[1], [2], [3]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[1], [2], [3]
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[4], [5], [6]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[4], [5], [6]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[8], [9], [10]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[4], [5], [6]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[4], [5], [6]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[4], [5], [6]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[4], [5], [6]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[4], [5], [6]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[4], [5], [6]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[4], [5], [6]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[4], [5], [6]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[4], [5], [6]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[4], [5], [6]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[4], [5], [6]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[4], [5], [6]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[4], [5], [6]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[4], [5], [6]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[4], [5], [6]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[4], [5], [6]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[4], [5], [6]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[4], [5], [6]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[4], [5], [6]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[4], [5], [6]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[4], [14], [15]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[4], [5], [6]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[4], [5], [6]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[4], [5], [6]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[4], [5], [6]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[4], [5], [6]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[4], [5], [6]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[4], [5], [6]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[4], [5], [6]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[4], [5], [6]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[4], [5], [6]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[4], [5], [6]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[4], [5], [6]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[4], [5], [6]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[4], [5], [6]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[4], [5], [6]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [5], [6]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[4], [5], [6]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[8], [16], [17]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[4], [5], [6]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[4], [5], [6]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[4], [5], [6]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[4], [5], [6]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[4], [5], [6]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[4], [5], [6]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 26
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[7], [3]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[7], [3]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[7], [3]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[7], [3]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[7], [3]
D0360		Clofibrate	C12H15ClO3	2796	Moderate		Inter Info	[7], [3]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[7], [3]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[7], [3]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[7], [3]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[7], [3]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[7], [3]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[7], [3]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[7], [3]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[7], [3]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[7], [3]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[7], [3]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[7], [3]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[7], [3]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[7], [3]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[7], [3]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[7], [3]
D0643		Fenofibric acid	C17H15ClO4	64929	Moderate		Inter Info	[7], [3]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[7], [3]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[7], [3]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[7], [3]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[7], [3]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Moderate		Inter Info	[11], [5], [12]

References
1	Product Information. PEG-Intron (peginterferon alfa-2b) Schering Corporation, Kenilworth, NJ.
2	Product Information. Pegasys (peginterferon alfa-2a). Roche Laboratories, Nutley, NJ.
3	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
4	Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
5	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
6	Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online."
7	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
8	Argov Z, Mastaglia FL "Drug-induced peripheral neuropathies." Br Med J 1 (1979): 663-6. [PMID: 219931]
9	Cavaletti G, Jakubowiak AJ "Peripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studies." Leuk Lymphoma 51 (2010): 1178-87. [PMID: 20497001]
10	Product Information. Velcade (bortezomib). Millennium Pharmaceuticals Inc, Cambridge, MA.
11	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
12	Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
13	MHRA. Medicines and Healthcare Products Regulatory Agency "Orlistat: theoretical interaction with antiretroviral HIV medicines.".
14	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
15	Product Information. Danyelza (naxitamab). Y-mAbs Therapeutics, New York, NY.
16	Cerner Multum, Inc. "Australian Product Information.".
17	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.

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