Details of Drug

Drug General Information (ID: D1538)
Drug Name	Tazemetostat
Drug Type	Small molecule
Drug Synonymous	EPZ-6438; 1403254-99-8; EPZ6438; UNII-Q40W93WPE1; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; Q40W93WPE1; EPZ 6438; E7438; (1,1'-Biphenyl)-3-carboxamide, N-((1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(4-morpholinylmethyl)- Click to Show/Hide
Disease Class	2A00: Brain cancer; 2A81: Diffuse large B-cell lymphoma; 2C51: Peritoneal cancer; 2A00-2F9Z: Solid tumour/cancer; 2B5A: Synovial sarcoma; 2A80: Follicular lymphoma
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C34H44N4O4
InChI	1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
InChIKey	NSQSAUGJQHDYNO-UHFFFAOYSA-N
Canonical SMILES	CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5
External Link
	Pubchem ID	66558664
	CAS Number	1403254-99-8
	TTD ID	D00EQL

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM044 Additive myelosuppressive effects BM050 Increased risk of bleeding
Relation Graph

Full list of drugs interacting with Tazemetostat
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 63
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[32]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[115], [116]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[6], [2], [162], [163]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[201], [202], [203], [1], [116], [204]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[226], [1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[226], [1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 232
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[1], [13]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[17], [18]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[1], [13]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[19]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[23]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [13]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[1], [13]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Major		Inter Info	[1], [13]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[33]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[1]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[34], [35], [36], [37]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[38]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[39]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[40], [1]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[40], [1]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[41], [42], [43], [44], [45]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[46]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[47], [48]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[1]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[1]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[1]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[6], [2], [49]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[1]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[1]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[1]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[53], [54], [55], [6], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[70]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[71], [72]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[73]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[2], [74]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[113]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[1]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[114]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[1]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[40], [1]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[40], [1]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[6], [2], [118]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[1]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[119]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[120], [121]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[40], [1]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[1]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[122]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[6], [2], [118]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[6], [2], [118]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[123], [124]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[1]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[1]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[1]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[40], [1]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[40], [1]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[40], [1]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[40], [1]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[125]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[40], [1]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[1]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[1]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[6], [2], [126]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[127]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[1]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[53], [54], [55], [6], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[128]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[1]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[1]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[123], [129]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[130]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[2], [131], [132]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[1]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[53], [54], [55], [6], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[1]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[135], [136], [141]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[1]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[2], [149]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[150]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[151]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[6], [2], [152]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[6], [153]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[1]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[1]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[154]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[1]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[155]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[156], [157]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[6], [158]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[40], [1]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[159]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[40], [1]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[53], [54], [55], [6], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[6], [2], [118]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[40], [1]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[1]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[6], [2], [118]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[1]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[160], [161]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[164], [165], [166], [167]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[168]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[169]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[170]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[1]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[1]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[173], [6], [2]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[40], [1]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[40], [1]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[6], [2], [174]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[175], [176], [177]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[178]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[1]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[53], [54], [55], [6], [2], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[179], [180], [181], [182]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[179], [180], [181]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[183]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[6], [2], [186]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[187], [6], [188], [189]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[1]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[1]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[1]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[6], [190], [191], [192], [193]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[194], [195], [196], [197], [198], [199]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[200]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[6], [15], [2], [205]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[206]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[207]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[208]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[209]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[210], [211], [212], [213]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[6], [2], [214]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[6], [2], [215], [216]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[217]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[1]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[218]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[219]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[6], [2], [220]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[6], [2], [215], [216]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[2], [221], [222]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[223]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[2], [224]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[54], [59], [69]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[225]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[227]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[54], [59], [69]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[228]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[6], [229]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[175], [230]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[1]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[231]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[40], [1]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[6], [2], [232]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[40], [1]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[1]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[40], [1]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[1]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[1]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[233], [6], [2], [234], [235]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[2], [236], [237]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[1]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[1]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[238]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[105]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[40], [1]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[1]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[2], [239], [240], [241]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[242], [243]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[2], [244], [245], [246], [247]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[248]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[249], [250], [251]
D0700		Fostemsavir	C25H26N7O8P	11319217	Minor		Inter Info	[175], [252], [177]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[17], [253]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[254], [255], [256], [257]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[258]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[259], [260]
Pharmacodynamic additive effects
	Additive myelosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[2], [8], [9]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[6], [10], [11]
	Increased risk of bleeding					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[2], [3]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[4], [5]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[6], [2], [7]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[12]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[14], [15], [2], [16]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[20], [21]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[2], [22]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[2], [24], [25]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[26]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[2], [20], [27]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[28]
D1613		Tositumomab	NA	NA	Major		Inter Info	[29], [30]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[29], [30]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[31]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[50], [51], [52]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[50], [51], [52]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[20], [117]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[78], [107], [108]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[50], [51], [52]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[50], [51], [52]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[50], [51], [52]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[50], [51], [52]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[50], [51], [52]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[50], [51], [52]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[50], [51], [52]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[133]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[50], [51], [52]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[50], [51], [52]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[50], [51], [52]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[50], [51], [52]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[50], [51], [52]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[50], [51], [52]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[50], [51], [52]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[50], [51], [52]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[50], [51], [52]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[50], [51], [52]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[50], [51], [52]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[171]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[2], [172]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[50], [51], [52]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[20], [184]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[173], [185]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[50], [51], [52]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[78], [107], [108]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[50], [51], [52]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[50], [51], [52]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[75], [76], [77], [78], [6], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112]

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22	Product Information. Effient (prasugrel). Lilly, Eli and Company, Indianapolis, IN.
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26	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
27	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
28	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
29	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
30	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
31	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
32	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
33	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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65	Product Information. Ionsys (fentanyl). Ortho McNeil Pharmaceutical, Raritan, NJ.
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73	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
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95	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
96	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
97	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
98	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
99	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
100	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
101	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
102	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
103	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
104	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
105	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
106	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
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114	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
115	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
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118	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
119	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
120	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
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122	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
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125	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
126	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
127	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
128	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
129	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
130	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
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144	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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150	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
151	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
152	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
153	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
154	Product Information. Tradjenta (linagliptin). Boehringer Ingelheim, Ridgefield, CT.
155	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
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158	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
159	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
160	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
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164	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
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169	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
170	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
171	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
172	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
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174	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
175	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
176	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
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180	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
181	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
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184	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
185	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
186	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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188	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
189	Ridtitid W, Wongnawa M, Mahatthanatrakul W, Punyo J, Sunbhanich M "Rifampin markedly decreases plasma concentrations of praziquantel in healthy volunteers." Clin Pharmacol Ther 72 (2002): 505-13. [PMID: 12426514]
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196	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
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200	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
201	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
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205	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
206	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
207	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
208	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
209	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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212	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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229	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
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