Details of Drug

Drug General Information (ID: D1531)
Drug Name	Tagraxofusp
Drug Type	Protein/peptide
Drug Synonymous	Tagraxofusp [INN]; Molecule 129; Tagraxofusp [USAN]; UNII-8ZHS5657EH; 8ZHS5657EH; Diphtheria toxin-il-3 fusion protein targeting IL-3 receptor Click to Show/Hide
Disease Class	2A60: Acute myeloid leukaemia
Therapeutic Class	Antineoplastics
External Link
External Link	TTD ID	D0R7NI

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM086 Antagonize the effect of antidiabetic agents
Relation Graph

Full list of drugs interacting with Tagraxofusp
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[34]
	Additive myelosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[1], [2], [3]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[4], [5], [6]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[7], [8], [9]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[10]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[11]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[12]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[7], [8], [9]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[16]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[17]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[1], [18]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[19]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[20], [21]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[4], [1], [22]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[23]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[24], [25], [26], [27]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[24], [25], [26], [27]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[28]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[24], [25], [26], [27]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[4], [1], [29], [30], [31]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[32], [33]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [35]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 42
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[13], [14], [15]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[13], [14], [15]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[13], [14], [15]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[13], [14], [15]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[13], [14], [15]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[13], [14], [15]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[13], [14], [15]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[13], [14], [15]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[13], [14], [15]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[13], [14], [15]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[13], [14], [15]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[13], [14], [15]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[13], [14], [15]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[13], [14], [15]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[13], [14], [15]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[13], [14], [15]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[13], [14], [15]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[13], [14], [15]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[13], [14], [15]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[13], [14], [15]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[13], [14], [15]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[13], [14], [15]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[13], [14], [15]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[13], [14], [15]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[13], [14], [15]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[13], [14], [15]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[13], [14], [15]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[13], [14], [15]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[13], [14], [15]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[13], [14], [15]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[13], [14], [15]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[13], [14], [15]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[13], [14], [15]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[13], [14], [15]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[13], [14], [15]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[13], [14], [15]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[13], [14], [15]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[13], [14], [15]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[13], [14], [15]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[13], [14], [15]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[13], [14], [15]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[13], [14], [15]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
3	Canadian Pharmacists Association "e-CPS."
4	Cerner Multum, Inc. "Australian Product Information.".
5	Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
6	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
7	Canadian Pharmacists Association.
8	EMEA "EMEA public statement on leflunomide (ARAVA) - severe and serious hepatic reactions.".
9	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
10	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
11	Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
12	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
13	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
14	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
15	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
16	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
17	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
18	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
19	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
20	Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
21	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
22	Product Information. Ellence (epirubicin) Pharmacia and Upjohn, Kalamazoo, MI.
23	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
24	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
25	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
26	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
27	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
28	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
29	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
30	Gilead Sciences, Inc "About Remdesivir.".
31	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
32	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
33	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
34	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
35	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.

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