Details of Drug

Details of Drug

 Drug General Information (ID: D1530)
  Drug Name
Tafenoquine
  Drug Type Small molecule
  Drug Synonymous
106635-80-7; WR-238605; WR 238605; Etaquine; WR238605; Tafenoquine [INN:BAN
    Click to Show/Hide
  Disease Class 1F40-1F45: Malaria
  Therapeutic Class Antimalarial Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C24H28F3N3O3
  InChI 1S/C24H28F3N3O3/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3
  InChIKey LBHLFPGPEGDCJG-UHFFFAOYSA-N
  Canonical SMILES CC1=CC(=NC2=C1C(=C(C=C2NC(C)CCCN)OC)OC3=CC=CC(=C3)C(F)(F)F)OC
  External Link
Pubchem ID 115358
CAS Number 106635-80-7
CHEBI ID 141487
TTD ID D07TWN
INTEDE ID DR1526

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM071  Increased risk of methemoglobinemia
BM100  Antagonize the effect of vaccine/toxoid
  Relation Graph
 Full list of drugs interacting with Tafenoquine
      Affected cellular transport
   Transporter inhibition Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic additive effects
   Increased risk of methemoglobinemia Drug Num:  14
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1337
 
Prilocaine
 
C13H20N2O
 
4906 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10]
D1148
 
Nitrous acid
 
HNO2
 
24529 
Major    Inter Info   
[11], [12], [13]
D0163
 
Benzocaine (topical)
 
C9H11NO2
 
2337 
Moderate    Inter Info   
[6], [7], [16]
D0339
 
Cinchocaine (topical)
 
C20H29N3O2
 
3025 
Moderate    Inter Info   
[6], [7], [16]
D0377
 
Cocaine (nasal)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[6], [7], [16]
D0378
 
Cocaine (topical)
 
C17H21NO4
 
446220 
Moderate    Inter Info   
[6], [7], [16]
D0419
 
Dapsone
 
C12H12N2O2S
 
2955 
Moderate    Inter Info   
[5], [17]
D0420
 
Dapsone (topical)
 
C12H12N2O2S
 
2955 
Moderate    Inter Info   
[5], [17]
D1835
 
Lidocaine (ophthalmic)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[6], [7], [16]
D0928
 
Lidocaine (topical)
 
C14H22N2O
 
3676 
Moderate    Inter Info   
[6], [7], [16]
D1852
 
Oxybuprocaine (ophthalmic)
 
C17H28N2O3
 
4633 
Moderate    Inter Info   
[6], [7], [16]
D1870
 
Proparacaine (ophthalmic)
 
C16H26N2O3
 
4935 
Moderate    Inter Info   
[6], [7], [16]
D1904
 
Tetracaine (ophthalmic)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[6], [7], [16]
D1562
 
Tetracaine (topical)
 
C15H24N2O2
 
5411 
Moderate    Inter Info   
[6], [7], [16]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[6], [14], [15]
References
1 Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
2 Abel S, Nichols DJ, Brearley CJ, Eve MD "Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide." Br J Clin Pharmacol 49 (2000): 64-71.[PMID: 10606839]
3 Johnson BF, Cheng SL, Venitz J "Transient kinetic and dynamic interactions between verapamil and dofetilide, a class III antiarrhythmic." J Clin Pharmacol 41 (2001): 1248-56.[PMID: 11697758]
4 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
5 Cerner Multum, Inc. "Australian Product Information.".
6 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
7 Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
8 Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
9 Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
10 Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
11 Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
12 Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
13 Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
14 UK government "Typhoid.".
15 American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
16 Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
17 Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.