Details of Drug

Details of Drug

 Drug General Information (ID: D1523)
  Drug Name
Suprofen (ophthalmic)
  Drug Type Small molecule
  Drug Synonymous
Maldocil; Masterfen; Profenal; Srendam; Sulproltin; Suprocil; Suprofene; Suprofenum; Suprol; Sutoprofen; R 25061; R25061; TN 762; TN762; Profenal (TN); R-25061; Suprofene [INN-French]; Suprofenum [INN-Latin]; TN-762; TYN-762P; P-2-Thenoylhydratropic acid; R-25,061; Suprofen (JAN/USP/INN); Suprofen [USAN:BAN:INN:JAN]; Alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid; (+-)-2-(p-(2-Thenoyl)phenyl)propionic acid; (-)-alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid; (R)-(Thien-2-ylcarbonyl)propionic acid; (S)-2-(4-(Thien-2-ylcarbonyl)phenyl)butyric acid; 2-(4-(2-Thenoyl)phenyl)propionsaeure; 2-(4-(2-Thienylcarbonyl)phenyl)propanoic acid; 2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid; 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid; 4-(2-Thenoyl)hydratropsaeure
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  Disease Class LA11: Eye anterior segment structural developmental anomaly
  Therapeutic Class Antiinflammatory Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C14H12O3S
  InChI 1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
  InChIKey MDKGKXOCJGEUJW-UHFFFAOYSA-N
  Canonical SMILES CC(C1=CC=C(C=C1)C(=O)C2=CC=CS2)C(=O)O
  External Link
Pubchem ID 5359
CAS Number 40828-46-4
CHEBI ID 9362
TTD ID D07BPS
INTEDE ID DR1520

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM050  Increased risk of bleeding
BM091  Antagonize the effect of cholinergic agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Suprofen (ophthalmic)
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1143
 
Nitisinone
 
C14H10F3NO5
 
115355 
Moderate    Inter Info   
[4], [5], [6]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[9], [10]
   CYP450 enzyme induction Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[5], [7], [8]
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  54
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0005
 
Abciximab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0047
 
Alteplase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0084
 
Anagrelide
 
C10H7Cl2N3O
 
135409400 
Moderate    Inter Info   
[1], [2], [3]
D0088
 
Anistreplase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0102
 
Ardeparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3]
D0104
 
Argatroban
 
C23H36N6O5S
 
92722 
Moderate    Inter Info   
[1], [2], [3]
D0189
 
Bivalirudin
 
C98H138N24O33
 
16129704 
Moderate    Inter Info   
[1], [2], [3]
D0364
 
Clopidogrel
 
C16H16ClNO2S
 
60606 
Moderate    Inter Info   
[1], [2], [3]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[1], [2], [3]
D0537
 
Drotrecogin alfa
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0588
 
Eptifibatide
 
C35H49N11O9S2
 
448812 
Moderate    Inter Info   
[1], [2], [3]
D0690
 
Fondaparinux
 
C31H53N3O49S8
 
5282448 
Moderate    Inter Info   
[1], [2], [3]
D0784
 
Ibritumomab tiuxetan
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0904
 
Lepirudin
 
C287H440N80O111S6
 
118856773 
Moderate    Inter Info   
[1], [2], [3]
D1395
 
Reteplase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1506
 
Streptokinase
 
C11H19NO2
 
9815560 
Moderate    Inter Info   
[1], [2], [3]
D0008
 
Acalabrutinib
 
C26H23N7O2
 
71226662 
Moderate    Inter Info   
[1], [2], [3]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[1], [2], [3]
D0092
 
Antithrombin Alfa
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0129
 
Avapritinib
 
C26H27FN10
 
118023034 
Moderate    Inter Info   
[1], [2], [3]
D0230
 
Cabozantinib
 
C28H24FN3O5
 
25102847 
Moderate    Inter Info   
[1], [2], [3]
D0247
 
Cangrelor
 
C17H25Cl2F3N5O12P3S2
 
9854012 
Moderate    Inter Info   
[1], [2], [3]
D0336
 
Cilostazol
 
C20H27N5O2
 
2754 
Moderate    Inter Info   
[1], [2], [3]
D0414
 
Dalteparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3]
D0415
 
Danaparoid
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[1], [2], [3]
D0435
 
Defibrotide
 
C20H21N4O6P
 
135565962 
Moderate    Inter Info   
[1], [2], [3]
D0447
 
Desirudin
 
C287H440N80O110S6
 
16129703 
Moderate    Inter Info   
[1], [2], [3]
D0506
 
Dipyridamole
 
C24H40N8O4
 
3108 
Moderate    Inter Info   
[1], [2], [3]
D0551
 
Edoxaban
 
C24H30ClN7O4S
 
10280735 
Moderate    Inter Info   
[1], [2], [3]
D0574
 
Enoxaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3]
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[1], [2], [3]
D0753
 
Heparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3]
D0785
 
Ibrutinib
 
C25H24N6O2
 
24821094 
Moderate    Inter Info   
[1], [2], [3]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[1], [2], [3]
D0805
 
Inotersen
 
C230H318N69O121P19S19
 
121492004 
Moderate    Inter Info   
[1], [2], [3]
D1221
 
Panobinostat
 
C21H23N3O2
 
6918837 
Moderate    Inter Info   
[1], [2], [3]
D1305
 
Plicamycin
 
C52H76O24
 
163659 
Moderate    Inter Info   
[1], [2], [3]
D1313
 
Ponatinib
 
C29H27F3N6O
 
24826799 
Moderate    Inter Info   
[1], [2], [3]
D1328
 
Prasugrel
 
C20H20FNO3S
 
6918456 
Moderate    Inter Info   
[1], [2], [3]
D1380
 
Ramucirumab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1387
 
Regorafenib
 
C21H15ClF4N4O3
 
11167602 
Moderate    Inter Info   
[1], [2], [3]
D1417
 
Rivaroxaban
 
C19H18ClN3O5S
 
9875401 
Moderate    Inter Info   
[1], [2], [3]
D1434
 
Ruxolitinib
 
C17H18N6
 
25126798 
Moderate    Inter Info   
[1], [2], [3]
D1538
 
Tazemetostat
 
C34H44N4O4
 
66558664 
Moderate    Inter Info   
[1], [2], [3]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Moderate    Inter Info   
[1], [2], [3]
D1588
 
Tinzaparin
 
C26H42N2O37S5
 
772 
Moderate    Inter Info   
[1], [2], [3]
D1705
 
Vorapaxar
 
C29H33FN2O4
 
10077130 
Moderate    Inter Info   
[1], [2], [3]
D1581
 
Ticlopidine
 
C14H14ClNS
 
5472 
Moderate    Inter Info   
[1], [2], [3]
D1593
 
Tirofiban
 
C22H36N2O5S
 
60947 
Moderate    Inter Info   
[1], [2], [3]
D1613
 
Tositumomab
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1614
 
Tositumomab (I-131)
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1669
 
Urokinase
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[1], [2], [3]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0674
 
Fluorometholone (ophthalmic)
 
C22H29FO4
 
9878 
Moderate    Inter Info   
[1], [2], [3]
D0774
 
Hydrocortisone (ophthalmic)
 
C21H30O5
 
5754 
Moderate    Inter Info   
[1], [2], [3]
D1333
 
Prednisolone (ophthalmic)
 
C21H28O5
 
5755 
Moderate    Inter Info   
[1], [2], [3]
D0455
 
Dexamethasone (ophthalmic)
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[1], [2], [3]
D0955
 
Loteprednol (ophthalmic)
 
C21H27ClO5
 
9865442 
Moderate    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of cholinergic agents Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0015
 
Acetylcholine
 
C7H16NO2+
 
187 
Minor    Inter Info   
[2], [11]
References
1 Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
2 Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
3 Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
4 Canadian Pharmacists Association.
5 Cerner Multum, Inc. "Australian Product Information.".
6 Product Information. Orfadin (nitisinone). Orphan Pharmaceuticals USA, Inc, Nashville, TN.
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
9 Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
10 EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
11 Holmes JM, Jay WM "The effect of preoperative flurbiprofen on miosis produced by acetylcholine during cataract surgery." Am J Ophthalmol 111 (1991): 735-8