Details of Drug

Drug General Information (ID: D1505)
Drug Name	Stiripentol
Drug Type	Small molecule
Drug Synonymous	Diacomit; ME-2080; Stiripentol (oral); Stiripentol (oral), Laboratoires Biocodex Click to Show/Hide
Disease Class	8A61-8A6Z: Epilepsy/seizure
Therapeutic Class	Gamma-Aminobutyric Acid Reuptake Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C14H18O3
InChI	1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
InChIKey	IBLNKMRFIPWSOY-FNORWQNLSA-N
Canonical SMILES	CC(C)(C)C(C=CC1=CC2=C(C=C1)OCO2)O
External Link
	Pubchem ID	5311454
	CAS Number	49763-96-4
	CHEBI ID	94435
	TTD ID	D02XSA
	INTEDE ID	DR1507

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM019 UGT inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM044 Additive myelosuppressive effects BM087 Antagonize the effect of antiepileptic agents
Relation Graph

Full list of drugs interacting with Stiripentol
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[16], [17], [307]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 276
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[15]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[16], [17], [18], [19]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[20]
D0342		Cisapride	C23H29ClFN3O4	6917698	Major		Inter Info	[26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[39]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[57], [16], [17], [58], [59], [19], [60], [61], [62], [63]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[64], [65]
D0585		Eplerenone	C24H30O6	443872	Major		Inter Info	[66]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[67]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[68]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[17], [69]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[70], [71]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[17], [22], [72]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[73], [74]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[75]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[16], [17], [76]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[17], [77]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[16], [17], [78]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[16], [17], [79]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[16], [80], [29], [81], [82], [83], [84], [85], [19]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[88]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[70], [71], [89]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[90]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[16], [17], [91]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[92]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[16], [17], [93]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[16], [95]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[96], [16], [97]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[98], [65]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[17], [99]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[100]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[16], [17], [101]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[17], [22], [24]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[22]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[22]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[102]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[106], [17], [107], [108]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[22]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[22]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[17], [22], [24]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[106], [16], [17], [109], [110]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[22]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[17], [22], [24]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[17], [22], [24]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[17], [111], [112]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[17], [22], [24]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[113]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[114], [115], [116]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[117], [112], [118]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[22]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[22]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[22]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[22]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[17], [22], [24]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[17], [22], [24]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[22]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[121], [16], [17], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[121], [16], [17]
D0218		Bupivacaine	C18H28N2O	2474	Moderate		Inter Info	[22]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[22]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[22]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[135]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[136]
D0231		Caffeine	C8H10N4O2	2519	Moderate		Inter Info	[22]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[22]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[17], [22], [24]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [29], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [112], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[198]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[17], [22], [24]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[22]
D0333		Ciclesonide	C32H44O7	6918155	Moderate		Inter Info	[202], [22], [203], [204]
D0334		Ciclesonide (nasal)	C32H44O7	6918155	Moderate		Inter Info	[205], [114], [203]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[17], [22], [24]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[17], [22], [24]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[17], [22], [24]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[22], [206], [23], [24]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[22]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[22]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[114], [115], [116]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[17], [22], [24]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[22]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[17], [22], [24]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[22]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[22]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[16], [17], [208]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[17], [114], [24]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[17], [22], [24]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[17], [22], [24]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[17], [22], [24]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[17], [22], [24]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[16], [17], [209], [210], [112], [211]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[22]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[22]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[22]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[17], [22], [24]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[212]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[22]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[22]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[114], [115], [116]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[17], [22], [24]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[22]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[213], [214]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[215]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[216]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[17], [22], [24]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[114], [115], [116]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[22]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[217], [218]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[17], [22], [24]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[22]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[17], [22], [24]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[22]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[22]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[219], [220], [221], [17], [29], [222], [223]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[114], [115], [116]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[22]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[22]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[224]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[22]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[17], [22], [24]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[17], [22], [24]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[22]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[22]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[16], [17], [225], [226]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[17], [22], [24]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[17], [22], [24]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[17], [22], [24]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[22]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[22]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[22]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[17], [22], [24]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[22]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[17], [22], [24]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[106], [16], [17], [227], [228], [229], [230]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[22]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[17], [22], [24]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[22]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[231]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[17], [22], [24]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[17], [22], [24]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[17], [22], [24]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[17], [232]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[22]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[17], [22], [24]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[22]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[235]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[114], [115], [116]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[22]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[241], [242], [243], [244], [245], [246], [247], [248]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[22]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[22]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[22]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[17], [22], [24]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[22]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[249], [250]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[17], [22], [24]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[251], [252], [65], [253], [254]
D1102		Nalidixic acid	C12H12N2O3	4421	Moderate		Inter Info	[17], [22], [24]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[22]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[17], [22], [24]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[22]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[17], [22], [24]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[22]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[22]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[106], [16], [17]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[114], [115], [116]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[17], [22], [24]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[22]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[17], [22], [24]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[16], [17], [24], [255]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[22]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[22]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[256], [257], [16], [258], [259], [260], [261], [61]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[256], [257], [16]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[22]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[262], [210]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[17], [263]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[22]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[17], [22], [24]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[17], [22], [24]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[264], [265]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[266]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[22]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[17], [267], [65]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[22]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[268]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[22]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[22]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[22]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[22]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[22]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[22]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[22]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[269], [270], [271], [272], [273], [274], [275], [276], [277]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[22]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[22]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[17], [22], [24]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[278], [279], [280], [281], [282], [283], [284]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[16], [17], [285]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[22]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[17], [22], [24]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[17], [286]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[22]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[22]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[16], [17], [287], [288], [289], [112], [290]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[291]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[292]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[16], [17], [293]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[295]
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[296]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[17], [297], [298]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[16], [17], [18], [299], [300], [301], [302]
D0684		Fluticasone (nasal)	C22H27F3O4S	5311101	Moderate		Inter Info	[16], [299], [301]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[303]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[17], [22], [24]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[304], [305]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[306]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[17], [22], [24]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[106], [16], [17], [109], [110]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[17], [309]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[22]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[17], [65], [310]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[311]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[312]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[17], [22], [24]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[313]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[16], [314]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[17], [22], [24]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[315]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[22]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[316]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[317], [318], [319], [65]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[320]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[17], [22], [24]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[321]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[22]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[22]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[22]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[22]
D1571		Thiabendazole	C10H7N3S	5430	Moderate		Inter Info	[17], [22], [24]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[22]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[22]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[17], [22], [24]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[17], [22], [24]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[22]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[22]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[22]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[16], [17], [324]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[325], [326]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[327]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[328]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[17], [329], [330]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[22]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[22]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[22]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[331], [112]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[17], [22], [24]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[16], [17], [332]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[17], [22], [24]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[22]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[22]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[17], [22], [24]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[17], [22], [24]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[333], [334]
D0248		Cannabidiol	C21H30O2	644019	Minor		Inter Info	[17], [335]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[336]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[337]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[338]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[339]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[340]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[341], [342], [343], [344], [345], [346], [347]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[17], [348]
D0425		Darolutamide	C19H19ClN6O2	67171867	Minor		Inter Info	[349]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[350]
	CYP450 enzyme induction					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[21], [17], [22], [23], [24], [25]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[17], [22], [23], [24]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[21], [17], [22], [23], [24], [25]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[21], [17], [22], [23], [24], [25]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[21], [17], [22], [23], [24], [25]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[21], [17], [22], [23], [24], [25]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[17], [22], [23], [24]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[17], [23], [24]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[17], [22], [23], [24]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[17], [22], [23], [24]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[17], [22], [23], [24]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[94]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[17], [23], [24]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[17], [22], [24]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[17], [22], [24]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[17], [22], [24]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[17], [22], [24]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[17], [207]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[17], [22], [24]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[17], [22], [24]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[17], [22], [24]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[17], [22], [24]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[17], [22], [24]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[17], [22], [24]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[17], [22], [24]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[17], [22], [24]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[17], [22], [24]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[17], [22], [24]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[17], [22], [24]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[17], [114], [24]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[17], [22], [24]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[17], [22], [24]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[17], [22], [24]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[17], [114], [24]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[17], [114], [24]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[17], [22], [24]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[17], [22], [24]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[17], [22], [24]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 110
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[86], [87]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[103], [104], [105]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[103], [104], [105]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[103], [104], [105]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[103], [104], [105]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[103], [104], [105]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[103], [104], [105]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[119], [17], [120]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[103], [104], [105]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[103], [104], [105]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[103], [104], [105]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[103], [104], [105]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[103], [104], [105]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[103], [104], [105]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[103], [104], [105]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[103], [104], [105]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[103], [104], [105]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[103], [104], [105]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[103], [104], [105]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[103], [104], [105]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[103], [104], [105]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[103], [104], [105]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[103], [104], [105]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[103], [104], [105]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[103], [104], [105]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[103], [104], [105]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[103], [104], [105]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[103], [104], [105]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[103], [104], [105]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[103], [104], [105]
D0488		Difenoxin	C28H28N2O2	34328	Moderate		Inter Info	[103], [104], [105]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[103], [104], [105]
D0504		Diphenoxylate	C30H32N2O2	13505	Moderate		Inter Info	[103], [104], [105]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[103], [104], [105]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[103], [104], [105]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[103], [104], [105]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[103], [104], [105]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[103], [104], [105]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[103], [104], [105]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[103], [104], [105]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[103], [104], [105]
D0705		Gabapentin	C9H17NO2	3446	Moderate		Inter Info	[103], [104], [105]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[103], [104], [105]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[103], [104], [105]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[103], [104], [105]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[103], [104], [105]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[103], [104], [105]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[103], [104], [105]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[103], [104], [105]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[103], [104], [105]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[233], [234]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[103], [104], [105]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[103], [104], [105]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[103], [104], [105]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[103], [104], [105]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[236], [237], [238], [239], [240]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[103], [104], [105]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[103], [104], [105]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[103], [104], [105]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[103], [104], [105]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[103], [104], [105]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[103], [104], [105]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[103], [104], [105]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[103], [104], [105]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[103], [104], [105]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[103], [104], [105]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[103], [104], [105]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[103], [104], [105]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[103], [104], [105]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[103], [104], [105]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[103], [104], [105]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[103], [104], [105]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[103], [104], [105]
D1225		Paramethadione	C7H11NO3	8280	Moderate		Inter Info	[103], [104], [105]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[103], [104], [105]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[103], [104], [105]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[103], [104], [105]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[103], [104], [105]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[103], [104], [105]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[103], [104], [105]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[103], [104], [105]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[103], [104], [105]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[103], [104], [105]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[103], [104], [105]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[103], [104], [105]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[294]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[308]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[103], [104], [105]
D1183		Opium	NA	NA	Moderate		Inter Info	[103], [104], [105]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[103], [104], [105]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[103], [104], [105]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[103], [104], [105]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[103], [104], [105]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[103], [104], [105]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[322]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[103], [104], [105]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[103], [104], [105]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[323]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[103], [104], [105]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[103], [104], [105]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[103], [104], [105]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[103], [104], [105]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[103], [104], [105]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[103], [104], [105]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[103], [104], [105]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[103], [104], [105]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[103], [104], [105]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[103], [104], [105]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[103], [104], [105]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[103], [104], [105]
	Additive myelosuppressive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[17], [37], [38]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antiepileptic agents					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[16], [17], [199], [200], [201]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[16], [17], [199], [200], [201]

References
1	Bartkowski RR, Goldberg ME, Larijani GE, Boerner T "Inhibition of alfentanil metabolism by erythromycin." Clin Pharmacol Ther 46 (1989): 99-102. [PMID: 2501060]
2	Bartkowski RR, McDonnell TE "Prolonged alfentanil effect following erythromycin administration." Anesthesiology 73 (1990): 566-8. [PMID: 2203286]
3	Kharasch ED, Thummel KE "Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?" Anesth Analg 76 (1993): 1033-9. [PMID: 8484504]
4	Kharasch ED, Walker A, Hoffer C, Sheffels P "Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis." Clin Pharmacol Ther 76 (2004): 452-66. [PMID: 15536460]
5	Klees TM, Sheffels P, Dale O, Kharasch ED "Metabolism of alfentanil by cytochrome P4503A enzymes." Drug Metab Dispos 33 (2005): 303-11. [PMID: 15557344]
6	Klees TM, Sheffels P, Thummel KE, Kharasch ED "Pharmacogenetic Determinants of Human Liver Microsomal Alfentanil Metabolism and the Role of Cytochrome P450 3A5." Anesthesiology 102 (2005): 550-556. [PMID: 15731592]
7	Koehntop DE, Noormohamed SE, Fletcher CV "Effects of long-term drugs on alfentanil clearance in patients undergoing renal transplantation." Pharmacotherapy 14 (1994): 592-9. [PMID: 7997393]
8	Labroo RB, Thummel KE, Kunze KL, Podoll T, Trager WF, Kharasch ED "Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism." Drug Metab Dispos 23 (1995): 490-6. [PMID: 7600917]
9	Palkama VJ, Isohanni MH, Neuvonen PJ, Olkkola KT "The effect of intravenous and oral fluconazole on the pharmacokinetics and pharmacodynamics of intravenous alfentanil." Anesth Analg 87 (1998): 190-4. [PMID: 9661572]
10	Product Information. Alfenta (alfentanil). Janssen Pharmaceutica, Titusville, NJ.
11	Yate PM, Thomas D, Short SM, Sebel PS, Morton J "Comparison of infusions of alfentanil or pethidine for sedation of ventilated patients on the ITU." Br J Anaesth 58 (1986): 1091-9. [PMID: 2876719]
12	Yun CH, Wood M, Wood AJ, Guengerich FP "Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4: an explanation of the variable elimination clearance." Anesthesiology 77 (1992): 467-74. [PMID: 1519785]
13	Ibrahim AE, Feldman J, Karim A, Kharasch ED "Simultaneous Assessment of Drug Interactions with Low- and High-Extraction Opioids: Application to Parecoxib Effects on the Pharmacokinetics and Pharmacodynamics of Fentanyl and Alfentanil." Anesthesiology 98 (2003): 853-861. [PMID: 12657846]
14	Kharasch ED, Russell M, Mautz D, Thummel KE, Kunze KL, Bowdle A, Cox K "The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions." Anesthesiology 87 (1997): 36-50. [PMID: 9232132]
15	Product Information. Stendra (avanafil). Vivus Inc, Mountain View, CA.
16	Cerner Multum, Inc. "Australian Product Information.".
17	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
18	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
19	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
20	Product Information. Butorphanol Tartrate (butorphanol). Apotex Corporation, Weston, FL.
21	Cazali N, Tran A, Treluyer JM, et al. "Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human." Br J Clin Pharmacol 56 (2003): 526-36. [PMID: 14651727]
22	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
23	May TW, Boor R, Mayer T, et al. "Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication." Ther Drug Monit 34 (2012): 390-7. [PMID: 22743350]
24	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
25	Tran A, Vauzellekervroedan F, Rey E, Pons G, Dathis P, Chiron C, Dulac O, Renard F, Olive G "Effect of stiripentol on carbamazepine plasma concentration and metabolism in epileptic children." Eur J Clin Pharmacol 50 (1996): 497-500. [PMID: 8858278]
26	Bedford TA, Rowbotham DJ "Cisapride: drug interactions of clinical significance." Drug Saf 15 (1996): 167-75. [PMID: 8879971]
27	Bran S, Murray WA, Hirsch IB, Palmer JP "Long QT syndrome during high-dose cisapride." Arch Intern Med 155 (1995): 765-8. [PMID: 7695465]
28	Desta Z, Soukhova N, Mahal SK, Flockhart DA "Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies." Drug Metab Dispos 28 (2000): 789-800. [PMID: 10859153]
29	Dresser GK, Spence JD, Bailey DG "Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition." Clin Pharmacokinet 38 (2000): 41-57. [PMID: 10668858]
30	Gray VS "Syncopal episodes associated with cisapride and concurrent drugs." Ann Pharmacother 32 (1998): 648-51. [PMID: 9640482]
31	Hill SL, Evangelista JK, Pizzi AM, Mobassaleh M, Fulton DR, Berul CI "Proarrhythmia associated with cisapride in children." Pediatrics 101 (1998): 1053-6. [PMID: 9606235]
32	Lewin MB, Bryant RM, Fenrich AL, Grifka RG "Cisapride-induced long QT interval." J Pediatr 128 (1996): 279-81. [PMID: 8636830]
33	Michalets EL "Update: clinically significant cytochrome P-450 drug interactions." Pharmacotherapy 18 (1998): 84-112. [PMID: 9469685]
34	Michalets EL, Williams CR "Drug interactions with cisapride: clinical implications." Clin Pharmacokinet 39 (2000): 49-75. [PMID: 10926350]
35	Product Information. Propulsid (cisapride). Janssen Pharmaceutica, Titusville, NJ.
36	Thomas AR, Chan LN, Bauman JL, Olopade CO "Prolongation of the QT interval related to cisapride-diltiazem interaction." Pharmacotherapy 18 (1998): 381-5. [PMID: 9545159]
37	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
38	Canadian Pharmacists Association "e-CPS."
39	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
40	Akdag I, Ersoy A, Kahvecioglu S, Gullulu M, Dilek K "Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure." J Nephrol 19 (2006): 515-7. [PMID: 17048210]
41	Boomershine KH "Colchicine-induced rhabdomyolysis." Ann Pharmacother 36 (2002): 824-6. [PMID: 11978160]
42	Caraco Y, Putterman C, Rahamimov R, Ben-Chetrit E "Acute colchicine intoxication: possible role of erythromycin administration." J Rheumatol 19 (1992): 494-6. [PMID: 1578471]
43	Cheng VC, Ho PL, Yuen KY "Two probable cases of serious drug interaction between clarithromycin and colchicine." South Med J 98 (2005): 811-3. [PMID: 16144178]
44	Colchicine: serious interactions. Prescrire Int 17 (2008): 151-3. [PMID: 19492485]
45	Dogukan A, Oymak FS, Taskapan H, Guven M, Tokgoz B, Utas C "Acute fatal colchicine intoxication in a patient on continuous ambulatory peritoneal dialysis (CAPD). Possible role of clarithromycin administration." Clin Nephrol 55 (2001): 181-2. [PMID: 11269688]
46	Hung IF, Wu AK, Cheng VC, et al. "Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study." Clin Infect Dis 41 (2005): 291-300. [PMID: 16007523]
47	McKinnell J, Tayek JA "Short term treatment with clarithromycin resulting in colchicine-induced rhabdomyolysis." J Clin Rheumatol 15 (2009): 303-5. [PMID: 19734738]
48	Product Information. Colcrys (colchicine). AR Scientific Inc, Philadelphia, PA.
49	Product Information. Lexiva (fosamprenavir). GlaxoSmithKline, Research Triangle Park, NC.
50	Putterman C, Ben-Chetrit E, Caraco Y, Levy M "Colchicine intoxication: clinical pharmacology, risk factors, features, and management." Semin Arthritis Rheum 21 (1991): 143-55. [PMID: 1788551]
51	Rollot F, Pajot O, Chauvelot-Moachon L, Nazal EM, Kelaidi C, Blanche P "Acute colchicine intoxication during clarithromycin administration." Ann Pharmacother 38 (2004): 2074-7. [PMID: 15494379]
52	Schiff D, Drislane FW "Rapid-onset colchicine myoneuropathy." Arthritis Rheum 35 (1992): 1535-6. [PMID: 1472131]
53	Severe colchicine-macrolide interactions. Prescrire Int 12 (2003): 18-9. [PMID: 12602385]
54	Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ "Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation." Biochem Pharmacol 53 (1996): 111-6. [PMID: 8960070]
55	van der Velden W, Huussen J, Ter Laak H, de Sevaux R "Colchicine-induced neuromyopathy in a patient with chronic renal failure: the role of clarithromycin." Neth J Med 66 (2008): 204-6. [PMID: 18490798]
56	Wilbur K, Makowsky M "Colchicine myotoxicity: case reports and literature review." Pharmacotherapy 24 (2004): 1784-92. [PMID: 15585444]
57	Aronson JK, Grahame-Smith DG "Clinical pharmacology: adverse drug interactions." Br Med J 282 (1981): 288-91. [PMID: 6779990]
58	Engels FK, Mathot RA, Loos WJ, van Schaik RH, Verweij J "Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel." Cancer Biol Ther 5 (2006): 833-9. [PMID: 16775418]
59	McInnes GT, Brodie MJ "Drug interactions that matter: a critical reappraisal." Drugs 36 (1988): 83-110. [PMID: 3063497]
60	Product Information. Taxotere (docetaxel). Rhone-Poulenc Rorer, Collegeville, PA.
61	Starr SP, Hammann F, Gotta V, et al. "Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity." Br J Clin Pharmacol 450 (2016): 22-27. [PMID: 27868228]
62	Vodovar D, Arnaout M, Mongardon N, et al. "Severe docetaxel overdose induced by pharmacokinetic interaction with dronedarone." J Clin Oncol 29 (2011): e694-5. [PMID: 21730272]
63	Yong WP, Wang LZ, Tham LS, et al. "A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers." Cancer Chemother Pharmacol 62 (2008): 243-51. [PMID: 17909805]
64	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
65	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
66	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
67	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
68	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
69	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
70	Hutchinson MR, Menelaou A, Foster DJ, Coller JK, Somogyi AA "CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes." Br J Clin Pharmacol 57 (2004): 287-97. [PMID: 14998425]
71	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
72	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
73	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
74	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
75	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
76	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
77	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
78	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
79	Product Information. OxyContin (oxycodone). Purdue Frederick Company, Norwalk, CT.
80	Desta Z, Kerbusch T, Flockhart DA "Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)." Clin Pharmacol Ther 65 (1999): 10-20. [PMID: 9951426]
81	Flockhart DA, Drici MD, Kerbusch T, et al "Studies on the mechanism of a fatal clarithromycin-pimozide interaction in a patient with tourette syndrome." J Clin Psychopharmacol 20 (2000): 317-24. [PMID: 10831018]
82	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
83	Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6. [PMID: 7771501]
84	Mangum EM, Graham KK "Lopinavir-Ritonavir: a new protease inhibitor." Pharmacotherapy 21 (2001): 1352-63. [PMID: 11714208]
85	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
86	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
87	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
88	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
89	Vizcaychipi MP, Walker S, Palazzo M "Serotonin syndrome triggered by tramadol." Br J Anaesth 99 (2007): 919. [PMID: 18006535]
90	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
91	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
92	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
93	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
94	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
95	Product Information. Dayvigo (lemborexant). Eisai Inc, Woodcliff Lake, NJ.
96	Abbas R, Hug BA, Leister C, Burns J, Sonnichsen D "Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects." Br J Clin Pharmacol 71 (2011): 522-7. [PMID: 21395644]
97	Product Information. Nerlynx (neratinib). Puma Biotechnology, Inc., Los Angeles, CA.
98	Product Information. Olinvyk (oliceridine). Trevena Inc, Chesterbrook, PA.
99	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
100	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
101	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
102	Product Information. Uroxatral (alfuzosin). sanofi-aventis , Bridgewater, NJ.
103	Divoll M, Greenblatt DJ, Lacasse Y, Shader RI "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl) 73 (1981): 381-3. [PMID: 6789361]
104	Grabowski BS, Cady WJ, Young WW, Emery JF "Effects of acute alcohol administration on propranolol absorption." Int J Clin Pharmacol Ther Toxicol 18 (1980): 317-9. [PMID: 7429677]
105	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
106	Canadian Pharmacists Association.
107	Product Information. Tekturna (aliskiren). Novartis Pharmaceuticals, East Hanover, NJ.
108	Tapaninen T, Backman JT, Kurkinen K, Neuvonen P, Niemi M "Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren." J Clin Pharmacol 51 (2011): 359-67. [PMID: 20400651]
109	Product Information. Norvasc (amlodipine). Pfizer US Pharmaceuticals, New York, NY.
110	Sasaki M, Maeda A, Fujimura A "Influence of diltiazem on the pharmacokinetics of amlodipine in elderly hypertensive patients." Eur J Clin Pharmacol 57 (2001): 85-6. [PMID: 11372598]
111	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
112	Product Information. Qelbree (viloxazine). Supernus Pharmaceuticals Inc, Rockville, MD.
113	Product Information. Abilify (aripiprazole). Bristol-Myers Squibb, Princeton, NJ.
114	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
115	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
116	Yamreudeewong W, Henann NE, Fazio A, Lower DL, Cassidy TG "Drug-food interactions in clinical practice." J Fam Pract 40 (1995): 376-84. [PMID: 7699352]
117	Belle DJ, Ernest CS, Sauer JM, Smith BP, Thomasson HR, Witcher JW "Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics." J Clin Pharmacol 42 (2002): 1219-27. [PMID: 12412820]
118	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
119	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
120	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
121	Bolland MJ, Bagg W, Thomas MG, Lucas JA, Ticehurst R, Black PN "Cushing's syndrome due to interaction between inhaled corticosteroids and itraconazole." Ann Pharmacother 38 (2004): 46-9. [PMID: 14742792]
122	Daveluy A, Raignoux C, Miremont-Salame G, et al. "Drug interactions between inhaled corticosteroids and enzymatic inhibitors." Eur J Clin Pharmacol (2009):. [PMID: 19399485]
123	De Wachter E, Malfroot A, De Schutter I, Vanbesien J, De Schepper J "Inhaled budesonide induced Cushing's syndrome in cystic fibrosis patients, due to drug inhibition of cytochrome P450." J Calif Dent Assoc 2 (2003): 72-5. [PMID: 15463853]
124	De Wachter E, Vanbesien J, De Schutter I, Malfroot A, De Schepper J "Rapidly developing Cushing syndrome in a 4-year-old patient during combined treatment with itraconazole and inhaled budesonide." Eur J Pediatr (2003):. [PMID: 12719971]
125	Edsbacker S, Andersson T "Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease." Clin Pharmacokinet 43 (2004): 803-21. [PMID: 15355126]
126	Jonsson G, Astrom A, Andersson P "Budesonide is metabolized by cytochrome P450 3A (CYP3A) enzymes in human liver." Drug Metab Dispos 23 (1995): 137-42. [PMID: 7720517]
127	Kedem E, Shahar E, Hassoun G, Pollack S "Iatrogenic Cushing's syndrome due to coadministration of ritonavir and inhaled budesonide in an asthmatic human immunodeficiency virus infected patient." J Asthma 47 (2010): 830-1. [PMID: 20653496]
128	Main KM, Skov M, Sillesen IB, et al. "Cushing's syndrome due to pharmacological interaction in a cystic fibrosis patient." Acta Paediatr 91 (2002): 1008-11. [PMID: 12412882]
129	Molimard M, Girodet PO, Pollet C, et al. "Inhaled corticosteroids and adrenal insufficiency: prevalence and clinical presentation." Drug Saf 31 (2008): 769-74. [PMID: 18707191]
130	Product Information. Entocort (budesonide). AstraZeneca Pharma Inc, Mississauga, ON.
131	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
132	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
133	Raaska K, Niemi M, Neuvonen M, Neuvonen PJ, Kivisto KT "Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole." Clin Pharmacol Ther 72 (2002): 362-369. [PMID: 12386638]
134	Skov M, Main KM, Sillesen IB, Muller J, Koch C, Lanng S "Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide." Eur Respir J 20 (2002): 127-33. [PMID: 12166560]
135	Product Information. Jevtana (cabazitaxel). sanofi-aventis , Bridgewater, NJ.
136	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
137	Agbin NE, Brater DC, Hall SD "Interaction of diltiazem with lovastatin and pravastatin." Clin Pharmacol Ther 61 (1997): 201. [PMID: 9797793]
138	Amsden GW, Kuye O, Wei GC "A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers." J Clin Pharmacol 42 (2002): 444-9. [PMID: 11936570]
139	Andreou ER, Ledger S "Potential drug interaction between simvastatin and danazol causing rhabdomyolysis." Can J Clin Pharmacol 10 (2003): 172-4. [PMID: 14712320]
140	Arnadottir M, Eriksson LO, Thysell H, Karkas JD "Plasma concentration profiles of simvastatin 3-hydroxy- 3-methylglutaryl-coenzyme A reductase inhibitory activity in kidney transplant recipients with and without ciclosporin." Nephron 65 (1993): 410-3. [PMID: 8289991]
141	Ayanian JZ, Fuchs CS, Stone RM "Lovastatin and rhabdomyolysis." Ann Intern Med 109 (1988): 682-3. [PMID: 3421582]
142	Azie NE, Brater DC, Becker PA, Jones DR, Hall SD "The interaction of diltiazem with lovastatin and pravastatin." Clin Pharmacol Ther 64 (1998): 369-77. [PMID: 9797793]
143	Barry M, Mulcahy F, Merry C, Gibbons S, Back D "Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection." Clin Pharmacokinet 36 (1999): 289-304. [PMID: 10320951]
144	Campana C, Iacona I, Regassi MB, et al. "Efficacy and pharmacokinetics of simvastatin in heart transplant recipients." Ann Pharmacother 29 (1995): 235-9. [PMID: 7606066]
145	Chouhan UM, Chakrabarti S, Millward LJ "Simvastatin interaction with clarithromycin and amiodarone causing myositis." Ann Pharmacother 39 (2005): 1760-1. [PMID: 16159992]
146	Corpier CL, Jones PH, Suki WN, et al. "Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients." JAMA 260 (1988): 239-41. [PMID: 3290520]
147	Corsini A, Bellosta S, Baetta R, Fumagalli R, Paoletti R, Bernini F "New insights into the pharmacodynamic and pharmacokinetic properties of statins." Pharmacol Ther 84 (1999): 413-28. [PMID: 10665838]
148	Dallaire M, Chamberland M "Severe rhabdomyolysis in a patient receiving lovastatin, danazol and doxycycline." Can Med Assoc J 150 (1994): 1991-4. [PMID: 8199978]
149	de Denus S, Spinler SA "Amiodarone's role in simvastatin-associated rhabdomyolysis." Am J Health Syst Pharm 60 (2003): 1791 author reply 1791-2. [PMID: 14503117]
150	East C, Alivizatos PA, Grundy SM, Jones PH, Farmer JA "Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation." N Engl J Med 318 (1988): 47-8. [PMID: 3275892]
151	Fichtenbaum CJ, Gerber JG, Rosenkranz SL, et al. "Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: ACTG Study A5047." AIDS 16 (2002): 569-577. [PMID: 11873000]
152	Garnett WR "Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors." Am J Health Syst Pharm 52 (1995): 1639-45. [PMID: 7583826]
153	Gilad R, Lampl Y "Rhabdomyolysis induced by simvastatin and ketoconazole treatment." Clin Neuropharmacol 22 (1999): 295-7. [PMID: 10516882]
154	Gruer PJK, Vega JM, Mercuri MF, Dobrinska MR, Tobert JA "Concomitant use of cytochrome P450 3A4 inhibitors and simvastatin." Am J Cardiol 84 (1999): 811-5. [PMID: 10513779]
155	Grunden JW, Fisher KA "Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin." Ann Pharmacother 31 (1997): 859-63. [PMID: 9220046]
156	Gullestad L, Nordal KP, Berg KJ, Cheng H, Schwartz MS, Simonsen S "Interaction between lovastatin and cyclosporine A after heart and kidney transplantation." Transplant Proc 31 (1999): 2163-5. [PMID: 10456002]
157	Horn M "Coadministration of itraconazole with hypolipidemic agents may induce rhabdomyolysis in healthy individuals." Arch Dermatol 132 (1996): 1254. [PMID: 8859048]
158	Huynh T, Cordato D, Yang F, et al. "HMG coA reductase-inhibitor-related myopathy and the influence of drug interactions." Intern Med J 32(9-10) (2002): 486-90. [PMID: 12380704]
159	Jacobson RH, Wang P, Glueck CJ "Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone." JAMA 277 (1997): 296. [PMID: 9002485]
160	Jacobson TA "Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors." Am J Cardiol 94 (2004): 1140-6. [PMID: 15518608]
161	Jardine A, Holdaas H "Fluvastatin in combination with cyclosporin in renal transplant recipients: a review of clinical and safety experience." J Clin Pharm Ther 24 (1999): 397-408. [PMID: 10651972]
162	Jody DN "Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone." JAMA 277 (1997): 296-7. [PMID: 9002485]
163	Kantola T, Kivisto KT, Neuvonen PJ "Effect of itraconazole on cerivastatin pharmacokinetics." Eur J Clin Pharmacol 54 (1999): 851-5. [PMID: 10027660]
164	Kantola T, Kivisto KT, Neuvonen PJ "Effect of itraconazole on the pharmacokinetics of atorvastatin." Clin Pharmacol Ther 64 (1998): 58-65. [PMID: 9695720]
165	Kantola T, Kivisto KT, Neuvonen PJ "Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations." Clin Pharmacol Ther 64 (1998): 177-82. [PMID: 9728898]
166	Karnik NS, Maldonado JR "Antidepressant and statin interactions: a review and case report of simvastatin and nefazodone-induced rhabdomyolysis and transaminitis." Psychosomatics 46 (2005): 565-8. [PMID: 16288136]
167	Kivisto KT, Kantola T, Neuvonen PJ "Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin." Br J Clin Pharmacol 46 (1998): 49-53. [PMID: 9690949]
168	Kusus M, Stapleton DD, Lertora JJL, Simon EE, Dreisbach AW "Rhabdomyolysis and acute renal failure in a cardiac transplant recipient due to multiple drug interactions." Am J Med Sci 320 (2000): 394-7. [PMID: 11149552]
169	Lee AJ, Maddix DS "Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin." Ann Pharmacother 35 (2001): 26-31. [PMID: 11197581]
170	Lees RS, Lees AM "Rhabdomyolysis from the coadministration of lovastatin and the antifungal agent itraconazole." N Engl J Med 333 (1995): 664-5. [PMID: 7637734]
171	Lomaestro BM, Piatek MA "Update on drug interactions with azole antifungal agents." Ann Pharmacother 32 (1998): 915-28. [PMID: 9762380]
172	Malaty LI, Kuper JJ "Drug interactions of HIV protease inhibitors." Drug Safety 20 (1999): 147-69. [PMID: 10082072]
173	Maltz HC, Balog DL, Cheigh JS "Rhabdomyolysis associated with concomitant use of atorvastatin and cyclosporine." Ann Pharmacother 33 (1999): 1176-9. [PMID: 10573315]
174	Mousa O, Brater DC, Sundblad KJ, Hall SD "The interaction of diltiazem with simvastatin." Clin Pharmacol Ther 67 (2000): 267-74. [PMID: 10741630]
175	Neuvonen PJ, Backman JT, Niemi M "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin." Clin Pharmacokinet 47 (2008): 463-74. [PMID: 18563955]
176	Neuvonen PJ, Jalava KM "Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid." Clin Pharmacol Ther 60 (1996): 54-61. [PMID: 8689812]
177	Neuvonen PJ, Kantola T, Kivisto KT "Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole." Clin Pharmacol Ther 63 (1998): 332-41. [PMID: 9542477]
178	Norman DJ, Illingworth DR, Munson J, Hosenpud J "Myolysis and acute renal failure in a heart-transplant recipient receiving lovastatin." N Engl J Med 318 (1988): 46-7. [PMID: 3275891]
179	Omar MA, Wilson JP "FDA adverse event reports on statin-associated rhabdomyolysis." Ann Pharmacother 36 (2002): 288-95. [PMID: 11847951]
180	Paoletti R, Corsini A, Bellosta S "Pharmacological interactions of statins." Atheroscler Suppl 3 (2002): 35-40. [PMID: 12044584]
181	Product Information. Baycol (cerivastatin). Bayer, West Haven, CT.
182	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
183	Product Information. Mevacor (lovastatin). Merck & Co, Inc, West Point, PA.
184	Product Information. Zocor (simvastatin). Merck & Co, Inc, West Point, PA.
185	Rodriguez JA, CrespoLeiro MG, Paniagua MJ, Cuenca JJ, Hermida LF, Juffe A, CastroBeiras A "Rhabdomyolysis in heart transplant patients on HMG-CoA reductase inhibitors and cyclosporine." Transplant Proc 31 (1999): 2522-3. [PMID: 10500698]
186	Roten L, Schoenenberger RA, Krahenbuhl S, Schlienger RG "Rhabdomyolysis in association with simvastatin and amiodarone." Ann Pharmacother 38 (2004): 978-81. [PMID: 15069169]
187	Siedlik PH, Olson SC, Yang BB, Stern RH "Erythromycin coadministration increases plasma atorvastatin concentrations." J Clin Pharmacol 39 (1999): 501-4. [PMID: 10234598]
188	Sipe BE, Jones RJ, Bokhart GH "Rhabdomyolysis Causing AV Blockade Due to Possible Atorvastatin, Esomeprazole, and Clarithromycin Interaction." Ann Pharmacother 37 (2003): 808-11. [PMID: 12773066]
189	Skrabal MZ, Stading JA, Monaghan MS "Rhabdomyolysis associated with simvastatin-nefazodone therapy." South Med J 96 (2003): 1034-5. [PMID: 14570351]
190	Spach DH, Bauwens JE, Clark CD, Burke WG "Rhabdomyolysis associated with lovastatin and erythromycin use." West J Med 154 (1991): 213-5. [PMID: 2006579]
191	Thompson M, Samuels S "Rhabdomyolysis with simvastatin and nefazodone." Am J Psychiatry 159 (2002): 1607. [PMID: 12202291]
192	Westphal JF "Macrolide - induced clinically relevant drug interactions with cytochrome P-450 (CYP) 3A4: an update focused on clarithromycin, azithromycin, and dirithromycin." Br J Clin Pharmacol 50 (2000): 285-95. [PMID: 11012550]
193	Williams D, Feely J "Pharmacokinetic-Pharmacodynamic Drug Interactions with HMG-CoA Reductase Inhibitors." Clin Pharmacokinet 41 (2002): 343-70. [PMID: 12036392]
194	Wong PW, Dillard TA, Kroenke K "Multiple organ toxicity from addition of erythromycin to long-term lovastatin therapy." South Med J 91 (1998): 202-5. [PMID: 9496876]
195	Yeo KR, Yeo WW "Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes." Br J Clin Pharmacol 51 (2001): 461-70. [PMID: 11422004]
196	Yeo KR, Yeo WW, Wallis EJ, Ramsay LE "Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients." Br J Clin Pharmacol 48 (1999): 610-5. [PMID: 10583033]
197	Zhou LX, Finley DK, Hassell AE, Holtzman JL "Pharmacokinetic interaction between isradipine and lovastatin in normal, female and male volunteers." J Pharmacol Exp Ther 273 (1995): 121-7. [PMID: 7714757]
198	Product Information. Evoxac (cevimeline) Daiichi Pharmaceuticals, Fort lee, NJ.
199	Product Information. Aralen (chloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
200	Product Information. Hydroxychloroquine Sulfate (hydroxychloroquine). Prasco Laboratories, Cincinnati, OH.
201	Product Information. Plaquenil (R). (hydroxychloroquine). Sanofi Winthrop Pharmaceuticals, New York, NY.
202	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
203	Product Information. Alvesco (ciclesonide). Nycomed USA, Florham Park, NJ.
204	Product Information. Omnaris (ciclesonide nasal). Sepracor Inc, Marlborough, MA.
205	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
206	Giraud C, Treluyer JM, Rey E, et al. "In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism." Drug Metab Dispos 34 (2006): 608-11. [PMID: 16415114]
207	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
208	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
209	Funck-Brentano C, Jacqz-Aigrain E, Leenhardt A, Roux A, Poirier JM, Jaillon P "Influence of amiodarone on genetically determined drug metabolism in humans." Clin Pharmacol Ther 50 (1991): 259-66. [PMID: 1914360]
210	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
211	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
212	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
213	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
214	Skinner MH, Kuan HY, Pan A, et al. "Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers." Clin Pharmacol Ther 73 (2003): 170-7. [PMID: 12621382]
215	Product Information. Duagen (dutasteride). GlaxoSmithKline Healthcare, Pittsburgh, PA.
216	Product Information. Relpax (eletriptan). Pfizer U.S. Pharmaceuticals, New York, NY.
217	Li J, Zhao M, He P, Hidalgo M, Baker SD "Differential metabolism of gefitinib and erlotinib by human cytochrome p450 enzymes." Clin Cancer Res 13 (2007): 3731-7. [PMID: 17575239]
218	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
219	Alderman CP, Gebauer MG, Gilbert AL, Condon JT "Possible interaction of zopiclone and nefazodone." Ann Pharmacother 35 (2001): 1378-80. [PMID: 11724087]
220	Aranko K, Luurila H, Backman JT, Neuvonen PJ, Olkkola KT "The effect of erythromycin on the pharmacokinetics and pharmacodymanics of zopiclone." Br J Clin Pharmacol 38 (1994): 363-7. [PMID: 7833227]
221	Becquemont L, Mouajjah S, Escaffre O, Beaune P, Funck-Bretano C, Jaillon P "Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism." Drug Metab Dispos 27 (1999): 1068-73. [PMID: 10460808]
222	Product Information. Imovane (zopiclone). Rhone-Poulenc Rorer Canada Inc, Laval, IN.
223	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
224	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
225	Kantola T, Backman JT, Niemi M, Kivisto KT, Neuvonen PJ "Effect of fluconazole on plasma fluvastatin and pravastatin concentrations." Eur J Clin Pharmacol 56 (2000): 225-9. [PMID: 10952477]
226	Product Information. Lescol (fluvastatin). Novartis Pharmaceuticals, East Hanover, NJ.
227	Corona G, Vaccher E, Sandron S, et al. "Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma." Clin Pharmacol Ther 83 (2008): 601-6. [PMID: 17713471]
228	Phansalker S, Desai AA, Bell D, et al "High-priority drug-drug interactions for use in electronic health records." J Am Med Inform Assoc 19 (2012): 735-43. [PMID: 22539083]
229	Product Information. Camptosar (irinotecan). Pharmacia and Upjohn, Kalamazoo, MI.
230	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
231	Product Information. Ixempra (ixabepilone). Bristol-Myers Squibb, Princeton, NJ.
232	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
233	Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
234	Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
235	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
236	Lambertsen CJ, Wendel H, Longenhagen JB "The separate and combined respiratory effects of chlorpromazine and meperidine in normal men controlled at 46 mm Hg alveolar pCO2." J Pharmacol Exp Ther 131 (1961): 381-93. [PMID: 13758472]
237	Hoffman JC, Smith TC "The respiratory effects of meperidine and propiomazine in man." Anesthesiology 32 (1970): 325-31. [PMID: 4392394]
238	Stambaugh JE, Wainer IW "Drug interaction: meperidine and chlorpromazine, a toxic combination." J Clin Pharmacol 21 (1981): 140-6. [PMID: 7240435]
239	Product Information. Meperidine Hydrochloride Injection, USP (meperidine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
240	Product Information. Demerol (meperidine). Sanofi Winthrop Pharmaceuticals, New York, NY.
241	Bell J, Seres V, Bowron P, Lewis J, Batey R "The use of serum methadone levels in patients receiving methadone maintenance." Clin Pharmacol Ther 43 (1988): 623-9. [PMID: 3378383]
242	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
243	Foster DJ, Somogyi AA, Bochner F "Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4." Br J Clin Pharmacol 47 (1999): 403-12. [PMID: 10233205]
244	Iribarne C, Berthou F, Baird S, Dreano Y, Picart D, Bail JP, Beaune P, Menez JF "Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes." Chem Res Toxicol 9 (1996): 365-73. [PMID: 8839037]
245	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
246	Moody DE, Alburges ME, Parker RJ, Collings JM, Strong JM "The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), norLAAM, and methadone." Drug Metab Dispos 25 (1997): 1347-53. [PMID: 9394023]
247	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
248	Oda Y, Kharasch ED "Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation." J Pharmacol Exp Ther 298 (2001): 1021-32. [PMID: 11504799]
249	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
250	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
251	Okubo M, Murayama N, Miura J, Chiba Y, Yamazaki H "Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients." Biochem Pharmacol 93 (2015): 104-9. [PMID: 25475885]
252	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
253	Sitsen JM, Maris FA, Timmer CJ "Concomitant use of mirtazapine and cimetidine: a drug-drug interaction study in healthy male subjects." Eur J Clin Pharmacol 56 (2000): 389-94. [PMID: 11009047]
254	Stormer E, von Moltke LL, Shader RI, Greenblatt DJ "Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4" Drug Metab Dispos 28 (2000): 1168-75. [PMID: 10997935]
255	Product Information. Zofran (ondansetron). Cerenex Pharmaceuticals, Research Triangle Pk, NC.
256	Bergmann TK, Filppula AM, Launiainen T, Nielsen F, Backman J, Brosen K "Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60 year old Caucasian woman with ovarian carcinoma." Br J Clin Pharmacol (2015):. [PMID: 26446447]
257	Bun SS, Ciccolini J, Bun H, Aubert C, Catalin J "Drug interactions of paclitaxel metabolism in human liver microsomes." J Chemother 15 (2003): 266-74. [PMID: 12868554]
258	Jamis-Dow CA, Klecker RW, Katki AG, Collins JM "Metabolism of Taxol by human liver microsomes and effect of inhibitors (Meeting abstract)." Proc Annu Meet Am Assoc Cancer Res 34 (1993): a21981993.
259	Product Information. Abraxane (paclitaxel protein-bound). American Pharmaceutical Partners, Schaumberg, IL.
260	Product Information. Taxol (paclitaxel). Bristol-Myers Squibb, Princeton, NJ.
261	Spencer CM, Faulds D "Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer." Drugs 48 (1994): 794-847. [PMID: 7530632]
262	Hamberg P, Woo MM, Chen LC, et al. "Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor." Cancer Chemother Pharmacol 68 (2011): 805-13. [PMID: 21706316]
263	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
264	Magnusson M, Bergstrand IC, Bjorkman S, Heijl A, Roth B, Hoglund P "A placebo-controlled study of retinal blood flow changes by pentoxifylline and metabolites in humans." Br J Clin Pharmacol 61 (2006): 138-47. [PMID: 16433868]
265	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
266	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
267	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
268	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
269	DeVane CL, Nemeroff CB "Clinical pharmacokinetics of quetiapine - An atypical antipsychotic." Clin Pharmacokinet 40 (2001): 509-22. [PMID: 11510628]
270	Grimm SW, Richtand NM, Winter HR, Stams KR, Reele SB "Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics." Br J Clin Pharmacol 61 (2006): 58-69. [PMID: 16390352]
271	Hantson P, Di Fazio V, Wallemacq P "Toxicokinetic interaction between quetiapine and antiretroviral therapy following quetiapine overdose." Drug Metab Lett 4 (2010): 7-8. [PMID: 20201782]
272	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
273	Quetiapine for schizophrenia. Med Lett Drugs Ther 39 (1997): 117-8. [PMID: 9422044]
274	Spina E, de Leon J "Metabolic drug interactions with newer antipsychotics: a comparative review." Basic Clin Pharmacol Toxicol 100 (2007): 4-22. [PMID: 17214606]
275	Spina E, Scordo MG, D'Arrigo C "Metabolic drug interactions with new psychotropic agents." Fundam Clin Pharmacol 17 (2003): 517-38. [PMID: 14703714]
276	Urichuk L, Prior TI, Dursun S, Baker G "Metabolism of atypical antipsychotics: involvement of cytochrome p450 enzymes and relevance for drug-drug interactions." Curr Drug Metab 9 (2008): 410-8. [PMID: 18537577]
277	Schulz-Du Bois C, Schulz-Du Bois AC, Bewig B, et al. "Major increase of quetiapine steady-state plasma concentration following co-administration of clarithromycin: confirmation of the pharmacokinetic interaction potential of quetiapine." Pharmacopsychiatry 41 (2008): 258-9. [PMID: 19067264]
278	Bidstrup TB, Bjornsdottir I, Sidelmann UG, Thomsen MS, Hansen KT "CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide." Br J Clin Pharmacol 56 (2003): 305-14. [PMID: 12919179]
279	Hatorp V, Hansen KT, Thomsen MS "Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide." J Clin Pharmacol 43 (2003): 649-60. [PMID: 12817528]
280	Khamaisi M, Leitersdorf E "Severe hypoglycemia from clarithromycin-repaglinide drug interaction." Pharmacotherapy 28 (2008): 682-4. [PMID: 18447665]
281	Niemi M, Neuvonen PJ, Kivisto KT "The cytochrome P4503A4 inhibitor clarithromycin increases the plasma concentrations and effects of repaglinide." Clin Pharmacol Ther 70 (2001): 58-65. [PMID: 11452245]
282	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
283	Tornio A, Niemi M, Neuvonen M, et al. "The effect of gemfibrozil on repaglinide pharmacokinetics persists for at least 12 h after the dose: evidence for mechanism-based inhibition of CYP2C8 in vivo." Clin Pharmacol Ther 84 (2008): 403-11. [PMID: 18388877]
284	Niemi M, Backman JT, Neuvonen M, Neuvonen PJ "Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide." Diabetologia 46 (2003): 347-51. [PMID: 12687332]
285	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
286	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
287	Christians U, Schmidt G, Bader A, et al "Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes." Br J Clin Pharmacol 41 (1996): 187-90. [PMID: 8866917]
288	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
289	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
290	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
291	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
292	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
293	Product Information. Biktarvy (bictegravir/emtricitabine/tenofovir). Gilead Sciences, Foster City, CA.
294	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
295	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
296	Product Information. Viberzi (eluxadoline). Actavis Pharma, Inc., Parsippany, NJ.
297	Fan W, Gopal K, Sekhar S "Physiologically based pharmacokinetic modeling to assess metabolic drug-drug interaction risks and inform the drug label for fedratinib." Cancer Chemother Pharmacol 86 (2020): 461-473. [PMID: 32886148]
298	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
299	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
300	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
301	St Clair K, Maguire JD "Role of fluconazole in a case of rapid onset ritonavir and inhaled fluticasone-associated secondary adrenal insufficiency." Int J STD AIDS 23 (2012): 371-2. [PMID: 22648897]
302	Hoover WC, Britton LJ, Gardner J, Jackson T, Gutierrez H "Rapid onset of iatrogenic adrenal insufficiency in a patient with cystic fibrosis-related liver disease treated with inhaled corticosteroids and a moderate CYP3A4 inhibitor." Ann Pharmacother 45 (2011): e38. [PMID: 21712512]
303	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
304	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
305	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
306	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
307	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
308	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
309	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
310	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
311	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
312	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
313	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
314	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
315	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
316	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
317	Franco-Salinas G, de la Rosette JJ, Michel MC "Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations." Clin Pharmacokinet 49 (2010): 177-88. [PMID: 20170206]
318	Kamimura H, Oishi S, Matsushima H, et al. "Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes." Xenobiotica 28 (1998): 909-22. [PMID: 9849639]
319	Product Information. Flomax (tamsulosin). Boehringer-Ingelheim, Ridgefield, CT.
320	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
321	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
322	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
323	Product Information. Zanaflex (tizanidine). Acorda Therapeutics, Hawthorne, NY.
324	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
325	Brynne N, Forslund C, Hallen B, Gustafsson LL, Bertilsson L "Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity." Br J Clin Pharmacol 48 (1999): 564-72. [PMID: 10583027]
326	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
327	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
328	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
329	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
330	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
331	Product Information. Levitra (vardenafil). Bayer, West Haven, CT.
332	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
333	Nakasa H, Nakamura H, Ono S, Tsutsui M, Kiuchi M, Ohmori S, Kitada M "Prediction of drug-drug interactions of zonisamide metabolism in humans from in vitro data." Eur J Clin Pharmacol 54 (1998): 177-83. [PMID: 9626925]
334	Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
335	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
336	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
337	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
338	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
339	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
340	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.
341	Ekstrom G, Gunnarsson UB "Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes." Drug Metab Dispos 24 (1996): 955-61. [PMID: 8886604]
342	Halldin MM, Bredberg E, Angelin B, Arvidsson T, Askemark Y, Elofsson S, Widman M "Metabolism and excretion of ropivacaine in humans." Drug Metab Dispos 24 (1996): 962-8. [PMID: 8886605]
343	Jokinen MJ, Ahonen J, Neuvonen PJ, Olkkola KT "The effect of erythromycin, fluvoxamine, and their combination on the pharmacokinetics of ropivacaine." Anesth Analg 91 (2000): 1207-12. [PMID: 11049910]
344	McClure JH "Ropivacaine." Br J Anaesth 76 (1996): 300-7. [PMID: 8777115]
345	Oda Y, Furuichi K, Tanaka K, Hiroi T, Imaoka S, Asada A, Fujimori M, Funae Y "Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450." Anesthesiology 82 (1995): 214-20. [PMID: 7832304]
346	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
347	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
348	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
349	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
350	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.

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