Details of Drug

Drug General Information (ID: D1493)
Drug Name	Somapacitan
Drug Type	Protein/peptide
Drug Synonymous	1338578-34-9; Somapacitan [INN]; Somapacitan [WHO-DD]; Somapacitan [USAN:INN]; UNII-8FOJ430U94; 8FOJ430U94; EX-A4353; UNII-F1 component VTUYEWRWJTWXPQ-IWWWZYECSA-N; Q27270325 Click to Show/Hide
Disease Class	5A60-5A61: Pituitary gland disorder
Therapeutic Class	Growth Hormones
Structure
Structure	3D Structure		2D Structure
Formula	C54H95N13O20S2
InChI	1S/C54H95N13O20S2/c55-39(52(76)77)37-88-38-50(74)57-25-15-14-17-40(51(56)75)60-48(72)35-86-32-30-85-29-27-59-45(69)23-21-41(53(78)79)61-46(70)24-22-42(54(80)81)62-49(73)36-87-33-31-84-28-26-58-44(68)20-16-34-89(82,83)65-47(71)19-13-11-9-7-5-3-1-2-4-6-8-10-12-18-43-63-66-67-64-43/h39-42H,1-38,55H2,(H2,56,75)(H,57,74)(H,58,68)(H,59,69)(H,60,72)(H,61,70)(H,62,73)(H,65,71)(H,76,77)(H,78,79)(H,80,81)(H,63,64,66,67)/t39-,40-,41-,42-/m0/s1
InChIKey	VTUYEWRWJTWXPQ-IWWWZYECSA-N
Canonical SMILES	C(CCCCCCCC1=NNN=N1)CCCCCCCC(=O)NS(=O)(=O)CCCC(=O)NCCOCCOCC(=O)NC(CCC(=O)NC(CCC(=O)NCCOCCOCC(=O)NC(CCCCNC(=O)CSCC(C(=O)O)N)C(=O)N)C(=O)O)C(=O)O
External Link
	Pubchem ID	129894493
	CAS Number	1338578-34-9
	TTD ID	D7S9LP

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM022 CYP450 enzyme induction BM026 Increased metabolism (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Somapacitan
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 315
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[3], [4]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[5]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[6]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[7], [1], [8]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[9]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[7], [1], [8]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[13], [14], [15]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[16]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[7], [1], [8]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[7], [1], [8]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[7], [1], [8]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[17], [18], [19]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[20]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[21], [22], [23]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[24], [25]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[26], [27], [28]
D0108		Artemether	C16H26O5	68911	Moderate		Inter Info	[7], [1], [29]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[7], [1], [8]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[17], [18], [19]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[7], [1], [8]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[30], [31], [32]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[33], [34]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[35]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[1], [39], [40]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[41], [42]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[7], [1], [8]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[43], [44], [28]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[7], [1], [8]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[7], [1], [8]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[7], [1], [45]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[43], [46], [28]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[47], [48], [49]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[50], [32]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[51], [52], [28]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[43], [53], [28]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[54], [55], [56]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[1], [57]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[3], [58]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[59]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[7], [1], [8]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[7], [1], [8]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[7], [1], [8]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[7], [1], [8]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[7], [1], [8]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[7], [1], [8]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1], [60], [61]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[43], [62], [28]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[7], [1], [8]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[7], [1], [8]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[63]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[64], [1], [65]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[7], [1], [8]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[7], [1], [8]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[7], [1], [8]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[7], [1], [8]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[43], [66], [28]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[17], [18], [19]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[7], [1], [67]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[68], [69], [28]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[7], [1], [8]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[7], [1], [8]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[7], [1], [8]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[7], [1], [8]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[7], [1], [71]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[72], [73], [74]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[7], [1], [8]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[75], [76], [77]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[7], [1], [8]
D0514		Dolasetron	C19H20N2O3	3033818	Moderate		Inter Info	[7], [1], [8]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[78], [79]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[7], [1], [8]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[7], [1], [8]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[80], [81], [82]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[80], [81], [82]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[7], [1], [8]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[7], [1], [8]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[7], [1], [8]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[7], [1], [8]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[83]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[84], [74]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[85]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[7], [1], [8]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Moderate		Inter Info	[7], [1], [86]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[87], [28]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[1], [88]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[7], [1], [8]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[7], [1], [71]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[7], [1], [71]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[89], [21], [90]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[7], [1], [8]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[7], [1], [8]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[7], [1], [8]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[7], [1], [8]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[7], [1], [8]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[7], [1], [8]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[21], [91], [28]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[7], [1], [8]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[7], [1], [8]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[7], [1], [8]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[7], [1], [8]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[92], [21], [28]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[7], [1], [8]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[7], [1], [8]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[47], [48], [49]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[21], [93], [28]
D0660		Finasteride	C23H36N2O2	57363	Moderate		Inter Info	[7], [1], [8]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[94], [21]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[7], [1], [8]
D0683		Fluticasone	C22H27F3O4S	5311101	Moderate		Inter Info	[7], [1], [8]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[7], [1], [8]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[17], [18], [19]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[21], [22], [23]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[21], [95], [28]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[7], [1], [8]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[89], [21], [96]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[97], [21], [28]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[7], [1], [8]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[1], [98], [99]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[7], [1], [8]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[7], [1], [8]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[7], [1], [8]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[47], [48], [49]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[1], [100]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[101]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[7], [1], [8]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[7], [1], [8]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[102], [7], [103]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[7], [1], [8]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[7], [1], [8]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[17], [18], [19]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[104], [105], [106]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[104], [105], [106]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[107]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[7], [1], [8]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[7], [1], [8]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[7], [1], [8]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[7], [1], [8]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[7], [1], [8]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[108], [109], [32]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[7], [1], [8]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[110]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[43], [111], [28]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[7], [1], [8]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[7], [1], [8]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[21], [112], [28]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[113], [21]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[7], [1], [8]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[7], [1], [8]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[7], [1], [8]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[114], [28]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[7], [1], [8]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[7], [1], [8]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[7], [1], [8]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[7], [1], [8]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[7], [1], [115]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[116], [117]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[118], [119], [120]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[121], [122]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[7], [1], [8]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[7], [1], [8]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[7], [1], [8]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[47], [48], [49]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[7], [1], [71]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[7], [1], [71]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7], [1], [8]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[123], [124]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[125], [126]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[127], [128], [129]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[26], [27], [28]
D1101		Naldemedine	C32H34N4O6	54732242	Moderate		Inter Info	[7], [1], [8]
D1104		Naloxegol	C34H53NO11	56959087	Moderate		Inter Info	[130], [28]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[7], [1], [8]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[17], [18], [19]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[7], [1], [8]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[7], [1], [8]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[7], [1], [8]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[7], [1], [8]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[21], [131]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[7], [1], [8]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[7], [1], [8]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[7], [1], [8]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[132], [7], [1]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[7], [1], [8]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[7], [1], [8]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [1], [133]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[47], [48], [49]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[7], [1], [8]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[7], [1], [8]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[21], [134], [28]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[7], [1], [8]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[47], [48], [49]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[7], [1], [135]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[21], [136], [28]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[7], [1], [8]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[7], [1], [8]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[21], [137]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[1], [138], [25]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[7], [1], [8]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[21], [139], [28]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[7], [1], [8]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[7], [1], [8]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[7], [1], [8]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[7], [1], [140]
D1330		Praziquantel	C19H24N2O2	4891	Moderate		Inter Info	[141], [7], [142]
D1336		Pretomanid	C14H12F3N3O5	456199	Moderate		Inter Info	[7], [1], [8]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[7], [1], [8]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[7], [1], [8]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[7], [1], [8]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[7], [143], [144]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[7], [1], [8]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[145], [146], [147]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[7], [1], [8]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[21], [148], [28]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[7], [1], [8]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[7], [1], [8]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[7], [1], [149]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[7], [1], [8]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[7], [1], [8]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[7], [1], [8]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[150], [21], [28]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[7], [151], [152]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[7], [1], [8]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[17], [18], [19]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[7], [1], [8]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [1], [8]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[153]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[7], [1], [8]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[7], [1], [8]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[7], [1], [8]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[154]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[7], [1], [8]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[17], [18], [19]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[7], [1], [8]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[155]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[7], [1], [8]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[7], [1], [8]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[156], [157], [158]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[7], [1], [8]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[7], [1], [8]
D1474		Siponimod	C29H35F3N2O3	44599207	Moderate		Inter Info	[7], [1], [8]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[7], [1], [159]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[7], [1], [8]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[1], [160]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[47], [48], [49]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[161]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[7], [1], [8]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[162]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[7], [1], [8]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[21], [163], [28]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1], [164], [165]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[7], [1], [8]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[7], [1], [166]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[167]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[7], [1], [159]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[1], [168], [169]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[170], [171], [2]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[7], [1], [8]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[21], [172], [28]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[173]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[41], [42]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[21], [174], [175]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[7], [1], [176]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[7], [1], [8]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[7], [1], [8]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[7], [1], [8]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[7], [1], [8]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[7], [1], [8]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[7], [1], [8]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[7], [1], [8]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[7], [1], [8]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[1], [177], [178]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[7], [1], [8]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[17], [18], [19]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[7], [179]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[7], [1], [8]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1], [180]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[7], [1], [181]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [182], [183]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[7], [1], [8]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[7], [1], [8]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[7], [1], [8]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7], [1], [8]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[7], [1], [8]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[21], [184], [28]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[7], [1], [8]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[7], [1], [8]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[7], [1], [8]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[7], [1], [8]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[7], [1], [8]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[7], [1], [8]
D1686		Velpatasvir	C49H54N8O8	67683363	Moderate		Inter Info	[7], [1], [8]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[21], [185], [28]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[21], [186]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[7], [1], [8]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[7], [1], [8]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[21], [187], [28]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[7], [1], [8]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[7], [1], [8]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[7], [1], [8]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[7], [1], [8]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[7], [1], [8]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[188], [21], [28]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[7], [1], [8]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[7], [1], [8]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[7], [1], [8]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[189], [21]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[7], [1], [8]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[7], [1], [8]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[7], [1], [8]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[1], [190], [191]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[192]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[193], [30], [32]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[3], [194]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[195], [196], [197]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[198], [21], [199]
	Increased metabolism (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[36], [37], [38]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[36], [37], [38]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[36], [37], [38]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[36], [37], [38]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[36], [37], [38]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[36], [37], [38]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[36], [37], [38]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[36], [37], [38]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[36], [37], [38]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[36], [37], [38]
Pharmacodynamic additive effects
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[1], [2]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[10], [11], [12]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[10], [11], [12]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[10], [11], [12]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[10], [11], [12]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[10], [11], [12]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[10], [11], [12]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[10], [11], [12]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[10], [11], [12]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[10], [11], [12]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[10], [11], [12]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[10], [11], [12]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[10], [11], [12]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[10], [11], [12]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[10], [11], [12]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[10], [11], [12]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[10], [11], [12]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[10], [11], [12]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[10], [11], [12]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[10], [11], [12]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[10], [11], [12]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [11], [12]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [11], [12]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [11], [12]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [11], [12]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [11], [12]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[10], [11], [12]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[10], [11], [12]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[10], [11], [12]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[10], [11], [12]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[10], [11], [12]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[10], [11], [12]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[10], [11], [12]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[10], [11], [12]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[10], [11], [12]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[10], [11], [12]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[10], [11], [12]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[10], [11], [12]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[10], [11], [12]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[10], [11], [12]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[10], [11], [12]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[10], [11], [12]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[10], [11], [12]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[10], [11], [12]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[10], [11], [12]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[7], [1], [70]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[7], [1], [70]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[7], [1], [70]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[7], [1], [70]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[7], [1], [70]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[7], [1], [70]

References
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2	Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
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149	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
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154	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
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159	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
160	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
161	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
162	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
163	Product Information. Nexavar (sorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
164	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
165	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
166	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
167	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
168	Product Information. Adcirca (tadalafil). United Therapeutics Corporation, Silver Spring, MD.
169	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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173	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
174	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
175	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
176	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
177	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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179	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
180	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
181	Product Information. Fareston (toremifene). Schering Laboratories, Kenilworth, NJ.
182	Machiels JP, Staddon A, Herremans C, et al. "Impact of cytochrome P450 3A4 inducer and inhibitor on the pharmacokinetics of trabectedin in patients with advanced malignancies: open-label, multicenter studies." Cancer Chemother Pharmacol 74 (2014): 729-37. [PMID: 25100135]
183	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
184	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
185	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
186	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
187	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
188	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
189	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
190	Hellmann A, Rule S, Walewski J, et al. "Effect of cytochrome P450 3A4 inducers on the pharmacokinetic, pharmacodynamic and safety profiles of bortezomib in patients with multiple myeloma or Non-Hodgkin's lymphoma." Clin Pharmacokinet 50 (2011): 781-91. [PMID: 22087865]
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193	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
194	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
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