Details of Drug

Details of Drug

 Drug General Information (ID: D1490)
  Drug Name
Sofosbuvir
  Drug Type Small molecule
  Drug Synonymous
1190307-88-0; SOVALDI; PSI 7977; GS-7977; GS 7977; UNII-WJ6CA3ZU8B; WJ6CA3ZU8B; CHEBI:85083; Sofosbuvir (PSI-7977, GS-7977); Hepcvir; Hepcinat; HSDB 8226; 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester; Sofosbuvir [USAN:INN]; Resof; SoviHep; Sovaldi (TN); Sofosbuvir (JAN/USAN); Sofosbuvir(PSI-7977); GTPL7368; SCHEMBL2010114; CHEMBL1259059; AMMD00019; EX-A389; MolPort-028-720-482; isopropyl (2S)-2-[[[(2R,
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  Disease Class 1E50-1E51: Hepatitis virus infection
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C22H29FN3O9P
  InChI 1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1
  InChIKey TTZHDVOVKQGIBA-IQWMDFIBSA-N
  Canonical SMILES CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
  External Link
Pubchem ID 45375808
CAS Number 1190307-88-0
CHEBI ID 85083
TTD ID D0D4YZ
INTEDE ID DR1495
VARIDT ID DR00372

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM011  Transporter induction
BM051  Increased risk of bradycardia
BM085  Antagonize the effect of antithrombotic agents
  Relation Graph
 Full list of drugs interacting with Sofosbuvir
      Affected cellular transport
   Transporter inhibition Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[2], [12]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[13]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[14]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[15]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[16]
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Minor    Inter Info   
[3]
   Transporter induction Drug Num:  15
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Major    Inter Info   
[2], [4], [5], [3]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[1], [2], [4], [5], [3]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Major    Inter Info   
[2], [4], [5], [3]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Major    Inter Info   
[1], [2], [4], [5], [3]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Major    Inter Info   
[1], [2], [4], [5], [3]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[2], [4], [5], [3]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[2], [4], [5], [3]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Major    Inter Info   
[2], [4], [5], [3]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Major    Inter Info   
[2], [4], [5], [3]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[2], [5], [3]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Major    Inter Info   
[1], [2], [4], [5], [3]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[1], [2], [4], [5], [3]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Major    Inter Info   
[1], [2], [4], [5], [3]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[2], [4], [5], [3]
D1592
 
Tipranavir
 
C31H33F3N2O5S
 
54682461 
Major    Inter Info   
[1], [2], [4], [5], [3]
      Pharmacodynamic additive effects
   Increased risk of bradycardia Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antithrombotic agents Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[6], [1], [2], [7], [8], [9], [10]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[2], [11], [8]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[6], [1], [2], [7], [8], [9], [10]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Sovaldi (sofosbuvir). Gilead Sciences, Foster City, CA.
4 Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
5 Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
6 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
7 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
8 Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
9 Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
10 Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
11 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
12 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
13 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
14 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
15 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
16 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.