Details of Drug

Drug General Information (ID: D1460)
Drug Name	Selumetinib
Drug Type	Small molecule
Drug Synonymous	Selumetinib; AZD-6244; ARRY142886; AZD6244; ARRY142886; AZD 6244; AZD-6244; 6UH91I579U; ARRY 142886; ARRY-142886; AZD6244 (Selumetinib); AZD6244(Selumetinib); CHEBI:90227; CHEMBL1614701; MEK inhibitors; Selumetinib (AZD6244); UNII-6UH91I579U Click to Show/Hide
Disease Class	2C25: Lung cancer; 2C30: Melanoma; 2D10: Thyroid cancer; 2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Multikinase Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C17H15BrClFN4O3
InChI	1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey	CYOHGALHFOKKQC-UHFFFAOYSA-N
Canonical SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
External Link
	Pubchem ID	10127622
	CAS Number	606143-52-6
	CHEBI ID	90227
	TTD ID	D0T5DP

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM050 Increased risk of bleeding
Relation Graph

Full list of drugs interacting with Selumetinib
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 65
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Major		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Major		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Major		Inter Info	[2], [3]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Major		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Major		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[2], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[2], [3]
D0906		Letermovir	C29H28F4N4O4	45138674	Major		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[1]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0416		Danazol	C22H27NO2	28417	Moderate		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[8], [1]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[1]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[9], [8], [10], [11]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1]
D0735		Goldenseal	NA	NA	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[2], [12]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[8], [1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[2], [4]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[2], [4]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[2]
D1050		Metreleptin	NA	NA	Moderate		Inter Info	[1]
D1186		Oritavancin	C86H97Cl3N10O26	16136912	Moderate		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[1]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Moderate		Inter Info	[1]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[2]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[2]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[2]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[1]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[5], [6], [7]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[5], [6], [7]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[5], [6], [7]
D0102		Ardeparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[5], [6], [7]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[5], [6], [7]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[5], [6], [7]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[5], [6], [7]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[5], [6], [7]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7]
D0415		Danaparoid	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[5], [6], [7]
D0447		Desirudin	C287H440N80O110S6	16129703	Moderate		Inter Info	[5], [6], [7]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[5], [6], [7]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[5], [6], [7]
D0537		Drotrecogin alfa	NA	NA	Moderate		Inter Info	[5], [6], [7]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[5], [6], [7]
D0574		Enoxaparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[5], [6], [7]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[5], [6], [7]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[5], [6], [7]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[5], [6], [7]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[5], [6], [7]
D1360		Protein C	NA	NA	Moderate		Inter Info	[5], [6], [7]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[5], [6], [7]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[5], [6], [7]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[5], [6], [7]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[5], [6], [7]
D1588		Tinzaparin	C26H42N2O37S5	772	Moderate		Inter Info	[5], [6], [7]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[5], [6], [7]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[5], [6], [7]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[5], [6], [7]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[5], [6], [7]

References
1	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
2	Multum Information Services, Inc. Expert Review Panel.
3	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
4	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
5	Booth SL, Golly I, Sacheck JM, Roubenoff R, Dallal GE, et al "Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status." Am J Clin Nutr 80 (2004): 143-8. [PMID: 15213041]
6	Murohara T, Ikeda H, Otsuka Y, Aoki M, Takajo Y, et al "Inhibition of platelet adherence to Mononuclear cells by alpha-tocopherol: role of P-selection." Circulation 110 (2004): 141-8. [PMID: 15197142]
7	Vitamin K, vitamin E and the coumarin drugs. Nutr Rev 40 (1982): 180-2. [PMID: 7121898]
8	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9	Cerner Multum, Inc. "Australian Product Information.".
10	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
11	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
12	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.

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