Details of Drug

Drug General Information (ID: D1448)
Drug Name	Satralizumab
Drug Type	Monoclonal antibody
Disease Class	8E4A: Nervous system paraneoplastic/autoimmune disorder
Therapeutic Class	Interleukin Inhibitors
External Link
External Link	TTD ID	D0MD0T

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM016 Altered formation of CYP450 enzymes BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Satralizumab
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 56
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[35], [37], [39]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[35], [37], [39]
D0485		Dienogest	C20H25NO2	68861	Moderate		Inter Info	[35], [37], [39]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[35], [37], [39]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0626		Etonogestrel	C22H28O2	6917715	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0922		Levonorgestrel	C21H28O2	13109	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0927		Lidocaine	C14H22N2O	3676	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[35], [37], [39]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[35], [37], [39]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[35], [37], [39]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1154		Norethisterone	C20H26O2	6230	Moderate		Inter Info	[35], [37], [39]
D1156		Norgestimate	C23H31NO3	6540478	Moderate		Inter Info	[35], [37], [39]
D1157		Norgestrel	C21H28O2	13109	Moderate		Inter Info	[35], [37], [39]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[35], [37], [39]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[35], [37], [39]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[8], [33], [30], [34], [35], [36], [37], [38], [1], [2], [3], [39], [40], [41], [42]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0004		Abatacept	NA	NA	Major		Inter Info	[1], [2], [3]
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0085		Anakinra	C20H23N5O7S2	146171046	Major		Inter Info	[1], [2], [3]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[7], [8], [9]
D0246		Canakinumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [2], [3]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[8], [10]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[15]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[8], [16]
D1111		Natalizumab	NA	NA	Major		Inter Info	[19]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[8], [20]
D1403		Rilonacept	NA	NA	Major		Inter Info	[1], [2], [3]
D1416		Rituximab	NA	NA	Major		Inter Info	[1], [2], [3]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[7], [23]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[16], [27]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[28]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[8], [29]
D1671		Ustekinumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[24], [30], [31]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[32]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[7], [8]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[7], [8], [65]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[67]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[68]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[68]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[69]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[68]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[83]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[84]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[8], [85]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[86]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[94]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[8], [98]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D1487		Sodium phosphate, monobasic (p32)	NA	NA	Moderate		Inter Info	[99]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[7], [8], [100]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[8], [34], [41]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[8], [33], [30], [34], [35], [37], [40], [41], [42]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[8], [11], [12]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[7], [13], [14]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[22]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[7], [8], [73], [74]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[7], [8], [73], [74]
	Increased risk of hepatotoxicity					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[17]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[18]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[21]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[45], [46], [47], [7], [8], [48], [49], [50], [51], [52], [53], [54], [55]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[46], [7], [54]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[56]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[60]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[45], [46], [47], [7], [8], [48], [49], [50], [51], [52], [53], [54], [55]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[8], [64]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[66]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[70], [71]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[7], [8], [72]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[75]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[76], [77], [78], [79]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[76], [77], [78], [79]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[8], [81]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[82]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[45], [46], [47], [7], [8], [48], [49], [50], [51], [52], [53], [54], [55]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[76], [77], [78], [79]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[7], [8], [95], [96], [97]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[27], [101]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[4], [5], [6]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[4], [5], [6]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[4], [5], [6]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[4], [5], [6]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[4], [5], [6]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[24], [7], [25]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[26]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[4], [5], [6]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[4], [5], [6]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[4], [5], [6]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[24], [43], [44]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[24], [43], [44]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[24], [43], [44]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[24], [43], [44]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[24], [43], [44]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[24], [43], [44]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[80]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[24], [43], [44]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[87], [24], [7], [88], [89], [90], [43], [91], [92], [93], [44]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[24], [43], [44]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[24], [43], [44]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[24], [43], [44]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[24], [43], [44]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[57], [58], [59]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[57], [58], [59]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[61], [62], [63]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[61], [62], [63]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[61], [62], [63]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[102], [103], [104]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[102], [103], [104]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[102], [103], [104]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[102], [103], [104]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[102], [103], [104]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[102], [103], [104]

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