Details of Drug

Drug General Information (ID: D1426)
Drug Name	Romosozumab
Drug Type	Monoclonal antibody
Drug Synonymous	AMG 785 Click to Show/Hide
Disease Class	FB83: Low bone mass disorder
Therapeutic Class	Bone Resorption Inhibitors
External Link
External Link	TTD ID	D0K3LO

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM063 Increased risk of hypocalcemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Romosozumab
Pharmacodynamic additive effects
	Increased risk of hypocalcemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[1]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[3], [4], [5]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[2]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[2]
D0133		Axitinib	C22H18N4OS	6450551	Moderate		Inter Info	[2]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[2]
D0177		Bevacizumab	NA	NA	Moderate		Inter Info	[2]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[2]
D0230		Cabozantinib	C28H24FN3O5	25102847	Moderate		Inter Info	[2]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[2]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[2]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[2]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[2]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[2]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[2]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[2]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[2]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[2]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[2]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[2]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[2]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[2]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[2]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[2]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[2]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[2]
D1380		Ramucirumab	NA	NA	Moderate		Inter Info	[2]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[2]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[2]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[2]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[2]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[2]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[2]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[2]
D1584		Tiludronic acid	C7H9ClO6P2S	60937	Moderate		Inter Info	[2]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[2]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[2]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[2]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.
3	Foscarnet: a review. Drugs 41 (1991): 106-29. [PMID: 1706982]
4	Product Information. Foscavir (foscarnet). Astra USA, Westborough, MA.
5	Youle M, Clarbour J, Gazzard B, Chanas A "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet 1 (1988): 1455-6. [PMID: 2898602]

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