Details of Drug

Drug General Information (ID: D1422)
Drug Name	Roflumilast
Drug Type	Small molecule
Drug Synonymous	162401-32-3; DAXAS; Daliresp; 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE; BY217; BYK20869; UNII-0P6C6ZOP5U; BY-217; Roflumilast (Daxas); B9302-107; 0P6C6ZOP5U; 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-; CHEMBL193240; CHEBI:47657; BYK-20869; ROF; Libertek; AK110425; 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide; DAXAS; Roflumilast [USAN]; APTA-2217; Roflumilast (JAN/USAN/INN); 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-di-chloropyrid-4-yl)benzamide; Alogliptin/roflumilast Click to Show/Hide
Disease Class	CA23: Asthma; EA80: Atopic eczema; 5A11: Type 2 diabetes mellitus; CA22: Chronic obstructive pulmonary disease
Therapeutic Class	Selective Phosphodiesterase-4 Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C17H14Cl2F2N2O3
InChI	1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey	MNDBXUUTURYVHR-UHFFFAOYSA-N
Canonical SMILES	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F
External Link
	Pubchem ID	449193
	CAS Number	162401-32-3
	CHEBI ID	47657
	TTD ID	D0R4UW
	INTEDE ID	DR1434

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM043 Additive immunosuppressive effects
Relation Graph

Full list of drugs interacting with Roflumilast
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1], [4], [3]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[1], [4], [3]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1], [4], [3]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1], [4], [3]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[1], [4], [3]
D0573		Enoxacin	C15H17FN4O3	3229	Moderate		Inter Info	[1], [4], [3]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[6], [4], [3]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[7], [1], [8]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[1], [4], [3]
D0740		Grepafloxacin	C19H22FN3O3	72474	Moderate		Inter Info	[1], [4], [3]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[1], [4], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[9], [4], [3]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[1], [4], [3]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1], [4], [3]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[11]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[12]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[1], [4], [3]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[13]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[1], [4], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1], [15]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[16]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[1], [4], [3]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[17], [18], [19]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[1], [4], [3]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[1], [4], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[27]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1], [4], [3]
D1571		Thiabendazole	C10H7N3S	5430	Moderate		Inter Info	[1], [4], [3]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[1], [4], [3]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1], [4], [3]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[1], [4], [3]
	CYP450 enzyme induction					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[5], [4]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[5], [4]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[5], [4]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[5], [4]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[5], [4]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[5], [10], [4]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[5], [4]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1], [14]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[5], [4]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[20]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[5], [10], [4]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[21]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[22]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[1], [23]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[7], [1], [24]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[7], [1], [25], [24]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[1], [26]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[7], [1], [24]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[5], [4]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 212
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[1], [2]
D0004		Abatacept	NA	NA	Moderate		Inter Info	[1], [3]
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[1], [3]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[1], [3]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[1], [3]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[1], [3]
D0048		Altretamine	C9H18N6	2123	Moderate		Inter Info	[1], [3]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[1], [3]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Moderate		Inter Info	[1], [3]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[1], [3]
D0134		Azacitidine	C8H12N4O5	9444	Moderate		Inter Info	[1], [3]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[1], [3]
D0147		Basiliximab	NA	NA	Moderate		Inter Info	[1], [3]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[1], [3]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1], [3]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[1], [3]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[1], [3]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[1], [3]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[1], [3]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[1], [3]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[1], [3]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[1], [3]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[1], [3]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[1], [3]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[1], [3]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[1], [3]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[1], [3]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [3]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[1], [3]
D0407		Dacarbazine	C6H10N6O	135398738	Moderate		Inter Info	[1], [3]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[1], [3]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[1], [3]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[1], [3]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[1], [3]
D0431		Decitabine	C8H12N4O4	451668	Moderate		Inter Info	[1], [3]
D0442		Denileukin diftitox	NA	NA	Moderate		Inter Info	[1], [3]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1], [3]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[1], [3]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[1], [3]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[1], [3]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[1], [3]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[1], [3]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[1], [3]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[1], [3]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[1], [3]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[1], [3]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[1], [3]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[1], [3]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[1], [3]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[1], [3]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[1], [3]
D0717		Gemtuzumab ozogamicin	NA	NA	Moderate		Inter Info	[1], [3]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[1], [3]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[1], [3]
D0784		Ibritumomab tiuxetan	NA	NA	Moderate		Inter Info	[1], [3]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[1], [3]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[1], [3]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1], [3]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[1], [3]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[1], [3]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[1], [3]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[1], [3]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[1], [3]
D0828		Interferon gamma-1b	NA	NA	Moderate		Inter Info	[1], [3]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[1], [3]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[1], [3]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[1], [3]
D0902		Lenalidomide	C13H13N3O3	216326	Moderate		Inter Info	[1], [3]
D0910		Levamisole	C11H12N2S	26879	Moderate		Inter Info	[1], [3]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[1], [3]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[1], [3]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[1], [3]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[1], [3]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[1], [3]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[1], [3]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[1], [3]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[1], [3]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[1], [3]
D1093		Muromonab	NA	NA	Moderate		Inter Info	[1], [3]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[1], [3]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[1], [3]
D1111		Natalizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[1], [3]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[1], [3]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[1], [3]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[1], [3]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[1], [3]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[1], [3]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[1], [3]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[1], [3]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[1], [3]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[1], [3]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[1], [3]
D1416		Rituximab	NA	NA	Moderate		Inter Info	[1], [3]
D0006		Abemaciclib	C27H32F2N8	46220502	Moderate		Inter Info	[1], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[1], [3]
D0027		Aflibercept	NA	NA	Moderate		Inter Info	[1], [3]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Moderate		Inter Info	[1], [3]
D0118		Atezolizumab	NA	NA	Moderate		Inter Info	[1], [3]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[1], [3]
D0132		Axicabtagene ciloleucel	NA	NA	Moderate		Inter Info	[1], [3]
D0146		Baricitinib	C16H17N7O2S	44205240	Moderate		Inter Info	[1], [3]
D0150		Belantamab mafodotin	NA	NA	Moderate		Inter Info	[1], [3]
D0151		Belatacept	NA	NA	Moderate		Inter Info	[1], [3]
D0152		Belimumab	NA	NA	Moderate		Inter Info	[1], [3]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[1], [3]
D0191		Blinatumomab	NA	NA	Moderate		Inter Info	[1], [3]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[1], [3]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[1], [3]
D0203		Brexucabtagene autoleucel	NA	NA	Moderate		Inter Info	[1], [3]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1], [3]
D0209		Brodalumab	NA	NA	Moderate		Inter Info	[1], [3]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[1], [3]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[1], [3]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[1], [3]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[1], [3]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[1], [3]
D0389		Copanlisib	C23H28N8O4	135565596	Moderate		Inter Info	[1], [3]
D0422		Daratumumab	NA	NA	Moderate		Inter Info	[1], [3]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[1], [3]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[1], [3]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[1], [3]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[1], [3]
D0540		Dupilumab	NA	NA	Moderate		Inter Info	[1], [3]
D0541		Durvalumab	NA	NA	Moderate		Inter Info	[1], [3]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1], [3]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[1], [3]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[1], [3]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[1], [3]
D0661		Fingolimod	C19H33NO2	107970	Moderate		Inter Info	[1], [3]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[1], [3]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[1], [3]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[1], [3]
D0801		Inebilizumab	NA	NA	Moderate		Inter Info	[1], [3]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[1], [3]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[1], [3]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[1], [3]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[1], [3]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[1], [3]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[1], [3]
D0939		Lisocabtagene maraleucel	NA	NA	Moderate		Inter Info	[1], [3]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[1], [3]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[1], [3]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1], [3]
D1083		Mogamulizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[1], [3]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[1], [3]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1], [3]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[1], [3]
D1161		Obinutuzumab	NA	NA	Moderate		Inter Info	[1], [3]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1164		Ofatumumab	NA	NA	Moderate		Inter Info	[1], [3]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[1], [3]
D1168		Olaratumab	NA	NA	Moderate		Inter Info	[1], [3]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[1], [3]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[1], [3]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[1], [3]
D1305		Plicamycin	C52H76O24	163659	Moderate		Inter Info	[1], [3]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[1], [3]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[1], [3]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1], [3]
D1323		Pralatrexate	C23H23N7O5	148121	Moderate		Inter Info	[1], [3]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1], [3]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[1], [3]
D1410		Risankizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[1], [3]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1], [3]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[1], [3]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[1], [3]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[1], [3]
D1458		Selinexor	C17H11F6N7O	71481097	Moderate		Inter Info	[1], [3]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[1], [3]
D1474		Siponimod	C29H35F3N2O3	44599207	Moderate		Inter Info	[1], [3]
D1529		Tafasitamab	NA	NA	Moderate		Inter Info	[1], [3]
D1532		Talazoparib	C19H14F2N6O	135565082	Moderate		Inter Info	[1], [3]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[1], [3]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[1], [3]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[1], [3]
D1583		Tildrakizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1594		Tisagenlecleucel	NA	NA	Moderate		Inter Info	[1], [3]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[1], [3]
D1622		Trastuzumab deruxtecan	NA	NA	Moderate		Inter Info	[1], [3]
D1666		Upadacitinib	C17H19F3N6O	58557659	Moderate		Inter Info	[1], [3]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[1], [3]
D1685		Vedolizumab	NA	NA	Moderate		Inter Info	[1], [3]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[1], [3]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[1], [3]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[1], [3]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[1], [3]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1], [3]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[1], [3]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[1], [3]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[1], [3]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[1], [3]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[1], [3]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[1], [3]
D1613		Tositumomab	NA	NA	Moderate		Inter Info	[1], [3]
D1614		Tositumomab (I-131)	NA	NA	Moderate		Inter Info	[1], [3]
D1621		Trastuzumab	NA	NA	Moderate		Inter Info	[1], [3]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[1], [3]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[1], [3]
D1639		Trifluridine	C10H11F3N2O5	6256	Moderate		Inter Info	[1], [3]
D1646		Trimetrexate	C19H23N5O3	5583	Moderate		Inter Info	[1], [3]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Moderate		Inter Info	[1], [3]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[1], [3]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[1], [3]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[1], [3]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[1], [3]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[1], [3]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[1], [3]

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