Details of Drug

Drug General Information (ID: D1421)
Drug Name	Rofecoxib
Drug Type	Small molecule
Drug Synonymous	Ceoxx; Refecoxib; Vioxx; Cahill May Roberts brand of rofecoxib; MSD brand of rofecoxib; Merck Frosst brandof rofecoxib; Merck brand of rofecoxib; Vioxx Dolor; MK 0966; MK 0996; MK 966; MK0966; Ceeoxx (TN); Ceoxx (TN); KS-1107; MK-0966; MK-966; Merck Sharp & Dhome brand of rofecoxib; Vioxx (TN); Vioxx (trademark); Rofecoxib (JAN/USAN/INN); 3-(4-methylsulfonylphenyl)-4-phenyl-2H-furan-5-one; 3-Phenyl-4-(4-(methylsulfonyl)phenyl))-2(5H)-furanone; 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone; 4-(4-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-(4-methylsulfonylphenyl)-3-phenyl-5H-furan-2-one; 4-(p-(Methylsulfonyl)phenyl)-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone; 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one Click to Show/Hide
Disease Class	FA00-FA05: Osteoarthritis
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C17H14O4S
InChI	1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
InChIKey	RZJQGNCSTQAWON-UHFFFAOYSA-N
Canonical SMILES	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3
External Link
	Pubchem ID	5090
	CAS Number	162011-90-7
	CHEBI ID	8887
	TTD ID	D05VLS
	INTEDE ID	DR1433
	VARIDT ID	DR00753

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM027 Decreased renal excretion due to nephrotoxicity BM032 Decreased renal excretion (Unspecific) BM038 Additive CNS depression effects BM039 Additive CNS stimulant effects BM050 Increased risk of bleeding BM054 Increased risk of GI mucosal injury/bleeding risk BM055 Increased risk of hepatotoxicity BM058 Increased risk of hyperkalemia BM064 Increased risk of hypoglycemia BM067 Increased risk of hyponatremia BM072 Increased risk of nephrotoxicity BM089 Antagonize the effect of antihypertensive agents BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Rofecoxib
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[44]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[46], [18], [59]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[271], [272], [46], [18], [273], [274], [275]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[276], [277], [278], [279]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[425]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[34]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[426]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[428]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[447]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[454], [455]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[456]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[46], [18], [457]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[462]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[465], [466]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[34]
	CYP450 enzyme induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[461]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[280]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[409]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[445]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[463]
	Decreased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[23], [24], [25]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406]
	Additive CNS stimulant effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[399], [396], [393]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[399], [396], [393]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[393], [394], [395], [396], [397], [398], [399], [400], [401], [402], [403], [404], [405], [406]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[399], [396], [393]
	Increased risk of bleeding					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Moderate		Inter Info	[37]
D0047		Alteplase	NA	NA	Moderate		Inter Info	[37]
D0104		Argatroban	C23H36N6O5S	92722	Moderate		Inter Info	[37]
D0189		Bivalirudin	C98H138N24O33	16129704	Moderate		Inter Info	[37]
D0588		Eptifibatide	C35H49N11O9S2	448812	Moderate		Inter Info	[37]
D0904		Lepirudin	C287H440N80O111S6	118856773	Moderate		Inter Info	[37]
D1395		Reteplase	NA	NA	Moderate		Inter Info	[37]
D0092		Antithrombin Alfa	NA	NA	Moderate		Inter Info	[37]
D0093		Antithrombin III human	NA	NA	Moderate		Inter Info	[37]
D0096		Apixaban	C25H25N5O4	10182969	Moderate		Inter Info	[37]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[37]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Moderate		Inter Info	[37]
D0250		Caplacizumab	NA	NA	Moderate		Inter Info	[37]
D0364		Clopidogrel	C16H16ClNO2S	60606	Moderate		Inter Info	[37]
D0414		Dalteparin	C26H42N2O37S5	772	Moderate		Inter Info	[37]
D0435		Defibrotide	C20H21N4O6P	135565962	Moderate		Inter Info	[37]
D0506		Dipyridamole	C24H40N8O4	3108	Moderate		Inter Info	[37]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Moderate		Inter Info	[37]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[37]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Moderate		Inter Info	[37]
D0753		Heparin	C26H42N2O37S5	772	Moderate		Inter Info	[37]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[37]
D1328		Prasugrel	C20H20FNO3S	6918456	Moderate		Inter Info	[37]
D1360		Protein C	NA	NA	Moderate		Inter Info	[37]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[37]
D1593		Tirofiban	C22H36N2O5S	60947	Moderate		Inter Info	[37]
D1705		Vorapaxar	C29H33FN2O4	10077130	Moderate		Inter Info	[37]
D1550		Tenecteplase	NA	NA	Moderate		Inter Info	[37]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[37]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[37]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 35
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[12]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[46], [18], [385]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[46], [18], [385]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[410], [411], [412]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[421], [18], [422]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[410], [411], [412]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[46], [18], [385]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[46], [18], [385]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[410], [411], [412]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[46], [18], [385]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[46], [18], [385]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[46], [18], [385]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[46], [18], [385]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[46], [18], [385]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[46], [18], [385]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[46], [18], [385]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[46], [18], [385]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[46], [18], [385]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[46], [18], [385]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[46], [18], [385]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[410], [411], [412]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[46], [18], [385]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Moderate		Inter Info	[52], [56], [58]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[46], [18], [385]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Moderate		Inter Info	[18], [471], [472], [410], [473], [411], [474], [412], [475], [476], [477]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[20], [21], [22]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[26]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[27]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[28]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[20], [21], [22]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[45], [46], [47]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[386], [387], [388], [389]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[386], [387], [388], [389]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[413], [45], [272], [46], [18], [414], [415], [416], [417], [418], [419], [47], [420]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[413], [45], [272], [46], [18], [414], [415], [416], [417], [418], [419], [47], [420]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[427]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[429]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[413], [45], [272], [46], [18], [414], [415], [416], [417], [418], [419], [47], [420]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[18], [430]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[18], [438]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[439]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[442], [443]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[446]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[18], [448]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[449]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[386], [387], [388], [389]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[46], [18], [458], [459], [460]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[18], [464]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[22], [467]
	Increased risk of hyperkalemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0536		Drospirenone	C24H30O3	68873	Moderate		Inter Info	[440], [441]
	Increased risk of hypoglycemia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[297], [312], [376]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[284], [285], [286], [287], [288], [289], [290], [291], [292], [293], [294], [295], [296], [297], [298], [299], [300], [301], [302], [303], [304], [305], [306], [307], [308], [309], [310], [311], [312], [313], [314], [315], [316], [317], [318], [319], [320], [321], [322], [323], [324], [325], [326], [327], [328], [329], [330], [331], [332], [333], [334], [335], [336], [337], [338], [339], [340], [341], [342], [343], [344], [345], [346], [347], [348], [349], [350], [351], [352], [353], [354], [355], [356], [357], [358], [359], [360], [361], [362], [363], [364], [365], [366], [367], [368], [369], [370], [371], [372], [373], [374], [375], [376], [377], [378], [379], [380], [381], [382], [383], [384]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[297], [312], [376]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[297], [312], [376]
	Increased risk of hyponatremia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[46], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [18], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[46], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168], [169], [170], [171], [172], [173], [174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198], [199], [200], [201], [202], [203], [204], [205], [206], [207], [208], [209], [210], [211], [212], [213], [214], [215], [216], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226], [227], [18], [228], [229], [230], [231], [232], [233], [234], [235], [236], [237], [238], [239], [240], [241], [242], [243], [244], [245], [246], [247], [248], [249], [250], [251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265], [266], [267], [268], [269], [270]
	Increased risk of nephrotoxicity					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[1]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[9], [10], [11]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[13], [14]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[15], [16], [17]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[9], [10], [11]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[9], [10], [11]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[9], [10], [11]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[18], [19]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[4], [5], [6]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[4], [5], [6]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[4], [5], [6]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[15], [16], [17]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[15], [16], [17]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[15], [16], [17]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[38], [39], [40], [41], [42], [43]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[39], [40], [42]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[86], [87], [88], [89], [90], [91]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[18]
D1009		Mesalazine	C7H7NO3	4075	Moderate		Inter Info	[390], [391], [392]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[38], [39], [40], [41], [42], [43]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[38], [39], [40], [41], [42], [43]
D1173		Olsalazine	C14H10N2O6	22419	Moderate		Inter Info	[450], [390], [391], [392]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[39], [40], [42]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[38], [39], [40], [41], [42], [43]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[450], [390], [391], [392]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[38], [39], [40], [41], [42], [43]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[46], [18], [468], [469], [12], [470]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[451], [452], [453]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[451], [452], [453]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[451], [452], [453]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[281], [282], [283]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[407], [12], [408]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[281], [282], [283]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[18], [423], [424]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[407], [12], [408]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[281], [282], [283]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[431], [281], [432], [433], [434], [37], [435], [12], [408], [436], [282], [283], [437]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[281], [282], [283]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[431], [408], [281], [282], [432], [444], [434], [283], [437], [433], [436]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[60], [61], [62]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[64], [61], [62], [75], [67], [82], [84], [63], [70], [66], [68], [78], [71], [60], [72], [81], [73], [85], [83], [77], [79], [65], [69], [74], [76], [80]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[60], [61], [62]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[281], [282], [283]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[407], [12], [408]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[281], [282], [283]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[281], [282], [283]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[60], [61], [62]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[281], [282], [283]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[407], [12], [408]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[60], [61], [62]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[281], [282], [283]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[407], [12], [408]

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347	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
348	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
349	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
350	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
351	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
352	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
353	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
354	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
355	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
356	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
357	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
358	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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386	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
387	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
388	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
389	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
390	Product Information. Canasa (mesalamine (5-aminosalicylic acid)). Axcan Scandipharm Inc, Birmingham, AL.
391	Product Information. Lialda (mesalamine (5-aminosalicylic acid)). Shire US Inc, Florence, KY.
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395	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
396	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
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409	Product Information. Eloxatin (oxaliplatin). Sanofi Winthrop Pharmaceuticals, New York, NY.
410	Product Information. Actonel (risedronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
411	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
412	Product Information. Didronel I.V. Infusion (etidronate). MGI Pharma Inc, Minnetonka, MN.
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417	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
418	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
419	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
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425	Product Information. Lotronex (alosetron). Glaxo Wellcome, Research Triangle Park, NC.
426	Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
427	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
428	Product Information. Treanda (bendamustine). Cephalon Inc, West Chester, PA.
429	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
430	Product Information. Epidiolex (cannabidiol). Greenwich Biosciences Inc, Carlsbad, CA.
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435	Product Information. Daypro (oxaprozin). Searle, Skokie, IL.
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438	Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
439	Product Information. Solaraze (diclofenac topical). Doak Dermatologics Division, Fairfield, NJ.
440	Product Information. Yasmin (drospirenone-ethinyl estradiol) Berlex Laboratories, Richmond, CA.
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443	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
444	Product Information. Inspra (eplerenone). Searle, Chicago, IL.
445	Product Information. Ancobon (flucytosine). Roche Laboratories, Nutley, NJ.
446	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
447	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
448	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
449	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
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451	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
452	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
453	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
454	Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6. [PMID: 7771501]
455	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
456	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
457	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
458	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
459	Gilead Sciences, Inc "About Remdesivir.".
460	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
461	Product Information. Vioxx (rofecoxib). Merck &amp Co, Inc, West Point, PA.
462	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
463	Product Information. Tyzeka (telbivudine). IDEC Pharmaceuticals Corporation, San Diego, CA.
464	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
465	Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
466	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.
467	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
468	Hazlewood KA, Brouse SD, Pitcher WD, Hall RG "Vancomycin-associated nephrotoxicity: grave concern or death by character assassination?" Am J Med 123 (2010): 182.e1-7. [PMID: 20103028]
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470	Product Information. Vancocin (vancomycin). Lilly, Eli and Company, Indianapolis, IN.
471	Graham DY, Malaty HM "Alendronate and naproxen are synergistic for development of gastric ulcers." Arch Intern Med 161 (2001): 107-10. [PMID: 11146706]
472	Graham, Malaty "Alendronate and naproxen are synergistic for development of gastric ulcers (Vol 161, pg 107, 1921)." Arch Intern Med 161 (2001): 1862. [PMID: 11146706]
473	Product Information. Aredia (pamidronate). Novartis Pharmaceuticals, East Hanover, NJ.
474	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
475	Product Information. Didronel Tablets (etidronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
476	Product Information. Fosamax (alendronate). Merck & Co, Inc, West Point, PA.
477	Product Information. Zometa (zoledronic acid). Novartis Pharmaceuticals, East Hanover, NJ.

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