Details of Drug

Drug General Information (ID: D1417)
Drug Name	Rivaroxaban
Drug Type	Small molecule
Drug Synonymous	XARELTO (TN) Click to Show/Hide
Disease Class	BD71: Deep vein thrombosis
Therapeutic Class	Anticoagulants/Factor Xa Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C19H18ClN3O5S
InChI	1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
InChIKey	KGFYHTZWPPHNLQ-AWEZNQCLSA-N
Canonical SMILES	C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl
External Link
	Pubchem ID	9875401
	CAS Number	366789-02-8
	CHEBI ID	68579
	TTD ID	D0KG3R
	INTEDE ID	DR1431
	VARIDT ID	DR00227

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM011 Transporter induction BM014 Interference of cell/tissue uptake BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM050 Increased risk of bleeding BM085 Antagonize the effect of antithrombotic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Rivaroxaban
Affected cellular transport
	Transporter inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[10], [151], [152]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[153]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[10], [155]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[156]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[9], [158]
D0590		Erdafitinib	C25H30N6O2	67462786	Moderate		Inter Info	[160]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[162]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[9], [10], [172]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[10], [174]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[179]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[180]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[10]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[184]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[10], [191]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[175], [176], [177]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[48], [50], [55]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[10], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58]
	CYP450 enzyme inhibition					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[9], [10], [21], [22], [1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[9], [10], [21], [22], [1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[9], [10], [21], [22], [1]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[9], [10], [21], [22], [1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[9], [10], [21], [22], [1]
D0192		Boceprevir	C27H45N5O5	10324367	Major		Inter Info	[9], [10], [21], [22], [1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[9], [10], [21], [22], [1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[9], [10], [21], [22], [1]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[9], [10], [21], [22], [1]
D1541		Telaprevir	C36H53N7O6	3010818	Major		Inter Info	[9], [10], [21], [22], [1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[9], [10], [21], [22], [1]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[9], [10], [21], [22], [1]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[9], [10], [1]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[9], [10], [1]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[9], [10], [1]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[1]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1]
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[9], [10], [1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[9], [10], [1]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[9], [10], [1]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[9], [10], [1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[9], [10], [1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[1]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[9], [10], [1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[9], [10], [1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[9], [10], [1]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[9], [10], [1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[9], [10], [1]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[9], [10], [1]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[150]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[9], [10], [1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[9], [10], [1]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[159]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[9], [10], [1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[9], [10], [1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[161]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[9], [10], [1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[9], [10], [178]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[181]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[9], [10], [1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[9], [10], [1]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[9], [10], [1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[185]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[1]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[9], [10], [1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[1]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[9], [10], [1]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[9], [10], [21], [22], [1]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[9], [10], [1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[12], [9], [10], [1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[12], [9], [10], [1]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[12], [9], [10], [1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[12], [9], [10], [1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[12], [9], [10], [1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[12], [9], [10], [1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[12], [9], [10]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[12], [9], [10], [1]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[12], [9], [10], [1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[12], [9], [10], [1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[12], [9], [10]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[12], [9], [10], [1]
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[1]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[1]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[1]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[1]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[1]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[1]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[1]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[1]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[1]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[1]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[1]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[9], [157]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[1]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[1]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[1]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[9], [10], [189]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[9], [10], [190], [189]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[10], [192]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[1]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[9], [10], [189]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[213], [214], [215], [216], [217]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[213], [214], [215], [216], [217]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 149
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0005		Abciximab	NA	NA	Major		Inter Info	[1]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[1]
D0047		Alteplase	NA	NA	Major		Inter Info	[1]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Major		Inter Info	[1]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[1]
D0088		Anistreplase	NA	NA	Major		Inter Info	[1]
D0102		Ardeparin	C26H42N2O37S5	772	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0104		Argatroban	C23H36N6O5S	92722	Major		Inter Info	[1]
D0189		Bivalirudin	C98H138N24O33	16129704	Major		Inter Info	[1]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1]
D0250		Caplacizumab	NA	NA	Major		Inter Info	[9], [10], [11]
D0336		Cilostazol	C20H27N5O2	2754	Major		Inter Info	[1]
D0364		Clopidogrel	C16H16ClNO2S	60606	Major		Inter Info	[1]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[13]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[14], [15]
D0435		Defibrotide	C20H21N4O6P	135565962	Major		Inter Info	[10], [16]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1]
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[1]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[17]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0586		Epoprostenol	C20H32O5	5282411	Major		Inter Info	[1]
D0588		Eptifibatide	C35H49N11O9S2	448812	Major		Inter Info	[1]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0753		Heparin	C26H42N2O37S5	772	Major		Inter Info	[1]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[18]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1]
D0792		Iloprost	C22H32O4	5311181	Major		Inter Info	[1]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1]
D0841		Ipilimumab	NA	NA	Major		Inter Info	[19], [10], [20]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1]
D0904		Lepirudin	C287H440N80O111S6	118856773	Major		Inter Info	[1]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[1]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[23], [24]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[14], [25]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[1]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[26]
D1395		Reteplase	NA	NA	Major		Inter Info	[1]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[27]
D0092		Antithrombin Alfa	NA	NA	Major		Inter Info	[1]
D0093		Antithrombin III human	NA	NA	Major		Inter Info	[1]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[1]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[10], [28]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[29]
D0247		Cangrelor	C17H25Cl2F3N5O12P3S2	9854012	Major		Inter Info	[10], [30]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0415		Danaparoid	NA	NA	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[1]
D0462		Dextran (-1)	C18H32O16	4125253	Major		Inter Info	[1]
D0463		Dextran (high molecular weight)	C18H32O16	4125253	Major		Inter Info	[1]
D0464		Dextran (low molecular weight)	C18H32O16	4125253	Major		Inter Info	[1]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[1]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[31], [32], [10], [33]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[10], [14], [34]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[9], [10], [35]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[36]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[10], [37], [38]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[1]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[1]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[39]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1]
D1588		Tinzaparin	C26H42N2O37S5	772	Major		Inter Info	[2], [3], [4], [5], [6], [7], [8]
D1705		Vorapaxar	C29H33FN2O4	10077130	Major		Inter Info	[40]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[14]
D1506		Streptokinase	C11H19NO2	9815560	Major		Inter Info	[1]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Major		Inter Info	[1]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1]
D1550		Tenecteplase	NA	NA	Major		Inter Info	[1]
D1581		Ticlopidine	C14H14ClNS	5472	Major		Inter Info	[1]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[41]
D1593		Tirofiban	C22H36N2O5S	60947	Major		Inter Info	[1]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1]
D1613		Tositumomab	NA	NA	Major		Inter Info	[42], [43]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[42], [43]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[9], [10], [44]
D1625		Treprostinil	C23H34O5	6918140	Major		Inter Info	[1]
D1669		Urokinase	NA	NA	Major		Inter Info	[1]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[1]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[59], [9], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0187		Bismuth subsalicylate	C7H6BiO4	16682734	Moderate		Inter Info	[70], [71], [72], [73], [74], [75], [76], [77]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[78], [79], [80]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[81]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0384		Collagenase clostridium histolyticum	NA	NA	Moderate		Inter Info	[120]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[14], [121]
D0457		Dexfenfluramine	C12H16F3N	66265	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[78], [79], [80]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[78], [79], [80]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[78], [79], [80]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140]
D0723		Ginseng	C42H66O17	420552	Moderate		Inter Info	[141], [129], [130], [142], [131], [143], [135], [139], [144]
D0752		Hemin	C34H32FeN4O4	26945	Moderate		Inter Info	[145]
D1815		Icosapent	C20H30O2	446284	Moderate		Inter Info	[10], [146], [147]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[78], [79], [80]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[59], [9], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[14], [148]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[12], [149]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[59], [9], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[59], [9], [10], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[70], [71], [72], [73], [74], [75], [76], [77]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D0711		Garlic	NA	NA	Moderate		Inter Info	[163], [164], [126], [129], [165], [130], [131], [166], [167], [135], [168], [169], [139], [170], [171]
D0721		Ginger	C30H40O6	442138	Moderate		Inter Info	[130], [133], [173], [135], [139]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[78], [79], [80]
D1139		Nintedanib	C31H33N5O4	135423438	Moderate		Inter Info	[182]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[10], [183]
D1178		Omega-3 fatty acids	C60H92O6	56842239	Moderate		Inter Info	[10], [146], [147]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[72], [73], [77]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[186], [187], [188]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[72], [73], [77]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[70], [71], [72], [73], [74], [75], [76], [77]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1894		Sugammadex	C72H112O48S8	6918585	Moderate		Inter Info	[10], [193]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[10], [194], [195]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[78], [79], [80]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[81]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[82], [83], [84], [85], [9], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119]
D1703		Vitamin E	C29H50O2	14985	Moderate		Inter Info	[186], [198], [10], [199], [200], [201], [202], [130], [203], [204], [205], [206], [207], [208], [209], [187], [210], [211], [188], [212]
D0253		Capsicum	NA	NA	Minor		Inter Info	[130]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[130], [218], [135]
D0368		Clove	NA	NA	Minor		Inter Info	[130], [219], [220], [221]
D1661		Turmeric	C21H20O6	969516	Minor		Inter Info	[222], [130], [223]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antithrombotic agents					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0373		Coagulation factor X human	NA	NA	Moderate		Inter Info	[154]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[196], [197]

References
1	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
2	Price AJ, Frcpath DO "Is there a clinical interaction between low molecular weight heparin and non-steroidal analgesics after total hip replacement?" Ann R Coll Surg Engl 77 (1995): 395. [PMID: 7486773]
3	Product Information. Arixtra (fondaparinux). Organon, West Orange, NJ.
4	Product Information. Fragmin (dalteparin). Pharmacia and Upjohn, Kalamazoo, MI.
5	Product Information. Innohep (tinzaparin) DuPont Pharmaceuticals, Wilmington, DE.
6	Product Information. Lovenox (enoxaparin). Rhone-Poulenc Rorer, Collegeville, PA.
7	Product Information. Normiflo (ardeparin). Wyeth-Ayerst Laboratories, Philadelphia, PA.
8	Product Information. Orgaran (danaparoid). Organon, West Orange, NJ.
9	Cerner Multum, Inc. "Australian Product Information.".
10	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11	Product Information. Cablivi (caplacizumab). Genzyme Corporation, Cambridge, MA.
12	Canadian Pharmacists Association.
13	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
14	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
15	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
16	Product Information. Defitelio (defibrotide). Jazz Pharmaceuticals, Palo Alto, CA.
17	Product Information. Xigris (drotrecogin alfa). Lilly, Eli and Company, Indianapolis, IN.
18	Product Information. In-111 Zevalin (ibritumomab). IDEC Pharmaceuticals Corporation, San Diego, CA.
19	Bodiford AB, Kessler FO, Fermo JD, Ragucci KR "Elevated international normalized ratio with the consumption of grapefruit and use of warfarin." SAGE Open Med Case Rep 0 (2013): 1-3. [PMID: 27489634]
20	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
21	Product Information. Evotaz (atazanavir-cobicistat). Bristol-Myers Squibb, Princeton, NJ.
22	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
23	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
24	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
25	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
26	Product Information. Cyramza (ramucirumab). Eli Lilly and Company, Indianapolis, IN.
27	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
28	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
29	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
30	Product Information. Kengreal (cangrelor). The Medicines Company, Parsippany, NJ.
31	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
32	Cerner Multum, Inc. "Canadian Product Information.".
33	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
34	Product Information. Tegsedi (inotersen). Akcea Therapeutics, Cambridge, MA.
35	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
36	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
37	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
38	Product Information. Stivarga (regorafenib). Bayer Pharmaceutical Inc, West Haven, CT.
39	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
40	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
41	Product Information. Aptivus (tipranavir). Boehringer-Ingelheim, Ridgefield, CT.
42	Product Information. Bexxar I 131 Therapeutic (iodine I 131 tositumomab). GlaxoSmithKline, Research Triangle Park, NC.
43	Product Information. BexxarTherapy (tositumomab). GlaxoSmithKline Inc, Oakville, IA.
44	Product Information. Kadcyla (ado-trastuzumab). Genentech, South San Francisco, CA.
45	Product Information. Actemra (tocilizumab). Genentech, South San Francisco, CA.
46	Product Information. Amevive (alefacept). Biogen, Cambridge, MA.
47	Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
48	Product Information. Cosentyx (secukinumab). Novartis Pharmaceuticals, East Hanover, NJ.
49	Product Information. Gamifant (emapalumab). Sobi Inc, Ardmore, PA.
50	Product Information. Ilaris (canakinumab). Novartis Pharmaceuticals, East Hanover, NJ.
51	Product Information. Ilumya (tildrakizumab). Merck & Company Inc, Whitehouse Station, NJ.
52	Product Information. Kevzara (sarilumab). sanofi-aventis, Bridgewater, NJ.
53	Product Information. Remicade (infliximab). Centocor Inc, Malvern, PA.
54	Product Information. Simponi (golimumab). Centocor Inc, Malvern, PA.
55	Product Information. Skyrizi (risankizumab). AbbVie US LLC, North Chicago, IL.
56	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
57	Product Information. Sylvant (siltuximab). Janssen Biotech, Inc., Horsham, PA, PA.
58	Product Information. Taltz Autoinjector (ixekizumab). Eli Lilly and Company, Indianapolis, IN.
59	Caruso V, Iacoviello L, Di Castelnuovo A, et.al "Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients." Blood 108 (2006): 2216-22. [PMID: 16804111]
60	Duarte X, Esteves S, Neto AM, Pereira F "Incidence and risk factors for central nervous system thrombosis in paediatric acute lymphoblastic leukaemia during intensive asparaginase treatment: a single-centre study." Br J Haematol 174 (2016): 280-91. [PMID: 27018199]
61	Elice F, Rodeghiero F "Hematologic malignancies and thrombosis." Thromb Res 129 (2012): 360-6. [PMID: 22197450]
62	Grace RF, DeAngelo DJ, Stevenson KE, et.al "The use of prophylactic anticoagulation during induction and consolidation chemotherapy in adults with acute lymphoblastic leukemia." J Thromb Thrombolysis 45 (2018): 306-14. [PMID: 29260426]
63	Kieslich M, Porto L, Lanfermann H, Jacobi G, Schwabe D, Bohles H "Cerebrovascular complications of L-asparaginase in the therapy of acute lymphoblastic leukemia." J Pediatr Hematol Oncol 25 (2003): 484-7. [PMID: 12794528]
64	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
65	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
66	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
67	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
68	Truelove E, Fielding AK, Hunt BJ "The coagulopathy and thrombotic risk associated with L-asparaginase treatment in adults with acute lymphoblastic leukaemia." Leukemia 27 (2013): 553-9. [PMID: 23099335]
69	Mitchell L, Andrew M, Hanna K, et.al "Trend to efficacy and safety using antithrombin concentrate in prevention of thrombosis in children receiving l-asparaginase for acute lymphoblastic leukemia. Results of the PAARKA study." Thromb Haemost 90 (2003): 235-44. [PMID: 12888870]
70	Richards JR, Garber D, Laurin EG, et al. Treatment of cocaine cardiovascular toxicity: a systematic review.?Clin Toxicol (Phila). 2016;54(5):345-364. [PMID: 26919414]
71	Barrow MV, Quick DT, Cunningham RW "Salicylate hypoprothrombinemia in rheumatoid arthritis with liver disease. Report of two cases." Arch Intern Med 120 (1967): 620-4. [PMID: 6054600]
72	Fausa O "Salicylate-induced hypoprothrombinemia: a report of four cases." Acta Med Scand 188 (1970): 403-8. [PMID: 5490567]
73	Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (first of two parts)." N Engl J Med 285 (1971): 487-98. [PMID: 4397794]
74	Koch-Weser J, Sellers EM "Drug interactions with coumarin anticoagulants (second of two parts)." N Engl J Med 285 (1971): 547-58. [PMID: 4397794]
75	Penning-van Beest F, Erkens J, Petersen KU, Koelz HR, Herings R "Main comedications associated with major bleeding during anticoagulant therapy with coumarins." Eur J Clin Pharmacol 61 (2005): 439-44. [PMID: 15947920]
76	Weiss HJ, Aledort LM, Kochwa S "The effect of salicylates on the hemostatic properties of platelets in man." J Clin Invest 47 (1968): 2169-80. [PMID: 5675432]
77	Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83. [PMID: 7944078]
78	Product Information. Acular (ketorolac). Allergan Inc, Irvine, CA.
79	Product Information. Nevanac (nepafenac ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
80	Product Information. Xibrom (bromfenac ophthalmic). ISTA Pharmaceuticals, Irvine, CA.
81	Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
82	Alderman CP, Moritz CK, Ben-Tovim DI "Abnormal platelet aggregation associated with fluoxetine therapy." Ann Pharmacother 26 (1992): 1517-9. [PMID: 1482806]
83	Alderman CP, Seshadri P, Ben-Tovim DI "Effects of serotonin reuptake inhibitors on hemostasis." Ann Pharmacother 30 (1996): 1232-4. [PMID: 8913401]
84	Aranth J, Lindberg C "Bleeding, a side effect of fluoxetine." Am J Psychiatry 149 (1992): 412. [PMID: 1536285]
85	Bannister SJ, Houser VP, Hulse JD, Kisicki JC, Rasmussen JG "Evaluation of the potential for interactions of paroxetine with diazepam, cimetidine, warfarin, and digoxin." Acta Psychiatr Scand Suppl 350 (1989): 102-6. [PMID: 2530759]
86	Ciraulo DA, Shader RI "Fluoxetine drug-drug interactions. II." J Clin Psychopharmacol 10 (1990): 213-7. [PMID: 2198298]
87	Claire RJ, Servis ME, Cram DL Jr "Potential interaction between warfarin sodium and fluoxetine." Am J Psychiatry 148 (1991): 1604. [PMID: 1928485]
88	Dalton SO, Johansen C, Mellemkjaer L, Norgard B, Sorensen HT, Olsen JH "Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study." Arch Intern Med 163 (2003): 59-64. [PMID: 12523917]
89	de Abajo FJ, Jick H, Derby L, Jick S, Schmitz S "Intracranial haemorrhage and use of selective serotonin reuptake inhibitors." Br J Clin Pharmacol 50 (2000): 43-7. [PMID: 10886117]
90	de Abajo FJ, Rodriguez LA, Montero D "Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study." BMJ 319 (1999): 1106-9. [PMID: 10531103]
91	de Maistre E, Allart C, Lecompte T, Bollaert PE "Severe bleeding associated with use of low molecular weight heparin and selective serotonin reuptake inhibitors." Am J Med 113 (2002): 530-2. [PMID: 12427509]
92	Dent LA, Orrock MW "Warfarin-fluoxetine and diazepam-fluoxetine interaction." Pharmacotherapy 17 (1997): 170-2. [PMID: 9017779]
93	Ford MA, Anderson ML, Rindone JP, Jaskar DW "Lack of effect of fluoxetine on the hypoprothrombinemic response of warfarin." J Clin Psychopharmacol 17 (1997): 110-2. [PMID: 10950474]
94	Hergovich N, Aigner M, Eichler HG, Entlicher J, Drucker C, Jilma B "Paroxetine decreases platelet serotonin storage and platelet function in human beings." Clin Pharmacol Ther 68 (2000): 435-42. [PMID: 11061584]
95	Humphries JE, Wheby MS, VandenBerg SR "Fluoxetine and the bleeding time." Arch Pathol Lab Med 114 (1990): 727-8. [PMID: 2363631]
96	Krivy J, Wiener J "Sertraline and platelet counts in idiopathic thrombocytopenia purpura." Lancet 345 (1995): 132. [PMID: 7815874]
97	Leung M, Shore R "Fluvoxamine-associated bleeding." Can J Psychiatry 41 (1996): 604-5. [PMID: 8946088]
98	Messiha FS "Fluoxetine - adverse effects and drug-drug interactions." J Toxicol Clin Toxicol 31 (1993): 603-30. [PMID: 8254702]
99	Ottervanger JP, Stricker BH, Huls J, Weeda JN "Bleeding attributed to the intake of paroxetine." Am J Psychiatry 151 (1994): 781-2. [PMID: 8166328]
100	Pai VB, Kelly MW "Bruising associated with the use of fluoxetine." Ann Pharmacother 30 (1996): 786-8. [PMID: 8826562]
101	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
102	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
103	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
104	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
105	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
106	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
107	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
108	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
109	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
110	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
111	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
112	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
113	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
114	Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30. [PMID: 9796863]
115	Skop BP, Brown TM "Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors." Psychosomatics 37 (1996): 12-6. [PMID: 8600488]
116	Woolfrey S, Gammack NS, Dewar MS, Brown PJ "Fluoxetine-warfarin interaction." BMJ 307 (1993): 241. [PMID: 8369688]
117	Yaryura-Tobias JA, Kirschen H, Ninan P, Mosberg HJ "Fluoxetine and bleeding in obsessive-compulsive disorder." Am J Psychiatry 148 (1991): 949. [PMID: 2053641]
118	Layton D, Clark DWJ, Pearce GL, Shakir SAW "Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England." Eur J Clin Pharmacol 57 (2001): 167-76. [PMID: 11417450]
119	Tata LJ, Fortun PJ, Hubbard RB, et al. "Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding?" Aliment Pharmacol Ther 22 (2005): 175-81. [PMID: 16091054]
120	Product Information. Xiaflex (collagenase clostridium histolyticum). Auxilium Pharmaceuticals Inc, Norristown, PA.
121	Product Information. Kybella (deoxycholic acid). Kythera Biopharmaceuticals, Inc., Westlake Village, CA.
122	Benjamin J, Muir T, Briggs K, Pentland B "A case of cerebral haemorrhage - can Ginkgo biloba be implicated?." Postgrad Med J 77 (2001): 112-3. [PMID: 11161079]
123	Chung KF, McCusker M, Page CP, Dent G, Guinot P, Barnes PJ "Effect of ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet acitivating factor in man." Lancet 1 (1987): 248-51. [PMID: 2880069]
124	Cupp MJ "Herbal remedies: adverse effects and drug interactions." Am Fam Physician 59 (1999): 1239-45. [PMID: 10088878]
125	Engelsen J, Nielsen JD, Winther K "Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial." Thromb Haemost 87 (2002): 1075-6. [PMID: 12083489]
126	Evans V "Herbs and the brain: friend or foe? The effects of ginkgo and garlic on warfarin use." J Neurosci Nurs 32 (2000): 229-32. [PMID: 10994537]
127	Fessenden JM, Wittenborn W, Clarke L "Gingko biloba: A case report of herbal medicine and bleeding postoperatively from a laparoscopic cholecystectomy." Am Surg 67 (2001): 33-5. [PMID: 11206893]
128	Fong KC, Kinnear PE "Retrobulbar haemorrhage associated with chronic Gingko biloba ingestion." Postgrad Med J 79 (2003): 531-2. [PMID: 13679551]
129	Fugh-Berman A "Herb-drug interactions." Lancet 355 (2000): 134-8. [PMID: 10675182]
130	Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
131	Izzo AA, Ernst E "Interactions between herbal medicines and prescribed drugs: a systematic review." Drugs 61 (2001): 2163-75. [PMID: 11772128]
132	Jayasekera N, Moghal A, Kashif F, Karalliedde L "Herbal medicines and postoperative haemorrhage." Anaesthesia 60 (2005): 725-6. [PMID: 15960738]
133	Jiang X, Williams KM, Liauw WS, et al. "Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects." Br J Clin Pharmacol 59 (2005): 425-32. [PMID: 15801937]
134	Matthews MK Jr "Association of Ginko biloba with intracerebral hemorrhage." Neurology 50 (1998): 1933-4. [PMID: 9633781]
135	Miller LG "Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions." Arch Intern Med 158 (1998): 2200-11. [PMID: 9818800]
136	Rosenblatt M, Mindel J "Spontaneous hyphema associated with ingestion of Ginkgo biloba extract." N Engl J Med 336 (1997): 1108. [PMID: 9091822]
137	Rowin J, Lewis SL "Spontaneous bilateral subdural hematomas associated with chronic Gingko biloba ingestion." Neurology 46 (1996): 1775-6. [PMID: 8649594]
138	Sierpina VS, Wollschlaeger B, Blumenthal M "Ginkgo biloba." Am Fam Physician 68 (2003): 923-6. [PMID: 13678141]
139	Vaes LP, Chyka PA "Interactions of warfarin with garlic, ginger, or ginseng: nature of evidence." Ann Pharmacother 34 (2000): 1478-82. [PMID: 11144706]
140	Wolf HR "Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily?" Drugs R D 7 (2006): 163-72. [PMID: 16752942]
141	Ang-Lee MK, Moss J, Yuan CS "Herbal medicines and perioperative care." JAMA 286 (2001): 208-16. [PMID: 11448284]
142	Hodges PJ, Kam PC "The peri-operative implications of herbal medicines." Anaesthesia 57 (2002): 889-99. [PMID: 12190754]
143	Janetzky K, Morreale AP "Probable interaction between warfarin and ginseng." Am J Health Syst Pharm 54 (1997): 692-3. [PMID: 9075501]
144	Yuan CS, Wei G, Dey L, et al. "Brief communication: American ginseng reduces warfarin's effect in healthy patients: a randomized, controlled Trial." Ann Intern Med 141 (2004): 23-7. [PMID: 15238367]
145	Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ.
146	Li XL, Steiner M "Fish oil: a potent inhibitor of platelet adhesiveness." Blood 76 (1990): 938-45. [PMID: 2118400]
147	Product Information. Vascepa (icosapent). Amarin Pharmaceuticals Inc, Warren, NJ.
148	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
149	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.
150	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
151	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
152	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
153	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
154	Product Information. Coagadex (coagulation factor X). Bio Products Laboratory, Raleigh, NC.
155	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
156	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
157	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
158	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
159	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
160	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
161	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
162	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
163	Burnham BE "Garlic as a possible risk for postoperative bleeding." Plast Reconstr Surg 95 (1995): 213. [PMID: 7809259]
164	Chutani SK, Bordia A "The effect of fried versus raw garlic on fibrinolytic activity in man." Atherosclerosis 38 (1981): 417-21. [PMID: 7225179]
165	German K, Kumar U, Blackford HN "Garlic and the risk of TURP bleeding." Br J Urol 76 (1996): 518. [PMID: 7551902]
166	Kiesewetter H, Jung F, Jung EM, Mrowietz C, Kosciehlny J, Wenzel E "Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack." Eur J Clin Pharmacol 45 (1993): 333-6. [PMID: 8299665]
167	Legnani C, Frascaro M, Guazzaloca G, Ludovici S, Cesarano G, Coccheri S "Effects of a dried garlic preparation on fibrinolysis and platelet aggregation in healthy subjects." Arzneimittelforschung 43 (1993): 119-22. [PMID: 8457236]
168	Morris J, Burke V, Mori TA, Vandongen R, Beilin LJ "Effects of garlic extract on platelet aggregation: a randomized placebo-controlled double-blind study." Clin Exp Pharmacol Physiol 22 (1995): 414-7. [PMID: 8582091]
169	Steiner M, Lin RS "Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract." J Cardiovasc Pharmacol 31 (1998): 904-8. [PMID: 9641475]
170	Apitz-Castro R, Escalante J, Vargas R, Jain MK "Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets." Thromb Res 42 (1986): 303-11. [PMID: 3520940]
171	Mulrow C, Lawrence V, Ackermann R, et al. Garlic: effects on cardiovascular risks and disease, protective effects against cancer, and clinical adverse effects.?Evid Rep Technol Assess (Summ). 2000;(20):1-4. [PMID: 11089496]
172	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
173	Kruth P, Brosi E, Fux R, Morike K, Gleiter CH "Ginger-associated overanticoagulation by phenprocoumon." Ann Pharmacother 38 (2004): 257-60. [PMID: 14742762]
174	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
175	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
176	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
177	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
178	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
179	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
180	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
181	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
182	Product Information. Ofev (nintedanib). Boehringer Ingelheim, Ridgefield, CT.
183	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
184	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
185	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
186	Booth SL, Golly I, Sacheck JM, Roubenoff R, Dallal GE, et al "Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status." Am J Clin Nutr 80 (2004): 143-8. [PMID: 15213041]
187	Murohara T, Ikeda H, Otsuka Y, Aoki M, Takajo Y, et al "Inhibition of platelet adherence to Mononuclear cells by alpha-tocopherol: role of P-selection." Circulation 110 (2004): 141-8. [PMID: 15197142]
188	Vitamin K, vitamin E and the coumarin drugs. Nutr Rev 40 (1982): 180-2. [PMID: 7121898]
189	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
190	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
191	Product Information. Sivextro (tedizolid). Cubist Pharmaceuticals Inc, Lexington, MA.
192	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
193	Product Information. Bridion (sugammadex). Merck &amp Company Inc, Whitehouse Station, NJ.
194	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
195	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
196	Product Information. Visudyne (verteporfin) Valeant Pharmaceuticals, Costa Mesa, CA.
197	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
198	Celestini A, Pulcinelli FM, Pignatelli P, et al. "Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets." Haematologica 87 (2002): 420-6. [PMID: 11940487]
199	Corrigan JJ "The effect of vitamin E on warfarin-induced vitamin K deficiency." Ann N Y Acad Sci 393 (1982): 361-8. [PMID: 6959563]
200	Corrigan JJ, Ulfers LL "Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency." Am J Clin Nutr 34 (1981): 1701-5. [PMID: 7282596]
201	Freedman JE, Farhat JH, Loscalzo J, Keaney JF "Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C--dependent mechanism." Circulation 94 (1996): 2434-40. [PMID: 8921785]
202	Gonzalez-Correa JA, Arrebola MM, Guerrero A, et al. "Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood." Platelets 16(3-4) (2005): 171-9. [PMID: 16011961]
203	Helson L "The effect of intravenous vitamin E and menadiol sodium diphosphate on vitamin K dependent clotting factors." Thromb Res 35 (1984): 11-8. [PMID: 6474408]
204	Jandak J, Steiner M, Richardson PD "Alpha-tocopherol, an effective inhibitor of platelet adhesion." Blood 73 (1989): 141-9. [PMID: 2910355]
205	Kakishita E, Suehiro A, Oura Y, Nagai K "Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood." Thromb Res 60 (1990): 489-99. [PMID: 2082481]
206	Kim JM, White RH "Effect of vitamin E on the anticoagulant response to warfarin." Am J Cardiol 77 (1996): 545-6. [PMID: 8629604]
207	Liu M, Wallmon A, Olsson-Mortlock C, Wallin R, Saldeen T "Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms." Am J Clin Nutr 77 (2003): 700-6. [PMID: 12600864]
208	Mardla V, Kobzar G, Samel N "Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin." Platelets 15 (2004): 319-24. [PMID: 15370103]
209	Megavitamin E supplementation and vitamin K-dependent carboxylation. Nutr Rev 41 (1983): 268-70. [PMID: 6358960]
210	Schrogie JJ "Coagulopathy and fat-soluble vitamins." JAMA 232 (1975): 19. [PMID: 1172961]
211	Stampfer MJ, Jakubowski JA, Faigel D, Vaillancourt R, Deykin D "Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels." Am J Clin Nutr 47 (1988): 700-6. [PMID: 3128100]
212	Shalansky S, Lynd L, Richardson K, Ingaszewski A, Kerr C "Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis." Pharmacotherapy 27 (2007): 1237-47. [PMID: 17723077]
213	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
214	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
215	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
216	Robertson P Jr, Hellriegel ET, Arora S, Nelson M "Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers." Clin Pharmacol Ther 71 (2002): 46-56. [PMID: 11823757]
217	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
218	Lambert JP, Cormier J "Potential interaction between warfarin and boldo-fenugreek." Pharmacotherapy 21 (2001): 509-12. [PMID: 11310527]
219	Saeed SA, Gilani AH "Antithrombotic activity of clove oil." J Pak Med Assoc 44 (1994): 112-5. [PMID: 8078176]
220	Srivasta KC "Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]" Prostaglandins Leukot Essent Fatty Acids 48 (1993): 363-72. [PMID: 8321872]
221	Srivstava KC, Malhotra N "Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets." Prostaglandins Leukot Essent Fatty Acids 42 (1991): 73-81. [PMID: 2011614]
222	Abebe W "Herbal medication: potential for adverse interactions with analgesic drugs." J Clin Pharm Ther 27 (2002): 391-401. [PMID: 12472978]
223	Yang X, Thomas DP, Zhang X, et al "Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation." Arterioscler Thromb Vasc Biol 26 (2006): 85-90. [PMID: 16239599]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence