Details of Drug

Drug General Information (ID: D1412)
Drug Name	Risedronic acid
Drug Type	Small molecule
Drug Synonymous	Risedronic acid; 105462-24-6; Actonel; Atelvia; Acido risedronico; Acidum risedronicum; Benet; Risedronic acid [INN:BAN]; Acidum risedronicum [INN-Latin]; Acido risedronico [INN-Spanish]; Acide risedronique [INN-French]; Risedronic acid monohydrate; NE-58095; UNII-KM2Z91756Z; C7H11NO7P2; NE 58019; HSDB 7326; [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid; (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid; Risedronic acid (Actonel); CHEMBL923; CHEBI:8869; Phosphonic acid,; Benet; RIS; Ridron; Acide risedronique; Bisphosphonate 1; Actonel (TN); Ridron (TN); Risedronic acid (INN); (1-Hydroxy-2-(3-pyridyl)ethylidene)diphosphonic acid; (1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid; (1-hydroxy-2-pyridin-3-ylethane-1,1-diyl)bis(phosphonic acid); 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID Click to Show/Hide
Disease Class	FB85: Bone paget disease
Therapeutic Class	Bone Density Conservation Agents
Structure
Structure	3D Structure		2D Structure
Formula	C7H11NO7P2
InChI	1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKey	IIDJRNMFWXDHID-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)O
External Link
	Pubchem ID	5245
	CAS Number	105462-24-6
	CHEBI ID	8869
	TTD ID	D0PA5S

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects BM003 Complex formation BM054 Increased risk of GI mucosal injury/bleeding risk BM063 Increased risk of hypocalcemia BM072 Increased risk of nephrotoxicity BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Risedronic acid
Affected gastrointestinal absorption
	Complex formation					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0235		Calcium acetate	C4H6CaO4	6116	Moderate		Inter Info	[10], [11], [4]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[10], [11], [4]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[3], [17], [18]
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[10], [11], [4]
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Moderate		Inter Info	[10], [11], [4]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[10], [11], [4]
D0238		Calcium citrate	C12H10Ca3O14	13136	Moderate		Inter Info	[10], [11], [4]
D0239		Calcium glubionate anhydrous	C18H32CaO19	64776	Moderate		Inter Info	[10], [11], [4]
D0241		Calcium gluconate	C12H22CaO14	9290	Moderate		Inter Info	[10], [11], [4]
D0242		Calcium glycerophosphate	C3H7CaO6P	120096	Moderate		Inter Info	[10], [11], [4]
D0243		Calcium lactate	C6H10CaO6	13144	Moderate		Inter Info	[10], [11], [4]
D0244		Calcium Phosphate	Ca3O8P2	24456	Moderate		Inter Info	[10], [11], [4]
D0332		Chromium picolinate	C18H12CrN3O6	151932	Moderate		Inter Info	[10], [11], [4]
D0390		Copper gluconate	C12H22CuO14	10692	Moderate		Inter Info	[10], [11], [4]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[10], [11], [4]
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[10], [11], [4]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Moderate		Inter Info	[10], [11], [4]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[10], [11], [4]
D0847		Iron	Fe	23925	Moderate		Inter Info	[10], [11], [4]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[10], [11], [4]
D0850		Iron sucrose	C12H29Fe5Na2O23	91663255	Moderate		Inter Info	[12], [10], [11]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[10], [11], [4]
D0893		Lanthanum carbonate	C3La2O9	168924	Moderate		Inter Info	[20], [3], [21]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[10], [11], [4]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[10], [11], [4]
D0969		Magnesium chloride	Cl2H12MgO6	643991	Moderate		Inter Info	[10], [11], [4]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[10], [11], [4]
D0971		Magnesium gluconate	C12H22MgO14	11418570	Moderate		Inter Info	[10], [11], [4]
D0972		Magnesium glycinate	C4H8MgN2O4	84645	Moderate		Inter Info	[10], [11], [4]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[10], [11], [4]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[10], [11], [4]
D1456		Selenium	Se	6326970	Moderate		Inter Info	[10], [11], [4]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[10], [11], [4]
D1722		Zinc acetate	C4H6O4Zn	11192	Moderate		Inter Info	[10], [11], [4]
D1724		Zinc gluconate	C12H22O14Zn	443445	Moderate		Inter Info	[10], [11], [4]
D1725		Zinc sulfate	O4SZn	24424	Moderate		Inter Info	[10], [11], [4]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Moderate		Inter Info	[10], [11], [4]
Pharmacodynamic additive effects
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[1], [2]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[12], [10], [13]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[12], [10], [13]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[12], [10], [13]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[12], [10], [13]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[12], [10], [13]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[12], [10], [13]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[12], [10], [13]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[12], [10], [13]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[12], [10], [13]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[12], [10], [13]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[12], [10], [13]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[12], [10], [13]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[12], [10], [13]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[12], [10], [13]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[12], [10], [13]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[12], [10], [13]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[12], [10], [13]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[12], [10], [13]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[12], [10], [13]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[12], [10], [13]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[12], [10], [13]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[12], [10], [13]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[12], [10], [13]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[12], [10], [13]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[12], [10], [13]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[12], [10], [13]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[12], [10], [13]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[12], [10], [13]
	Increased risk of hypocalcemia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0615		Etelcalcetide	C38H73N21O10S2	71511839	Major		Inter Info	[3], [4]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[5], [6], [7]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[14], [15], [16]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[4], [7]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[5], [6], [7]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[4], [7]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[4], [7]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[5], [6], [7]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[5], [6], [7]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[5], [6], [7]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[5], [6], [7]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[5], [6], [7]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[5], [6], [7]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[4], [7]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0177		Bevacizumab	NA	NA	Moderate		Inter Info	[8], [3], [9]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[3], [19]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[8], [3], [9]
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[22]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[8], [3], [9]

References
1	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
2	Rafat C, Fakhouri F, Ribeil JA, Delarue R, Le Quintrec M "Fanconi Syndrome Due to Deferasirox." Am J Kidney Dis (2009):. [PMID: 19493602]
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
4	Product Information. Skelid (tilundronate). Sanofi Winthrop Pharmaceuticals, New York, NY.
5	Chang JT, Green L, Beitz J "Renal failure with the use of zoledronic acid." N Engl J Med 349 (2003): 1676-9 discussion 1676-9. [PMID: 14573746]
6	Kanis JA, Preston CJ, Yates AJ, Percival RC, Mundy KI, Russell RG "Effects of intravenous diphosphonates on renal function." Lancet 1 (1983): 1328. [PMID: 6134112]
7	Product Information. Zometa (zoledronic acid). Novartis Pharmaceuticals, East Hanover, NJ.
8	Cerner Multum, Inc. "Australian Product Information.".
9	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
10	Product Information. Bonefos (clodronate). Rhone-Poulenc Rorer Canada Inc, Laval, QC.
11	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
12	Product Information. Actonel (risedronate). Procter and Gamble Pharmaceuticals, Cincinnati, OH.
13	Product Information. Didronel I.V. Infusion (etidronate). MGI Pharma Inc, Minnetonka, MN.
14	Foscarnet: a review. Drugs 41 (1991): 106-29. [PMID: 1706982]
15	Product Information. Foscavir (foscarnet). Astra USA, Westborough, MA.
16	Youle M, Clarbour J, Gazzard B, Chanas A "Severe hypocalcemia in AIDS patients treated with foscarnet and pentamidine." Lancet 1 (1988): 1455-6. [PMID: 2898602]
17	Multum Information Services, Inc. Expert Review Panel.
18	Ray K, Dorman S, Watson R "Severe hyperkalaemia due to the concomitant use of salt substitutes and ACE inhibitors in hypertension: a potentially life threatening interaction." J Hum Hypertens 13 (1999): 717-20. [PMID: 10516744]
19	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
20	Canadian Pharmacists Association.
21	Product Information. Seysara (sarecycline). Allergan Inc, Irvine, CA.
22	Product Information. Evenity (romosozumab). Amgen USA, Thousand Oaks, CA.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence