Details of Drug

Drug General Information (ID: D1411)
Drug Name	Risdiplam
Drug Type	Small molecule
Drug Synonymous	UNII-76RS4S2ET1; 76RS4S2ET1; 1825352-65-5; Risdiplam [INN]; SCHEMBL17260852; EX-A2074; RG-7916; HY-109101; RO7034067; CS-0039501; 4H-Pyrido(1,2-a)pyrimidin-4-one, 7-(4,7-diazaspiro(2.5)oct-7-yl)-2-(2,8-dimethylimidazo(1,2-b)pyridazin-6-yl)-; 2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one Click to Show/Hide
Disease Class	8B61: Muscular atrophy
Therapeutic Class	Mrna Splicing Modifier
Structure
Structure	3D Structure		2D Structure
Formula	C22H23N7O
InChI	1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3
InChIKey	ASKZRYGFUPSJPN-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=NN2C1=NC(=C2)C)C3=CC(=O)N4C=C(C=CC4=N3)N5CCNC6(C5)CC6
External Link
	Pubchem ID	118513932
	CAS Number	1825352-65-5
	TTD ID	D0N5MH
	INTEDE ID	DR1823

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport BM010 Transporter inhibition
Relation Graph

Full list of drugs interacting with Risdiplam
Affected cellular transport
	Transporter inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[1], [2], [3]
D1038		Methylnaltrexone	C21H26NO4+	5361918	Moderate		Inter Info	[1], [2], [3]
D1591		Tipiracil	C9H11ClN4O2	6323266	Moderate		Inter Info	[2], [4]

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Evrysdi (risdiplam). Genentech, South San Francisco, CA.
3	Yonezawa A, Inui K "Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics." Br J Pharmacol 164 (2011): 1817-25. [PMID: 21457222]
4	Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.