Details of Drug

Drug General Information (ID: D1407)
Drug Name	Rimegepant
Drug Type	Small molecule
Drug Synonymous	BMS-927711; 1289023-67-1; UNII-997WVV895X; BMS 927711; CHEMBL2178422; 997WVV895X; (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate; Rimegepant [USAN:INN]; Rimegepant (USAN/INN); SCHEMBL1670580; DTXSID70156003; C28H28F2N6O3; EX-A1922; 3504AH; ZINC68267814; BDBM50400098; AKOS030526382; DB12457; CS-1027; NCGC00378677-01; HY-15498; KB-145921; W-5991 Click to Show/Hide
Disease Class	8A80: Migraine
Therapeutic Class	Cgrp Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C28H28F2N6O3
InChI	1S/C28H28F2N6O3/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37)/t18-,22+,24-/m0/s1
InChIKey	KRNAOFGYEFKHPB-ANJVHQHFSA-N
Canonical SMILES	C1CC(C2=C(C=CC=N2)C(C1C3=C(C(=CC=C3)F)F)N)OC(=O)N4CCC(CC4)N5C6=C(NC5=O)N=CC=C6
External Link
	Pubchem ID	51049968
	CAS Number	1289023-67-1
	TTD ID	D0V9VG
	VARIDT ID	DR00758

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Rimegepant
Affected cellular transport
	Transporter inhibition					Drug Num: 44
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[1]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[1]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[1]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[1]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1]
D0556		Elbasvir	C49H55N9O7	71661251	Moderate		Inter Info	[1], [4]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[1]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[1]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[1]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[1]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[1]
D0866		Istradefylline	C20H24N4O4	5311037	Moderate		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[1]
D0898		Ledipasvir	C49H54F2N8O6	67505836	Moderate		Inter Info	[1], [4]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[1]
D1124		Neratinib	C30H29ClN6O3	9915743	Moderate		Inter Info	[1]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[1]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[1]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[1]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[1]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[1]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[1]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[1]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[6], [7]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[1]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[1]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[1]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[1]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[1]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1]
D1528		Tafamidis	C14H7Cl2NO3	11001318	Moderate		Inter Info	[1]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[1]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[1]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[1]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 48
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[3]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[1]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[1]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[1]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[1]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[1]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[1]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[1]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[1]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[1]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[1]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[1]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[1]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[1]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[1]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[1]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[1]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[1]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[1]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[5]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[1]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[1]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[6], [8], [9]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[8], [10]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[1]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[1]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[1]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[1]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[1]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1]
	CYP450 enzyme induction					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[1]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0300		Cenobamate	C10H10ClN5O2	11962412	Major		Inter Info	[1]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Major		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[1]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[1]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[1]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Major		Inter Info	[1], [2]
D1078		Mitotane	C14H10Cl4	4211	Major		Inter Info	[1]
D1081		Modafinil	C15H15NO2S	4236	Major		Inter Info	[1]
D1099		Nafcillin	C21H22N2O5S	8982	Major		Inter Info	[1]
D1128		Nevirapine	C15H14N4O	4463	Major		Inter Info	[1]
D1265		Phenobarbital	C12H12N2O3	4763	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1340		Primidone	C12H14N2O2	4909	Major		Inter Info	[1]
D1399		Rifabutin	C46H62N4O11	135398743	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[1], [2]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Major		Inter Info	[1]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Major		Inter Info	[1], [2]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[6], [8], [11]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[6], [8], [11]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[6], [8], [12], [11]

References
1	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
2	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
3	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
4	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
5	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
6	Cerner Multum, Inc. "Australian Product Information.".
7	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
8	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
10	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
11	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
12	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.

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