Details of Drug

Details of Drug

 Drug General Information (ID: D1402)
  Drug Name
Rifaximin
  Drug Type Small molecule
  Drug Synonymous
RCIFAX; Rifaximin (bioadhesive/ gastrointestinal extended release); Rifaximin (bioadhesive/ gastrointestinal extended release), Salix Pharmaceuticals
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  Disease Class 1A00-1C4Z: Bacterial infection
  Therapeutic Class Antibiotics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C43H51N3O11
  InChI 1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11+,17-15+,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1
  InChIKey NZCRJKRKKOLAOJ-XRCRFVBUSA-N
  Canonical SMILES CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C
  External Link
Pubchem ID 6436173
CAS Number 80621-81-4
CHEBI ID 75246
TTD ID D04ITO
INTEDE ID DR1422
VARIDT ID DR00073

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM007  Pharmacodynamic antagonistic effects
BM010  Transporter inhibition
BM011  Transporter induction
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Rifaximin
      Affected cellular transport
   Transporter inhibition Drug Num:  21
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Moderate    Inter Info   
[5], [6], [1], [7]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[1], [8], [9]
D0155
 
Bempedoic acid
 
C19H36O5
 
10472693 
Moderate    Inter Info   
[11], [12]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[1], [13], [14]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Moderate    Inter Info   
[15]
D0408
 
Daclatasvir
 
C40H50N8O6
 
25154714 
Moderate    Inter Info   
[1], [16]
D0425
 
Darolutamide
 
C19H19ClN6O2
 
67171867 
Moderate    Inter Info   
[1], [17]
D0569
 
Encorafenib
 
C22H27ClFN7O4S
 
50922675 
Moderate    Inter Info   
[1], [18]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[6], [1], [19]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[22]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[23]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[6], [1], [24]
D0725
 
Glasdegib
 
C21H22N6O
 
25166913 
Moderate    Inter Info   
[1], [25]
D0785
 
Ibrutinib
 
C25H24N6O2
 
24821094 
Moderate    Inter Info   
[1], [26]
D0898
 
Ledipasvir
 
C49H54F2N8O6
 
67505836 
Moderate    Inter Info   
[27]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[28]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Moderate    Inter Info   
[1]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Moderate    Inter Info   
[29]
D1423
 
Rolapitant
 
C25H26F6N2O2
 
10311306 
Moderate    Inter Info   
[33]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Moderate    Inter Info   
[6], [1], [34], [35]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[36]
   Transporter induction Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[1], [10]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[20], [6], [1], [21]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D1693
 
Vibrio cholerae CVD 103-HgR strain live antigen (live)
 
NA
 
NA
Major    Inter Info   
[4]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[30], [31], [32]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 UK government "Typhoid.".
3 American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
4 Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
5 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
6 Cerner Multum, Inc. "Australian Product Information.".
7 Product Information. Xifaxan (rifaximin). Salix Pharmaceuticals, Raleigh, NC.
8 Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
9 Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
10 Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
11 Product Information. Nexletol (bempedoic acid). Esperion Therapeutics, Ann Arbor, MI.
12 Product Information. Nexlizet (bempedoic acid-ezetimibe). Esperion Therapeutics, Ann Arbor, MI.
13 Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
14 Product Information. Lonsurf (tipiracil-trifluridine). Taiho Oncology, Inc., Princeton, NJ.
15 Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
16 Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
17 Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
18 Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
19 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
20 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
21 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
22 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
23 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
24 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
25 Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
26 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
27 Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
28 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
29 Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
30 Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
31 MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
32 Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
33 Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
34 Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
35 Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
36 Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.