Details of Drug

Drug General Information (ID: D1401)
Drug Name	Rifapentine
Drug Type	Small molecule
Drug Synonymous	RIFAPENTINE; Rifapentina; Rifapentinum; Cyclopentylrifampicin; Rifamycin AF/ACPP; Antibiotic DL 473IT; KTC 1; 61379-65-5; MDL 473; DRG-0283; DL 473; R-773; R 77-3; 3-(N-(4-Cyclopentyl-1-piperazinyl)formimidoyl)rifamycin; 3-(4-Cyclopentyl-1-piperazinyl)iminomethylrifamycin SV; 3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)rifamycin; Rifapentin,(S); NCGC00167431-01; ZINC169621228; NCGC00167431-03; AN-15578; RPE Click to Show/Hide
Disease Class	1B10-1B14: HIV-infected patients with tuberculosis; 9B71: Retinopathy
Therapeutic Class	Antituberculosis Agents
Structure
Structure	3D Structure		2D Structure
Formula	C47H64N4O12
InChI	1S/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27+,28+,33-,38-,39+,43+,47-/m0/s1
InChIKey	WDZCUPBHRAEYDL-GZAUEHORSA-N
Canonical SMILES	CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C6CCCC6)C
External Link
	Pubchem ID	135403821
	CAS Number	61379-65-5
	CHEBI ID	45304
	TTD ID	D0G9IU
	INTEDE ID	DR1421

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM007 Pharmacodynamic antagonistic effects BM011 Transporter induction BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM028 Competitive inhibition of renal tubular secretion BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Rifapentine
Affected cellular transport
	Transporter induction					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0171		Berotralstat	C30H26F4N6O	137528262	Major		Inter Info	[148], [149]
D1490		Sofosbuvir	C22H29FN3O9P	45375808	Major		Inter Info	[10], [11], [234], [235], [236]
D0026		Afatinib	C24H25ClFN5O3	10184653	Moderate		Inter Info	[369]
D0176		Betrixaban	C23H22ClN5O3	10275777	Moderate		Inter Info	[373], [374]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Moderate		Inter Info	[10], [11], [375], [376]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[11], [416]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[397]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[204]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[218]
	CYP450 enzyme induction					Drug Num: 374
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3]
D0069		Amlodipine	C20H25ClN2O5	2162	Major		Inter Info	[4], [5], [6]
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0116		Atazanavir	C38H52N6O7	148192	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[11], [25], [26], [27], [28], [29]
D0222		Buspirone	C21H31N5O2	2477	Major		Inter Info	[30], [31], [32]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[9], [10], [11], [33], [34], [35], [4], [36], [5], [37]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0450		Desogestrel	C22H30O	40973	Major		Inter Info	[56], [19], [57]
D0619		Ethinylestradiol	C20H24O2	5991	Major		Inter Info	[56], [19], [57]
D0626		Etonogestrel	C22H28O2	6917715	Major		Inter Info	[58], [59], [60], [56], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [4], [19], [5], [79], [50], [80], [57], [81], [82], [83]
D0640		Felodipine	C18H19Cl2NO4	3333	Major		Inter Info	[4], [5], [6]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[9], [10], [11], [33], [34], [35], [4], [36], [5], [37]
D0745		Guanfacine	C9H9Cl2N3O	3519	Major		Inter Info	[11], [84], [85]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[86], [67], [87], [10], [11], [88], [89], [90], [91], [5], [50], [92], [93]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[9], [10], [11], [33], [34], [35], [4], [36], [5], [37]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[94], [9], [10], [11], [95], [96]
D0799		Indinavir	C36H47N5O4	5362440	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Major		Inter Info	[100], [103], [105]
D0865		Isradipine	C19H21N3O5	3784	Major		Inter Info	[4], [5], [6]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[108], [109], [67], [110], [10], [11], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [50], [121], [57]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[108], [109], [67], [110], [10], [11], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [50], [121], [57]
D0922		Levonorgestrel	C21H28O2	13109	Major		Inter Info	[58], [59], [60], [56], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [4], [19], [5], [79], [50], [80], [57], [81], [82], [83]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1130		Nicardipine	C26H29N3O6	4474	Major		Inter Info	[4], [5], [6]
D1134		Nifedipine	C17H18N2O6	4485	Major		Inter Info	[4], [5], [6]
D1138		Nimodipine	C21H26N2O7	4497	Major		Inter Info	[4], [5], [6]
D1141		Nisoldipine	C20H24N2O6	4499	Major		Inter Info	[4], [5], [6]
D1154		Norethisterone	C20H26O2	6230	Major		Inter Info	[56], [19], [57]
D1156		Norgestimate	C23H31NO3	6540478	Major		Inter Info	[56], [19], [57]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[9], [10], [11], [33], [34], [35], [4], [36], [5], [37]
D1330		Praziquantel	C19H24N2O2	4891	Major		Inter Info	[134], [10], [135], [136]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[137]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[138]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[139]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[140]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Major		Inter Info	[141]
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[11], [142]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[11], [143]
D0130		Avatrombopag	C29H34Cl2N6O3S2	9852519	Major		Inter Info	[144], [145]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[146], [147]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[4], [36], [5]
D0170		Bepridil	C24H34N2O	2351	Major		Inter Info	[4], [5], [6]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[150]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[151]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[155], [156]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[157]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[10], [11], [158], [159], [160]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[10], [11], [161]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[162]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[10], [152], [11], [163]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[11], [164]
D0425		Darolutamide	C19H19ClN6O2	67171867	Major		Inter Info	[165]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[10], [11], [166]
D0485		Dienogest	C20H25NO2	68861	Major		Inter Info	[56], [19], [57]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Major		Inter Info	[167]
D0536		Drospirenone	C24H30O3	68873	Major		Inter Info	[58], [59], [60], [56], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [4], [19], [5], [79], [50], [80], [57], [81], [82], [83]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[168]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[10], [169]
D0563		Elvitegravir	C23H23ClFNO5	5277135	Major		Inter Info	[10], [11], [170], [158], [159], [160]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Major		Inter Info	[171]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[172]
D0589		Eravacycline	C27H31FN4O8	54726192	Major		Inter Info	[173]
D0590		Erdafitinib	C25H30N6O2	67462786	Major		Inter Info	[174]
D0628		Etravirine	C20H15BrN6O	193962	Major		Inter Info	[175]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[9], [10], [11], [176], [177]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[11], [178]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[179]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Major		Inter Info	[10], [180], [181]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[182]
D0700		Fostemsavir	C25H26N7O8P	11319217	Major		Inter Info	[183]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[184]
D0725		Glasdegib	C21H22N6O	25166913	Major		Inter Info	[185]
D0739		Grazoprevir	C38H50N6O9S	44603531	Major		Inter Info	[148], [186]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[11], [187]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Major		Inter Info	[188]
D0866		Istradefylline	C20H24N4O4	5311037	Major		Inter Info	[189]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[11], [190], [191]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[10], [11], [192], [91], [193], [194]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[195]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[196]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[10], [11], [197]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[198]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[148], [199]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Major		Inter Info	[4], [5], [6]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[200]
D0953		Lorlatinib	C21H19FN6O2	71731823	Major		Inter Info	[201]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[202]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[203]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[205], [206]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[207], [208]
D1101		Naldemedine	C32H34N4O6	54732242	Major		Inter Info	[209]
D1104		Naloxegol	C34H53NO11	56959087	Major		Inter Info	[11], [210]
D1127		Netupitant	C30H32F6N4O	6451149	Major		Inter Info	[10], [180], [181]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[211]
D1157		Norgestrel	C21H28O2	13109	Major		Inter Info	[58], [59], [60], [56], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [4], [19], [5], [79], [50], [80], [57], [81], [82], [83]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[10], [11], [212]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[9], [10], [11], [33], [34], [35], [4], [36], [5], [37]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[11], [213]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[10], [11], [214]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[10], [11], [215]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[216]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Major		Inter Info	[11], [217]
D1302		Pitolisant	C17H26ClNO	9948102	Major		Inter Info	[11], [219]
D1324		Pralsetinib	C27H32FN9O2	129073603	Major		Inter Info	[220]
D1336		Pretomanid	C14H12F3N3O5	456199	Major		Inter Info	[221]
D1388		Relugolix	C29H27F2N7O5S	10348973	Major		Inter Info	[222]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[223]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[224]
D1407		Rimegepant	C28H28F2N6O3	51049968	Major		Inter Info	[225]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Major		Inter Info	[226]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[9], [10], [11], [227]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[11], [228]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[11], [229]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Major		Inter Info	[230]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[231], [232]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [233]
D1496		Sonidegib	C26H26F3N3O3	24775005	Major		Inter Info	[237]
D1505		Stiripentol	C14H18O3	5311454	Major		Inter Info	[11], [95], [238], [239]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[10], [11], [240]
D1536		Tasimelteon	C15H19NO2	10220503	Major		Inter Info	[241]
D1538		Tazemetostat	C34H44N4O4	66558664	Major		Inter Info	[242]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[10], [11], [243]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[244], [245]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[10], [246]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[11], [247]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[248]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Major		Inter Info	[251]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[252]
D1673		Valbenazine	C24H38N2O4	24795069	Major		Inter Info	[253]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[10], [11], [254]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[255]
D1709		Voxelotor	C19H19N3O3	71602803	Major		Inter Info	[257]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[258]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[10], [11], [259]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[260], [10], [11], [261], [262], [263], [264], [265], [266], [267]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[11], [268], [269]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[19], [270]
D0028		Albendazole	C12H15N3O2S	2082	Moderate		Inter Info	[19], [270]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[19], [270]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[19], [270]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[19], [270]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[271], [272]
D0115		Astemizole	C28H31FN4O	2247	Moderate		Inter Info	[19], [270]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[273], [274], [275], [276], [277]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[19], [270]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[19], [270]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[19], [270]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[278]
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[279], [280], [281], [282]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[279], [280], [281], [282]
D0268		Caspofungin	C52H88N10O15	2826718	Moderate		Inter Info	[283]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[19], [270]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[10]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[19], [270]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[19], [270]
D0342		Cisapride	C23H29ClFN3O4	6917698	Moderate		Inter Info	[19], [270]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[284], [285]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[19], [270]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[19], [270]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[286], [10], [152], [11], [287], [288], [289]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[19], [270]
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[59], [60], [290], [61], [62], [63], [64], [66], [67], [291], [292], [293], [294], [69], [71], [72], [295], [73], [296], [297], [298], [299], [300], [301], [302], [76], [303], [304], [77], [305], [78], [306], [307], [308], [309], [79], [50], [80], [310], [311], [57], [81], [312], [82], [313], [83], [314]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[19], [270]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[315]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[316], [317]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[19], [270]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[19], [270]
D0494		Dihydroergotamine	C33H37N5O5	10531	Moderate		Inter Info	[10], [11], [318]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[279], [280], [281], [282]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[67], [319], [320], [232], [50]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[19], [270]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[19], [270]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[11], [321], [322], [323]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[321], [322], [323]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[19], [270]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[89], [5], [324]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[19], [270]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[325], [232]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[19], [270]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[279], [280], [281], [282]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[10], [11], [318]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[326], [327]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[19], [270]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[59], [60], [290], [61], [62], [63], [64], [66], [67], [291], [292], [293], [294], [69], [71], [72], [295], [73], [296], [297], [298], [299], [300], [301], [302], [76], [303], [304], [77], [305], [78], [306], [307], [308], [309], [79], [50], [80], [310], [311], [57], [81], [312], [82], [313], [83], [314]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[62], [71], [311]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[59], [60], [290], [61], [62], [63], [64], [66], [67], [291], [292], [293], [294], [69], [71], [72], [295], [73], [296], [297], [298], [299], [300], [301], [302], [76], [303], [304], [77], [305], [78], [306], [307], [308], [309], [79], [50], [80], [310], [311], [57], [81], [312], [82], [313], [83], [314]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[328]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[19], [270]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[19], [270]
D0630		Exemestane	C20H24O2	60198	Moderate		Inter Info	[329]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[330], [331], [332], [333], [334], [5], [335], [336]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[19], [270]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[19], [270]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[19], [270]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[19], [270]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[326], [337]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[19], [270]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[19], [270]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[19], [270]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[19], [270]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[19], [270]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[19], [270]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[19], [270]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[19], [270]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[19], [270]
D0870		Ivermectin	C48H74O14	6321424	Moderate		Inter Info	[19], [270]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[19], [270]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[10], [11], [338], [5]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[10], [11], [338], [5]
D0950		Loratadine	C22H23ClN2O2	3957	Moderate		Inter Info	[19], [270]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[19], [270]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[19], [270]
D0990		Medroxyprogesterone acetate	C24H34O4	6279	Moderate		Inter Info	[339], [340], [314]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[19], [270]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[341]
D0993		Megestrol acetate	C24H32O4	11683	Moderate		Inter Info	[62], [71], [311]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[19], [270]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[10], [11], [318]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[19], [270]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[10], [11], [318]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[342]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[19], [270]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[343], [344], [345], [346]
D1081		Modafinil	C15H15NO2S	4236	Moderate		Inter Info	[347], [348]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[349]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[19], [270]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[19], [270]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[19], [270]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[19], [270]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[9], [10], [11]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[350]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[19], [270]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[279], [280], [281], [282]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[19], [270]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[19], [270]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[351], [352], [353], [354], [355]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[19], [270]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[19], [270]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[19], [270]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[59], [60], [290], [61], [62], [63], [64], [66], [67], [291], [292], [293], [294], [69], [71], [72], [295], [73], [296], [297], [298], [299], [300], [301], [302], [76], [303], [304], [77], [305], [78], [306], [307], [308], [309], [79], [50], [80], [310], [311], [57], [81], [312], [82], [313], [83], [314]
D1349		Progesterone (topical)	C21H30O2	5994	Moderate		Inter Info	[62], [71], [311]
D1353		Propafenone	C21H27NO3	4932	Moderate		Inter Info	[19], [270]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[356], [67], [357], [358], [359], [50], [360], [57]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[361], [362], [5], [363], [360], [364]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[19], [270]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[365]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[366], [367], [368]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[19], [270]
D0099		Apremilast	C22H24N2O7S	11561674	Moderate		Inter Info	[370]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[371]
D0106		Armodafinil	C15H15NO2S	9690109	Moderate		Inter Info	[347], [348]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[372]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[377], [378]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[379]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[380]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[11], [381]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[382]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[383]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[19], [270]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[19], [270]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[10], [11], [384]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[19], [270]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[286], [10], [11]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[385], [386], [387], [388], [389]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[279], [280], [281], [282]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[390]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[391]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[392]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[10], [11], [318]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[19], [270]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[59], [60], [290], [61], [62], [63], [64], [66], [67], [291], [292], [293], [294], [69], [71], [72], [295], [73], [296], [297], [298], [299], [300], [301], [302], [76], [303], [304], [77], [305], [78], [306], [307], [308], [309], [79], [50], [80], [310], [311], [57], [81], [312], [82], [313], [83], [314]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[62], [71], [311]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[393]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[271], [272]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[19], [270]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Moderate		Inter Info	[395]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Moderate		Inter Info	[19], [270]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[10]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[396]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[398]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[10], [11], [399]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[400]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[401]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[402]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[10], [11], [338], [5]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Moderate		Inter Info	[19], [270]
D0965		Macimorelin	C26H30N6O3	9804938	Moderate		Inter Info	[403]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[10], [404]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[405]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[406], [407], [408], [409]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[406], [407], [408]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[410]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[414]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[415]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[19], [270]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[10], [417], [418], [419], [420]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[59], [60], [290], [61], [62], [63], [64], [66], [67], [291], [292], [293], [294], [69], [71], [72], [295], [73], [296], [297], [298], [299], [300], [301], [302], [76], [303], [304], [77], [305], [78], [306], [307], [308], [309], [79], [50], [80], [310], [311], [57], [81], [312], [82], [313], [83], [314]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Moderate		Inter Info	[421]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[11], [422], [423], [424]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[425]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[426]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[376]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[427]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[428]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[10], [11], [429]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[10], [11], [430]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[431]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[432]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[377], [378]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[10], [338], [5]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[11], [433], [434]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[19], [270]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[11], [435]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Moderate		Inter Info	[436], [437]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[438]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[439]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[440], [441], [442], [443], [354], [355]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[19], [270]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[444], [445], [446], [447]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[19], [270]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[11], [448], [449]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[450], [451], [452], [453]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[19], [270]
D1555		Terfenadine	C32H41NO2	5405	Moderate		Inter Info	[19], [270]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[19], [270]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[19], [270]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[19], [270]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[342]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[19], [270]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[19], [270]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[19], [270]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[19], [270]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[19], [270]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[86], [152], [11], [454]
D1626		Tretinoin	C20H28O2	444795	Moderate		Inter Info	[19], [270]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[19], [270]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[19], [270]
D1645		Trimethoprim	C14H18N4O3	5578	Moderate		Inter Info	[455], [456], [457]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[19], [270]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[19], [270]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[19], [270]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[19], [270]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[458]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[458]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[458]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[458]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[19], [270]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[19], [270]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[19], [270]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[459], [460], [461], [462]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[19], [270]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[11], [463], [464], [465]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[466], [467]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[453]
D0308		Cevimeline	C10H17NOS	83898	Minor		Inter Info	[468]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[469], [192], [194]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[470]
D0916		Levobupivacaine	C18H28N2O	92253	Minor		Inter Info	[471]
D0927		Lidocaine	C14H22N2O	3676	Minor		Inter Info	[472], [473], [474], [475]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[476]
D0571		Enfortumab vedotin	NA	NA	Minor		Inter Info	[11], [477], [478], [479]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[480]
D1306		Polatuzumab vedotin	NA	NA	Minor		Inter Info	[10], [481]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[483]
D1716		Zaleplon	C17H15N5O	5719	Minor		Inter Info	[484]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[485], [486]
	UGT induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0229		Cabotegravir	C19H17F2N3O5	54713659	Major		Inter Info	[152], [153], [154]
D1377		Raltegravir	C20H21FN6O5	54671008	Minor		Inter Info	[9], [10], [11], [482]
Affected excretion pathways
	Competitive inhibition of renal tubular secretion					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0706		Gadoxetic acid	C23H30GdN3O11	56841043	Moderate		Inter Info	[394]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[11], [249], [250]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[256]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[411], [412], [413]

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135	Product Information. Biltricide (praziquantel). Bayer, West Haven, CT.
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137	Product Information. Ranexa (ranolazine). Calmoseptine Inc, Huntington Beach, CA.
138	Product Information. Verzenio (abemaciclib). Lilly, Eli and Company, Indianapolis, IN.
139	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
140	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
141	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
142	Product Information. Eliquis (apixaban). Bristol-Myers Squibb Canada Inc, Montreal, IN.
143	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
144	Nomo, Zamora, Schuck, et al. "Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting." PubMed 84 (2018): 1. [PMID: 29341245]
145	Product Information. Doptelet (avatrombopag). Dova Pharmaceuticals, Durham, NC.
146	Pithavala YK, Tortorici M, Toh M, et al "Effect of rifampin on the pharmacokinetics of axitinib (AG-013736) in Japanese and Caucasian healthy volunteers." Cancer Chemother Pharmacol 65 (2010): 563-70. [PMID: 19603168]
147	Product Information. Inlyta (axitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
148	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
149	Product Information. Orladeyo (berotralstat). BioCryst Pharmaceuticals Inc, Durham, NC.
150	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
151	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
152	Cerner Multum, Inc. "Canadian Product Information.".
153	Product Information. Cabenuva (cabotegravir-rilpivirine). ViiV Healthcare ULC, Laval, QU.
154	Product Information. Vocabria (cabotegravir). ViiV Healthcare, Research Triangle Park, NC.
155	Product Information. Cabometyx (cabozantinib). Exelixis Inc, S San Francisco, CA.
156	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
157	Product Information. Tabrecta (capmatinib). Novartis Pharmaceuticals, East Hanover, NJ.
158	Product Information. Stribild (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
159	Product Information. Tybost (cobicistat). Gilead Sciences, Foster City, CA.
160	Product Information. Vitekta (elvitegravir). Gilead Sciences, Foster City, CA.
161	Product Information. Cotellic (cobimetinib). Genentech, South San Francisco, CA.
162	Product Information. Aliqopa (copanlisib). Bayer Pharmaceutical Inc, West Haven, CT.
163	Product Information. Xalkori (crizotinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
164	Product Information. Daklinza (daclatasvir). Bristol-Myers Squibb, Princeton, NJ.
165	Product Information. Nubeqa (darolutamide). Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ.
166	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
167	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
168	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
169	Product Information. Cerdelga (eliglustat). Genzyme Corporation, Cambridge, MA.
170	Product Information. Genvoya (cobicistat/elvitegravir/emtricitabine/tenofov). Gilead Sciences, Foster City, CA.
171	Product Information. Braftovi (encorafenib). Array BioPharma Inc., Boulder, CO.
172	Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
173	Product Information. Xerava (eravacycline). Tetraphase Pharmaceuticals, Inc, Watertown, MA.
174	Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
175	Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
176	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
177	Product Information. Zortress (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
178	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
179	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
180	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
181	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
182	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
183	Product Information. Rukobia (fostemsavir). ViiV Healthcare, Research Triangle Park, NC.
184	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
185	Product Information. Daurismo (glasdegib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
186	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
187	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
188	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
189	Product Information. Nourianz (istradefylline). Kyowa Kirin, Inc, Bedminster, NJ.
190	Portoles A, Terleira A, Calvo A, Martinez I, Resplandy G "Effects of Hypericum perforatum on ivabradine pharmacokinetics in healthy volunteers: an open-label, pharmacokinetic interaction clinical trial." J Clin Pharmacol 46 (2006): 1188-94. [PMID: 16988208]
191	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
192	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
193	Product Information. Symdeko 4-Week (ivacaftor-tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
194	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
195	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
196	Product Information. Ninlaro (ixazomib). Takeda Pharmaceuticals America, Lincolnshire, IL.
197	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
198	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
199	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
200	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
201	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
202	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
203	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
204	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
205	Bruderer S, Aanismaa P, Homery MC, et al. "Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan, a tissue-targeting dual endothelin receptor antagonist." AAPS J 14 (2012): 68-78. [PMID: 22189899]
206	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
207	Dutreix C, Munarini F, Lorenzo S, Roesel J, Wang Y "Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers." Cancer Chemother Pharmacol 72 (2013): 1223-34. [PMID: 24085261]
208	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
209	Product Information. Symproic (naldemedine). Shionogi USA Inc, Florham Park, NJ.
210	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
211	Product Information. Tasigna (nilotinib). Novartis Pharmaceuticals, East Hanover, NJ.
212	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
213	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
214	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
215	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
216	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
217	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
218	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
219	Product Information. Wakix (pitolisant). Harmony Biosciences, LLC, Plymouth Meeting, PA.
220	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
221	Product Information. Pretomanid (pretomanid). The Global Alliance for TB Drug Development, New York, NY.
222	Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
223	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
224	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
225	Product Information. Nurtec ODT (rimegepant). Biohaven Pharmaceuticals, New Haven, CT.
226	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
227	Product Information. Xarelto (rivaroxaban). Bayer Inc, Toronto, IA.
228	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
229	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
230	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
231	Product Information. Olysio (simeprevir). Janssen Pharmaceuticals, Titusville, NJ.
232	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
233	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
234	Product Information. Epclusa (sofosbuvir-velpatasvir). Gilead Sciences, Foster City, CA.
235	Product Information. Harvoni (ledipasvir-sofosbuvir). Gilead Sciences, Foster City, CA.
236	Product Information. Sovaldi (sofosbuvir). Gilead Sciences, Foster City, CA.
237	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
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239	Product Information. Diacomit (stiripentol). Biocodex Inc, Creswell, OR.
240	Product Information. Sutent (sunitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
241	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
242	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
243	Product Information. Torisel (temsirolimus). Wyeth-Ayerst Laboratories, Philadelphia, PA.
244	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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246	Product Information. Xeljanz (tofacitinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
247	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
248	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
249	UK government "Typhoid.".
250	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
251	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
252	Product Information. Rinvoq (upadacitinib). AbbVie US LLC, North Chicago, IL.
253	Product Information. Ingrezza (valbenazine). Neurocrine Biosciences, Inc., San Diego, CA.
254	Product Information. Zelboraf (vemurafenib). Genentech, South San Francisco, CA.
255	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
256	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
257	Product Information. Oxbryta (voxelotor). Global Blood Therapeutics, Inc., South San Francisco, CA.
258	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
259	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
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268	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
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271	Product Information. Emend (aprepitant). Merck & Company Inc, West Point, PA.
272	Product Information. Emend for Injection (fosaprepitant). Merck & Company Inc, West Point, PA.
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278	Product Information. Buprenex (buprenorphine). Reckitt and Colman Pharmaceutical, Richmond, VA.
279	Product Information. Hectorol (doxercalciferol). Genzyme Corporation, Cambridge, MA.
280	Product Information. One-Alpha (alfacalcidol). Pharmel Inc, Montreal, IN.
281	Product Information. Rocaltrol (calcitriol). Roche Laboratories, Nutley, NJ.
282	Product Information. Zemplar (paricalcitol). Abbott Pharmaceutical, Abbott Park, IL.
283	Product Information. Cancidas (caspofungin) Merck & Co, Inc, West Point, PA.
284	Bernard A, Kermarrec G, Parize P, et.al "Dramatic reduction of clindamycin serum concentration in staphylococcal osteoarticular infection patients treated with the oral clindamycin-rifampicin combination." J Infect 71 (2015): 200-6. [PMID: 25936632]
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287	Product Information. Acetaminophen-Codeine Phosphate (acetaminophen-codeine). Qualitest Pharmaceuticals Inc, Huntsville, ON.
288	Product Information. Codeine Sulfate (codeine). Lannett Company Inc, Philadelphia, PA.
289	Product Information. Tuzistra XR (chlorpheniramine-codeine). Vernalis Pharmaceuticals Inc, Morristown, NJ.
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315	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
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317	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.
318	Product Information. Methergine (methylergonovine). Novartis Pharmaceuticals, East Hanover, NJ.
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320	Product Information. Cardizem (diltiazem). Hoechst Marion-Roussel Inc, Kansas City, MO.
321	Product Information. Adriamycin PFS (doxorubicin). Pharmacia and Upjohn, Kalamazoo, MI.
322	Product Information. Doxil (doxorubicin liposomal). Sequis Pharmaceuticals Inc, Menlo Park, CA.
323	Kaytser V, Zhang P. Non-interacting, Non-opioid, and Non-barbiturate Containing Acute Medication Combinations in Headache: A Pilot Combinatorics Approach Based on DrugBank Database.?Front Neurol. 2021;12:632830. [PMID: 33679591]
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327	Product Information. Tarceva (erlotinib). Genentech, South San Francisco, CA.
328	Product Information. Lunesta (eszopiclone). Sepracor Inc, Marlborough, MA.
329	Product Information. Aromasin (exemestane) Pharmacia & Upjohn, Kalamazoo, MI.
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331	Product Information. Carbatrol (carbamazepine). Athena Neurosciences Inc, South San Francisco, CA.
332	Product Information. Dilantin (phenytoin). Parke-Davis, Morris Plains, NJ.
333	Product Information. Felbatol (felbamate). Wallace Laboratories, Cranbury, NJ.
334	Product Information. Phenobarbital (phenobarbital). Lilly, Eli and Company, Indianapolis, IN.
335	Product Information. Rifamate (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
336	Product Information. Tegretol (carbamazepine). Novartis Pharmaceuticals, East Hanover, NJ.
337	Product Information. Iressa (gefitinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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340	Product Information. Provera (medroxyprogesterone). Pharmacia and Upjohn, Kalamazoo, MI.
341	Product Information. Lariam (mefloquine). Roche Laboratories, Nutley, NJ.
342	Product Information. Tindamax (tinidazole). Presutti Laboratories Inc, Arlington Heights, IL.
343	Product Information. Remeron (mirtazapine). Organon, West Orange, NJ.
344	Sitsen JM, Maris FA, Timmer CJ "Drug-drug interaction studies with mirtazapine and carbamazepine in healthy male subjects." Eur J Drug Metab Pharmacokinet 26 (2001): 109-21. [PMID: 11554425]
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383	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
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393	Product Information. Toviaz (fesoterodine). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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395	Product Information. Mavyret (glecaprevir-pibrentasvir). Abbott Pharmaceutical, Abbott Park, IL.
396	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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412	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
413	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
414	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
415	Product Information. Pomalyst (pomalidomide). QLT Phototherapeutics Inc, Vancouver, AZ.
416	Product Information. Noxafil (posaconazole). Schering-Plough Corporation, Kenilworth, NJ.
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426	Product Information. Istodax (romidepsin). Gloucester Pharmaceuticals, Cambridge, MA.
427	Product Information. Jakafi (ruxolitinib). Incyte Corporation, Wilmington, DE.
428	Product Information. Onglyza (saxagliptin). Bristol-Myers Squibb, Princeton, NJ.
429	Product Information. Uptravi (selexipag). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
430	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
431	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
432	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
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438	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
439	Product Information. Brintellix (vortioxetine). Takeda Pharmaceuticals America, Lincolnshire, IL.
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446	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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449	Product Information. Cialis (tadalafil). Lilly, Eli and Company, Indianapolis, IN.
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469	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
470	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
471	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
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479	Product Information. Padcev (enfortumab vedotin). Seattle Genetics Inc, Bothell, WA.
480	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
481	Product Information. Polivy (polatuzumab vedotin). Genentech, South San Francisco, CA.
482	Product Information. Isentress (raltegravir). Merck & Company Inc, West Point, PA.
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484	Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
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