Details of Drug

Drug General Information (ID: D1394)
Drug Name	Retapamulin (topical)
Drug Type	Small molecule
Drug Synonymous	Altabax; Altargo; SB 275833; Altabax (Glaxo); Altabax (TN); Altargo (TN); Retapamulin (USAN/INN) Click to Show/Hide
Disease Class	1B72: Impetigo
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C30H47NO4S
InChI	1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
InChIKey	STZYTFJPGGDRJD-FJJJPKKESA-N
Canonical SMILES	CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CC5CCC(C4)N5C)C
External Link
	Pubchem ID	6918462
	CAS Number	224452-66-8
	CHEBI ID	166679
	TTD ID	D03UQM

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction
Relation Graph

Full list of drugs interacting with Retapamulin (topical)
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 66
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[4]
D0066		Amiodarone	C25H29I2NO3	2157	Minor		Inter Info	[7]
D0080		Amprenavir	C25H35N3O6S	65016	Minor		Inter Info	[7]
D0100		Aprepitant	C23H21F7N4O3	135413536	Minor		Inter Info	[7]
D0116		Atazanavir	C38H52N6O7	148192	Minor		Inter Info	[7]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[7]
D0212		Bromocriptine	C32H40BrN5O5	31101	Minor		Inter Info	[7]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Minor		Inter Info	[7]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[7]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[7]
D0349		Clarithromycin	C38H69NO13	84029	Minor		Inter Info	[7]
D0367		Clotrimazole	C22H17ClN2	2812	Minor		Inter Info	[7]
D0386		Conivaptan	C32H26N4O2	151171	Minor		Inter Info	[7]
D0402		Cyclosporine	C62H111N11O12	5284373	Minor		Inter Info	[7]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Minor		Inter Info	[7]
D0439		Delavirdine	C22H28N6O3S	5625	Minor		Inter Info	[7]
D0494		Dihydroergotamine	C33H37N5O5	10531	Minor		Inter Info	[7]
D0497		Diltiazem	C22H26N2O4S	39186	Minor		Inter Info	[7]
D0593		Ergotamine	C33H35N5O5	8223	Minor		Inter Info	[7]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[7]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[7]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Minor		Inter Info	[7]
D0793		Imatinib	C29H31N7O	5291	Minor		Inter Info	[7]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[7]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[7]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Minor		Inter Info	[7]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[7]
D1057		Miconazole	C18H14Cl4N2O	4189	Minor		Inter Info	[7]
D1117		Nefazodone	C25H32ClN5O2	4449	Minor		Inter Info	[7]
D1119		Nelfinavir	C32H45N3O4S	64143	Minor		Inter Info	[7]
D1134		Nifedipine	C17H18N2O6	4485	Minor		Inter Info	[7]
D0171		Berotralstat	C30H26F4N6O	137528262	Minor		Inter Info	[7]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Minor		Inter Info	[7]
D0375		Cobicistat	C40H53N7O5S2	25151504	Minor		Inter Info	[7]
D0413		Dalfopristin	C34H50N4O9S	6323289	Minor		Inter Info	[7]
D0416		Danazol	C22H27NO2	28417	Minor		Inter Info	[7]
D0426		Darunavir	C27H37N3O7S	213039	Minor		Inter Info	[7]
D0543		Duvelisib	C22H17ClN6O	50905713	Minor		Inter Info	[7]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[7]
D0638		Fedratinib	C27H36N6O3S	16722836	Minor		Inter Info	[7]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Minor		Inter Info	[7]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Minor		Inter Info	[7]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Minor		Inter Info	[7]
D0789		Idelalisib	C22H18FN7O	11625818	Minor		Inter Info	[7]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Minor		Inter Info	[7]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[7]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Minor		Inter Info	[7]
D0906		Letermovir	C29H28F4N4O4	45138674	Minor		Inter Info	[7]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Minor		Inter Info	[7]
D1127		Netupitant	C30H32F6N4O	6451149	Minor		Inter Info	[7]
D1189		Osilodrostat	C13H10FN3	44139752	Minor		Inter Info	[7]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[7]
D1398		Ribociclib	C23H30N8O	44631912	Minor		Inter Info	[7]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[7]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[7]
D1505		Stiripentol	C14H18O3	5311454	Minor		Inter Info	[7]
D1653		Troleandomycin	C41H67NO15	202225	Minor		Inter Info	[7]
D1660		Tucatinib	C26H24N8O2	51039094	Minor		Inter Info	[7]
D1709		Voxelotor	C19H19N3O3	71602803	Minor		Inter Info	[7]
D1415		Ritonavir	C37H48N6O5S2	392622	Minor		Inter Info	[7]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[7]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[7]
D1690		Verapamil	C27H38N2O4	2520	Minor		Inter Info	[7]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[7]
D1714		Zafirlukast	C31H33N3O6S	5717	Minor		Inter Info	[7]
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Moderate		Inter Info	[2], [3]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[5], [6]

References
1	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
2	Cerner Multum, Inc. "Australian Product Information.".
3	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
4	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
5	Product Information. Sonata (zaleplon) Wyeth-Ayerst Laboratories, Philadelphia, PA.
6	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
7	Product Information. Altabax (retapamulin topical). GlaxoSmithKline, Research Triangle Park, NC.

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