Details of Drug

Drug General Information (ID: D1388)
Drug Name	Relugolix
Drug Type	Small molecule
Drug Synonymous	737789-87-6; TAK-385; TAK 385; UNII-P76B05O5V6; CHEMBL1800159; TAK-385/TAK385; P76B05O5V6; 1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-3-methoxyurea; Relugolix [USAN:INN]; TAK385; Relugolix (JAN/INN); SCHEMBL778416; GTPL5586; DTXSID40224167; MolPort-044-567-649; AOMXMOCNKJTRQP-UHFFFAOYSA-N; EX-A1083; BCP21587; ZINC43206033; BDBM50347982; AKOS027440398; SB16721; DB11853; CS-5917 Click to Show/Hide
Disease Class	GA10: Endometriosis; 2C82: Prostate cancer
Therapeutic Class	Gonadotropin-Releasing Hormone Antagonists
Structure
Structure	3D Structure		2D Structure
Formula	C29H27F2N7O5S
InChI	1S/C29H27F2N7O5S/c1-36(2)14-19-24-26(39)38(22-12-13-23(42-3)34-33-22)29(41)37(15-18-20(30)6-5-7-21(18)31)27(24)44-25(19)16-8-10-17(11-9-16)32-28(40)35-43-4/h5-13H,14-15H2,1-4H3,(H2,32,35,40)
InChIKey	AOMXMOCNKJTRQP-UHFFFAOYSA-N
Canonical SMILES	CN(C)CC1=C(SC2=C1C(=O)N(C(=O)N2CC3=C(C=CC=C3F)F)C4=NN=C(C=C4)OC)C5=CC=C(C=C5)NC(=O)NOC
External Link
	Pubchem ID	10348973
	CAS Number	737789-87-6
	TTD ID	D0F2WP
	VARIDT ID	DR00186

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM010 Transporter inhibition BM011 Transporter induction BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias
Relation Graph

Full list of drugs interacting with Relugolix
Affected cellular transport
	Transporter inhibition					Drug Num: 29
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[1]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[1]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1]
D0408		Daclatasvir	C40H50N8O6	25154714	Major		Inter Info	[1]
D0497		Diltiazem	C22H26N2O4S	39186	Major		Inter Info	[1]
D0559		Eliglustat	C23H36N2O4	23652731	Major		Inter Info	[1]
D0658		Fidaxomicin	C52H74Cl2O18	10034073	Major		Inter Info	[4], [30], [5], [31]
D0665		Flibanserin	C20H21F3N4O	6918248	Major		Inter Info	[1]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[1]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Major		Inter Info	[1]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[1]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1]
D1124		Neratinib	C30H29ClN6O3	9915743	Major		Inter Info	[1]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[1]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Major		Inter Info	[88], [1]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1]
D1423		Rolapitant	C25H26F6N2O2	10311306	Major		Inter Info	[1]
D1471		Simeprevir	C38H47N5O7S2	24873435	Major		Inter Info	[1]
D1501		Spironolactone	C24H32O4S	5833	Major		Inter Info	[1]
D1524		Suvorexant	C23H23ClN6O2	24965990	Major		Inter Info	[1]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Major		Inter Info	[1]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1]
D1686		Velpatasvir	C49H54N8O8	67683363	Major		Inter Info	[88], [1]
D1690		Verapamil	C27H38N2O4	2520	Major		Inter Info	[1]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[5], [153]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[154]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[4], [5], [161], [162]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[1]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1]
D0597		Erythromycin	C37H67NO13	12560	Major		Inter Info	[1]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1]
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[1]
D1136		Nilotinib	C28H22F3N7O	644241	Major		Inter Info	[1]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[1]
D1353		Propafenone	C21H27NO3	4932	Major		Inter Info	[1]
D1371		Quinidine	C20H24N2O2	441074	Major		Inter Info	[1]
D1372		Quinine	C20H24N2O2	3034034	Major		Inter Info	[1]
D1383		Ranolazine	C24H33N3O4	56959	Major		Inter Info	[1]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[1]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1]
D1544		Telithromycin	C43H65N5O10	3002190	Major		Inter Info	[1]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[4], [5]
	CYP450 enzyme induction					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[97], [1]
D1401		Rifapentine	C47H64N4O12	135403821	Major		Inter Info	[1]
D1502		St. John's Wort	NA	NA	Major		Inter Info	[1]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[1]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Moderate		Inter Info	[1]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[1]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Moderate		Inter Info	[1]
Pharmacodynamic additive effects
	Increased risk of prolong QT interval					Drug Num: 125
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[2]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[3], [4], [5], [6]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[3], [4], [5], [7], [8], [9], [10]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[3], [4], [5], [11], [9]
D0508		Disopyramide	C21H29N3O	3114	Major		Inter Info	[3], [4], [5], [12], [13], [14], [15], [16], [17], [18], [19], [20], [9]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[3], [4], [5], [21]
D0514		Dolasetron	C19H20N2O3	3033818	Major		Inter Info	[3], [4], [5], [22]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[3], [4], [5], [23]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[3], [4], [5], [24], [25], [9]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[26]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[3], [27], [4], [5], [28], [29], [9]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[33], [34], [35], [3], [4], [5], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[3], [4], [5], [56], [57], [58], [59], [60], [61], [9]
D0787		Ibutilide	C20H36N2O3S	60753	Major		Inter Info	[3], [4], [5], [62]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[3], [4], [5], [63], [9]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[3], [4], [5], [66], [9]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[3], [4], [5], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [9]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[33], [34], [35], [3], [4], [5], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[77]
D1223		Papaverine	C20H21NO4	4680	Major		Inter Info	[78], [79], [80], [81], [82], [83], [84], [85]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[3], [4], [5], [86]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[5], [24], [87], [9]
D1343		Procainamide	C13H21N3O	4913	Major		Inter Info	[3], [4], [5], [12], [13], [14], [15], [16], [17], [18], [19], [20], [9]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Major		Inter Info	[89]
D0899		Lefamulin	C28H45NO5S	25185057	Major		Inter Info	[90]
D0965		Macimorelin	C26H30N6O3	9804938	Major		Inter Info	[91]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[5], [93]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[3], [4], [5], [24], [40], [95], [96], [9]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[98], [99], [3], [4], [5], [100], [101]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[3], [4], [5], [12], [13], [14], [15], [16], [17], [18], [19], [20], [9]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[3], [4], [5], [102], [24], [103], [104], [105], [9]
D1612		Toremifene	C26H28ClNO	3005573	Major		Inter Info	[3], [4], [5], [106]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Major		Inter Info	[3], [4], [5], [107]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[3], [4], [5], [24], [108], [9]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0358		Clofazimine	C27H22Cl2N4	2794	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[5], [114], [115]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[5], [114], [115]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[5], [114], [115]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0636		Famotidine	C8H15N7O2S3	5702160	Moderate		Inter Info	[4], [5], [122]
D0664		Flecainide	C17H20F6N2O3	3356	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0738		Granisetron	C18H24N4O	5284566	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0751		Halothane	C2HBrClF3	3562	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0806		Inotuzumab ozogamicin	NA	NA	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[4], [5], [155]
D1181		Ondansetron	C18H19N3O	4595	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1216		Palonosetron	C19H24N2O	6337614	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1254		Perflutren	C3F8	6432	Moderate		Inter Info	[156], [157]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[5], [114], [115]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1424		Romidepsin	C24H36N4O6S2	5352062	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1463		Sevoflurane	C4H3F7O	5206	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1522		Sunitinib	C22H27FN4O2	5329102	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[5], [109], [110], [111], [112], [113], [114], [115]
D1051		Metronidazole	C6H9N3O3	4173	Minor		Inter Info	[4], [163], [164], [165]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[3], [4], [5], [166], [167], [168], [169]
	Increased risk of ventricular arrhythmias					Drug Num: 30
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[3], [4], [5], [32], [10]
D0868		Ivabradine	C27H36N2O5	132999	Major		Inter Info	[5], [64], [65]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[92]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[4], [94]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[3], [4], [5], [119], [120], [121]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[3], [4], [5], [119], [120], [121]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[136], [146], [149]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D0970		Magnesium citrate	C12H10Mg3O14	6099959	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[136], [146], [149]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[5], [158], [159]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[5], [158], [159]
D1309		Polyethylene glycol (3350)	C2H6O2	174	Moderate		Inter Info	[4], [5], [118]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[4], [5], [118]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[3], [4], [5], [116], [117], [118]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[136], [146], [149]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[3], [4], [5], [119], [120], [121]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[136], [146], [149]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[4], [5], [160]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[136], [146], [149]

References
1	Product Information. Orgovyx (relugolix). Myovant Sciences, Inc., Brisbane, CA.
2	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
3	Canadian Pharmacists Association.
4	Cerner Multum, Inc. "Australian Product Information.".
5	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6	Product Information. Zykadia (ceritinib). Novartis Pharmaceuticals, East Hanover, NJ.
7	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide).".
8	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
9	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
10	FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Revised recommendations for cardiovascular monitoring and use of multiple sclerosis drug Gilenya (fingolimod).".
11	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
12	Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6. [PMID: 17106497]
13	Product Information. Betapace (sotalol). Berlex, Richmond, CA.
14	Product Information. Cordarone (amiodarone). Wyeth-Ayerst Laboratories, Philadelphia, PA.
15	Product Information. Norpace (disopyramide). Searle, Skokie, IL.
16	Product Information. Procan SR (procainamide). Parke-Davis, Morris Plains, NJ.
17	Product Information. Quiniglute (quinidine). Berlex, Richmond, CA.
18	Product Information. Vascor (bepridil). McNeil Pharmaceutical, Raritan, NJ.
19	Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32. [PMID: 11144659]
20	Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38. [PMID: 12688833]
21	Product Information. Tikosyn (dofetilide) Pfizer US Pharmaceuticals, Atlanta, GA.
22	Product Information. Anzemet (dolasetron). Hoechst Marion-Roussel Inc, Kansas City, MO.
23	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
24	Glassman AH, Bigger JT Jr "Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death." Am J Psychiatry 158 (2001): 1774-82. [PMID: 11691681]
25	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
26	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
27	Castro VM, Clements CC, Murphy SN, et al. "QT interval and antidepressant use: a cross sectional study of electronic health records." BMJ 346 (2013): f288. [PMID: 23360890]
28	Do A, Noohi S, Elie D, et al. Health Canada Warning on Citalopram and Escitalopram--Its Effects on Prescribing in Consultation-Liaison Psychiatry.?Psychosomatics. 2016;57(1):57-63. [PMID: 26633294]
29	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
30	Cerner Multum, Inc. "Canadian Product Information.".
31	Product Information. Dificid (fidaxomicin). Optimer Pharmaceuticals, San Diego, CA.
32	Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
33	Ansari SR, Chopra N "Gatifloxacin and Prolonged QT Interval." Am J Med Sci 327 (2004): 55-6. [PMID: 14722399]
34	Ball P "Quinolone-induced QT interval prolongation: a not-so-unexpected class effect." J Antimicrob Chemother 45 (2000): 557-9. [PMID: 10797074]
35	Bertino JS Jr, Owens RC Jr, Carnes TD, Iannini PB "Gatifloxacin-associated corrected QT interval prolongation, torsades de pointes, and ventricular fibrillation in patients with known risk factors." Clin Infect Dis 34 (2002): 861-3. [PMID: 11830802]
36	Dale KM, Lertsburapa K, Kluger J, White CM "Moxifloxacin and torsade de pointes." Ann Pharmacother 41 (2007): 336-40. [PMID: 17284508]
37	Demolis JL, Kubitza D, Tenneze L, Funck-Bretano C "Effect of a single oral dose of moxifloxacin (400 mg and 800 mg) on ventricular repolarization in healthy subjects." Clin Pharmacol Ther 68 (2000): 658-66. [PMID: 11180026]
38	Falagas ME, Rafailidis PI, Rosmarakis ES "Arrhythmias associated with fluoroquinolone therapy." Int J Antimicrob Agents 29 (2007): 374-9. [PMID: 17241772]
39	Frothingham R "Rates of torsades de pointes associated with ciprofloxacin, ofloxacin, levofloxacin, gatifloxacin, and moxifloxacin." Pharmacotherapy 21 (2001): 1468-72. [PMID: 11765299]
40	Iannini PB "Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval." Expert Opin Drug Saf 1 (2002): 121-8. [PMID: 12904146]
41	Iannini PB, Circiumaru I "Gatifloxacin-induced QTc prolongation and ventricular tachycardia." Pharmacotherapy 21 (2001): 361-2. [PMID: 11253862]
42	Iannini PB, Doddamani S, Byazrova E, Curciumaru I, Kramer H "Risk of torsades de pointes with non-cardiac drugs." BMJ 322 (2001): 46-7. [PMID: 11141163]
43	Kang J, Wang L, Chen XL, Triggle DJ, Rampe D "Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG." Mol Pharmacol 59 (2001): 122-6. [PMID: 11125032]
44	Katritsis D, Camm AJ "Quinolones: cardioprotective or cardiotoxic." Pacing Clin Electrophysiol 26 (2003): 2317-20. [PMID: 14675020]
45	Noel GJ, Natarajan J, Chien S, Hunt TL, Goodman DB, Abels R "Effects of three fluoroquinolones on QT interval in healthy adults after single doses." Clin Pharmacol Ther 73 (2003): 292-303. [PMID: 12709719]
46	Oliphant CM, Green GM "Quinolones: a comprehensive review." Am Fam Physician 65 (2002): 455-64. [PMID: 11858629]
47	Owens RC "QT Prolongation with Antimicrobial Agents : Understanding the Significance." Drugs 64 (2004): 1091-124. [PMID: 15139788]
48	Owens RC "Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes." Pharmacotherapy 21 (2001): 301-19. [PMID: 11253855]
49	Owens RC Jr, Ambrose PG "Torsades de pointes associated with fluoroquinolones." Pharmacotherapy 22 (2002): 663-8 discussion 668-72. [PMID: 12013370]
50	Product Information. Avelox (moxifloxacin) Bayer, West Haven, CT.
51	Product Information. Tequin (gatifloxacin) Bristol-Myers Squibb, Princeton, NJ.
52	Siepmann M, Kirch W "Drug points - Tachycardia associated with moxifloxacin." Br Med J 322 (2001): 23. [PMID: 11141146]
53	Stahlmann R "Clinical toxicological aspects of fluoroquinolones." Toxicol Lett 127 (2002): 269-77. [PMID: 12052667]
54	Tsikouris JP, Peeters MJ, Cox CD, Meyerrose GE, Seifert CF "Effects of three fluoroquinolones on QT analysis after standard treatment courses." Ann Noninvasive Electrocardiol 11 (2006): 52-6. [PMID: 16472283]
55	White CM, Grant EM, Quintiliani R "Moxifloxacin does increase the corrected QT interval." Clin Infect Dis 33 (2001): 1441-2. [PMID: 11565091]
56	Hatta K, Takahashi T, Nakamura H, Yamashiro H, Asukai N, Matsuzaki I, Yonezawa Y "The association between intravenous haloperidol and prolonged QT interval." J Clin Psychopharmacol 21 (2001): 257-61. [PMID: 11386487]
57	Huyse F, van Schijndel RS "Haloperidol and cardiac arrest." Lancet 2 (1988): 568-9. [PMID: 2900948]
58	Metzger E, Friedman R "Prolongation of the corrected QT and torsades de pointes cardiac arrhythmia associated with intravenous haloperidol in the medically ill." J Clin Psychopharmacol 13 (1993): 128-32. [PMID: 8463445]
59	O'Brien JM, Rockwood RP, Suh KI "Haloperidol-induced torsade de pointes." Ann Pharmacother 33 (1999): 1046-9. [PMID: 10534216]
60	Product Information. Haldol (haloperidol). McNeil Pharmaceutical, Raritan, NJ.
61	Wilt JL, Minnema AM, Johnson RF, Rosenblum AM "Torsade de pointes associated with the use of intravenous haloperidol." Ann Intern Med 119 (1993): 391-4. [PMID: 8338292]
62	Product Information. Corvert (ibutilide). Pharmacia and Upjohn, Kalamazoo, MI.
63	Product Information. Exforge HCT (amlodipine/hydrochlorothiazide/valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
64	Mittal SR "Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine." J Assoc Physicians India 62 (2014): 426-7. [PMID: 25438492]
65	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
66	Product Information. Serentil (mesoridazine) Boehringer-Ingelheim, Ridgefield, CT.
67	De Bels D, Staroukine M, Devriendt J "Torsades de pointes due to methadone." Ann Intern Med 139 (2003): E156. [PMID: 12859181]
68	Ehret GB, Desmeules JA, Broers B "Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology." Expert Opin Drug Saf 6 (2007): 289-303. [PMID: 17480178]
69	Gil M, Sala M, Anguera I, et al. "QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone." Am J Cardiol 92 (2003): 995-7. [PMID: 14556883]
70	Krantz MJ, Kutinsky IB, Robertson AD, Mehler PS "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes." Pharmacotherapy 23 (2003): 802-5. [PMID: 12820821]
71	Krantz MJ, Lewkowiez L, Hays H, et al "Torsade de pointes associated with very-high-dose methadone." Ann Intern Med 137 (2002): 501-4. [PMID: 12230351]
72	Krantz MJ, Mehler PS "Synthetic opioids and QT prolongation." Arch Intern Med 163 (2003): 1615 author reply 1615. [PMID: 12860589]
73	Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN "Impact of methadone treatment on cardiac repolarization and conduction in opioid users." Am J Cardiol 95 (2005): 915-8. [PMID: 15781034]
74	Mokwe EO, Ositadinma O "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966000]
75	Sala M, Anguera I, Cervantes M "Torsade de pointes due to methadone." Ann Intern Med 139 (2003): W64. [PMID: 12966001]
76	Walker PW, Klein D, Kasza L "High dose methadone and ventricular arrhythmias: a report of three cases." Pain 103 (2003): 321-4. [PMID: 12791438]
77	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
78	Goto M, Sato M, Kitzazawa H, et.al "Papaverine-induced QT interval prolongation and ventricular fibrillation in a patient with a history of drug-induced QT prolongation." Intern Med 53 (2014): 1629-31. [PMID: 25088875]
79	Inoue T, Asahi S, Takayanagi K, Morooka S, Takabatake Y "QT prolongation and possibility of ventricular arrhythmias after intracoronary papaverine." Cardiology 84 (1994): 9-13. [PMID: 7511988]
80	Jain A, Jenkins MG "Intracoronary electrocardiogram during torsade des pointes secondary to intracoronary papaverine." Cathet Cardiovasc Diagn 18 (1989): 255-7. [PMID: 2605630]
81	Kern MJ, Deligonul U, Serota H, Gudipati C, Buckingham T "Ventricular arrhythmia due to intracoronary papaverine: analysis of QT intervals and coronary vasodilatory reserve." Cathet Cardiovasc Diagn 19 (1990): 229-36. [PMID: 2334953]
82	Nakayama M, Saito A, Kitazawa H, et.al "Papaverine-induced polymorphic ventricular tachycardia in relation to QTU and giant T-U waves in four cases." Intern Med 51 (2012): 351-6. [PMID: 22333368]
83	Nakayama M, Tanaka N, Sakoda K, et.al "Papaverine-induced polymorphic ventricular tachycardia during coronary flow reserve study of patients with moderate coronary artery disease." Circ J 79 (2015): 530-6. [PMID: 25746536]
84	Talman CL, Winniford MD, Rossen JD, Simonetti I, Kienzle MG, Marcus ML "Polymorphous ventricular tachycardia: a side effect of intracoronary papaverine." J Am Coll Cardiol 15 (1990): 275-8. [PMID: 2299067]
85	Vrolix M, Piessens J, De Geest H "Torsades de pointes after intracoronary papaverine." Eur Heart J 12 (1991): 273-6. [PMID: 2044564]
86	Product Information. Signifor (pasireotide). Novartis Pharmaceuticals, East Hanover, NJ.
87	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
88	Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
89	Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
90	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
91	Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
92	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
93	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
94	Product Information. Mayzent (siponimod). Novartis Pharmaceuticals, East Hanover, NJ.
95	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
96	Witchel HJ, Hancox JC, Nutt DJ "Psychotropic drugs, cardiac arrhythmia, and sudden death." J Clin Psychopharmacol 23 (2003): 58-77. [PMID: 12544377]
97	Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
98	Anson BD, Weaver JG, Ackerman MJ, et al. "Blockade of HERG channels by HIV protease inhibitors." Lancet 365 (2005): 682-686. [PMID: 15721475]
99	Biondi L "Health Canada endorsed important safety information on Invirase (saquinavir mesylate)." .
100	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
101	FDA. U.S. Food and Drug Administration "FDA drug safety communication: Ongoing safety review of Invirase (saquinavir) and possible association with abnormal heart rhythms.".
102	Fletcher GF, Kazamias TM "Cardiotoxic effects of Mellaril: conduction disturbances and supraventricular arrhythmias." Am Heart J 78 (1969): 135-8. [PMID: 5794785]
103	Hartigan-Go K, Bateman DN, Nyberg G, Martensson E, Thomas SHL "Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans." Clin Pharmacol Ther 60 (1996): 543-53. [PMID: 8941027]
104	Liberatore MA, Robinson DS "Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy?" J Clin Psychopharmacol 4 (1984): 143-6. [PMID: 6145728]
105	Product Information. Mellaril (thioridazine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
106	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
107	Product Information. Vandetanib (vandetanib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
108	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
109	Product Information. Eligard (leuprolide). Sanofi Winthrop Pharmaceuticals, New York, NY.
110	Product Information. Firmagon (degarelix). Ferring Pharmaceuticals Inc, Tarrytown, NY.
111	Product Information. Lupron (leuprolide). TAP Pharmaceuticals Inc, Deerfield, IL.
112	Product Information. Plenaxis (abarelix). Praecis Pharmaceuticals Inc, Waltham, MA.
113	Product Information. Trelstar (triptorelin) Pharmacia and Upjohn, Kalamazoo, MI.
114	Product Information. Vantas (histrelin). Endo Pharmaceuticals (formally Indevus Pharmaceuticals Inc), Lexington, MA.
115	Product Information. Zoladex (goserelin). Zeneca Pharmaceuticals, Wilmington, DE.
116	Chin RL "Laxative-induced hypokalemia." Ann Emerg Med 32 (1998): 517-8. [PMID: 9774942]
117	Muller-Lissner SA "Adverse effects of laxatives: fact and fiction." Pharmacology 47 (1993): 138-45. [PMID: 8234421]
118	Schaefer DC, Cheskin LJ "Constipation in the elderly." Am Fam Physician 58 (1998): 907-14. [PMID: 9767726]
119	Product Information. Aricept (donepezil). Pfizer US Pharmaceuticals, New York, NY.
120	Product Information. Exelon (rivastigmine) Novartis Pharmaceuticals, East Hanover, NJ.
121	Product Information. Razadyne (galantamine). Johnson and Johnson Medical Inc, Arlington, TX.
122	Product Information. Pepcid (famotidine). Merck & Co, Inc, West Point, PA.
123	Bengtsson B, Fagerstrom PO "Extrapulmonary effects of terbutaline during prolonged administration." Clin Pharmacol Ther 31 (1982): 726-32. [PMID: 7042176]
124	Braden GL, vonOeyen PT, Germain MJ, Watson DJ, Haag BL "Ritodrine- and terbutaline-induced hypokalemia in preterm labor: Mechanisms and consequences." Kidney Int 51 (1997): 1867-75. [PMID: 9186877]
125	Clifton GD, Hunt BA, Patel RC, Burki NK "Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses." Am Rev Respir Dis 141 (1990): 575-9. [PMID: 2178522]
126	Dickens GR, Mccoy RA, West R, Stapczynski JS, Clifton GD "Effect of nebulized albuterol on serum potassium and cardiac rhythm in patients with asthma or chronic obstructive pulmonary disease." Pharmacotherapy 14 (1994): 729-33. [PMID: 7885977]
127	Ferguson GT, Funck-Brentano C, Fischer T, Darken P, Reisner C "Cardiovascular Safety of Salmeterol in COPD." Chest 123 (2003): 1817-24. [PMID: 12796155]
128	Gelmont DM, Balmes JR, Yee A "Hypokalemia induced by inhaled bronchodilators." Chest 94 (1988): 763-6. [PMID: 3168573]
129	Gross TL, Sokol RJ "Severe hypokalemia and acidosis: a potential complication of beta- adrenergic treatment." Am J Obstet Gynecol 138 (1980): 1225-6. [PMID: 7446635]
130	Hastwell G, Lambert BE "The effect of oral salbutamol on serum potassium and blood sugar." Br J Obstet Gynaecol 85 (1978): 767-9. [PMID: 708661]
131	Hurlbert BJ, Edelman JD, David K "Serum potassium levels during and after terbutaline." Anesth Analg 60 (1981): 723-5. [PMID: 7197475]
132	Hypokalaemia due to salbutamol overdosage. Br Med J (Clin Res Ed) 283 (1981): 500-1. [PMID: 6114774]
133	Kantola I, Tarssanen L "Hypokalemia from usual salbutamol dosage ." Chest 89 (1986): 619-20. [PMID: 3956296]
134	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
135	Milic M, Bao X, Rizos D, Liu F, Ziegler MG "Literature review and pilot studies of the effect of qt correction formulas on reported beta(2)-agonist-induced QTc prolongation." Clin Ther 28 (2006): 582-90. [PMID: 16750469]
136	Product Information. Arcapta Neohaler (indacaterol). Novartis Pharmaceuticals, East Hanover, NJ.
137	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
138	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
139	Product Information. Foradil (formoterol) Novartis Pharmaceuticals, East Hanover, NJ.
140	Product Information. Maxair (pirbuterol). 3M Pharmaceuticals, St. Paul, MN.
141	Product Information. Proventil (albuterol). Schering Laboratories, Kenilworth, NJ.
142	Product Information. Severent (salmeterol). Glaxo Wellcome, Research Triangle Park, NC.
143	Product Information. Striverdi Respimat (olodaterol). Boehringer Ingelheim, Ridgefield, CT.
144	Product Information. Xopenex (levalbuterol). Sepracor, Marlborough, MA.
145	Rakhmanina NY, Kearns GL, Farrar HC "Hypokalemia in an asthmatic child from abuse of albuterol metered dose inhaler." Pediatr Emerg Care 14 (1998): 145-7. [PMID: 9583400]
146	Sanders JP, Potter DE, Ellis S, Bee DE, Grant JA "Metabolic and cardiovascular effects of carbuterol and metaproterenol." J Allergy Clin Immunol 60 (1977): 174-9. [PMID: 19514]
147	Sun ZH, Swan H, Vitasalo M, Toivonen L "Effects of epinephrine and phenylephrine on QT interval dispersion in congenital long QT syndrome." J Am Coll Cardiol 31 (1998): 1400-5. [PMID: 9581741]
148	Tveskov C, Djurhuus MS, Klitgaard NAH, Egstrup K "Potassium and magnesium distribution, ECG changes, and ventricular ectopic beats during beta(2)-adrenergic stimulation with terbutaline in healthy subjects." Chest 106 (1994): 1654-9. [PMID: 7988180]
149	Whyte KF, Addis GJ, Whitesmith R, Reid JL "The mechanism of salbutamol-induced hypokalaemia." Br J Clin Pharmacol 23 (1987): 65-71. [PMID: 3545273]
150	Windom H, Grainger J, Burgess C, Crane J, Pearce N, Beasley R "A comparison of the haemodynamic and hypokalaemic effects of inhaled pirbuterol and salbutamol." N Z Med J 103 (1990): 259-61. [PMID: 1972557]
151	Wong CS, Pavord ID, Williams J, Britton JR, Tattersfield AE "Bronchodilator, cardiovascular, and hypokalaemic effects of fenoterol, salbutamol, and terbutaline in asthma." Lancet 336 (1990): 1396-9. [PMID: 1978872]
152	Larsson S, Svedmyr N "Bronchodilating effect and side effects of beta2- adrenoceptor stimulants by different modes of administration (tablets, metered aerosol, and combinations thereof). A study with salbutamol inasthmatics." Am Rev Respir Dis 116 (1977): 861-9. [PMID: 921062]
153	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
154	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
155	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
156	Product Information. Definity (perflutren). Lantheus Medical Imaging Inc, North Billerica, MA.
157	Product Information. Optison (perflutren). Mallinckrodt Medical Inc, St. Louis, MO.
158	Product Information. Suclear (polyethylene glycol 3350 with electrolytes). Braintree Laboratories, Braintree, MA.
159	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
160	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
161	Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
162	Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
163	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
164	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
165	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.
166	Crouch MA, Limon L, Cassano AT "Clinical relevance and management of drug-related QT interval prolongation." Pharmacotherapy 23 (2003): 881-908. [PMID: 12885102]
167	Darpo B "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes." Eur Heart J Suppl 3(Suppl K) (2001): K70-80.
168	Lopez JA, Harold JG, Rosenthal MC, Oseran DS, Schapira JN, Peter T "QT prolongation and torsades de pointes after administration of trimethoprin-sulfamethoxazole." Am J Cardiol 59 (1987): 376-7. [PMID: 3492908]
169	Wiener I, Rubin D, Martinez E, et al "QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration." Mt Sinai J Med 48 (1981): 53-5. [PMID: 6970886]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence