Details of Drug

Drug General Information (ID: D1386)
Drug Name	Rasburicase
Drug Type	Protein/peptide
Drug Synonymous	Fasturtec (TN) Click to Show/Hide
Disease Class	5C55: Inborn purine/pyrimidine/nucleotide metabolism error
Therapeutic Class	Antihyperuricemic Agents
External Link
External Link	TTD ID	D08LJP

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects BM071 Increased risk of methemoglobinemia BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Rasburicase
Pharmacodynamic additive effects
	Increased risk of methemoglobinemia					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[1], [2], [3]
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[4], [5], [6], [7], [8], [9], [10]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[6], [7], [11]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[6], [7], [11]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[6], [7], [11]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[6], [7], [11]
D1835		Lidocaine (ophthalmic)	C14H22N2O	3676	Moderate		Inter Info	[6], [7], [11]
D0928		Lidocaine (topical)	C14H22N2O	3676	Moderate		Inter Info	[6], [7], [11]
D1852		Oxybuprocaine (ophthalmic)	C17H28N2O3	4633	Moderate		Inter Info	[6], [7], [11]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[6], [7], [11]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[6], [7], [11]
D1562		Tetracaine (topical)	C15H24N2O2	5411	Moderate		Inter Info	[6], [7], [11]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[12]

References
1	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
2	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
3	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
4	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
5	Cerner Multum, Inc. "Australian Product Information.".
6	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
7	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
8	Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
9	Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
10	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
11	Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
12	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.