Details of Drug

Details of Drug

 Drug General Information (ID: D1360)
  Drug Name
Protein C
  Drug Type Protein/peptide
  Drug Synonymous
Activated Protein C (390-404), human
    Click to Show/Hide
  Therapeutic Class Coagulation Modifiers

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
BM050  Increased risk of bleeding
  Relation Graph
 Full list of drugs interacting with Protein C
      Pharmacodynamic additive effects
   Increased risk of bleeding Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0250
 
Caplacizumab
 
NA
 
NA
Major    Inter Info   
[1], [2], [3]
D0298
 
Celecoxib
 
C17H14F3N3O2S
 
2662 
Moderate    Inter Info   
[4]
D1460
 
Selumetinib
 
C17H15BrClFN4O3
 
10127622 
Moderate    Inter Info   
[5], [6], [7]
D1421
 
Rofecoxib
 
C17H14O4S
 
5090 
Moderate    Inter Info   
[4]
D1674
 
Valdecoxib
 
C16H14N2O3S
 
119607 
Moderate    Inter Info   
[4]
D1703
 
Vitamin E
 
C29H50O2
 
14985 
Moderate    Inter Info   
[5], [8], [2], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [6], [21], [22], [7], [23]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3 Product Information. Cablivi (caplacizumab). Genzyme Corporation, Cambridge, MA.
4 Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
5 Booth SL, Golly I, Sacheck JM, Roubenoff R, Dallal GE, et al "Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status." Am J Clin Nutr 80 (2004): 143-8. [PMID: 15213041]
6 Murohara T, Ikeda H, Otsuka Y, Aoki M, Takajo Y, et al "Inhibition of platelet adherence to Mononuclear cells by alpha-tocopherol: role of P-selection." Circulation 110 (2004): 141-8. [PMID: 15197142]
7 Vitamin K, vitamin E and the coumarin drugs. Nutr Rev 40 (1982): 180-2. [PMID: 7121898]
8 Celestini A, Pulcinelli FM, Pignatelli P, et al. "Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets." Haematologica 87 (2002): 420-6. [PMID: 11940487]
9 Corrigan JJ "The effect of vitamin E on warfarin-induced vitamin K deficiency." Ann N Y Acad Sci 393 (1982): 361-8. [PMID: 6959563]
10 Corrigan JJ, Ulfers LL "Effect of vitamin E on prothrombin levels in warfarin-induced vitamin K deficiency." Am J Clin Nutr 34 (1981): 1701-5. [PMID: 7282596]
11 Freedman JE, Farhat JH, Loscalzo J, Keaney JF "Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C--dependent mechanism." Circulation 94 (1996): 2434-40. [PMID: 8921785]
12 Gonzalez-Correa JA, Arrebola MM, Guerrero A, et al. "Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood." Platelets 16(3-4) (2005): 171-9. [PMID: 16011961]
13 Heck AM, DeWitt BA, Lukes AL "Potential interactions between alternative therapies and warfarin." Am J Health Syst Pharm 57 (2000): 1221-7 quiz 1228-30. [PMID: 10902065]
14 Helson L "The effect of intravenous vitamin E and menadiol sodium diphosphate on vitamin K dependent clotting factors." Thromb Res 35 (1984): 11-8. [PMID: 6474408]
15 Jandak J, Steiner M, Richardson PD "Alpha-tocopherol, an effective inhibitor of platelet adhesion." Blood 73 (1989): 141-9. [PMID: 2910355]
16 Kakishita E, Suehiro A, Oura Y, Nagai K "Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood." Thromb Res 60 (1990): 489-99. [PMID: 2082481]
17 Kim JM, White RH "Effect of vitamin E on the anticoagulant response to warfarin." Am J Cardiol 77 (1996): 545-6. [PMID: 8629604]
18 Liu M, Wallmon A, Olsson-Mortlock C, Wallin R, Saldeen T "Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms." Am J Clin Nutr 77 (2003): 700-6. [PMID: 12600864]
19 Mardla V, Kobzar G, Samel N "Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin." Platelets 15 (2004): 319-24. [PMID: 15370103]
20 Megavitamin E supplementation and vitamin K-dependent carboxylation. Nutr Rev 41 (1983): 268-70. [PMID: 6358960]
21 Schrogie JJ "Coagulopathy and fat-soluble vitamins." JAMA 232 (1975): 19. [PMID: 1172961]
22 Stampfer MJ, Jakubowski JA, Faigel D, Vaillancourt R, Deykin D "Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels." Am J Clin Nutr 47 (1988): 700-6. [PMID: 3128100]
23 Shalansky S, Lynd L, Richardson K, Ingaszewski A, Kerr C "Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis." Pharmacotherapy 27 (2007): 1237-47. [PMID: 17723077]