Details of Drug

Drug General Information (ID: D1349)
Drug Name	Progesterone (topical)
Drug Type	Small molecule
Drug Synonymous	progesterone; 57-83-0; Agolutin; Pregn-4-ene-3,20-dione; Luteohormone; Crinone; 4-Pregnene-3,20-dione; Utrogestan; Syngesterone; Progestin; Luteol; Corpus luteum hormone; Progesterol; Progesteronum; Pregnenedione; Glanducorpin; Prometrium; Corlutin; Cyclogest; Progestron; Gestormone; Progestone; Gestone; Progestasert; Progestronol; Methylpregnone; Hormoflaveine; Syngestrets; Proluton; Progekan; Nalutron; Lutoform; Gynlutin; Gesterol; Fologenon; Corporin; Corlutina; Syntolutan; Prolidon; Membrettes; Lutocyclin; Luteodyn; Lucorteum; Corluvite; LPCN-1107; Progesterone (oral, preterm labor); Progesterone (oral, preterm labor), Lipocine Click to Show/Hide
Disease Class	JB00: Preterm labour/delivery; QA21: Contraceptive management
Therapeutic Class	Progesterone Receptor Modulators
Structure
Structure	3D Structure		2D Structure
Formula	C21H30O2
InChI	1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChIKey	RJKFOVLPORLFTN-LEKSSAKUSA-N
Canonical SMILES	CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
External Link
	Pubchem ID	5994
	CAS Number	57-83-0
	CHEBI ID	17026
	TTD ID	D07BSQ
	INTEDE ID	DR1346
	VARIDT ID	DR00281

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM023 UGT induction BM024 Competitive inhibition of metabolic enzyme BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Progesterone (topical)
Affected cellular transport
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0367		Clotrimazole	C22H17ClN2	2812	Moderate		Inter Info	[7], [8], [9]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[10], [11], [12]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[7], [8], [9]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[13]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[14], [15]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[16]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[17], [18], [19]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[20], [21]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[22]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[23], [24]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[17], [25]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[26], [27]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[28]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[30], [20], [31]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[14], [15]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[34]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[17], [18], [35]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[18], [26], [36]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[7], [8], [9]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[7], [8], [9]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[17], [18], [40]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[17], [18], [41]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[42]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[7], [8], [9]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[18], [43], [44]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[7], [8], [9]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[45]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[17], [46], [47]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[48], [49]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[53]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[54], [49], [55]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[7], [8], [9]
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[60], [61]
D0120		Atorvastatin	C33H35FN2O5	60823	Minor		Inter Info	[62], [63]
	CYP450 enzyme induction					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[4], [5], [6]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[4], [5], [6]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[4], [5], [6]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[4], [5], [6]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[4], [5], [6]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[4], [5], [6]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [5], [6]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[4], [5], [6]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[4], [5], [6]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[4], [5], [6]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[4], [5], [6]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[4], [5], [6]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[4], [5], [6]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[17], [29]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[4], [5], [6]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[4], [5], [6]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[4], [5], [6]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[4], [5], [6]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[4], [5], [6]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [5], [6]
D0741		Griseofulvin	C17H17ClO6	441140	Moderate		Inter Info	[4], [5], [6]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[4], [5], [6]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[4], [5], [6]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[4], [5], [6]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[4], [5], [6]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[4], [5], [6]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[4], [5], [6]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[4], [5], [6]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[4], [5], [6]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[4], [5], [6]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[4], [5], [6]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[4], [5], [6]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[4], [5], [6]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[4], [5], [6]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[4], [5], [6]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[4], [5], [6]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[17], [18], [52]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[17], [18], [52]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[4], [5], [6]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[4], [5], [6]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[4], [5], [6]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[17], [18], [52]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[4], [5], [6]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[56], [57], [58], [59]
	Competitive inhibition of metabolic enzyme					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[17], [32], [33]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[17], [32], [33]
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[50], [51], [49]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[50], [51], [49]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[50], [51], [49]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[1], [2], [3]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[1], [2], [3]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[1], [2], [3]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[1], [2], [3]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[1], [2], [3]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[1], [2], [3]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[1], [2], [3]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[1], [2], [3]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[1], [2], [3]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[1], [2], [3]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[1], [2], [3]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[1], [2], [3]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[1], [2], [3]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[1], [2], [3]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[1], [2], [3]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[1], [2], [3]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[1], [2], [3]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[1], [2], [3]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[1], [2], [3]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[1], [2], [3]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[1], [2], [3]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[1], [2], [3]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[1], [2], [3]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[1], [2], [3]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[1], [2], [3]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[1], [2], [3]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[1], [2], [3]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[1], [2], [3]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[1], [2], [3]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[1], [2], [3]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[1], [2], [3]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[1], [2], [3]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[1], [2], [3]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[1], [2], [3]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[1], [2], [3]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[1], [2], [3]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[1], [2], [3]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[1], [2], [3]
	Antagonize the effect of antihypertensive agents					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[1], [2], [3]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[1], [2], [3]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[37], [38], [39]

References
1	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
2	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
3	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
4	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
5	Dickinson BD, Altman RD, Nielsen NH, Sterling ML "Drug interactions between oral contraceptives and antibiotics." Obstet Gynecol 98(5 Pt 1) (2001): 853-60. [PMID: 11704183]
6	van Dijke CP, Weber JC "Interaction between oral contraceptives and griseofulvin." Br Med J (Clin Res Ed) 288 (1984): 1125-6. [PMID: 2143563]
7	Lazar JD, Wilner KD "Drug interactions with fluconazole." Rev Infect Dis 12 Suppl 3 (1990): s327-33. [PMID: 2330488]
8	Pillans PI, Sparrow MJ "Pregnancy associated with a combined oral contraceptive and itraconazole." N Z Med J 106 (1993): 436. [PMID: 8414287]
9	Weisberg E "Interactions between oral contraceptives and antifungals antibacterials - Is contraceptive failure the result?." Clin Pharmacokinet 36 (1999): 309-13. [PMID: 10384856]
10	Renton KW "Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil." Biochem Pharmacol 34 (1985): 2549-53. [PMID: 4015695]
11	Sakai H, Kobayashi S, Hamada K, et al "The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates." Br J Clin Pharmacol 31 (1991): 353-5. [PMID: 2054276]
12	Sutton D, Butler AM, Nadin L, Murray M "Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites." J Pharmacol Exp Ther 282 (1997): 294-300. [PMID: 9223567]
13	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
14	Product Information. Emend (aprepitant). Merck &amp Company Inc, West Point, PA.
15	Product Information. Emend for Injection (fosaprepitant). Merck &amp Company Inc, West Point, PA.
16	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
17	Cerner Multum, Inc. "Australian Product Information.".
18	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
19	Faculty of Sexual & Reproductive Healthcare "FSRH Clinical Guidance: Drug Interactions with Hormonal Contraception.".
20	Gunston GD, Mehta U "Potentially serious drug interactions with grapefruit juice." S Afr Med J 90 (2000): 41. [PMID: 10721388]
21	Product Information. Vaprisol (conivaptan). Cumberland Pharmaceuticals Inc, Nashville, TN.
22	Product Information. Synercid (dalfopristin-quinupristin) Rhone-Poulenc Rorer, Collegeville, PA.
23	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
24	Schubert W, Eriksson U, Edgar B, Cullberg G, Hedner T "Flavonoids in grapefruit juice inhibit the in vitro hepatic metabolism of 17B-estradiol." Eur J Drug Metab Pharmacokinet 20 (1995): 219-24. [PMID: 8751044]
25	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
26	Product Information. Ambien (zolpidem). sanofi-aventis, Bridgewater, NJ.
27	Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
28	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
29	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
30	Bailey DG, Arnold JMO, Spence JD "Grapefruit juice and drugs - how significant is the interaction." Clin Pharmacokinet 26 (1994): 91-8. [PMID: 8162660]
31	Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
32	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
33	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
34	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
35	Product Information. Gleevec (imatinib mesylate). Novartis Pharmaceuticals, East Hanover, NJ.
36	Product Information. Cresemba (isavuconazonium). Astellas Pharma US, Inc, Deerfield, IL.
37	Wilbur K, Ensom MHH "Pharmacokinetic drug interactions between oral contraceptives and second-generation anticonvulsants." Clin Pharmacokinet 38 (2000): 355-65. [PMID: 10803456]
38	Ohman I, Vitols S, Tomson T "Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation." Epilepsia 41 (2000): 706-13
39	Sidhu J, Job S, Singh S, Philipson R. The pharmacokinetic and pharmacodynamic consequences of the co-administration of lamotrigine and a combined oral contraceptive in healthy female subjects. Br J Clin Pharmacol. 2006 Feb;61(2):191-9.
40	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
41	Product Information. Prevymis (letermovir). Merck &amp Company Inc, Whitehouse Station, NJ.
42	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
43	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
44	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
45	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
46	Product Information. Fortovase (saquinavir) Roche Laboratories, Nutley, NJ.
47	Product Information. Invirase (saquinavir). Roche Laboratories, Nutley, NJ.
48	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
49	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
50	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
51	Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
52	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
53	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
54	Product Information. Ketek (telithromycin). Aventis Pharmaceuticals, Bridgewater, NJ.
55	European Agency for the Evaluation of Medicinal Products. Committee for Proprietary Medicinal Products "European Public Assessment Report Ketek (telithromycin) (Rev. 2) ".
56	Product Information. Depakote (divalproex sodium). Abbott Pharmaceutical, Abbott Park, IL.
57	Product Information. Depacon (valproic acid). Abbott Pharmaceutical, Abbott Park, IL.
58	Herzog AG, Farina EL, Blum AS "Serum valproate levels with oral contraceptive use." Epilepsia 46 (2005): 970-1.
59	Reimers A, Brodtkorb E, Sabers A. "Interactions between hormonal contraception and antiepileptic drugs: Clinical and mechanistic considerations." Seizure. 2015;28:66-70.
60	Product Information. Crixivan (indinavir). Merck &amp Co, Inc, West Point, PA.
61	Shelton MJ, Wynn HE, Newitt RG, DiFrancesco R "Effects of grapefruit juice on pharmacokinetic exposure to indinavir in HIV-positive subjects." J Clin Pharmacol 41 (2001): 435-42. [PMID: 11304900]
62	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
63	Richter WO, Jacob BG, Schwandt P "Interaction between fibre and lovastatin." Lancet 338 (1991): 706. [PMID: 1679514]

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence