Details of Drug

Drug General Information (ID: D1344)
Drug Name	Procaine
Drug Type	Small molecule
Drug Synonymous	Allocaine; Anticort; Anuject; Duracaine; Gerokit; Gerovital; Jenacain; Jenacaine; Nissocaine; Norocaine; Novocain; Novocaine; Procain; Procaina; Procainum; Scurocaine; Spinocaine; Solution of novocain; Factor H3; SP01; SP01A; Stoff H3; Vitamin H3; Anticort (TM); Diethylaminoethyl p-aminobenzoate; Gerovital H-3; Novocain (TN); P-Aminobenzoyldiethylaminoethanol; P-Aminobenzyoyldiethylaminoethanol; Procaina [INN-Spanish]; Procaine (INN); Procaine [INN:BAN]; Procaine, base; Procainum [INN-Latin]; SP-01A; Solution of novocain (TN); Beta-Diethylaminoethyl 4-aminobenzoate; P-Aminobenzoic acid 2-diethylaminoethyl ester; Beta-(Diethylamino)ethyl 4-aminobenzoate; Beta-(Diethylamino)ethyl p-aminobenzoate; BENZOIC ACID,4-AMINO,2-DIETHYLAMINOETHYL ESTER PROCAIN BASE; Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester; Benzoic acid, p-amino-, 2-(diethylamino)ethyl ester; 2-(Diethylamino)ethyl 4-aminobenzoate; 2-(Diethylamino)ethyl p-aminobenzoate; 2-(Diethylamino)ethyl-4-aminobenzoate; 2-Diethylaminoethyl 4-aminobenzoate; 2-Diethylaminoethyl p-aminobenzoate; 2-Diethylaminoethylester kyseliny p-aminobenzoove; 2-Diethylaminoethylester kyseliny p-aminobenzoove [Czech]; 4-Aminobenzoesaeure-beta-diethylaminoethylester; 4-Aminobenzoic acid 2-(diethylamino) ethyl ester; 4-Aminobenzoic acid diethylaminoethyl ester Click to Show/Hide
Disease Class	9A76-9A78: Corneal disease
Therapeutic Class	Anesthetics
Structure
Structure	3D Structure		2D Structure
Formula	C13H20N2O2
InChI	1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3
InChIKey	MFDFERRIHVXMIY-UHFFFAOYSA-N
Canonical SMILES	CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
External Link
	Pubchem ID	4914
	CAS Number	59-46-1
	CHEBI ID	8430
	TTD ID	D0TZ1G

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM071 Increased risk of methemoglobinemia BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Procaine
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0895		Laronidase	NA	NA	Minor		Inter Info	[18], [8], [19]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[7], [8], [13]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[7], [8], [13]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[7], [8], [13]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[7], [8], [13]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[7], [8], [13]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[7], [8], [13]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[7], [8], [13]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[7], [8], [13]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[7], [8], [13]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[7], [8], [13]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[7], [8], [13]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[7], [8], [13]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[7], [8], [13]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[7], [8], [13]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[7], [8], [13]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[7], [8], [13]
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1752		Bupivacaine (liposome)	C18H28N2O	2474	Major		Inter Info	[1], [2]
	Additive neuromuscular blocking effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[15], [16]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[15], [16]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[15], [16]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[15], [16]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[15], [16]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[15], [16]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[15], [16]
	Increased risk of methemoglobinemia					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[3], [4], [5]
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[6], [7], [8], [9], [10], [11], [12]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[8], [9], [14]
D1835		Lidocaine (ophthalmic)	C14H22N2O	3676	Moderate		Inter Info	[8], [9], [14]
D0928		Lidocaine (topical)	C14H22N2O	3676	Moderate		Inter Info	[8], [9], [14]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[8], [9], [14]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[8], [9], [14]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[8], [9], [14]
D1852		Oxybuprocaine (ophthalmic)	C17H28N2O3	4633	Moderate		Inter Info	[8], [9], [14]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[8], [9], [14]
D1514		Sulfadoxine	C12H14N4O4S	17134	Moderate		Inter Info	[8]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Moderate		Inter Info	[8]
D1517		Sulfasalazine	C18H14N4O5S	5339	Moderate		Inter Info	[8]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[8], [9], [14]
D1562		Tetracaine (topical)	C15H24N2O2	5411	Moderate		Inter Info	[8], [9], [14]
D1513		Sulfadiazine	C10H10N4O2S	5215	Moderate		Inter Info	[8]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1909		Tilmanocept	NA	NA	Moderate		Inter Info	[17]

References
1	Product Information. Exparel (bupivacaine liposome). Pacira Pharmaceuticals Inc, San Diego, CA.
2	Kharitonov V "A review of the compatibility of liposome bupivacaine with other drug products and commonly used implant materials." Postgrad Med 126 (2014): 129-38. [PMID: 24393760]
3	Coleman MD, Coleman NA "Drug-induced methaemoglobinaemia: treatment issues." Drug Saf 14 (1996): 394-405. [PMID: 8828017]
4	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
5	Rehman HU "Methemoglobinemia." West J Med 175 (2001): 193-6. [PMID: 11527852]
6	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
7	Cerner Multum, Inc. "Australian Product Information.".
8	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9	Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
10	Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
11	Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
12	Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
13	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
14	Product Information. Hurricaine (benzocaine topical). Beutlich, Waukegan, IL.
15	Multum Information Services, Inc. Expert Review Panel.
16	Product Information. Anectine (succinylcholine). Glaxo Wellcome, Research Triangle Park, NC.
17	Product Information. Lymphoseek (tilmanocept). Navidea Biopharmaceuticals, Dublin, OH.
18	Canadian Pharmacists Association.
19	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".

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