Details of Drug

Details of Drug

 Drug General Information (ID: D1337)
  Drug Name
Prilocaine
  Drug Type Small molecule
  Drug Synonymous
Citanest; Prilocaina; Prilocainum; Propitocaine; Prilocaine [USAN]; Prilocaine base; Astra 1512; Astra 1515; L 67; Citanest (TN); Prilocaina [INN-Spanish]; Prilocainum [INN-Latin]; Propitocaine (JAN); Prilocaine (USP/INN); O-Methyl-2-propylaminopropionanilide; O-Methyl-alpha-propylaminopropionanilide; Alpha-n-Propylamino-2-methylpropionanilide; N-[2-Methylphenyl]-2-[propylamino]propanamide; N-(2-methylphenyl)-N2-propylalaninamide; N-(2-Methylphenyl)-2-(propylamino)propanamide; N-(2-methylphenyl)-N(2)-propylalaninamide; Propanamide, N-(2-methylphenyl)-2-(propylamino)-(9CI); 2-(Propylamino)-o-propionotoluidide; 2-Methyl-.alpha.-propylaminopropionanilide; 2-Methyl-alpha-propylaminopropionanilide
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  Disease Class MG30-MG3Z: Pain
  Therapeutic Class Anesthetics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C13H20N2O
  InChI 1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
  InChIKey MVFGUOIZUNYYSO-UHFFFAOYSA-N
  Canonical SMILES CCCNC(C)C(=O)NC1=CC=CC=C1C
  External Link
Pubchem ID 4906
CAS Number 721-50-6
CHEBI ID 8404
TTD ID D06LYG

Drug-Drug Interaction Network
  Sunburst Graph
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM038  Additive CNS depression effects
BM042  Additive hypotensive effects
BM049  Increased risk of atrioventricular block
BM051  Increased risk of bradycardia
BM071  Increased risk of methemoglobinemia
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Prilocaine
      Pharmacodynamic additive effects
   Additive CNS depression effects Drug Num:  16
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0045
 
Alprazolam
 
C17H13ClN4
 
2118 
Moderate    Inter Info   
[1], [5], [11]
D0317
 
Chlordiazepoxide
 
C16H14ClN3O
 
2712 
Moderate    Inter Info   
[1], [5], [11]
D0356
 
Clobazam
 
C16H13ClN2O2
 
2789 
Moderate    Inter Info   
[1], [5], [11]
D0365
 
Clorazepic acid
 
C16H11ClN2O3
 
2809 
Moderate    Inter Info   
[1], [5], [11]
D0679
 
Flurazepam
 
C21H23ClFN3O
 
3393 
Moderate    Inter Info   
[1], [5], [11]
D0951
 
Lorazepam
 
C15H10Cl2N2O2
 
3958 
Moderate    Inter Info   
[1], [5], [11]
D1060
 
Midazolam
 
C18H13ClFN3
 
4192 
Moderate    Inter Info   
[1], [5], [11]
D0362
 
Clonazepam
 
C15H10ClN3O3
 
2802 
Moderate    Inter Info   
[1], [5], [11]
D0473
 
Diazepam
 
C16H13ClN2O
 
3016 
Moderate    Inter Info   
[1], [5], [11]
D0604
 
Estazolam
 
C16H11ClN4
 
3261 
Moderate    Inter Info   
[1], [5], [11]
D0748
 
Halazepam
 
C17H12ClF3N2O
 
31640 
Moderate    Inter Info   
[1], [5], [11]
D1197
 
Oxazepam
 
C15H11ClN2O2
 
4616 
Moderate    Inter Info   
[1], [5], [11]
D1367
 
Quazepam
 
C17H11ClF4N2S
 
4999 
Moderate    Inter Info   
[1], [5], [11]
D1391
 
Remimazolam
 
C21H19BrN4O2
 
9867812 
Moderate    Inter Info   
[1], [5], [11]
D1632
 
Triazolam
 
C17H12Cl2N4
 
5556 
Moderate    Inter Info   
[1], [5], [11]
D1547
 
Temazepam
 
C16H13ClN2O2
 
5391 
Moderate    Inter Info   
[1], [5], [11]
   Additive hypotensive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1752
 
Bupivacaine (liposome)
 
C18H28N2O
 
2474 
Major    Inter Info   
[9], [10]
   Increased risk of bradycardia Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0513
 
Dofetilide
 
C19H27N3O5S2
 
71329 
Moderate    Inter Info   
[12], [13]
D0787
 
Ibutilide
 
C20H36N2O3S
 
60753 
Moderate    Inter Info   
[12], [13]
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Moderate    Inter Info   
[12], [13]
D0200
 
Bretylium
 
C11H17BrN+
 
2431 
Moderate    Inter Info   
[12], [13]
D1498
 
Sotalol
 
C12H20N2O3S
 
5253 
Moderate    Inter Info   
[12], [13]
   Increased risk of methemoglobinemia Drug Num:  38
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0011
 
Acetaminophen
 
C8H9NO2
 
1983 
Major    Inter Info   
[1], [2], [3]
D0065
 
Aminosalicylic acid
 
C7H7NO3
 
4649 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0218
 
Bupivacaine
 
C18H28N2O
 
2474 
Major    Inter Info   
[1], [5], [8]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0339
 
Cinchocaine (topical)
 
C20H29N3O2
 
3025 
Major    Inter Info   
[1], [2], [3]
D0419
 
Dapsone
 
C12H12N2O2S
 
2955 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0420
 
Dapsone (topical)
 
C12H12N2O2S
 
2955 
Major    Inter Info   
[1], [2], [3]
D0682
 
Flutamide
 
C11H11F3N2O3
 
3397 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0927
 
Lidocaine
 
C14H22N2O
 
3676 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0928
 
Lidocaine (topical)
 
C14H22N2O
 
3676 
Major    Inter Info   
[1], [2], [3]
D1144
 
Nitric Oxide
 
NO
 
145068 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1145
 
Nitrofurantoin
 
C8H6N4O5
 
6604200 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1146
 
Nitroglycerin
 
C3H5N3O9
 
4510 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1147
 
Nitroprusside
 
C5FeN6O
 
11953891 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0083
 
Amyl Nitrite
 
C5H11NO2
 
10026 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0163
 
Benzocaine (topical)
 
C9H11NO2
 
2337 
Major    Inter Info   
[1], [2], [3]
D0622
 
Etidocaine
 
C17H28N2O
 
37497 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0861
 
Isosorbide dinitrate
 
C6H8N2O8
 
6883 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0862
 
Isosorbide mononitrate
 
C6H9NO6
 
27661 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D0916
 
Levobupivacaine
 
C18H28N2O
 
92253 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1004
 
Mepivacaine
 
C15H22N2O
 
4062 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1046
 
Metoclopramide
 
C14H22ClN3O2
 
4168 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1148
 
Nitrous acid
 
HNO2
 
24529 
Major    Inter Info   
[1], [2], [3]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1339
 
Primaquine
 
C15H21N3O
 
4908 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1469
 
Silver nitrate (topical)
 
AgNO3
 
24470 
Major    Inter Info   
[1], [2], [3]
D1470
 
Silver sulfadiazine (topical)
 
C10H9AgN4O2S
 
441244 
Major    Inter Info   
[1], [2], [3]
D1514
 
Sulfadoxine
 
C12H14N4O4S
 
17134 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1530
 
Tafenoquine
 
C24H28F3N3O3
 
115358 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1562
 
Tetracaine (topical)
 
C15H24N2O2
 
5411 
Major    Inter Info   
[1], [2], [3]
D1344
 
Procaine
 
C13H20N2O2
 
4914 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1386
 
Rasburicase
 
NA
 
NA
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1428
 
Ropivacaine
 
C17H26N2O
 
175805 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
D1513
 
Sulfadiazine
 
C10H10N4O2S
 
5215 
Major    Inter Info   
[4], [1], [5], [6], [7], [2], [3]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1909
 
Tilmanocept
 
NA
 
NA
Moderate    Inter Info   
[14]
References
1 Cerner Multum, Inc. "Australian Product Information.".
2 Product Information. Citanest Plain (prilocaine) Astra-Zeneca Pharmaceuticals, Wilmingtoon, DE.
3 Skold A, Cosco DL, Klein R "Methemoglobinemia: pathogenesis, diagnosis, and management." South Med J 104 (2011): 757-61. [PMID: 22024786]
4 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
5 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
6 Guay J "Methemoglobinemia related to local anesthetics: a summary of 242 episodes." Anesth Analg 108 (2009): 837-45. [PMID: 19224791]
7 Product Information. Citanest Forte (epinephrine-prilocaine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
8 Product Information. Zynrelef (bupivacaine-meloxicam). Heron Therapeutics, Redwood City, CA.
9 Product Information. Exparel (bupivacaine liposome). Pacira Pharmaceuticals Inc, San Diego, CA.
10 Kharitonov V "A review of the compatibility of liposome bupivacaine with other drug products and commonly used implant materials." Postgrad Med 126 (2014): 129-38. [PMID: 24393760]
11 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
12 Keidar S, Grenadier E, Palant A "Sinoatrial arrest due to lidocaine injection in sick sinus syndrome during amiodarone administration." Am Heart J 104 (1982): 1384-5. [PMID: 7148661]
13 Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
14 Product Information. Lymphoseek (tilmanocept). Navidea Biopharmaceuticals, Dublin, OH.