Details of Drug

Details of Drug

 Drug General Information (ID: D1336)
  Drug Name
Pretomanid
  Drug Type Small molecule
  Drug Synonymous
PA-824; 187235-37-6; Pretomanid; PA 824; PA824; UNII-2XOI31YC4N; (S)-PA 824; (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine; 2XOI31YC4N; CHEMBL227875; MMV688755; AK161427; (6S)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine; (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine; Pretomanid [USAN:INN]; C14H12F3N3O5; PA-824(Pretomanid); AC1L9UFX; Pretomanid (USAN/INN); MLS006011141; SCHEMBL2983011
    Click to Show/Hide
  Disease Class 1B10-1B21: Mycobacterium infection; 1B10-1B14: HIV-infected patients with tuberculosis
  Therapeutic Class Antituberculosis Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C14H12F3N3O5
  InChI 1S/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1
  InChIKey ZLHZLMOSPGACSZ-NSHDSACASA-N
  Canonical SMILES C1C(COC2=NC(=CN21)[N+](=O)[O-])OCC3=CC=C(C=C3)OC(F)(F)F
  External Link
Pubchem ID 456199
CAS Number 187235-37-6
TTD ID D02AYL
INTEDE ID DR1338

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
  Relation Graph
 Full list of drugs interacting with Pretomanid
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[3]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[4], [5], [6]
   CYP450 enzyme induction Drug Num:  30
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Major    Inter Info   
[1]
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Major    Inter Info   
[1]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Major    Inter Info   
[1]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[1]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Major    Inter Info   
[1]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Major    Inter Info   
[1]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Major    Inter Info   
[1]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Major    Inter Info   
[1]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Major    Inter Info   
[1]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[1]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[1]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[1]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Major    Inter Info   
[1]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Major    Inter Info   
[1]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[1]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Major    Inter Info   
[1]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Major    Inter Info   
[1]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Major    Inter Info   
[1]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Major    Inter Info   
[2], [1]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Major    Inter Info   
[1]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Major    Inter Info   
[1]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Major    Inter Info   
[2], [1]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Major    Inter Info   
[1]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Major    Inter Info   
[1]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[2], [1]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Major    Inter Info   
[1]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[1]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[7], [8], [9]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[7], [8], [10], [9]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[7], [8], [9]
References
1 Product Information. Pretomanid (pretomanid). The Global Alliance for TB Drug Development, New York, NY.
2 Patel S, Robinson R, Burk M "Hypertensive crisis associated with St. John's Wort." Am J Med 112 (2002): 507-8. [PMID: 11959071]
3 Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
4 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
5 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
6 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
7 Cerner Multum, Inc. "Australian Product Information.".
8 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
9 Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
10 Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.