Details of Drug

Details of Drug

 Drug General Information (ID: D1330)
  Drug Name
Praziquantel
  Drug Type Small molecule
  Drug Synonymous
Azinox; Biliricide; Biltricide; Cesol; Cisticid; Cutter; Cysticide; Droncit; Drontsit; Prasiquantel; Praziquantelum; Pyquiton; Traziquantel; Bayer Brand of Praziquantel; Cutter Tape Tabs; Merck Brand of Praziquantel; Embay 8440; P 4668; Bay-8440; Biltricide (TN); EMBAY-8440; NPFAPI-02; Praziquantelum [INN-Latin]; Biltricide, Droncit, Praziquantel; Praziquantel (JAN/USP/INN); Praziquantel [USAN:INN:BAN:JAN]; Praziquantel, (R)-Isomer; Praziquantel, (S)-Isomer; Praziquantel, (+-)-Isomer; (+-)-2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1a)isoquinolin-4-one; (11bS)-2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one; 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]-isoquinolin-4-one; 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino(2,1a)isoquinolin-4-one; 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazinoe(2,1a)isoquinolin-4-one; 2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one; 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one; 2-Cyclohexanecarbonyl-1,2,3,6,7,11b-hexahydro-pyrazino[2,1-a]isoquinolin-4-one; 2-Cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a) isoquinolin-4-one; 8440, EMBAY
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  Disease Class 1F70-1F86: Flatworm infection
  Therapeutic Class Anthelmintics
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C19H24N2O2
  InChI 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
  InChIKey FSVJFNAIGNNGKK-UHFFFAOYSA-N
  Canonical SMILES C1CCC(CC1)C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2
  External Link
Pubchem ID 4891
CAS Number 55268-74-1
CHEBI ID 91583
TTD ID D0L9ZR
INTEDE ID DR1329

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM024  Competitive inhibition of metabolic enzyme
  Relation Graph
 Full list of drugs interacting with Praziquantel
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[16], [17], [18]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  16
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[6]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Moderate    Inter Info   
[7]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Moderate    Inter Info   
[8]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[10], [11]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[14]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[15]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Moderate    Inter Info   
[10], [19]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Moderate    Inter Info   
[20], [2], [21], [22], [23], [24], [25], [26], [27]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[2], [10], [28]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[29]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Moderate    Inter Info   
[30]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Moderate    Inter Info   
[31]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Moderate    Inter Info   
[32], [33], [34], [35], [36], [37], [38], [39], [40]
D1432
 
Rucaparib
 
C19H18FN3O
 
9931954 
Moderate    Inter Info   
[41]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[10], [42]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Moderate    Inter Info   
[43]
   CYP450 enzyme induction Drug Num:  59
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0255
 
Carbamazepine
 
C15H12N2O
 
2554 
Major    Inter Info   
[1], [2], [3], [4]
D1078
 
Mitotane
 
C14H10Cl4
 
4211 
Major    Inter Info   
[1], [2], [3], [4]
D1283
 
Phenytoin
 
C15H12N2O2
 
1775 
Major    Inter Info   
[1], [2], [3], [4]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Major    Inter Info   
[1], [2], [3], [4]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Major    Inter Info   
[1], [2], [3], [4]
D0697
 
Fosphenytoin
 
C16H15N2O6P
 
56339 
Major    Inter Info   
[1], [2], [3], [4]
D0958
 
Lumacaftor
 
C24H18F2N2O5
 
16678941 
Major    Inter Info   
[2], [3], [4]
D1265
 
Phenobarbital
 
C12H12N2O3
 
4763 
Major    Inter Info   
[1], [2], [3], [4]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Major    Inter Info   
[1], [2], [3], [4]
D1502
 
St. John's Wort
 
NA
 
NA
Major    Inter Info   
[1], [2], [3], [4]
D1340
 
Primidone
 
C12H14N2O2
 
4909 
Major    Inter Info   
[1], [2], [3], [4]
D1399
 
Rifabutin
 
C46H62N4O11
 
135398743 
Major    Inter Info   
[1], [2], [3], [4]
D1400
 
Rifampicin
 
C43H58N4O12
 
135398735 
Major    Inter Info   
[5], [3], [4]
D0061
 
Aminoglutethimide
 
C13H16N2O2
 
2145 
Moderate    Inter Info   
[1], [2], [3], [4]
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Moderate    Inter Info   
[1], [2], [3], [4]
D0194
 
Bosentan
 
C27H29N5O6S
 
104865 
Moderate    Inter Info   
[1], [2], [3], [4]
D0224
 
Butabarbital
 
C10H16N2O3
 
2479 
Moderate    Inter Info   
[1], [2], [3], [4]
D0225
 
Butalbital
 
C11H16N2O3
 
2481 
Moderate    Inter Info   
[1], [2], [3], [4]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[1], [2], [3], [4]
D0639
 
Felbamate
 
C11H14N2O4
 
3331 
Moderate    Inter Info   
[1], [2], [3], [4]
D0741
 
Griseofulvin
 
C17H17ClO6
 
441140 
Moderate    Inter Info   
[1], [2], [3], [4]
D1040
 
Methylphenobarbital
 
C13H14N2O3
 
8271 
Moderate    Inter Info   
[1], [2], [4]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Moderate    Inter Info   
[1], [2], [3], [4]
D1099
 
Nafcillin
 
C21H22N2O5S
 
8982 
Moderate    Inter Info   
[1], [2], [3], [4]
D1128
 
Nevirapine
 
C15H14N4O
 
4463 
Moderate    Inter Info   
[1], [2], [3], [4]
D1198
 
Oxcarbazepine
 
C15H12N2O2
 
34312 
Moderate    Inter Info   
[1], [2], [3], [4]
D1248
 
Pentobarbital
 
C11H18N2O3
 
4737 
Moderate    Inter Info   
[1], [2], [3], [4]
D1274
 
Phenylbutazone
 
C19H20N2O2
 
4781 
Moderate    Inter Info   
[1], [2], [3], [4]
D0071
 
Amobarbital
 
C11H18N2O3
 
2164 
Moderate    Inter Info   
[1], [2], [3], [4]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Moderate    Inter Info   
[1], [2], [3], [4]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[1], [2], [3], [4]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[1], [2], [3], [4]
D0406
 
Dabrafenib
 
C23H20F3N5O2S2
 
44462760 
Moderate    Inter Info   
[1], [2], [3], [4]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[1], [2], [3], [4]
D0453
 
Dexamethasone
 
C22H29FO5
 
5743 
Moderate    Inter Info   
[1], [2], [3], [4]
D0518
 
Doravirine
 
C17H11ClF3N5O3
 
58460047 
Moderate    Inter Info   
[1], [2], [3], [4]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[2], [9]
D0555
 
Elagolix
 
C32H30F5N3O5
 
11250647 
Moderate    Inter Info   
[1], [2], [3], [4]
D0601
 
Eslicarbazepine
 
C15H14N2O2
 
9881504 
Moderate    Inter Info   
[1], [2], [3], [4]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[1], [2], [3], [4]
D0732
 
Glycerol phenylbutyrate
 
C33H38O6
 
10482134 
Moderate    Inter Info   
[1], [2], [3], [4]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[1], [2], [3], [4]
D0901
 
Lemborexant
 
C22H20F2N4O2
 
56944144 
Moderate    Inter Info   
[1], [2], [4]
D0905
 
Lesinurad
 
C17H14BrN3O2S
 
53465279 
Moderate    Inter Info   
[1], [2], [3], [4]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[1], [2], [3], [4]
D1050
 
Metreleptin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [3], [4]
D1186
 
Oritavancin
 
C86H97Cl3N10O26
 
16136912 
Moderate    Inter Info   
[1], [2], [3], [4]
D1258
 
Pexidartinib
 
C20H15ClF3N5
 
25151352 
Moderate    Inter Info   
[1], [2], [3], [4]
D1302
 
Pitolisant
 
C17H26ClNO
 
9948102 
Moderate    Inter Info   
[1], [2], [3], [4]
D1433
 
Rufinamide
 
C10H8F2N4O
 
129228 
Moderate    Inter Info   
[1], [2], [3], [4]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[1], [2], [4]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[1], [2], [3], [4]
D1518
 
Sulfinpyrazone
 
C23H20N2O3S
 
5342 
Moderate    Inter Info   
[1], [2], [3], [4]
D1538
 
Tazemetostat
 
C34H44N4O4
 
66558664 
Moderate    Inter Info   
[1], [2], [3], [4]
D1546
 
Telotristat ethyl
 
C27H26ClF3N6O3
 
25181577 
Moderate    Inter Info   
[1], [2], [4]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Moderate    Inter Info   
[1], [2], [3], [4]
D1453
 
Secobarbital
 
C12H18N2O3
 
5193 
Moderate    Inter Info   
[1], [2], [3], [4]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[1], [2], [4]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[1], [2], [3], [4]
   Competitive inhibition of metabolic enzyme Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0696
 
Fosnetupitant
 
C31H35F6N4O5P
 
71544786 
Moderate    Inter Info   
[2], [12], [13]
D1127
 
Netupitant
 
C30H32F6N4O
 
6451149 
Moderate    Inter Info   
[2], [12], [13]
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