Details of Drug

Drug General Information (ID: D1305)
Drug Name	Plicamycin
Drug Type	Small molecule
Drug Synonymous	A-2371; NSC24559; PA-144; MTM A; AC1O3EQZ; CHEMBL413720; SCHEMBL14066059; NSC-24559; AKOS030213136; EC-7071; CCG-208236; NCGC00160390-01; NCI60_004287; AB01273958-01 Click to Show/Hide
Disease Class	2C25: Lung cancer; 2C73: Ovarian cancer; 2C80: Testicular cancer; 5B91: Mineral excesses; 2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C52H76O24
InChI	1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3/t19-,20-,21-,22-,23-,24-,27+,28-,30-,31-,32-,33+,34+,35+,36+,37+,41+,42-,43-,44-,45+,49+,50+,51-,52+/m1/s1
InChIKey	CFCUWKMKBJTWLW-BKHRDMLASA-N
Canonical SMILES	CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
External Link
	Pubchem ID	163659
	CAS Number	18378-89-7
	CHEBI ID	31856
	TTD ID	D06EPF
	VARIDT ID	DR01399

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM050 Increased risk of bleeding BM063 Increased risk of hypocalcemia BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Plicamycin
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[146]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[146]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[146]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[146]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[146]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[146]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[146]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[146]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[146]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[24], [25]
D1111		Natalizumab	NA	NA	Major		Inter Info	[26]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[28], [7], [31]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[38]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [46]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[28], [50]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[24], [25]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[54]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[55]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[51], [66], [67]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[68]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[69], [70], [71]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[69], [70], [71]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[28], [7], [75]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[28], [7], [75]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[114]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[127]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[131]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[131]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[131]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[136]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[7], [137]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[28], [7], [138]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[69], [70], [71]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[7], [143]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[144]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[145]
	Additive myelosuppressive effects					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[7], [9]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[7], [10], [11]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[28], [35], [36]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[59]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[28], [7]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[28], [7], [125], [126]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[28], [7], [125], [126]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[60], [61], [62]
	Increased risk of bleeding					Drug Num: 52
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0096		Apixaban	C25H25N5O4	10182969	Major		Inter Info	[7], [8]
D0414		Dalteparin	C26H42N2O37S5	772	Major		Inter Info	[12], [13], [14], [15], [16], [17], [18]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[19]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[20], [21]
D0537		Drotrecogin alfa	NA	NA	Major		Inter Info	[22]
D0574		Enoxaparin	C26H42N2O37S5	772	Major		Inter Info	[12], [13], [14], [15], [16], [17], [18]
D0690		Fondaparinux	C31H53N3O49S8	5282448	Major		Inter Info	[12], [13], [14], [15], [16], [17], [18]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[23]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[20], [27]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[28], [7], [29]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[7], [30]
D0176		Betrixaban	C23H22ClN5O3	10275777	Major		Inter Info	[32], [33]
D0230		Cabozantinib	C28H24FN3O5	25102847	Major		Inter Info	[34]
D0551		Edoxaban	C24H30ClN7O4S	10280735	Major		Inter Info	[37]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[39], [40], [7], [41]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[7], [20], [42]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[47]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[7], [48], [49]
D1328		Prasugrel	C20H20FNO3S	6918456	Major		Inter Info	[7], [56]
D1380		Ramucirumab	NA	NA	Major		Inter Info	[57]
D1417		Rivaroxaban	C19H18ClN3O5S	9875401	Major		Inter Info	[58]
D1592		Tipranavir	C31H33F3N2O5S	54682461	Major		Inter Info	[63]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[64], [65]
D0211		Bromfenac (ophthalmic)	C15H12BrNO3	60726	Moderate		Inter Info	[72], [73], [74]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1769		Deoxycholic acid	C24H40O4	222528	Moderate		Inter Info	[20], [115]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0477		Diclofenac (ophthalmic)	C14H11Cl2NO2	3033	Moderate		Inter Info	[72], [73], [74]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Moderate		Inter Info	[72], [73], [74]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[72], [73], [74]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[116], [117], [118]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0681		Flurbiprofen (ophthalmic)	C15H13FO2	3394	Moderate		Inter Info	[72], [73], [74]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[116], [117], [118]
D0883		Ketorolac (ophthalmic)	C15H13NO3	3826	Moderate		Inter Info	[72], [73], [74]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1123		Nepafenac (ophthalmic)	C15H14N2O2	151075	Moderate		Inter Info	[72], [73], [74]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1249		Pentosan polysulfate	C10H18O21S4	37720	Moderate		Inter Info	[20], [128]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1579		Ticagrelor	C23H28F2N6O4S	9871419	Moderate		Inter Info	[7], [139]
D1708		Vortioxetine	C18H22N2S	9966051	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[79], [108], [109]
D1523		Suprofen (ophthalmic)	C14H12O3S	5359	Moderate		Inter Info	[72], [73], [74]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[116], [117], [118]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[76], [77], [78], [79], [28], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113]
D0253		Capsicum	NA	NA	Minor		Inter Info	[147]
D0309		Chamomile	C15H10O5	5280443	Minor		Inter Info	[147], [148], [149]
	Increased risk of hypocalcemia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[122], [123], [124]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[132]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[43], [44], [45]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[43], [44], [45]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[43], [44], [45]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[51], [28], [52]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[53]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[43], [44], [45]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[43], [44], [45]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[43], [44], [45]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[51], [129], [130]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[51], [129], [130]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[51], [129], [130]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[51], [129], [130]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[51], [129], [130]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[51], [129], [130]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[51], [129], [130]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[51], [129], [130]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[51], [129], [130]
	Antagonize the effect of probiotics					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[133], [134], [135]
	Diminish the response to diagnostic skin test antigens					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[140], [141], [142]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[140], [141], [142]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[119], [120], [121]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[119], [120], [121]

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27	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
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30	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
31	Product Information. Olumiant (baricitinib). Lilly, Eli and Company, Indianapolis, IN.
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96	Product Information. Celexa (citalopram). Forest Pharmaceuticals, St. Louis, MO.
97	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
98	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
99	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
100	Product Information. Lexapro (escitalopram). Forest Pharmaceuticals, St. Louis, MO.
101	Product Information. Luvox (fluvoxamine). Solvay Pharmaceuticals Inc, Marietta, GA.
102	Product Information. Paxil (paroxetine). GlaxoSmithKline, Research Triangle Park, NC.
103	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
104	Product Information. Prozac (fluoxetine). Dista Products Company, Indianapolis, IN.
105	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
106	Product Information. Viibryd (vilazodone). Trovis Pharmaceuticals LLC, New Haven, CT.
107	Product Information. Zoloft (sertraline). Roerig Division, New York, NY.
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115	Product Information. Kybella (deoxycholic acid). Kythera Biopharmaceuticals, Inc., Westlake Village, CA.
116	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
117	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
118	Product Information. Ventavis (iloprost). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
119	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
120	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
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126	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
127	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
128	Product Information. Elmiron (pentosan polysulfate sodium). Baker Norton Pharmaceuticals, Miami, FL.
129	Product Information. Imovax Rabies (rabies vaccine). sanofi pasteur, Swiftwater, PA.
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132	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
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137	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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139	Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
140	Product Information. Tuberculin PPD (Mantoux) (tuberculin purified protein derivative). Connaught Laboratories Ltd, Toronto, ON.
141	Product Information. Candin (candida albicans extract). Nielsen Biosciences Inc, San Diego, CA.
142	Product Information. Spherulin (coccidioidin skin test). ALK Laboratories Inc, Wallingford, CT.
143	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
144	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
145	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
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