Details of Drug

Drug General Information (ID: D1299)
Drug Name	Pirfenidone
Drug Type	Small molecule
Drug Synonymous	Deskar; Esbriet; Pirespa; Pirfenidona; Pirfenidonum; AMR 69; P 2116; AMR-69; F-647; KS-5041; Pirfenidona [INN-Spanish]; Pirfenidone (Deskar); Pirfenidone [USAN:INN]; Pirfenidonum [INN-Latin]; S-7701; Pirfenidone (JAN/USAN/INN); 5-Methyl-1-phenyl-1H-pyridin-2-one; 5-Methyl-1-phenyl-2(1H)-pyridone; 5-Methyl-1-phenyl-2-(1H)-pyridone; 5-methyl-1-phenylpyridin-2(1H)-one; 5-methyl-1-phenylpyridin-2-one Click to Show/Hide
Disease Class	CB03: Idiopathic interstitial pneumonitis
Therapeutic Class	Pulmonary Fibrosis Inhibitors
Structure
Structure	3D Structure		2D Structure
Formula	C12H11NO
InChI	1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChIKey	ISWRGOKTTBVCFA-UHFFFAOYSA-N
Canonical SMILES	CC1=CN(C(=O)C=C1)C2=CC=CC=C2
External Link
	Pubchem ID	40632
	CAS Number	53179-13-8
	CHEBI ID	32016
	TTD ID	D02WCI
	INTEDE ID	DR1299

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity BM075 Increased risk of photosensitivity reactions
Relation Graph

Full list of drugs interacting with Pirfenidone
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 69
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[3], [4], [5]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[4], [5]
D0573		Enoxacin	C15H17FN4O3	3229	Major		Inter Info	[4], [5]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[4], [5]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[3], [4], [5]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[3], [4], [5]
D1189		Osilodrostat	C13H10FN3	44139752	Major		Inter Info	[3], [4], [5]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[3], [4], [5]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[3], [4], [5]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[4], [5]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[4], [5], [24]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[4], [5], [24]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[4], [5], [24]
D0338		Cinacalcet	C22H22F3N	156419	Moderate		Inter Info	[4], [5], [24]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[4], [5]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[4], [5], [24]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[4], [5], [24]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[4], [5], [24]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[4], [5], [24]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[4], [5], [24]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[4], [5]
D0642		Fenofibrate	C20H21ClO4	3339	Moderate		Inter Info	[4], [5], [24]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[4], [5], [24]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[4], [5], [24]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[4], [5], [24]
D0715		Gemfibrozil	C15H22O3	3463	Moderate		Inter Info	[4], [5], [24]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[4], [5], [24]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[4], [5], [24]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[4], [5], [24]
D0907		Letrozole	C17H11N5	3902	Moderate		Inter Info	[4], [5], [24]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[4], [5], [24]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[4], [5]
D1054		Mexiletine	C11H17NO	4178	Moderate		Inter Info	[4], [5]
D1057		Miconazole	C18H14Cl4N2O	4189	Moderate		Inter Info	[4], [5], [24]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[4], [5], [24]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[4], [5], [24]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[4], [5], [24]
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[4], [5], [24]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[4], [5], [24]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[4], [5], [24]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[34]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[4], [5], [24]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[36]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[4], [5], [24]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[3], [4], [39]
D0409		Dacomitinib	C24H25ClFN5O2	11511120	Moderate		Inter Info	[4], [5], [24]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[4], [5], [24]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[4], [5], [24]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[4], [5], [24]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[4], [5], [24]
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[4], [40]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[42], [43], [44], [45]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[4], [5], [24]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Moderate		Inter Info	[4], [5], [48]
D1074		Mirabegron	C21H24N4O2S	9865528	Moderate		Inter Info	[4], [5], [24]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[4], [5]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[4], [5], [24]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[4], [5], [24]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[4], [5], [24]
D1339		Primaquine	C15H21N3O	4908	Moderate		Inter Info	[4], [5]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[4], [5], [24]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[4], [5], [24]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[4], [5], [24]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[4], [5], [24]
D1571		Thiabendazole	C10H7N3S	5430	Moderate		Inter Info	[4], [5]
D1581		Ticlopidine	C14H14ClNS	5472	Moderate		Inter Info	[4], [5]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[4], [5], [24]
D1721		Zileuton	C11H12N2O2S	60490	Moderate		Inter Info	[4], [5]
D0193		Bortezomib	C19H25BN4O4	387447	Minor		Inter Info	[59]
	CYP450 enzyme induction					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[4], [5]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [5]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [5]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[46]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[3], [4], [47]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[4], [5]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[6], [7], [8]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[9]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[10]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[11]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[6], [7], [8]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[13], [14], [15], [3], [4], [16], [17], [18], [19], [20], [21], [22], [23]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[25]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[26], [27]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[28], [29], [30], [31]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[28], [29], [30], [31]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[4], [32]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[33]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[13], [14], [15], [3], [4], [16], [17], [18], [19], [20], [21], [22], [23]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[13], [14], [15], [3], [4], [16], [17], [18], [19], [20], [21], [22], [23]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[35]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[37]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[13], [14], [15], [3], [4], [16], [17], [18], [19], [20], [21], [22], [23]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[4], [38]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[41]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[28], [29], [30], [31]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[3], [4], [49], [50], [51]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[4], [52]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[55], [56]
	Increased risk of photosensitivity reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[1], [2]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[3], [4], [12]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[3], [4], [12]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[53], [4], [54]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[4], [57], [1], [58]

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